Dr. Dipak Datta
 
...




Senior Scientist  Sc. E-I
CSIR-Central Drug Research Institute
Biochemistry Division
Lucknow - 226031, India
E-Mail:  [email protected]
Google Scholar Citation:  https://scholar.google.co.in/citations?user=hZS4ItwAAAAJ&hl;=en

 
 
POSITIONS / EMPLOYMENT
 
Scientist E-I   (2011) Central Drug Research Institute, Lucknow, India
Instructor   (2010-2011)

Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, USA

Post-Doctoral Fellow   (2004-2010) Harvard Medical School and Children's Hospital Boston, Boston, USA
 

AREA OF SPECIALIZATION

 
Cancer Stem Cells

Chemokine Receptor Signaling

Anti-Cancer Screening
 

HONORS/AWARDS

 
1sT Class 1st Award in B.Sc - University of Burdwan

Young Investigator Award 2007 – American Transplant Society

Young Investigator Award 2010 – American Transplant Society
 
SELECTED PUBLICATIONS (total of 26)
 
   

Singh AK, Arya RK, Maheshwari S, Singh A, Meena S, Pandey P, Dormond O, Datta D #. Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance. Int J Cancer. 2015 May 1;136(9):1991-2000. (JIF:5.47) #Corresponding Author

Singh AK, Arya RK, Trivedi AK, Sanyal S, Baral R, Dormond O, Briscoe DM, Datta D#. Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12. #Corresponding author Cytokine Growth Factor Rev. 2013 Feb;24(1):41-9. (JIF:7.9) # Corresponding Author

Hasanain M, Bhattacharjee A, Pandey P, Ashraf R, Singh N, Sharma S, Vishwakarma A, Datta D, and Mitra K and Sarkar J . α- solanine induces ROS mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway. Cell Death Disease. 2015 Aug 27;6:e1860. doi: 10.1038/cddis.2015.219. (JIF:5.1)

Pawar VK, Panchal SB, Singh Y, Meher JG, Sharma K, Singh P, Bora HK, Singh A, Datta D, Chourasia MK. Immunotherapeutic vitamin E nanoemulsion synergies the antiproliferative activity of paclitaxel in breast cancer cells via modulating Th1 and Th2 immune response. J Control Release 2014 Dec 28;196:295-306 (JIF:7.6)

Chakravarti B, Akhtar T, Rai B, Yadav M, Akhtar Siddiqui J, Dhar Dwivedi SK, Thakur R, Singh AK, Singh AK, Kumar H, Khan K, Pal S, Rath SK, Lal J, Konwar R, Trivedi AK, Datta D, Mishra DP, Godbole MM, Sanyal, Chattopadhyay N, Kumar A. Thioaryl naphthylmethanone oxime ether analogs as novel anticancer agents. J Med Chem. 2014 Oct 9;57(19):8010-25 (JIF:5.6)

Datta D, Banerjee P, Gasser M, Waaga-Gasser AM, Pal S. CXCR3-B can mediate growth-inhibitory signals in human renal cancer cells by down-regulating the expression of heme oxygenase-1. J Biol Chem. 2010;285:36842-8. (JIF-4.65)

Edelbauer M, Datta D, Vos IH, Basu A, Stack MP, Reinders ME, et al. Effect of vascular endothelial growth factor and its receptor KDR on the transendothelial migration and local trafficking of human T cells in vitro and in vivo. Blood. 2010;116:1980-9. (JIF-9.06)

Basu A#, Hoerning A#, Datta D, Edelbauer M, Stack MP, Calzadilla K, et al. Cutting edge: Vascular endothelial growth factor-mediated signaling in human CD45RO+ CD4+ T cells promotes Akt and ERK activation and costimulates IFN-gamma production. J Immunol. 2010;184:545-9. ( # Co-First Author) (JIF-5.52)

Datta D, Contreras AG, Basu A, Dormond O, Flynn E, Briscoe DM, et al. Calcineurin inhibitors activate the proto-oncogene Ras and promote protumorigenic signals in renal cancer cells. Cancer Res. 2009;69:8902-9. (JIF-9.3)

Datta D, Contreras AG, Grimm M, Waaga-Gasser AM, Briscoe DM, Pal S. Calcineurin inhibitors modulate CXCR3 splice variant expression and mediate renal cancer progression. J Am Soc Nephrol. 2008;19:2437-46. (JIF-8.98)

Basu A#, Contreras AG#, Datta D, Flynn E, Zeng L, Cohen HT, et al. Overexpression of vascular endothelial growth factor and the development of post-transplantation cancer. Cancer Res. 2008;68:5689-98. ( # Co-First Author) (JIF-9.3)

Datta D, Flaxenburg JA, Laxmanan S, Geehan C, Grimm M, Waaga-Gasser AM, et al. Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer. Cancer Res. 2006;66:9509-18. (JIF-9.3)

 
 

LAB MEMBERS

  
Graduate Students:
Mr. Anup Kumar Singh, Mr. Rakesh Kumar Arya, Ms. Shrankhla Maheshwari, Mr. Priyank Chaturvedi
Research Associate/PA:
Dr. Deepti Pandey, Dr. Akhilesh Singh
Research Technician:
Mr. Sanjeev Meena
 

FOREIGN COLLABORATORS

  
Dr. VM Rangnekar, University of Kentucky, Lexington, USA
Dr. Olivier Dormond, University of Lausanne, Lausanne, Switzerland