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Wahajuddin |
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Scientist C
Pharmacokinetics & Metabolism Division
Central Drug Research Institute
Chattar Manzil Palace, Post Box No. 173
Lucknow - 226001 |
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| Educational Qualifications |
M. S. (Pharm.) N. I. P. E. R. (S.
A. S. Nagar) |
| Fax/ Telephone |
91-522-2623405/ (O) 91-522-2612414,
Ext. 4377 |
| Date of Birth |
02.11.1981 |
| E-Mail |
wahajuddin@cdri.res.in
wahajuddin@gmail.com
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| RESEARCH
ACTIVITIES |
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Bio-analysis
Bio-analytical method development and validation, as per
the regulatory (US-FDA, ICH etc.) guidelines, on HPLC
and LC-MS/MS platform for quantitative determination of
small molecules (NCEs/Drugs and/or metabolites) in different
biological matrices |
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Pharmacokinetic
studies
Characterization of the in vivo pharmacokinetics (bio-availability,
dose-proportionality, gender variation, inter-species
comparison) following oral and parenteral routes of administration
in animal models. Toxicokinetic and tissue distribution
studies to support regulatory toxicology |
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Metabolism, Metabolite
Identification and CYP Phenotyping
In vitro/in vivo Metabolism of new chemical entities and/or
drugs using animal models, scaling preclinical and in-vitro
data to predict events in humans for preliminary assessment
of safe exposure levels, determination of the metabolite
profiles of drug candidates using liver microsomes/human
recombinant CYP450 isozymes, Identify Phase I or Phase
II enzymes responsible for metabolite formation, predict
drug interactions due to inhibition or induction of drug
metabolizing enzymes. |
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Interaction Studies
Drug-drug, herb-drug and food-drug interaction studies
for suggesting benefits (as potential combination)/risks
of the same in therapies. |
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Biopharmaceutics
Permeability/Absorption Characterization Studies across
Parallel Artificial Membrane Permeability Assay (PAMPA)
and in situ rat model, Protein Binding and Simulated Gastro-intestinal
Stability for new chemical entities/drugs. |
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| HUMAN
RESOURCE DEVELOPMENT |
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Training
provided to Post Graduates: 8 |
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| RECENT PUBLICATION
: Research Articles : 11 Patents: 2 Abstract:
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Singh SP*, Wahajuddin*§,
Tewari D, Pradhan T and Jain GK (2011)
PAMPA permeability, plasma protein binding, blood Partition,
pharmacokinetics and metabolism of formononetin, a methoxylated
isoflavone. Food and Chemical Toxicology.
PMID: 21266188, DOI: 10.1016/j.fct.2011.01.012 (*Authors
contributed equally; §Corresponding author) |
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Wahajuddin*§,
Singh SP*, Singh SK and Jain GK (2011)
Quantitation of Lumefantrine in biological matrices.
Curr. Pharm. Anal. 7(1): 42-46. (*Authors contributed
equally; §Corresponding author) |
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Singh SP*, Wahajuddin*§,
Ali MM, Jain GK (2010) Determination
and pharmacokinetic study of biochanin A and its metabolite
genistein in rat plasma by liquid chromatography–mass
spectrometry. Journal of Separation Science,
33 (21): 3326-34. PMID: 21049521
(*Authors contributed equally; §Corresponding author) |
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Singh SP*, Wahajuddin*§
and Jain GK. Intravenous Pharmacokinetics and Oral Bioavailability
of Biochanin A in Rats. Medicinal Chemistry Research,
DOI: 10.1007/s00044-010-9445-8 (*Authors contributed equally;
§Corresponding author) |
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Abnish K. Gautam, Biju
Bhargavan, Abdul M. Tyagi, Kamini Srivastava, Dinesh K.
Yadav, Manmeet Kumar, Akanksha, Jay S. Mishra, Amar Bahadur
Singh, Sabyasachi Sanyal, Rakesh Maurya, Lakshmi Manickavasagam,
Sheelendra P. Singh, Wahajuddin, Girish
K. Jain, Naibedya Chattopadhyay, Divya Singh, (2010)
Effects of Mathoxylated Daidzeins, Cladrin and Formononetin
on Osteoblast function, Peak Bone Mass achievement and
Bioavailability. Journal of Nutritional Biochemistry
(In Press) |
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Kunal Sharan, Gaurav Swarnkar,
Jawed A Siddique, Avinash Kumar, Preeti Rawat, Manmeet
Kumar, Geet K Nagar, Lakshmi Manickavasagam, Sheelendra
P Singh; Geetanjali Mishra, Wahajuddin,
Girish K Jain, Rakesh Maurya, Naibedya Chattopadhyay,
(2010) A Novel Flavonoid, 6-C-ß-D-glucopyranosyl-(2S,3S)-(+)-3',4',5,7-tetrahydroxyflavanone,
Isolated From Ulmus wallichiana-Planchon Mitigates Ovariectomy-induced
Osteoporosis in Rats. 17(3): 577-86. Menopause.
PMID: 20393370. |
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Singh SP, Wahajuddin,
Yadav DK, Rawat P, Maurya R, Jain GK (2010)
Quantitative determination of formononetin and its metabolite
in rat plasma after intravenous bolus administration by
HPLC coupled with tandem mass spectrometry., Journal
of Chromatography B 878 (3-4): 391-7. PMID: 20034859. |
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Wahajuddin,
Singh SP and Jain GK, (2009) “Determination
of lumefantrine in rat plasma by liquid-liquid extraction
using LC-MS/MS with electrospray ionization: Assay development,
validation and application to pharmacokinetic study”
Journal of Chromatography B, 877 (11-12):
1133-9 |
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Singh S. P., Singh R.
S. P., Wahajuddin, Jain G. K., (2008
) “Development, validation of a rapid, sensitive
liquid chromatography-tandem mass spectrometry method
using electrospray ionization for quantitation of centchroman
in rat plasma and its application to preclinical pharmacokinetic
study”, Journal of Chromatography B,
876 (1): 1-7 |
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