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| DR.
SUSANTA KAR |
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Scientist
LSN106, Parasitology Division
CSIR-Central Drug Research Institute
Lucknow - 226031, India |
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| Educational Qualifications |
M. Sc. – Dept. Of Biochemistry, Calcutta University,
Ph. D. (2010) – CSIR-Indian Institute of Chemical Biology |
| Date of Birth |
02.01.1979 |
| Phone |
91-522-2771-950 , Extn-4495 |
| E-Mail |
[email protected] |
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| WORK EXPERIENCE |
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Quick Hire Scientist (2011–12) |
Parasitology division, CSIR-CDRI, Lucknow, India |
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Post-Doctoral research (2010–2011) |
Infectious Diseases and Immunology Division, CSIR-IICB, Kolkata, India |
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Doctoral research (2005–2010) |
Infectious Diseases and Immunology Division, CSIR-IICB, Kolkata, India |
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| CURRENT
AREAS OF INTEREST |
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Understanding the mode of action of promising anti-leishmanial agents and characterise new pathways and their components to better understand the molecular and cellular mechanisms of the infection process in leishmaniasis |
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Deciphering the basic mechanism of macrophage-Leishmania interaction with special emphasis on identification of negative regulatory proteins by which Leishmania turns off the various signaling cascades in phagocytic cells |
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Isolation and functional characterization of murine splenic dendritic cell subtypes in experimental visceral leishmaniasis |
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| AWARDS AND RECOGNITIONS |
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Young Scientist Award from the Indian National Science Academy (INSA), India |
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Young Scientist Award from the Indian Society for Parasitology (ISP), India |
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| GROUP MEMBERS |
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Preeti Vishwakarma (CSIR SRF) |
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Naveen Parmer (UGC JRF) |
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Pawan Yadav (CSIR JRF) |
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Pragya Chandrakar (CSIR JRF) |
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| SELECTED PUBLICATIONS |
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Kar, S.,1 Ukil, A1 and Das, P.K. (2009) Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-kB and JAK/STAT pathways. Eur. J. Immunol. 39, 741-751. (1Equal contribution). (Impact Factor – 5.179) |
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Kar, S., Ukil, A., Sharma, G. and Das, P.K. (2010) MAPK-directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: involvement of distinct protein kinase C isoforms. J. Leukocyte Biol. 88, 9-20. (Impact Factor – 4.4) |
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Kar, S., Ukil, A. and Das, P.K. (2011) Cystatin cures visceral leishmaniasis by NF-kB-mediated proinflammatory response through co-ordination of TLR/MyD88 signaling with p105-Tpl2-ERK pathway. Eur. J. Immunol. 41, 116-127. (Impact Factor – 5.179) |
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Kar, S.,1 Sharma, G1 and Das, P.K. (2011) Fucoidan cures infection against both antimony-susceptible and –resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants. J. Antimicrob. Chemother. 66, 618-625 (1Equal contribution). (Impact Factor – 4.659) |
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Biswas, A., Bhattacharya, A., Kar, S and Das, P.K. (2011) Expression of IL-10-triggered STAT3-dependent IL-4Ra is required for induction of arginase 1 in visceral leishmaniasis. Eur. J. Immunol. 41, 992-1003. (Impact Factor – 5.179) |
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Basu Ball, W., Kar, S., Mukherjee, M., Chande, A.G., Mukhopadhyaya, R. and Das, P.K. (2011) Uncoupling protein 2 negatively regulates reactive oxygen species generation and induces phosphatase-mediated anti-inflammatory response in experimental visceral leishmaniasis. J. Immunol. 187, 1322-1332. (Impact Factor – 5.745) |
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Ukil, A.,1 Kar, S.,1 Srivastav, S and Das, P.K. (2011) Curative effect of 18β-glycyrrhetinic acid in experimental visceral leishmaniasis depends on phosphatase-dependent modulation of cellular MAP kinases Plos one 12, e29062 (1Equal contribution). (Impact Factor – 4.09) |
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Sharma, G., Kar, S., Palit, S. and Das, P.K. (2012) 18β-Glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. J.Cell. Physiol. 227, 1923-31. (Impact Factor – 3.874) |
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Kar, S., Palit, S. and Das, P.K. (2012) Carnosic acid modulates Akt/IKK/NF-kB signalling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. Apoptosis , 17, 735-747 (1Equal contribution) (Impact Factor – 4.788) |
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Srivastav, S.,1 Kar, S1 and Das, P.K. (2012) Leishmania donovani exploits host deubiquitinating enzyme A20, a negative regulator of TLR signaling, to subvert host immune response. J. Immunol 189, 924-934 (1Equal contribution). (Impact Factor – 5.745) |
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Ghosh K, Sharma G, Saha A, Kar S, Das P.K. and Ukil A. (2012).Successful therapy of visceral leishmaniasis with curdlan involved T-helper 17 cytokines J Infect. Dis. 207.1016-25 (Impact Factor – 6.4) |
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Curative effect of fucoidan on visceral leishmaniasis is mediated by activation of MAP kinases through specific protein kinase C isoforms. Cell Mol. Immunol. (2014) 11, 263-274. Sharma, G., Kar, S., Basu Ball, W., Ghosh, K., and Das, P.K. (Impact Factor - 3.4) |
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Liposomal CpG Oligodeoxynucleotide 2006 Induced Strong Cell-mediated Immunity during Combination Therapy with Miltefosine in Experimental Visceral Leishmaniasis. Plos One (2014) 14;9(4):e94596. Shivahare, R.,Vishwakarma, P., Haq, W., Gupta., S, and Kar., S. (Impact Factor - 3.7) |
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Hesperetin induces apoptosis in breast carcinoma by triggering accumulation of ROS and activation of ASK1/JNK pathway. J.Cell. Physiol. (2014) (ahead of print) Palit, S. Kar, S., Sharma, G., and Das, P.K. (Impact Factor - 3.8) |
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15. Protection against filarial infection by 45-49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction. Vaccine (2015) 33:527-34. Verma SK, Joseph SK, Verma R, Kushwaha V, Parmar N, Yadav PK, Thota JR, Kar S, Murthy PK. (Impact Factor - 3.38) |
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| AWARDS TO STUDENTS |
Pawan Yadav (CSIR JRF) |
3rd Best Poster Award in X Joint Annual Conference of ISMOCD & IAE |
Preeti Vishwakarma |
Best Poster award in 25th National Congress of Parasitology |
Best Poster award in 25th National Symposium on Animals in Research and Testing: A Cross-talk Between Relevance and Ethics |
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