Biodata of Dr Rajesh Jha :::: Central Drug Research Institute

Dr. RAJESH KUMAR JHA

Scientist
Endocrinology Division
Central Drug Research Institute
Lucknow 226 031

Phone No.	Ext. 4493
E- mail	[email protected]
Educational Qualifications	M.Sc, Ph.D
Date of Birth	5th September 1978

POST DOCTORAL EXPERIENCE

•	DST SERC Fast Track Young Scientist, Division of Molecular Reproduction , Rajiv Gandhi Center for Biotechnology, Trivandrum, Kerala (2008-2010).
•	Cleveland Clinic Foundation, Cleveland, Ohio, USA. (November 2006- November 2007).

ONGOING EXTRAMURAL GRANT SUPPORT

•	ICMR, New Delhi (2013-2016)
•	DST, New Delhi (2013-2016)

RESEARCH TEAM

•	Mr. Vineet Kumar Maurya (CSIR-SRF) (Viva Voced)
•	Mr. Vijay Kumar (UGC-SRF) (Thesis submitted)
•	Mr. Sangappa Chadchan (ICMR-SRF)
•	Mr. Vabhave Ubba (UGC JRF)
•	Mr. Satish Kumar Kashera (CSIR JRF)
•	Mr. Pranshu Dwivedi (DST, JRF)

Alumni

•	Miss Anubha Joshi (SRF-UGC)
•	Miss Archana Singh (JRF-UGC)
•	Dr. Sahil Mahfooz (RA-BSC0101)

RESEARCH GRANTS

•	DBT, New Delhi (2015 approved)
•	DST SERC Fast Track under young scientist scheme (2008- 2011), DST, New Delhi
•	Cleveland Clinic Research Education Grant (2007-2008), Cleveland Clinic, Cleveland, Ohio, USA.

•	ICMR, New Delhi (2013-2016)
•	DST, New Delhi (2013-2016)

CURRENT AREAS OF INTEREST

A major effort in the lab is to characterized some cellular and molecular events of ‘Endometrial Receptivity ‘ for blastocyst implantation regulation in order to identify the potential drug target for female contraceptive approach. Another component of my research is to decipher the intra-ovarian signaling of ‘Polycystic Ovary (PCOS)’ and ‘Prematurely Failed Ovary (POF/POI)’ so that the ovarian follicle health improvement ways can be exploited. We also are trying to understand the mechanism of ‘Endometriosis’ using mice model to identify cellular signaling for drug targets.

Award/Recognition

•	Prof. G.P. Talwar Young Scientist Award.Indian Society for the Study in Reproduction and Fertility (ISSRF) 2016, NIOH, Ahmedabad.
•	International Best Abstract Representing India, Middle East, Southeast Asia and Africa, SSR 2014, Grand Rapids, Michigan, USA.
•	International Travel Grant DST, New Delhi by to participate in the Society for the Study in Reproduction (SSR) at Grand Rapids, MI, USA from (2014).
•	International Travel Grant DST, New Delhi by to participate in the Gordon Research Conference at Andover, NH, USA from (2010).
•	DST Fast Track Young Scientist Grant, 2008-2011.

Reviewer of Scientific Journal

•	Molecular and Cellular Endocrinology
•	OncoTargets and Therapy
•	Molecular Human Reproduction
•	PLOS ONE
•	Reproductive Sciences

Affiliation with Scientific Society

•	Indian Society for the Study of Reproduction & Fertility (ISSRF)
•	The Society for the Study of Reproduction (SSR)
•	Laboratory Animal Science Association of India (LASAI)

RESEARCH EXPERIENCE

•	Female uterine tissue remodeling signaling
•	Embryo implantation biology
•	Male Reproductive Biochemistry, Andrology and Antifertility
•	Liver fibrosis signaling mechanism

SELECTED PUBLICATIONS

•	Carlus SJ, Sarkar S, Bansal SK, Singh V, Singh K, Jha RK, Sadasivam N, Sadasivam SR, Gireesha PS, Thangaraj K, Rajender S. Is MTHFR 677 C>T Polymorphism Clinically Important in Polycystic Ovarian Syndrome (PCOS)? A Case-Control Study, Meta-Analysis and Trial Sequential Analysis. PLoS One. 2016 Mar 16;11(3):e0151510. doi: 10.1371/journal.pone.0151510. eCollection 2016.
•	Rajesh Kumar Jha, Vineet Kumar Maurya, Ruchika Maurya, Himanshu Chaturvedi, Sangappa Chadchan. Expression of RHOG in the ovary and uterus during estrus cycle and receptive endometrium. (Communicated ).
•	Chadchan SB, Kumar V, Maurya VK, Soni UK, Jha RK.Endoglin (CD105) coordinates the process of endometrial receptivity for embryo implantation. Mol Cell Endocrinol. 2016 Jan 20. pii: S0303-7207(16)30014-4. doi: 10.1016/j.mce.2016.01.014.
•	Kumar V, Maurya VK, Joshi A, Meeran SM, Jha RK. Integrin Beta 8 (ITGB8) Regulates Embryo Implantation Potentially via Controlling the Activity of TGF-B1 in Mice. Biol Reprod. 2015 Mar 18. biolreprod.114.122838. [Epub ahead of print]
•	Maurya VK, Sangappa C, Kumar V, Mahfooz S, Singh A, Rajender S, Jha RK. Expression and activity of Rac1 is negatively affected in the dehydroepiandrosterone induced polycystic ovary of mouse. J Ovarian Res. 2014 Mar 14;7:32. doi: 10.1186/1757-2215-7-32
•	Joshi A, Mahfooz S, Maurya VK, Kumar V, Basanna CS, Kaur G, Hanif K, Jha RK. PARP1 during embryo implantation and its upregulation by oestradiol in mice. Reproduction. 2014 Jun;147(6):765-80. doi: 10.1530/REP-13-0588. Epub 2014 Feb 10.
•	4. Renjini AP, Titus S, Narayan P, Murali M, Jha RK, Laloraya M. STAT3 and MCL-1 associate to cause a mesenchymal epithelial transition. J Cell Sci. 2014 Apr 15;127(Pt 8):1738-50. doi: 10.1242/jcs.138214. Epub 2014 Jan 30.
•	Maurya VK, Jha RK, Kumar V, Joshi A, Chadchan S, Mohan JJ, Laloraya M. Transforming growth factor-beta 1 (TGF-B1) liberation from its latent complex during embryo implantation and its regulation by estradiol in mouse. Biol Reprod. 2013 Oct 10;89(4):84. doi: 10.1095/biolreprod.112.106542. Print 2013 Oct. Erratum in: Biol Reprod. 2014 Dec;91(6):147.
•	Aziz N, Sharma RK, Mahfouz R, Jha R, Agarwal A. Association of sperm morphology and the sperm deformity index (SDI) with poly (ADP-ribose) polymerase (PARP) cleavage inhibition. Fertil Steril. 2011 Jun 30;95(8):2481-4. doi: 10.1016/j.fertnstert.2011.03.095. Epub 2011 Apr 20.
•	Mahfouz RZ, Sharma RK, Poenicke K, Jha R, Paasch U, Grunewald S, Agarwal A. Evaluation of poly(ADP-ribose) polymerase cleavage (cPARP) in ejaculated human sperm fractions after induction of apoptosis. Fertil Steril. 2009 May;91(5 Suppl):2210-20. doi: 10.1016/j.fertnstert.2008.02.173. Epub 2008 May 23.
•	Jha R, Agarwal A, Mahfouz R, Paasch U, Grunewald S, Sabanegh E, Yadav SP, Sharma R. Determination of Poly (ADP-ribose) polymerase (PARP) homologues in human ejaculated sperm and its correlation with sperm maturation. Fertil Steril. 2009 Mar;91(3):782-90. doi: 10.1016/j.fertnstert.2007.12.079. Epub 2008 Mar 12
•	Jha RK, Titus S, Saxena D, Kumar PG, Laloraya M.Profiling of E-cadherin, beta-catenin and Ca(2+) in embryo-uterine interactions at implantation. FEBS Lett. 2006 Oct 16;580(24):5653-60. Epub 2006 Sep 18. Erratum in: FEBS Lett. 2009 Feb 4;583(3):595
•	Shukla S, Jha RK, Laloraya M, Kumar PG.Identification of non-mitochondrial NADPH oxidase and the spatio-temporal organization of its components in mouse spermatozoa. Biochem Biophys Res Commun. 2005 Jun 3;331(2):476-83.
•	Davoodi-Semiromi A, Laloraya M, Kumar GP, Purohit S, Jha RK, She JX. A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in nonobese diabetic mice. J Biol Chem. 2004 Mar 19;279(12):11553-61. Epub 2003 Dec 29.