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Crystallography |
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Determining the
three dimensional structure of a protein
and its mode of interaction with a
ligand/inhibitor is a key step in
the drug discovery pathway. CDRI boasts
of state-of-the-art facilities for
collecting diffraction data from both
protein and small molecule crystals.
The macromolecular data-collection
facility consists of a MAR345 area
detector mounted on a RIGAKU rotating
anode. The data collection is automated
and controlled by a computer while
the small molecule data collection
facility consists of a modern BRUKER-AXS
system.
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Both facilities
are supported by UPS and Generator power
backup for uninterrupted operation.
Structure solution, analysis and novel
inhibitor design is facilitated by graphics
intensive workstations (Silicon Graphics
Inc). |
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