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Dr. ANIL KUMAR BALAPURE |
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Chief Scientist
Biochemistry
Central Drug Research Institute (CDRI)
Post Box-173
Lucknow-226031
India
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| POST-DOCTORAL
RESEARCH |
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Mar 15, 1983
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Nov 30, 1983
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Visiting Fellow,
Laboratory of Molecular Biophysics, National Institute
of Environmental Health Sciences, NIH, Research Triangle
Park, NC 27709. |
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Dec 2, 1983 -
June 15, 1986
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Guest Researcher, June 16, 1986 -
Dec 31, 1986
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Visiting Fellow, Laboratory
of Biochemistry & Metabolism,
NIDDK, NIH, Bethesda, MD 20814.
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June 16, 1986 -
Dec 31, 1988
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Post-doctoral Research
Associate, Dept. of Obstetrics & Gynecology, Uniformed
Services, University of Health Sciences, Bethesda, MD
20814. |
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Jan 1, 1989 -
Sept 30, 1990
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Research Associate, Department
of Medicine, Uniformed Services University of Health Sciences,
Bethesda, MD 20814. |
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| CURRENT
AREAS OF INTEREST |
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Creation,
Organization & Operation of Tissue & Cell Culture
Facility for the Institute’s Primary Biological
Screening Program including need-based incorporation of
new cell lines; Provision of Cell Culture Flasks on payment
basis to Pharma Industry etc. Development of New Cell
Lines e.g. hGF - Human Gingival Fibroblasts [Nigam
et al: Life Sciences 82(2008),577-590]; Serum-free explant
culture of tissues and organs [Sharma et al: In vitro
Cellular and Developmental Biology - Animal 38(2002),293-297];
In vitro cell based assays for the primary screening of
ligands with special reference to antineoplastic, Antiestrogenic
properties etc. |
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Molecular Basis of Action
of Antineoplastic Agents with special reference to Centchroman,
the in-house developed and marketed contraceptive, vis-à-vis
Tamoxifen. |
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| SELECTED
PUBLICATIONS |
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Pharmacological inhibition
of gut-derived serotonin synthesis is a potential bone
anabolic treatment for osteoporosis Vijay K Yadav, Santhanam
Balaji, Padmanaban S Suresh, X Sherry Liu, Xin Lu, Zhishan
Li, X Edward Guo, J John Mann, Anil K Balapure,
Michael D Gershon, et al. Nature Medicine
16, 308-312 (2010) doi:10.1038/nm.2098
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Regulation
of extracellular matrix genes by arecoline in primary
gingival fibroblasts requires epithelial factors. G.S.
Thangjam, P. Agarwal, Anil K. Balapure,
S.G. Rao and P. Kondaiah. J Periodontal. Res.
(In Press; 2009). |
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Evaluation of In-vivo
Anti-implantation and In-vitro Anti-proliferate
Activities of Substituted 3-phenyl-4-phenylvinyl Benzopyranone
Derivatives. A. Gupta, R.Sharma, Anil K. Balapure,
G. Keshri, M.M. Singh and S. Ray. Letters in Drug
Design & Discovery 6, 46-50, (2009). |
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Caspase mediated enhanced
apoptotic action of Cyclophosphamide and Resveratrol treated
MCF-7 cells. Neetu Singh, M. Nigam, V. Ranjan, R. Sharma,
Anil K. Balapure and S.K. Rath. J.
Pharmacological Sciences 109, 473-485, (2009). |
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Generalized Lymphadenopathy
and Nasal Obstruction: Rosai-Dorfman disease in an adult
Asian Indian. Neetu Singh, Ramesh Sharma,*Sanjay Singh
& Anil K. Balapure. ENT-
Ear, Nose & Throat Journal (USA), 88, E20-E23,
(2009). |
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Transglutaminase-2 Regulation
by Arecoline in Gingival Fibroblasts. Thangjam GS, Agarwal
P, Verma UP, Anil K. Balapure, Rao SG
and Kondaiah P. J Dental. Res. 88, 170-175,
(2009). |
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DNA Aneuploidy Study for
Early Detection of Chromosomal Abnormality in Patients
with Aplastic Anemia: Prognostic and Therapeutic implications.
P. Tripathi, A.K. Tripathi, A. Kumar, R. Ahmed, Anil
K. Balapure, A.L. Vishwakerma and R.K. Singh.
In vivo 22, 837-844, (2008). |
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S-phase fraction as a
useful marker for prognosis and therapeutic response in
patients with aplastic anemia. A.K. Tripathi, P. Tripathi,
A. Kumar, R. Ahmed, Anil K. Balapure,
A.L. Vishwakerma. Hematolo. Stem Cell Ther
1, 216-220, (2008). |
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Centchroman induces G0/G1
arrest and caspase-dependent apoptosis involving mitochondrial
membrane depolarization in MCF-7 and MDA MB-231 Human
Breast Cancer Cells. M. Nigam, V. Ranjan, S. Srivastava,
R. Sharma and Anil K. Balapure.
Life Sciences (USA) 82, 577-590, (2008). |
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Stimulatory effect of
Ceriops tagal on hexose uptake in L6 muscle cells in culture.
A K. Tamrakar, R. Kumar, R. Sharma, Anil K. Balapure,
V. Lakshmi and A.K. Srivastava. Natural Products
Research (USA) 22(7), 592-599, (2008). |
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pH regulated scavenging
activity of beer antioxidants through modified DPPH Assay.
Neetu Singh, Ramesh Sharma and Anil K. Balapure.
Toxicology and Industrial Health 23,
75-78, (2007). |
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A. Shrivastava, M.Tewari,
R.A. Sinha, A.Kumar, A.K. Balapure, V.K.
Bajpai, R. Sharma, K.Mitra, A.Tandon and M.M.Godbole.
Molecular iodine induces caspase-independent apoptosis
in human breast carcinoma cells involving mitochondria-mediated
pathway. J Biol Chem. 281: 19762 (2006). |
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Mechanism of 4-HPR- induced
apoptosis in glioma cells: evidences suggesting role of
mitochondrial-mediated pathway and endoplasmic reticulum
stress. M. Tewari, -------- A.K. Balapure,
Ramesh Sharma. V.K.Bajpai, K. Mitra S. Babu and M.M. Godbole.
Carcinogenesis 27, 2047-2058, (2006). |
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Rapid synthesis of -----------
coupling reaction. A. Gupta, A. Dwivedi, G. Keshri, R.
Sharma, A.K. Balapure, M.M. Singh and
S. Ray. Bioorg. Medicinal Chem. Letters.
16, 6006-12, (2006). |
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Shagufta, A.K. Srivastava,
Ramesh Sharma, R. Mishra, A.K. Balapure,
P.S.R. Murthy and G. Panda. Substituted phenanthrenes
with basic amino side chains: A new series of anti-breast
cancer agents. Bioorg. Medcinal Chem. Letters.
14: 1497-1505, (2006). |
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Morphological and biochemical
basis of Centchroman as a novel antineoplastic agent in
MCF-7 Human Breast Cancer Cells, S. Srivastava, R. Sharma
and Anil K. Balapure. Indian J Pharmacol.
36,238-243, (2004). |
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Histological and ultrastructural
regulation in rabbit endometrial explants in serum- free
culture, R. Sharma, S. Srivastava, V. K. Bajpai &
A.K. Balapure - In Vitro Cell Dev Biol-Animal
38: 293-297, (2002). |
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Differential action of
iodine on mitochondria from human tumoral- and extra-
tumoral tissue in inducing the release of apoptogenic
proteins. Geeta Upadhyay, Rajesh Singh, Ramesh Sharma,
Anil K. Balapure and Madan M. Godbole.
Mitochondrion 2 (3): 199- 210, (2002). |
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Simplified cryopreservation
of mammalian cell lines. A.K.Saxena, S.Ramchandani, A.Dwivedi,
R.Sharma, V.K.Bajpai, K.R.Bhardwaj and A.K. Balapure.
In Vitro Cell & Develop Biol (Animal), USA
31, 326, (1995). |
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