Manju Y K
 
...


Scientist C
DTDD Division
Central Drug Research Institute
LUCKNOW
 
Educational qualifications M. Sc Biotech (Calicut), Ph. D (RGCB, Trivandrum)
E mail manju@cdri.res.in
Date of Birth 03.047.1976
 
POST-DOCTORAL EXPERIENCE
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University of Wisconsin-Madison, WI, USA (July 2007-May 2009)
RESEARCH SPECIALIZATION
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Drug research (microbiology) and molecular biology of Mycobacterium tuberculosis and M. avium sub sp paratuberculosis
 
CURRENT AREA OF RESEARCH
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Host-pathogen interactions in persistent mycobacterial infections
•
 Molecular strategies to overcome intrinsic drug resistance in mycobacteria
SELECTED PUBLICATIONS
 
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 Krishnan MY, Manning EJB and Collins MT (2009). Effects of interactions of antibacterial drugs with each other and with 6-mercaptopurine on in vitro growth of Mycobacterium avium subspecies paratuberculosis. J Antimicrob Chemother., advance access, doi:10.1093/jac/dkp339.
• Krishnan MY, Manning EJB and Collins MT (2009). Comparison of three methods for susceptibility testing of Mycobacterium avium subsp. paratuberculosis to 11 antimicrobial drugs. J Antimicrob Chemother., 64, 310-316.
• Krishnan MY, Manning EJB and Collins MT (2009). Stability of antibacterial agents in MGIT (TM) Para TB Medium. Int J Antimicrob Agents Chemother., 33: 186-7.
• Sharma M, Chaturvedi V, Manju YK, Bhatnagar S, Srivastava K, Puri SK, Chauhan PM (2009). Substituted quinolinyl chalcones and quinolinyl pyrimidines as a new class of anti-infective agents. Eur J Med Chem 44(5):2081-91.
• Parai MK, Panda G, Chaturvedi V, Manju YK, Sinha S (2008). Thiophene containing triarylmethanes as antitubercular agents. Bioorg Med Chem Lett 18(1):289-92.
• Krishnan MY, Radhakrishnan I, Joseph BV, Madhavilata GK, Kumar A and Mundayoor S (2007). Combined use of amplified fragment length polymorphism and IS6110-RFLP in fingerprinting clinical isolates of Mycobacterium tuberculosis from Kerala, South India. BMC Infect Dis.,7:86.
• Das SK, Panda G, Chaturvedi V, Manju YK, Gaikwad AK, Sinha S (2007). Design, synthesis and antitubercular activity of diarylmethyinaphthol derivatives. Bioorg Med Chem Lett 17(20):5586-9.
• Panda G, Parai MK, Das SK, shagufta, Sinha M, Chaturvedi V, Srivastava AK, Manju YK,Gaikwad AN and Sinha S (2007). Effect of substituents on diarylmethanes for antitubercular activity. Eur J Med Chem. 42(3):410-419.
• Akhtar MS, Krishnan MY and Bhakuni V (2006). Insights into the mechanism of action of hyaluronate lyase - Role of C-terminal domain and Ca2+ in the functional regulation of enzyme. J. Biol Chem, 281, 28336-28344
• Tripathi RP, Saxena N, Tiwari VK, Verma SS, Chaturvedi V, Manju YK, Srivastava AK, Gaikwad A, Sinha S (2006). Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines. Bioorg Med Chem. 14(24):8186-96
• Tripathi RP, Verma SS, Pandey J, Agarwal KC, Chaturvedi V, Manju YK, Srivastava AK, Gaikwad A,Sinha S (2006). Search of antitubercular activities in tetrahydroacridines: Synthesis and biological evaluation. Bioorg Med Chem Lett. 16(19):5144-47
• Dwivedi, N, Tewari N, Tiwari VK, Chaturvedi V, Manju YK, Srivastava A, Gaikwad, A, Sinha S., Tripathi RP (2005). An efficient synthesis of aryloxyphenyl cyclopropyl methanones: a new class of anti-mycobacterial agents. Bioorg Med Chem Lett. 15(20): 4526-30.
• Tripathi RP., Tiwari, VK, Tewari N, Katiyar D, Saxena N, Sinha S, Gaikwad A, Srivastava A, Chaturvedi V, Manju YK, Srivastava R, Srivastava BS (2005). Synthesis and antitubercular activities of bis-glycosylated diamino alcohols. Bioorg. Med Chem 13 (19); 5668-79
• Radhakrishnan I, Manju YK, Kumar RA, Mundayoor S (2001). Implications of low frequency of IS6110 in fingerprinting field isolates of Mycobacterium tuberculosis from Kerala, India. J Clin Microbiol. 39(4):1683.