Dr. MRIGANK SRIVASTAVA, Ph.D.
 
Scientist
Parasitology Division
CSIR-Central Drug Research Institute
Lucknow 226 031.
 
E- mail [email protected]
Tel 0522-2772450 Ext. 4521(o) 4522 (Lab)
Fax 0522-2771941
Educational Qualifications M.Sc. (HP University, Shimla)
Ph.D. (Justus-Liebig University, Giessen, Germany)
Date of Birth

2nd December, 1977
 
RESEARCH EXPERIENCE
 
22/11/2010-Continuing Scientist, CSIR-CDRI, Lucknow
2008-2010 Post-Doctoral Fellow, Harvard Medical School, Boston, USA
2005-2008 Post-Doc, Hannover Medical School, Hannover, Germany
2005 Ph.D. (Immunology-Excellent Grade), Justus-Liebig University, Germany
2000 Masters in Biotechnology, H.P. University, Shimla, India
 
AREAS OF INTEREST
 
Our research group is interested in investigating the various immune evasion strategies adopted by the filarial nematode Brugia malayi to overcome the protective host immune response. The focal points of research are several excretory-secretory (ES) products of the filarial nematode that cause alternative activation of the host immune cells (Macrophages and Dendritic cells) thereby impairing the priming of the host adaptive immune response. In addition to this, we are also interested in elucidating the role of eosinophils during Tropical Pulmonay Eosinophilia (TPE) which is a rare, but fatal manifestation of filariasis. The lab also routinely carries out screening of synthetic and natural plant products for evaluation of their anti-filarial activity both in vitro and in vivo using rodent models of filarial infection.
 
RESEARCH PUBLICATIONS (LAST FIVE YEARS)
 
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 1. Regulatory T cells neutralization in mice during filariasis helps in parasite clearance by enhancing Th17 mediated pro-inflammatory response. Pathak M, Sharma P, Sharma A, Verma M, Srivastava M, Bhattacharya SM. Immunology, 2015. Joint Corresponding Author
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 2. Host lung immunity is severely compromised during tropical pulmonary eosinophilia: role of lung eosinophils and macrophages. Sharma P, Sharma A, Vishwakarma AL, Agnihotri PK, Sharma S, Srivastava M. J Leukoc Biol., 2015.
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 3. Host immune response is severely compromised during lethal Plasmodium vinckei infection. Bhardwaj J, Siddiqui AJ, Goyal M, Prakash K, Soni A, Puri SK, Srivastava M. Parasitol Res., 2015.
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 4. Wolbachia endosymbiont of Brugia malayi elicits a T helper type 17-mediated pro-inflammatory immune response through Wolbachia surface protein. Pathak M, Verma M, Srivastava M, Misra-Bhattacharya S. Immunology, 2015. Joint Corresponding Author
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 5. Combination of liposomal CpG oligodeoxynucleotide 2006 and miltefosine induces strong cell-mediated immunity during experimental visceral leishmaniasis. Shivahare R, Vishwakarma P, Parmar N, Yadav PK, Haq W, Srivastava M, Gupta S, Kar S. PLoS One. 2014.
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 6. Increased virulence of Mycobacterium tuberculosis H37Rv overexpressing LipY in a murine model. Singh VK, Srivastava M, Dasgupta A, Singh MP, Srivastava R, Srivastava BS. Tuberculosis, 2014. Joint Corresponding Author
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 7. Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection. Herbold W, Maus R, Hahn I, Ding N, Srivastava M, Christman JW, Mack M, Reutershan J, Briles DE, Paton JC, Winter C, Welte T, Maus UA. Infect Immun. 2010.
 
 
SELECTED PUBLICATIONS
 
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 1. Srivastava M et al., Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis. Respir Res. 2008.
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 2. Schreiber O, Steinwede K, Ding N, Srivastava M, et al., Mice that overexpress CC chemokine ligand 2 in their lungs show increased protective immunity to infection with Mycobacterium bovis bacille Calmette-Guérin. J Infect Dis. 2008.
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 3. Srivastava M et al., Mediator responses of alveolar macrophages and kinetics of mononuclear phagocyte subset recruitment during acute primary and secondary mycobacterial infections in the lungs of mice. Cell Microbiol. 2007.
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 4. Maus UA, Backi M, Winter C, Srivastava M, et al., Importance of Phosphoinositide 3-Kinase γ in the host defense against Pneumococcal infection. Am J Respir Crit Care Med. 2007. Cover page illustration.
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 5. Winter C, Taut K, Srivastava M, et al., Lung specific overexpression of CCL2 enhances the host defense to S. pneumoniae infection in mice: Role of CCL2-CCR2 axis. J Immunol. 2007. Cover page illustration.
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 6. Steinmueller M, Srivastava M, et al., Endotoxin induced peritonitis elicits monocyte immigration into the lung: Implications on alveolar space inflammatory responsiveness. Respir Res. 2006.
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 7. Srivastava M et al., The inflammatory versus constitutive trafficking of mononuclear phagocytes into the alveolar space of mice is associated with drastic changes in their gene expression profiles. J. Immunol. 2005.
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 8. Maus UA, Srivastava M, et al., Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space. J Immunol. 2004.
Current lab Members
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 Pankaj Sharma (UGC-SRF)
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 Aditi Sharma (CSIR-SRF)
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 Laxmi Ganga (UGC-JRF)