|
| |
|
DR. T. NARENDER |
|
 |
Scientist-E-I
Medicinal and Process Chemistry Division
Central Drug Research Institute
Lucknow-226 001 (U.P), India |
| Educational Qualifications |
M Sc., B Ed., Ph.D. |
| Phone No. |
+91-0522-2612411-18 Ext:
4440 |
| Fax No. |
+91-0522-2623405, 2623938 |
| E-Mail |
t_narendra@cdri.res.in |
| Date of Birth |
20.06.1969 |
|
| |
| RESEARCH
EXPERIENCE |
| |
|
|
Natural Products Chemistry (Medicinal plants, Marine organisms,
Marine bacteria and fungus) |
|
| |
| POST-DOCTORAL
EXPERIENCE |
| |
|
|
One year at Scripps Institution of Oceanography, University
of California, San Diego, USA from March 2007 to April
2008 with Prof. William Fenical on Marine microorganisms
(bacteria and fungus) |
|
| |
| AWARDS |
| |
|
|
DST, New Delhi awarded BOYSCAST fellowship |
|
CDRI Incentive
Award in the years 2008 |
|
| |
| RESEARCH
GROUP |
1. Dr.
Shweta (Currently Post-Doc at Turku University, Finland)
2. Dr. Tanvir Khaliq (Currently Post-Doc at Washington University,
USA)
3. Mr. Papi Reddy (Currently Post-Doc at Portland State
University, USA)
4. Mr. Satinath Sarkar (JRF)
5. Mr. Gaurav Madhur (JRF)
6. Mr. Sriniwas Tiwari (JRF)
7. Mr. Venkateswarlu (JRF)
8. Mr. Vinay Kumar Singh (JRF)
9. Mr. K. Rajendar (JRF)
10. Mr. Prasanta Ghosal (JRF)
11. Mr. J.P.Chaturvedi (TO)
|
| |
| |
| CURRENT
AREAS OF INTEREST |
| Written
records of the use of natural products as medicinal agents date
back thousands of years. The oldest records come from Mesopotamia
and date from about 2600 BC, however, it was not until the early
1800’s that the active principles from plants were isolated.
Natural products isolated from plants, animals and microorganisms
have made an important impact on curing the dreadful diseases
for example taxol, vinca alkaloids, podophyllotoxins camptothecin
derivatives for cancer treatment; pencillins, streptomycins,
tetracyclines as antibiotics; quinine and artemisinin for malaria
treatment. Our
major research activities are identification of biologically
active lead molecules through activity guided fraction and
isolation work on the medicinal plants, marine organisms and
microorganisms for metabolic diseases (hyperglycemia, dyslipidemia),
parasitic diseases (leishmania and malaria), cancer, HIV etc.,
and chemical transformation of natural products of biological
importance to improve their potency. We synthesize these biologically
active lead molecules and their analogues in our laboratory.
During this process we develop new methods for the synthesis
of bioactive compounds and exploit some reagents to perform
selective functions in the synthesis of biologically active
compounds. We also isolate new chemical constituents from
plants, marine organisms, microorganisms and elucidate their
complex chemical structures by using modern 2D-NMR techniques
such as COSY, HSQC, HMBC, NOESY, ROESY etc.
|
| Antihyperglycemic
and Antidyslipidemic Agents
Obesity,
insulin resistance (Diabetes) and dyslipidemia are generally
found as a part of a complex mixture of metabolic abnormalities
collectively known as the metabolic syndrome. As a part of
our natural products program we identified few lead molecules
from Indian medicinal plants for metabolic disorder diseases
for example Aegeline, an alkaloidal amide isolated from the
leaves of Aegle marmelos (bael), exhibits the potent lipid
lowering activity and mild antihyperglycemic activity; 4-hydroxyisoleucine
an unusual amino acid from Trigonella foenum graecum (methi
seeds) exhibits dual activity (antidyslipidemic and antihyperglycemic).
terpenoid derivatives (a-amyrin and lupeol) exhibits antihyperglycemic
activity. Modified furanoflavonoids (pseudosemiglabrin and
semiglabrin) isolated from Indigofera tinctoria showed good
lipid lowering activity.
|
 |
|
|
|
|
|
|
|
| Antihyperglycemic
and Antidyslipidemic Agents
The
protozoan parasite Leishmania cause a broad spectrum of diseases
ranging from cutaneous healing skin lesions caused by L. major
to a fatal visceral form called kala azar caused by L. donovani.
We identified an orally active antileishmnaial agent i. e.,
Peganine from the seeds of Peganum harmala. It induces apoptosis-
like cell death in L. donovani. The binding interactions between
peganine and DNA topoisomerase I in molecular modeling studies
(docking) and experimental studies suggested that the apoptosis
like cell death appears to be due to L. donovani’s topoisomerase
I inhibition. We also obtained few natural chromenodihydrochalcones,
which exhibits antileishmanial activity in in-vitro studies.
We synthesized several analogues of these chalcones and studied
their in-vitro and in-vivo antileishmanial activity.
|
|
|
|
|
|
|
 |
|
|
| Anticancer
taxanes
In
continuation of our drug discovery program on anticancer agents
we isolated 2-deacetoxytaxinine J (2-DAT-J) in reasonably
good yield (0.1%) from the Indian T. baccata (ssp. wallichiana).
It has effects on the Ca2+ induced microtubule depolymerization.
2-DAT-J is a powerful inhibitor of P-glycoprotein (P-gp) activity,
acting as efficient reversing agent in multi-drug resistant
(MDR) cancer cells. |
|
|
|
 |
|
|
|
|
|
| Anti
HIV coumarins
Recently we initiated research work on the
calanolide class of compounds, which are known for their HIV
reverse transcriptase inhibiting activity. We isolated few
coumarins from Calophyllum inophyllum to develop anti HIV
and anti TB compounds.
|
|
|
|
 |
|
|
|
|
|
| We also isolate novel
compounds from natural sources and identify their complex
chemical structures using modern NMR tools. For example we
isolated few novel limonoids from
Xylocarpus molluccensis,a triterpene from Peganum harmala
and bisuracil derivative from marine sea hare (Dolabella auricularia).
|
 |
|
|
|
|
|
|
|
| |
| |
| SELECTED
PUBLICATIONS |
| |
|
T.Narender,
K.P.Reddy, and G. Madhur. Synthesis of (E)-Stilbenes and
(E,E)-1,4-Diphenylbuta-1,3-diene promoted by Borontrifluoride-etherate
complex. Synthesis 2009, 22, 3791-3796. |
|
T. Narender,
T. Khaliq, A.B. Singh, M.D. Joshi, P. Mishra, J.P. Chaturvedi,
A.K. Srivastava, R. Maurya, S.C. Agarwal. Synthesis of
a-amyrin derivatives and their in vivo antihyperglycemic
activity. European Journal of Medicinal Chemistry
2009, 44, 1215-1222. |
|
Tanvir Khaliq, Pragya
Misra, Swati Gupta, K. Papi Reddy, Ruchir Kant, P. R.
Maulik, Anuradha Dube and T. Narender.
Peganine hydrochloride dehydrate an orally active antileishmanial
agent. Bioorg. Med. Chem. Lett. 2009,
19, 2585-2586 |
|
K. Papi Reddy, Hemant
K Bid, V. Lakshma Nayak, Preeti Choudhury, J. P. Chaturvedi,
K. R. Arya, Rituraj Konwar, T. Narender
In vitro and in vivo anticancer activity
of 2-deacetoxytaxinine J and synthesis of novel taxoids
and their in vitro anticancer activity. Europ.
J. Med.Chem. 2009, 44, 3947-3953. |
|
K. Papi Reddy, A. B. Singh,
A. Puri, A. K. Srivastava and T. Narender
Synthesis of novel Triterpenoid (Lupeol) derivatives and
their in vivo Antihyperglycemic and Antidyslipidemic
activity Bioorg. and Med. Chem. Lett. 2009,
19, 4463-4466. |
|
T. Narender,
K. Papi Reddy and Shweta.BF3.OEt2 mediated One-pot Synthesis
of Acetylchromans from Polyhydroxyacetophenones and Isoprene/Allylalcohol.
Synthetic Communications. 2009, 39, 384-394. |
|
T. Narender, K. Papi Reddy
and G. Madhur. NaOAc mediated selective deprotection of
aromatic acetates and its application in the synthesis
of natural products. Synthetic Communications
2009, 39, 1949-1956. |
|
Misra Pragya, Khaliq Tanvir,
Dixit Anshuman, Sengupta Souvik, Samant Mukesh, Kumari
Shraddha, Kumar Awanish, Kushawaha Pramod, Majumder Hemanta,
Saxena Anil, Narender T and Dube Anuradha.
Antileishmanial activity mediated by apoptosis and structure
based target study of Peganine hydrochloride dihydrate:
An approach for rational drug designing Journal
of Antimicrobial Chemotherapy, 2008, 62, 998-1002. |
|
T. Narender, * T. Khaliq
and Shweta 13C-NMR Spectroscopy of B,D-Ring Seco Limonoids
of Meliaceae family. Natural Product Research. 2008,
22, 763,-800. |
|
T. Narender,*
K. Papi Reddy, Brijesh Kumar. BF3.OEt2 mediated regioselective
deacetylation of polyacetoxyacetophenones and its application
in the synthesis of natural products. Tetrahedron
Letters 2008, 49, 4409–4415. |
|
A. Sankaranarayanan, T.
Narender, S.Kumar and M. Dikshit. Allium sativum
constituents: effect on free radical generation from rat
neutrophils. Cellular and Molecular Biology 2007,
53, 63-67. |
|
T. Narender*
and K. Papi Reddy. A simple and highly efficient method
for the synthesis of chalcones by using borontrifluoride-etherate.
Tetrahedron Letters 2007, 48, 3177–3180.
(This article ranked 3 out of 25 hottest articles listed
by Elsevier publications during the period of second quarter
of the year 2007, April-June) |
|
T. Narender*
and K. Papi Reddy. BF3.OEt2 mediated biogenetic type synthesis
of chromanochalcones from prenylated chalcones via a regioselective
cyclization reaction. Tetrahedron Letters 2007,
48, 7628–7632. |
|
T. Narender,*
K. Papi Reddy, Shweta, Kumkum Srivastava, D. K. Mishra
and S. K. Puri. Total Synthesis of Munchiwarin, a Triprenylated
Chalcone from Crotalaria medicagenia. Organic
letters 2007, 9, 5369-5372. |
|
K.V.Shashidhara,* N. Rosiah,
T. Narender*. Highly Efficient and Regioselective
Synthesis of 7-Hydroxy-4-methyl-2-oxo-2H-benzo[h]chromene-8,10
dicarbaldehyde’s and 1-Hydroxynaphthalene-2,4-dicarbaldehyde’s
Keto-Enamine Schiff bases. Tetrahedron Letters.
2007, 48, 1699-1702. |
|
T. Narender* and T. Khaliq.
A New Triterpenoid from Peganum harmala. Natural Products
Communications 2007, 2, 1079-1081. |
|
T. Narender,*
T. Khaliq, Shweta, K.Papi Reddy, R.K. Sharma Occurrence,
Biosynthesis, Biological activity and NMR Spectroscopy
of D and B, D Ring Seco-limonoids of Meliaceae Family.
Natural Products Communication 2007, 2, 203-221. |
|
T. Narender,*
Shweta, P. Tiwari, K. Papi Reddy, T. Khaliq, A. K. Srivastava,
S. C. Agarwal, and K. Raj Antihyperglycemic agent and
Antidyslipidemic agent from Aegle marmelos Bio-org.
Med. Chem. Letters 2007, 17, 1808-1811. |
|
T. Narender,*
T. Khaliq and M.N.Srivastava. 2007 Naturally
occurring Uracil dimer from the Marine sea hare Dolabella
auricularia Natural Products Communications
2, 71-73. |
|
Anju Puri, Tanvir Khaliq,
Rashmi Saxena, Geetica Bhatia and Ramesh Chander Tadigoppula
Narender*, 2007. Antidyslipidemic
activity of Indigofera tinctoria. J. Herbal Pharmacotherapy,1,
57-64. |
|
Xyloccensin X and Y, Two
New Limonoids from Xylocarpus molluccensis: NMR Investigation
in Mixture. Abhijeet Deb Roya, Rajesh Kumar, Poonam Gupta,
Tanvir Khaliq, T. Narender, Vijailakshmi
and Raja Roy 2006. Magnetic Resonance in Chemistry,
44, 1054-1057. |
|
Antidyslipidemic activity
of Furano Flavonoids isolated from Indigofera tinctoria.
T. Narender, T. Khaliq, A. Puri, R. Chander,
2006. Bio-org. Med. Chem. Lett., 16,
3422-3414. |
|
4-Hydorxyisoleucine an
unusual Amino acid as Antidyslipidemic and Antihyperglycemic
agent. T. Narender, Anju Puri, Shweta,
Tanvir Khaliq, Rashmi Saxena, Geetica Bhatia and Ramesh
Chander, 2006. Bio-org. Med. Chem. Lett. 16,
293-296. |
|
Synthesis of Chromenochalcones
and Evaluation of their in-vitro Antileishmanial activity.
T.Narender, K. Tanvir,. Shweta., Nishi. N.Goel,
S. Gupta, 2005. Bio-org. Med. Chem. 13,
6543-6550 |
| |
Prenylated
Chalcones isolated from Crotalaria genus inhibits in-vitro
growth of the human malaria parasite Plasmodium falciparum
T. Narender, Shweta, K.Tanvir, M.Srinivasa Rao, K.Srivastava
and S.K.Puri.2005, Bioorg. Med. Chem. Lett.,
. 15, 2453-2455 |
| |
A Convenient
and Biogenetic type Synthesis of few naturally occurring
Chromenodihydrochalcones and their in-vitro antileishmanial
activity T. Narender, Shweta and S.Gupta 2004.
Bioorg. Med. Chem. Lett., 14, 3913-3916. |
| |
Neoadifoline
a New Indole Alkaloid from the Adina cardifolia,
B.Balazs, G. Toth, P.S.Rao, T. Narender, N.Subbarao,
Gy.Howarth and H.Duddeck., 1999. Magn. Res.
Chem., 37, 751-753. |
| |
Further dihydro
chalcones from the Crotalaria ramosissima, J.K.Kumar,
T. Narender, M.S.Rao, P.S.Rao, G.Toth, B.Balazs and
H.Duddeck,1999. J. Braz. Chem. Soc., 10, 278-280 |
| |
| |
|
|
| |
|
| |
|