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| Dr.
SYED MUSTHAPA M. |
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Senior Scientist
Division of Endocrinology
CSIR-Central Drug Research Institute
Jankipuram Extn., Sect-10,
Sitapur Road
Lucknow-226 031, U.P.
India |
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| Educational Qualifications |
M.Sc, Ph.D (Biochemistry) |
| Phone No. |
+91-522-2771940 Ext. 4491 |
| Fax |
+91-522-2771941 |
| E- mail |
[email protected] |
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| POST
DOCTORAL EXPERIENCE |
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Postdoctoral Fellow
: University of Alabama at Birmingham, Birmingham, USA,
2005-2006 |
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Research
Associate : University of Alabama at Birmingham, Birmingham,
USA, 2006-2010. |
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Assistant Professor :
University of Alabama at Birmingham, Birmingham, USA,
2010-2011 |
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| CURRENT
AREAS OF INTEREST |
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Studying
the novel genetic and epigenetic drug targets in cancer
biology |
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Developing in vitro and
in vivo models for cancer prevention and therapy |
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Studying the mechanistic
role of bioactive dietary supplements on cancer prevention
and therapy |
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Epigeniomics of breast and lung cancer. |
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Citation to all Publications: Sum of times cites-2075, h-index-28 |
Google scholar Citation: http://scholar.google.com/citations?hl=en&user=Y8xGSyYAAAAJ |
Total no. of publications in peer-reviewed scientific journals: 51 |
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| Selected
Book Chapters/Review Articles |
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Shukla S and *Meeran SM (2014) Epigenetics of cancer stem cells: Pathways and therapeutics. Biochim. Biophys. Acta (BBA), 1840 (12): 3494-3502. |
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Shukla S, *Meeran SM and *Katiyar SK (2014) Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention. Cancer Letters, 355: 9-17 |
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Khan S, Shukla S, Sinha S and *Meeran SM (2013) Role of Adipokines and Cytokines in Obesity-associated Breast Cancer: Therapeutic Targets. Cytokine and Growth Factor Reviews. 24: 503-513 |
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Shukla S and Meeran SM (2013) Epigenetic Factors in Breast Cancer Progression. Book title-Breast Cancer Metastasis and Drug Resistance. A. Ahmad (ed.),, Springer Publications, New York, USA. Page 341-365, DOI: 10.1007/978-1-4614-5647-6_19 |
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Shukla S, Khan S, Tollefsbol TO and Meeran SM (2013) Genetics and epigenetics of lung cancer: Genetics and Epigenetics of Lung Cancer: Mechanisms and Future Perspectives. Current Cancer Therapy Reviews: 9 (2):97-110. |
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| SELECTED
ORIGINAL ARTICLES |
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Khan S, Shukla S, Sinha S and Meeran SM (2015) Centchroman altered the expressions of tumor-related genes through active chromatin modifications in mammary cancer. Mol. Carcinog. In Press. |
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Shukla S, Khan S, Kumar S, Sinha S, Mohd. Farhan, Bora HK, Maurya R and Meeran SM (2015) Cucurbitacin B alters the expression of tumor-related genes by epigenetic modifications in NSCLC and inhibits NNK-induced lung tumorigenesis. Cancer Prev. Res., 8(6): 552-62. |
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Dighe SU#, Khan S#, Soni I, Jain P, Shukla S, Yadav R, Sen P, Meeran SM and Batra S (2015) Synthesis of β-carboline-based N-heterocyclic carbenes and their anti-proliferative and anti-metastatic activities against human breast cancer cells. Journal of Medicinal Chemistry, 58 (8): 3485-3499. |
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Kumar V, Maurya VK, Joshi A, Meeran SM and Jha RK (2015) Integrin beta 8 (ITGB8) regulates embryo implantation potentially via controlling the activity of TGF-B1 in Mice. Biol. Reprod., 92(4): Article# 109: 1-17. |
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Sinha S, Shukla S, Khan S, Mohd. Farhan, Kamal MA and *Meeran SM (2015) Telomeric Repeat containing RNA (TERRA): Aging and Cancer. CNS Neurol Disord Drug Targets, 14 (7): 936-46. |
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Sinha S, Shukla S, Khan S, Tollefsbol TO and *Meeran SM (2015) Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells. Mol. Cell Endocrinol., 406: 102-114. |
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Khan S, Shukla S, Sinha S, Lakra AD, Bora HK and *Meeran SM (2015) Centchroman suppresses breast cancer metastasis by reversing epithelial-mesenchymal transition via downregulation of HER2/ERK1/2/MMP-9 signaling. Int. J. Biochem. & Cell Biol. 58: 1-16. |
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Li Y, Meeran SM, Patel SN, Chen H, Hardy TM, and Tollefsbol TO (2013) Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. Mol Cancer 12(9):1-17 |
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Meeran SM, Patel SN, Chan TH and Tollefsbol T (2011) A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells. Cancer Prev Res. 4. (8): 1243-54 |
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Li Y, Yuan YY, Meeran
SM and Tollefsbol TO (2010)
Synergistic epigenetic reactivation of estrogen receptor-a
by combined green tea polyphenols and histone deacetylase
inhibitor in ERa-negative breast cancer cells. Molecular
Cancer, 9: 274 |
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Meeran SM,
Patel SN and Tollefsbol T (2010) Sulforaphane
causes epigenetic repression of hTERT expression in human
breast cancer cells. PLoS ONE. 5(7):
e11457. |
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Sharma SD, Meeran
SM and Katiyar SK (2010) Proanthocyanidins
Inhibit In vitro and In vivo Growth of Human Non-Small
Cell Lung Cancer Cells by Inhibiting the Prostaglandin
E2 and Prostaglandin E2 Receptors. Mol Cancer
Ther. 9(3): 569-80. |
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Katiyar SK, Vaid M, van
Steeg H and Meeran SM (2010)
Green Tea Polyphenols Prevent UV-Induced Immunosuppression
by Rapid Repair of DNA Damage and Enhancement of Nucleotide
Excision Repair Genes. Cancer Prev Res.
3(2): 179-89. |
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Meeran SM,
Singh T, Nagy TR and Katiyar SK (2009)
High-Fat Diet Exacerbates Inflammation and Cell Survival
Signals in the Skin of Ultraviolet B-Irradiated C57BL/6
Mice. Toxicol Appl Pharmacol. 241(3):
303-10. |
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Sharma SD, Meeran
SM, Katiyar N, Tisdale B, Yusuf N, Xu H, Elmets
CA and Katiyar SK (2009). IL-12-deficiency
suppresses 12-O-tetradecanoylphorbol-13-acetate-induced
skin tumor development in 7, 12-dimethylbenz (a)anthracene-initiated
mouse skin through inhibition of inflammation. Carcinogenesis.
30(11): 1970-7. |
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Meeran SM,
Katiyar N, Singh T and Katiyar SK (2009)
Loss of endogenous interleukin-12 activates survival signals
in UV-exposed mouse skin and skin tumors. Neoplasia
11(9): 846-55. |
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Meeran SM,
Vaid M, Punathil T and Katiyar SK (2009)
Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl
phorbol-13-acetate-caused skin tumor promotion in 7, 12-dimethylbenz(a)anthracene-initiated
mouse skin, which is associated with the inhibition of
inflammatory responses. Carcinogenesis.
30(3): 520-8. |
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Akhtar S, Meeran
SM, Katiyar N and Katiyar SK (2009)
Grape seed proanthocyanidins inhibit the growth of human
Non-small cell lung cancer xenografts by targeting Insulin-like
growth factor binding protein-3, tumor cell proliferation,
and angiogenic factors. Clin Cancer Res.
15(3): 821-31 |
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Meeran SM,
Akhtar S and Katiyar SK (2009) Inhibition
of UVB-Induced Skin Tumor Development by Drinking Green
Tea Polyphenols Is Mediated Through DNA Repair and Subsequent
Inhibition of Inflammation. J Invest Dermatol.
129(5):1258-70. |
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Meeran SM,
Punathil T and Katiyar SK (2008) IL-12
deficiency exacerbates inflammatory responses in UV-irradiated
skin and skin tumors. J Invest Dermatol.
128: 2716-27. |
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Katiyar SK, Meeran
SM, Katiyar N and Akhtar S (2009)
p53 cooperates berberine-induced growth inhibition and
apoptosis of non-small cell human lung cancer cells in
vitro and tumor xenograft growth in vivo. Mol.
Carcinog. 48(1): 24-37. |
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Meeran SM,
Katiyar S and Katiyar SK (2008) Berberine-induced
apoptosis in human prostate cancer cells is initiated
by reactive oxygen species generation. Toxicol
Appl Pharmacol. 229: 33-43. |
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Meeran SM
and Katiyar SK (2008) Cell cycle control
as a basis for cancer chemoprevention through dietary
agents. Front Biosci. 13: 2191-2202 (Review).
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Meeran SM
and Katiyar SK (2008) Proanthocyanidin
inhibit mitogenic and survival-signalling invitro and
tumor growth in vivo. Front Biosci. 13:
887-897. |
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Meeran SM,
Katiyar S, Elmets CA, Katiyar SK. (2007)
Interleukin-12 deficiency is permissive for angiogenesis
in UV radiation-induced skin tumors. Cancer Res.
15; 67(8):3785-93. |
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Meeran SM
and Katiyar SK (2007) Grape seed proanthocyanidins
promote apoptosis in human epidermoid carcinoma A431 cells
through alterations in Cdki-Cdk-cyclin cascade, and caspase-3
activation via loss of mitochondrial membrane potential.
Exp Dermatol. 16(5):405-15. |
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Katiyar SK and
Meeran SM (2007). Obesity increases
the risk of UV radiation-induced oxidative stress and
activation of MAPK and NF-kappaB signaling. Free
Radic Biol Med 42 (2): 299-310. |
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Meeran SM,
Katiyar S, Elmets CA and Katiyar SK (2006).
Silymarin inhibits UV radiation-induced immunosuppression
through augmentation of interleukin-12 in mice.
Mol Cancer Ther 5(7): 1660-1668. |
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Meeran SM,
Mantena SK, Elmets CA and Katiyar SK (2006).
(-)-Epigallocatechin-3-gallate prevents photocarcinogenesis
in mice through interleukin-12-dependent DNA repair. Cancer
Res 66(10): 5512-5520. |
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Meeran SM,
Mantena SK, Meleth S, Elmets CA and Katiyar SK (2006).
Interleukin-12-deficient mice are at greater risk of UV
radiation-induced skin tumors and malignant transformation
of papillomas to carcinomas. Mol Cancer Ther
5(4): 825-832. |
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Meeran SM,
Mantena SK and Katiyar SK (2006). Prevention
of ultraviolet radiation-induced immunosuppression by
(-)-epigallocatechin-3-gallate in mice is mediated through
interleukin 12-dependent DNA repair. Clin Cancer
Res 12 (7): 2272-2280. |
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| Lab Members |
PhD Students
- Samriddhi Shukla (CSIR-SRF)
- Sajid Khan (CSIR-SRF)
- Sonam Sinha (PA)
Technical Assistant
Lab Assistant
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