|
| |
| DR.
VINOD BHAKUNI |
|
| |
 |
Scientist-in-Charge
Molecular and Structural Biology Division
P.O. Box No. 173
Chhattar Manzil
Lucknow -226001
India |
|
|
|
| |
| POST-DOCTORAL
RESEARCH |
| |
|
•
|
John Hopkins
University, Baltimore, USA 1990 - 1992 |
|
| RESEARCH
AREAS |
| |
|
•
|
Protein Folding/
Engineering ; Biophysical Chemistry |
|
| |
| CURRENT
AREAS OF INTEREST |
| |
|
•
|
Mechanism
of Subunit Assembly of multimemeric Proteins |
|
•
|
Role of Domain
Structures in Protein Stability and Function |
|
| |
| SELECTED
PUBLICATIONS |
| |
• |
Mishra, Parul; Akhtar,
Md Sohail; Bhakuni, Vinod (2006),
Unusual structural features of the bacteriophage-associated
hyaluronate lyase (hylp2), Journal Of Biological
Chemistry , Volume 281, Issue 11,7143-7150 |
| • |
Akhtar MS,
Krishnan MY, Bhakuni V.(2006) Insight
into the mechanism of action of hyaluronate lyase: Role
of C-terminal domain and Ca++ in the functional regulation
of enzyme. Journal Of Biological Chemistry, 2006
Jul 19; [Epub ahead of print] |
• |
Bhatt Anant Narayan, Shukla
Nidhi, Aliverti Alessandro, Zanetti Giuliana,
Bhakuni Vinod. (2005) Modulation of cooperativity
in Mycobacterium tuberculosis NADPH-ferredoxin reductase:
Cation-and pH-induced alterations in native conformation
and destabilization of the NADP+-binding domain.
Protein Science, 14, 980-92. |
• |
Shukla Nidhi, Bhatt Anant
Narayan, Aliverti Alessandro, Zanetti Giuliana & Bhakuni
Vinod. (2005) Guanidinium chloride-
and urea-induced unfolding of FprA, a mycobacterium NADPH-ferredoxin
reductase. FEBS J, 272, 2216-24.
|
• |
Avasthi, A, Dutta, G P,
Bhakuni, V, Tripathi,
R ( 2004), Resistance reversal action
of ketoconazole againstmefloquine resistance of Plasmodium
yeolii nigerensis, Parasitology, 107, 115-19 |
• |
Bhatt, A.N., Khan, M.Y.,
and Bhakuni, V. (2004) The Terminal Lysines
of Dimeric Serine Hydroxymethyl Transferase Play an Important
Role in Stabilization of the Quarternary Structure : Differences
in Alkaline Denaturation of Mesophilic and Thermophilic
Proteins and its Chimeras. Protein Science ,13 (8),
2184-95 |
| • |
Chaturvedi,
S. & Bhakuni, V. (2003) Unusual Structural,
Functional and Stability Properties of Serine Hydroxymethyltransferase
from Mycobacterium tuberculosis. J. Biol. Chem.
278 (42), 40793-40805 |
| • |
Akhtar, Md.
S. & Bhakuni, V. (2003) Streptococcus
pneumoniae hyaluronate lyase contains two non-cooperative
independent folding/unfolding domains. Characterization
of functional domain and inhibitors of enzyme. J. Biol.
Chem., 278, 25509-25516 |
| • |
Misra, S.K.
& Vinod Bhakuni (2003) Unique Holoenzyme
Dimers of Tetrameric Enzyme E. coli Methylenetetrahydrofolate
reductase: Characterization of structural features associated
with modulation of the enzyme s function. Biochemistry
42, 3921-3928. |
| • |
Bhatt, A.N.,
Prakash, K., Subramanya, H.S. & Vinod Bhakuni
(2002) Different unfolding pathways for mesophilic
and thermophilic homologs of serine hydroxymethyltransferase
Biochemistry 41,
12115-12123. |
| • |
Akhtar, Md.
S., Ahmad A. & Vinod Bhakuni. (2002)
Divalent cations induced changes in structural properties
of dimeric enzyme glucose oxidase: Dual effect of stabilization
and dissociation and loss of cooperative interactions
in enzyme monomer Biochemistry 41, 7142-7149. |
| • |
Akhtar, Md.
S., Ahmad A. & Vinod Bhakuni. (2002)
Guanidine hydrochloride- and Urea-induced unfolding of
dimeric enzyme Glucose Oxidase. Biochemistry 41,
3819-3827. |
| • |
Prakash,
K, Prajapati, S, Ahmad, A, Jain, S.K & Vinod Bhakuni
(2002) Unique oligomeric intermediates of bovine
liver catalase. Protein Science 11, 46-57. |
| • |
Ahmad, A.,
Akhtar, Md. S. & Vinod Bhakuni (2001)
Monovalent cation-induced conformational changes in glucose
oxidase leading to stabilization of the enzyme. Biochemistry
40, 1945-1955. |
| • |
Ali, V.,
Prakash, K., Kulkarni, S., Ahmad , A., Madhusudan, K.P.
& Vinod Bhakuni (1999) 8-anilino-1-naphthalene
sulphonic acid (ANS) induces folding of acid unfolded
cytochrome c to molten globule state as a result of electrostatic
interactions. Biochemistry 38, 13635-13642. |
| |
| |
|
|
| |
|
| |
|