DR. ATUL GOEL
 
...

Principal Scientist (CSIR) and Associate Professor (AcSIR).
Medicinal and Process Chemistry Division
Lab No. CSN-208
CSIR-Central Drug Research Institute
Sector 10, Jankipuram Extension, Sitapur Road,
Lucknow 226031, INDIA
Ph:+91-522-2772450, 2772550 Extn. 4765 (off), 4766 (lab)
Fax: +91-522-2771941
Email: [email protected], [email protected]
URL: http://www.cdriindia.org/agoel.htm
 
Educational Qualifications

M.Sc (Organic Chemistry, University of Lucknow, Lucknow, India, 1992)
Ph.D. (Chemistry, CSIR-Central Drug Research Institute, Lucknow, 1998)
Date of Birth 13th March, 1970
E Mail [email protected] , [email protected]
 
POSTDOCTORAL RESEARCH ( ABROAD)
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 National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA with Dr. Ettore Appella during May 1999 - Oct. 2001
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 Alexander von Humboldt Fellow (Experienced Researcher) with Prof. Dr. Dr. h. c. Gerhard Bringmann, Institute of Organic Chemistry, University of Wuerzburg, Germany (July 2008-March 2009)
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 Alexander von Humboldt Visiting Scientist, Institute of Organic Chemistry, University of Wuerzburg, Germany (Oct. 2010-Dec. 2010)
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 Alexander von Humboldt Visiting Scientist, Institute of Organic Chemistry, University of Wuerzburg, Germany (May 2011-July 2011)
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 Raman Research Fellow (Visiting Academic) with Prof. Thomas Wirth, School of Chemistry, Cardiff University, Cardiff.
 
CURRENT AREAS OF INTEREST
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 Design and synthesis of biologically important natural and synthetic compounds and evaluation of their medicinal properties in the area of Reproductive Health Research, Diabetes and Energy Metabolism
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 New Fluorescent dyes/probes for biological and electroluminescent material applications such as fluorescent sensors, fluorescent probes, Organic Light Emitting Diodes (OLEDs) etc.
 
HONOURS & AWARDS
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 DAE-SRC Outstanding Investigator Award 2014-15, Department of Atomic Energy, Govt. of India
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 CRSI Bronze Medal 2015, Chemical Research Society of India (Announced)
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 Raman Research Fellowship Award for the year 2014-15 by Council of Scientific and Industrial Research, Ministry of Science and Technology, Govt. of India.
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 Honorary Diploma in Chemical Sciences for the year 2014-15 by International Scientific Partnership Foundation, Russia
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 Alexander von Humboldt Fellowship (Experienced Researcher category) in 2008 by AvH Stiftung, Bonn, Federal Republic of Germany
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 Dr. Ghanshyam Srivastava Memorial Award 2007-08 by Indian Chemical Society of India
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 CDRI Incentive Award in the years 2007- 2011, 2013-2015
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 Ramanna Fellowship in 2007-2010 by Department of Science and Technology, New Delhi, India
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 Young Scientist Award 2005 of Council of Science and Technology by Chief Minister, Government of Uttar Pradesh, India
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 DST Fast Track Young Scientist Award-2004
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 National Institutes of Health Fellowship, USA in 1999
 
RESEARCH APPRECIATION
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 Certificate of Appreciation for Thesis Advisor of 2012 Eli Lilly and Company Asia Outstanding Thesis Awardee (Dr. Vijay Kumar-First Prize)
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 Certificate of Appreciation for Thesis Advisor of 2010 Eli Lilly and Company Asia Outstanding Thesis Awardee (Dr. Amit Kumar-First Prize)
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 Certificate of Appreciation for Thesis Advisor of 2009 Eli Lilly and Company Asia Outstanding Thesis Awardee (Dr. Sumit Chaurasia-Second Prize)
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 Our paper on ‘novel concept’ for inhibiting Green Emission Defect (GED) (Organic Letters, 2009, 6, 1289) was highlighted in the slide show by American Chemical Society (ACS) during May 2009
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 Our article on Yellow Fluoranthenes (J. Org Chem., 2010, 75, 3656) was highlighted in the slide show by American Chemical Society (ACS) during June 2010
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 The article on Nonaggregating Blue Pyrenylarenes (J. Org. Chem., 2011, 76, 7474) was highlighted in the slide show by American Chemical Society (ACS) during September 2011
RESEARCH GROUP
Former Ph.D. Students
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 Dr. Fateh Veer Singh (PDF, FAPESP Fellowship in Brazil, Prestigious Marie Curie Fellowship with Prof. Thomas Wirth at Cardiff University,UK)
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 Dr. Manish Dixit (PDF, Dr. S. Bhattacharya at National Institutes of Health, NCI, USA)
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 Dr. Deepti Verma (PDF with Prof. I. N. N. Namboothiri at IIT, Mumbai)
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 Dr. Sumit Chaurasia (PDF with Prof. J. T. Lin at Academia Sinica, Taipei; 2009 Eli-Lilly and Company   Asia Outstanding Thesis Award )
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 Dr. Amit Kumar (PDF, Skaggs School of Pharmacy and Pharmaceutical Sciences,University of Colorado, USA; 2010 Eli-Lilly and Company Asia Outstanding Thesis Award)
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Dr. Vijay Kumar (PDF, Skaggs School of Pharmacy and Pharmaceutical Sciences,University of Colorado, USA; 2012 Eli-Lilly and Company Asia Outstanding Thesis Award)

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 Dr. Salil P. Singh
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 DR. Amrita Parihar
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 Dr. Pankaj Nag
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 Dr. Gaurav Taneja
Current Ph.D. Students
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 Mr. Ashutosh Raghuvanshi (SRF, Thesis Submitted)
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 Mr. Ashutosh Sharma (SRF)
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 Ms. Shahida Umar (JRF)
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 Mr. Ajay Kumar Jha (JRF)
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 Ms. Sachi Mishra (JRF)
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 Mr. Chandra Prakash (JRF)
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Mr. Deepak Purohit (JRF)
Project Fellow/Research Trainee
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Ms. Vartika Vaishya (under CSIR Network 'HOPE' Project, 2013-14)
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Ms. Pallavi Awasthi (under ICMR ‘DHR’ Project
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Ms. Archita Gupta (under CSIR Network ‘HOPE’ Project)
  NIPER Students
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 Mr. Madan Lal Soni (NIPER, Raibareli)(2010-11)
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 Mr. Govind Tiwari (NIPER, Raibareli)(2011-12)
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 Mr. Mullapudi Mohan Reddy (NIPER, Raibareli)(2012-13)
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 Mr.KalluriAnkarao (2013-14)
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 Mr.VibhuJha (2014-15)
  Current Project Fellow
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 Ms. Vartika Vaishya (PA under 'HOPE' Project)
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 Mr Kalluri Ankarao
   
 
RESEARCH ACTIVITIES
My research group is mainly focused on two major topics of organic and medicinal chemistry as mentioned below:
(i) Drug Development of Biologically Important Natural and Synthetic Products
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During drug development program on Reproductive health including management of osteoporosis and bone related disorders, CSIR-CDRI research group observed that crude extract of Butea monosperma exhibited in vitro and in vivo bone forming (osteoblast mineralization) activity (Pandey et al. Menopause, 2010, 17, 602-610). Fractionation-guided activity showed a mixture of five isoflavonoids having good osteogenic activity. In order to identify the activity of individual isoflavonoids, high quantities of medicarpin and cajanin were required. We developed efficient protocol for the synthesis of these natural isoflavonoids (medicarpin and cajanin) and their new derivatives, and demonstrated their differential actions in osteoblasts and parameters of acquisition of PBM in growing female rats (Tyagi et al. Molecular and Cellular Endocrinology 2010, 325, 101-109; J. Nutritional Biochemistry, 2012, 23, 27-38; Osteoporosis International, 2012, 23, 1151-1161). We further prepared a series of new pterocarpans and showed that they hold therapeutic promise in postmenopausal osteoporosis (Goel et al.: Substituted benzofurochromenes and related compounds for the prevention and treatment of bone related disorders:US-8686028 dated 01-04-2014).Several New leads were identified as potent osteogenic agents and one of the pterocarpans CDRI-1500 (Pteroheal) significantly stimulated callus formation and increased fracture healing at only 1.0 mg/kg/day dose in adult rats. New bone formation at the fracture site is increased by ~40% in rats treated with CDRI-1500 compared to vehicle treated rats. Pteroheal (CDRI-1500) is currently under development mode and it is found safe in regulatory toxicology and pharmacology studies. Pteroheal is now ready for Licensing and we are looking for industrial partner for further development.

 
 
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(ii)New Organic Fluorescent Molecules through Ring Transformation Strategy and their Applications

In Biological Sciences

We have designed and synthesized Donor-Acceptor Fluoranthene Dye FLUN-550 for Selective Fluorescence Staining of cytoplasmic lipid droplets of 3T3-L1 pre-adipocytes as well as for selective staining of neutral lipid droplets of Leishmania donovani parasite and soil nematode C. elegans for live and fixed cell imaging applications in chemical and molecular biology (Goel et al. Patent Appl. No. 807DEL2013 dated 19/03/2013; Organic Letters, 2014, 16, 756-759). Very recently, our group has discovered and reported ‘First’ dual colorimetric-ratiometric fluorescent probe ‘NAP-3’ for selective and direct visualization of Labile Iron (III) pools in multicellular oragnaisms (Soil nematode C. elegans) (Goel et al. Chem. Commun. 2015, 51, 5001). This probe has opened new avenues for enhancing our understanding on the crucial role of iron-catalyzed generation of reactive oxygen species, which is associated with diseases like cancer, diabetes and neuro-degenerative disorders.
 
 

In Material Sciences

Our group is engaged in the development of New Organic Fluorescent Dyes with absorption and emission at variety of wavelength for biological (as drug candidates or biomarkers) and material (smart electroluminescent devices) applications. Recently we have demonstrated a novel ‘concept’ of inhibiting “Green Emission Defect” in fluorene-based OLEDs by transforming “green-yellow” fluorenone molecules to “blue” fluorenone compounds by appropriate positioning of donor-acceptor and chromophoric groups onto widely used fluorene/fluorenone -conjugated system (Goel et al. PCT patent WO/2009/122445 dated 08.10.2009; PCT/IN2009/000215 dated 31.03.09). The performance of a blue fluorene was investigated by fabricating a multilayer OLED with a configuration of ITO/PEDOT:PSS/TPD (30nm)/D/A-fluorene (60nm)/BCP (8nm)/ LiF(0.5nm)/Al (160 nm), which revealed stable bright blue emission with a low turn on voltage of 3.5V and a brightness of 573 Cd/m2 with good chemical, thermal and electrochemical stability (Goel et al. Organic Letters, 2009, 6, 1289). We have shown that emission color can be effectively controlled from ‘blue to green to yellow to red’ by modulating the aromatic -characteristic not only in solution (photoluminescence) but also in solid electroluminescent devices (Goel et al. J. Mater. Chem. 2012, 22,14880). We have successfully prepared (In collaboration with IIT Electrical Engineer Dr. RS Anand at Kanpur) Yellow Fluorescent ‘Panels’ for exploring their potential for technology development.

 
LIST OF PATENTS
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Atul Goel, Ashutosh Sharma, Kalyan Mitra, Arindam Bhattacharjee, Manoj Kathuria; Substituted fluoranthene-7-carbonitriles/esters as fluorescent dyes for cell imaging applications,PCT/IN2014/000156 dated 10MAR2014; 807DEL2013 dated 19.03.13.
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Atul Goel, Gaurav Taneja, Neha Rahuja, Arun Kumar Rawat, Natasha Jaiswal, Akhilesh Kumar Tamrakar, Arvind Kumar Srivastava, Novel substituted 2H-benzo[e]indazole-9-carboxylates for the treatment of diabetes and related disorders, (PCT/IN2013/000056 dt Jan 29, 2013; 0262DEL2012 Dated 31Jan-2012).

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Goel, A., Kumar, A., Chaurasia, S., Singh, D., Gautam, A. K., Pandey, R., Trivedi, R., Singh, M. M., Chattopadhyay, N., Manickavasagam, L., Jain, G. K., Dwivedi, A. K. (2008): Substituted benzofurochromenes and related compounds for the prevention and treatment of bone related disorders: Patent Pub No. WO/2010/052734 dated 14.05.2010; PCT filing Appl. No. PCT/IN2009/000285 dated 14-05-09; CSIR No. 2511/DEL/2008 dated 06.11.08; CDRI Ref No. 0095/NF/2008  dated 31-03-08.
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Goel, A., Chaurasia, S., Kumar, V., Manoharan, S., Anand, R. S. (2008): Novel Donor-acceptor fluorene scaffolds: A process and uses thereof. Pub. No. WO/2009/122445 dated 08.10.09; PCT/IN2009/000215 dated 31.03.09. Indian Patent Appl. No. 0838DEL2008 dated 28/03/2008; CDRI Ref. No. 0053/NF/2008 dated 04-03-08.
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 Goel, A., Singh, F. V., Garg, P., Dohare, P., Ray, M. (2007): Novel tetrahydrocyclopropa[a]naphthalenes for the treatment of neurocerebrovascular disorders.  Indian patent No. 0271/NF2006/IN, dated  06-07-07; Pat. Appl. No. 1523DEL2007, date 18-07-2007.
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Maurya, R., Goel, A., Narender, T., Srivastava, A. K., Rastogi, A. K., Agarwal, S. C., M. Rajendran, S., Nath, C., Gupta, C. M., Yadav, P. P., Shweta, Dixit, M., Tiwari, P., Tripathi, B. K. (2006): Isolation and synthesis of novel furano- and pyranoflavonoids as antidiabetic agents:  Indian Patent Appl. No. 0199NF2005/IN, dated  20-02-06.
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Goel, A., Dixit, M. (2004): A new process for the synthesis of hydroxy-5-acetylcoumarones: Indian Patent No. 0048NF2004/IN, dated 13-09-04.
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 Inman, J.K., Goel, A., Appella, E., Turpin, J. A., Schito, M. (2001): Acylthiol and Component Thiol Compositions as Anti-HIV and Anti-Retroviral Agents: United States (WO 2003/014062 dated 20.02.2003); Patent Application No.: 60/310,133, PCT/US02/23924; 03-08-01.
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Ram, V. J., Goel, A., Dubey, M. P., Pandey, C. P. (1997): A process for the synthesis of novel functionalized biaryls as hepatoprotective agents: Indian Patent No. 3517/DEL/97 dated 08‑12‑97.

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Ram, V. J., Goel, A., Shukla, P. K. (1996): A process for the preparation of substituted thiophenes useful as antimycotic agents. Indian Patent, No. 2955/DEL/96 dated 27-12-96.

 
 
SELECTED PUBLICATIONS (Total Number of Publications: >85)
 
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 Ashutosh Sharma, Shahida Umar, ParmitaKar, Kavita Singh, Monika Sachdev, and AtulGoel*, A New Class of Biocompatible Fluorescent Probe AFN for Fixed and Live Cell Imaging of Intracellular Lipid Droplets, Analyst 2015, Accepted.
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 Atul Goel,* Shahida Umar, Pankaj Nag, Ashutosh Sharma, Lalit Kumar, Shamsuzzama, ZakirHossain, Jiaur R. Gayen, AamirNazir, A dual colorimetric-ratiometric fluorescent probe NAP-3 for selective detection and imaging of endogenous labile iron(III) pools in C. elegans, Chem. Commun. 2015, 51, 5001-5004.
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 AtulGoel,* AshutoshRaghuvanshi, Amit Kumar, AbnishGautam, KaminiSrivastava, JyotiKureel, Divya Singh, 9-Demethoxy-medicarpin promotes peak bone mass achievement and has bone conserving effect in ovariectomized mice: positively regulates osteoblast functions and suppresses osteoclastogenesis, Mol. Cell. Endocrinol. 2015, 411, 155-166.
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 IshaTaneja, KSR Raja, MuralikrishnaChallagundla, AshutoshRaghuvanshi, AtulGoel, Muhammad Wahajuddin, LC-ESI–MS/MS method for bioanalytical determination of osteogenicphytoalexin, medicarpin, and its application to preliminary pharmacokinetic studies in rats, J. Chromatograhy B, 2015, 1001, 9-16.
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 Atul Goel,* Shahida Umar, Pankaj Nag, Ashutosh Sharma, Lalit Kumar, Shamsuzzama, Zakir Hossain, Jiaur R. Gayen, Aamir Nazir, A dual colorimetric-ratiometric fluorescent probe NAP-3 for selective detection and imaging of endogenous labile iron(III) pools in C. elegans, Chem. Commun. 2015, 51, 5001-5004.
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 Atul Goel*, Ashutosh Sharma, Madhu Rawat, R. S. Anand, and Ruchir Kant, Synthesis of Fluorescent C2-Bridged Teraryls and Quateraryls for Blue, Sky-Blue, and Green Color Light-Emitting Devices, J. Org. Chem. 2014, 79, 10873-10880.
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 Atul Goel,* Pankaj Nag, Neha Rahuja, Rohit Srivastava, Sumit Chaurasia, Sudeep Gautam, Sharat Chandra, Mohammad Imran Siddiqi, Arvind K. Srivastava, Discovery of Biaryl-4-carbonitriles as Antihyperglycemic Agents that may act through AMPK-p38 MAPK pathway, Mol. Cell. Endo. 2014, 394, 1-12.
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 Atul Goel,* Ashutosh Sharma, Manoj Kathuria, Arindam Bhattacharjee, Ashwni Verma, Prabhat R. Mishra, Aamir Nazir, Kalyan Mitra, New Fluoranthene FLUN-550 as a Fluorescent Probe for Selective Staining and Quantification of Intracellular Lipid Droplets, Organic Letters 2014, 16, 756-759.
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 J Kureel, M Dixit, A M Tyagi, M N Mansoori, K Srivastava, A Raghuvanshi, R Maurya, R Trivedi, A Goel and D Singh, miR-542-3p suppresses osteoblast cell proliferation and differentiation, targets BMP-7 signaling and inhibits bone formation, Cell Death and Disease, 2014, 5, e1050; doi:10.1038/cddis.2014.4.
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 Atul Goel, Amrita Parihar, Pratibha Mishra, Salil Varshney, Pankaj Nag, Muheeb Beg, Anil Gaikwad, and S. K. Rath, Design and Synthesis of Novel Pyranone-Based Insulin Sensitizers Exhibiting In Vivo Hepatoprotective Activity, Med. Chem. Commun., 2013, 4, 1532-1536.
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 Atul Goel*, Amit Kumar, Ashutosh Raghuvanshi: Synthesis, Stereochemistry, Structural Classification and Chemical Reactivity of Natural Pterocarpans, Chemical Reviews, 2013, 113, 1614-1640.
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 Atul Goel,* Gaurav Taneja, Ashutosh Raghuvanshi, Ruchir Kant, Prakas R. Maulik: Diversity-Oriented General Protocol for the Synthesis of Privileged Oxygen Scaffolds: Pyrones, Coumarins, Benzocoumarins and Naphthocoumarins, Org. Biomol. Chem.2013, 11, 5239
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 Atul Goel*, Amit Kumar, Ashutosh Raghuvanshi, Ram Jeet, Yasmin Hemberger, Michael Knauer, Jyoti Kureel, Anuj K. Singh, Abnish Gautam, Ritu Trivedi, Divya Singh, Gerhard Bringmann: Synthesis, optical resolution, absolute configuration, and osteogenic activity of enantiomerically pure pterocarpans, Org. Biomol. Chem. 2012, 10, 9583 (Cover Page).
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 Atul Goel,* Vijay Kumar, Salil P. Singh, Ashutosh Sharma, Sattey Prakash, Charan Singh, R. S. Anand, Non-aggregating Solvatochromic Bipolar Benzo[f]quinolines and Benzo[a]acridines for Organic Electronics, J. Mater. Chem. 2012, 22, 14880-14888.
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 Abdul Malik Tyagi, Kamini Srivastava, Jyoti Kureel, Anuj Kumar Singh, Kunal Sharan, Amit Kumar, Atul Goel, Divya Singh: Premature T Cell Senescense in Ovx Mice is inhibited by repletion of Estrogen and Medicarpin: A Possible Mechanism for Alleviating Bone Loss, Osteoporosis International, 2012, 23, 1151-1161.
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 Biju Bhargavan, Divya Singh, Abnish Kumar Gautam, Jay Sharan Mishra, Amit Kumar, Atul Goel, Manish Dixit, Rashmi Pandey, Lakshmi Manickavasagam, Shailendra Dhar Dwivedi, Bandana Chakravarti, Girish Kumar Jain, Ravishankar Ramachandran, Naibedya Chattopadhyay,  Sabyasachi Sanyal: Medicarpin, a Legume Phytoalexin, Stimulates Osteoblast Differentiation and Promotes Peak Bone Mass Achievement in Rats: Evidence for Estrogen Receptor b-mediated Osteogenic Action of Medicarpin, J. Nutritional Biochemistry, 2012, 23, 27-38.
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 Atul Goel*, Vijay Kumar, Pankaj Nag, Vikas Bajpai, Brijesh Kumar, Charan Singh, Sattey Prakash, and R. S. Anand: Thermally Stable Nonaggregating Pyrenylarenes for Blue Organic Light-Emitting Devices, J. Org. Chem., 2011, 76, 7474-7481.
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 Atul Goel,* Vijay Kumar, Sumit Chaurasia, Madhu Rawat, Ramesh Prasad, R. S. Anand: Synthesis, Electrochemical and Optical Properties of Novel and Stable Yellow Fluorescent Fluoranthenes, J. Org. Chem., 2010, 75, 3656-3662.
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 Abdul M Tyagi,; Abnish K Gautam,; Amit Kumar; Biju Bhargavan; Kamini Srivastava; Ritu Trivedi; Dinesh K Yadav, S Saravanan, Caroline Pollet, Michel Brazier, Romuald Mentaverri, Rakesh Maurya, Naibedya Chattopadhyay, Atul Goel*, Divya Singh*: Medicarpin inhibits osteoclastogenesis and has nonestrogenic bone conserving effect in ovariectomized mice, Molecular and Cellular Endocrinology 2010, 325, 101-109.
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 Goel, A., Singh, S. P., Kumar, A., Kant, R., Maulik, P. R.: Unprecedented ‘Bridged Annulation’ Approach to the Construction of 5,6-Dihydro-4H-benzo[kl]acridines. Organic  Letters 2009, 11, 5122-5125.
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 Goel, A.*, Chaurasia, S., Dixit, M., Kumar, V., Prakash, S., Jena, B., Verma, J. K., Jain, M., Anand, R. S., Manoharan, S. S.: Donor-Acceptor 9-Uncapped Fluorenes and Fluorenones as Stable Blue Light Emitters. Organic Letters 2009,11, 1289-1292.
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 Goel, A.; Dixit, M.; Chaurasia, S.; Kumar, A.; Raghunandan, R.; Maulik, P. R.; Anand, R. S.: Vapor-Phase Processable Novel Nonplanar Donor-Acceptor Quateraryls for Blue-OLEDs. Organic Letters 2008,10, 2553-2556.
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 Goel Atul, Singh Fateh Veer, Dixit Manish, Verma Deepti, Raghunandan Resmi and Maulik Prakas R. - Highly efficient non-palladium-catalyzed controlled synthesis and X-ray analysis of functionalized 1,2-diaryl-, 1,2,3-triaryl-, and 1,2,3,4-tetraarylbenzenes. Chemistry-An Asian Journal 2007, 2, 239-247.
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 Goel Atul, Singh FV, Kumar V, Reichert M, Gulder TA and Bringmann G. - Synthesis, optical resolution and configurational assignment of novel axiallychiral quateraryls. 2007, J. Org. Chem., 72, 7765-7768.
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 Atul Goel,* Deepti Verma, Manish Dixit, Resmi Raghunandan, P. R. Maulik: Acetyltrimethylsilane: A Novel Reagent for the Transformation of 2H-Pyran-2-ones to Unsymmetrical Biaryls J. Org. Chem., 2006, 71, 804-807.
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 Farhanullah, Agarwal, N., Goel, A., Ram, V.J.: A concerted synthesis of aminonicotinonitriles and diaminopyridines through base catalyzed ring transformation of 2H-Pyran-2-ones. J. Org. Chem. 2003, 68, 2983-2985