ANIL NILKANTH GAIKWAD
 
 

Sr. Scientist
Pharmacology Division
CSIR-Central Drug Research Institute
Sector-10, Jankipuram Extension
Lucknow-226031
 
E-Mail anil_gaikwad<at>cdri.res.in
Educational qualifications M.S. Pharm (NIPER-M), Ph.D. (JNU)
Date of Birth 12.05.1977
 
PROFESSIONAL EXPERIENCE
 
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2006-2010: Scientist C, Drug Target Discovery and Development Division, CSIR-Central Drug Research Institute, Lucknow
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2008-09: BOYSCAST Fellowship: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden Germany
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2003-2006: Scientist B, Drug Target Discovery and Development Division, CSIR-Central Drug Research Institute, Lucknow
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2003-2006: Scientist B, Drug Target Discovery and Development Division, CSIR-Central Drug Research Institute, Lucknow
 
RESEARCH INTEREST
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  • Adipocyte Biology
  • Adipocyte insulin resistance
 
AREAS OF INTEREST

Our group is working presently in adipocyte biology and adipocyte insulin resistance from year 2010.

(1) Adipocyte differentiation: Our group is involved in basic as well as applied research in this field. Our interest is work in molecular mechanisms of adipocyte differentiation under hormonal stimuli. We are interested in identifying novel anti-adipogenic and pro-adipogenic compounds and their mechanisms adipogenic alterations. Towards this, we use 3T3-L1 preadipocyte as model. The outcome of 3T3-L1 studies are further substantiated using other in vitro model of adipogenesis using murine stem cell line C3H10T1/2 or human mesenchymal stem cell derived adipocyte. For in vivo evaluations, we have high fat diet induced dyslipidemia model of hamster and high fat diet induced obesity model using C57BL6 mice.

(2) Adipocyte insulin resistance: Glucose homeostasis is mainly regulated by 3 major organs which include liver, adipocyte and skeletal muscle. As adipocyte is major chunk of body tissue and by virtue of its capabilities to secrete adipokines and cytokines, have emerged as a major endocrine organ. Slight dysfunction of this organ has major impact on overall body glucose homeostasis. We are presently working towards identification of mechanism(s) of insulin resistance in adipocytes employing various approaches including phosphoproteomics, differential gene and miRNA expression.  Overall aim of group is to develop systems understanding and identification of major pathways and proteins as contributors of insulin resistance.
For in vivo studies, we use various approaches including STZ Nicotinamide induced insulin resistance in rats, High fat diet induced insulin resistance development in mice, Dexamethasone induced insulin resistance and chronic insulin mediated insulin resistance.
The overall aim of these studies is towards identification of novel molecules those capable to prevent development of insulin resistance or reverse insulin resistance development.
 
RESEARCH GROUP
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Mr. Muheeb Beg (M.Sc.): Senior Research Fellow
Mr. Kripa Shankar (M. Sc): Junior Research Fellow
Mr. Sujith Rajan (M.Sc.): Junior Research Fellow
Mr. Abhishek Gupta (M.Sc.): Junior Research Fellow
Ms. Ankita Srivastava (M.Sc.): Junior Research Fellow
Mr. Salil Varshney (M.Sc.): Project Fellow
Mr. Durgesh Kumar Nema (M. Pharm.):GATE- Junior Research Fellow

Mr. Anil Kumar Verma (): Sr. Technician (I)
 
 
SELECTED PUBLICATIONS
 
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Salil Varshney, Kripa Shankar, Muheeb Beg, Vishal M. Balaramnavar, Sunil Kumar Mishra, Pankaj Jagdale, Shishir Srivastava, Yashpal S. Chhonker, Vijai Lakshmi, Bhushan Pradosh Chaudhari, Rabi Shankar Bhatta, Anil Kumar Saxena, and Anil Nilkanth Gaikwad*, "Rohitukine inhibits in vitro adipogenesis arresting mitotic clonal expansion and improves dyslipidemia in vivo", J. Lipid Res. jlr.M039925. First Published on March 19, 2014, doi:10.1194/jlr.M039925
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Beg M, Chauhan P, Varshney S, Shankar K, Rajan S, Saini D, Srivastava MN, Yadav PP, Gaikwad AN*. 2013, "A withanolide coagulin-L inhibits adipogenesis modulating Wnt/β-catenin pathway and cell cycle in mitotic clonal expansion." Phytomedicine. 2013 Nov 16. pii: S0944-7113(13)00418-2. doi: 10.1016/j.phymed.2013.10.009
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Atul Goel, Amrita Parihar, Pratibha Mishra, Salil Varshney, Pankaj Nag, Muheeb Beg, Anil Gaikwad and S. K. Rath , "Design and synthesis of novel pyranone-based insulin sensitizers exhibiting in vivo hepatoprotective activity", Med. Chem. Commun., 2013,4, 1532-1536
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Kumar KA, Reddy TC, Reddy GV, Reddy DB, Mahipal SV, Sinha S, Gaikwad AN, Reddanna P.High-throughput screening assays for cyclooxygenase-2 and 5-lipoxygenase, the targets for inflammatory disorders.Indian J Biochem Biophys. 2011 Aug;48(4):256-61.
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Dwivedi SK, Singh N, Kumari R, Mishra JS, Tripathi S, Banerjee P, Shah P, Kukshal V, Tyagi AM, Gaikwad AN, Chaturvedi RK, Mishra DP, Trivedi AK, Sanyal S, Chattopadhyay N, Ramachandran R, Siddiqi MI, Bandyopadhyay A, Arora A, Lundåsen T, Anakk SP, Moore DD, Sanyal SBile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor α.Mol Endocrinol. 2011 Jun;25(6):922-32. doi: 10.1210/me.2010-0512
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 Gaikwad AN and Sinha S - Determinants of natural immunity against tuberculosis in an endemic setting: factors operating at the level of macrophage-Mycobacterium tuberculosis interaction (2008) - Clin Exp Immunol 151, 414-22
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 Ghosh S, Tiwari P, Pandey S, Misra AK, Chaturvedi V, Gaikwad A, Bhatnagar S and Sinha S - Synthesis and evaluation of antitubercular activity of glycosyl thio- and sulfonyl acetamide derivatives (2008) - Bioorganic and Medicinal Chemistry Letters 18, 4002-5
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 Singh BK, Yadav AK, Kumar B, Gaikwad AN, Sinha SK, Chaturvedi V and Tripathi RP - Preparation and reactions of sugar azides with alkynes: synthesis of sugar triazoles as antitubercular agents (2008) - Carbohydrate Research 343, 1153-1162
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 Das Sajal Kumar, Panda Gautam, Chaturvedi Vinita, Manju YK, Gaikwad Anil K and Sinha Sudhir. - Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives. (2007) - Bioorganic & Medicinal Chemistry Letters 17, 5586-5589
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 Panda Gautam, Parai Maloy Kumar, Das Sajal Kumar, Shagufta, Sinha Manish, Chaturvedi Vinita, Srivastava Anil K, Manju YK, Gaikwad Anil N and Sinha Sudhir. - Effect of substituents on diarylmethanes for antitubercular activity. (2007) - European Journal of Medicinal Chemistry 42, 410-419
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 Saquib M, Gupta MK, Sagar R, Prabhakar YS, Shaw AK, Kumar R, Maulik PR, Gaikwad AN, Sinha S, Srivastava AK, Chaturvedi V, Srivastava R and Srivastava BS - C-3 alkyl/arylalkyl-2,3-dideoxy hex-2-enopyranosides as antitubercular agents: Synthesis, biological evaluation, and QSAR study. (2007) - Journal of Medicinal Chemistry 50, 2942-2950
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 Tripathi, R P; Saxena, Nisha; Tiwari, V K; Verma, S S; Chaturvedi, Vinita; Manju, Y K; Srivastva, A K; Gaikwad, A; Sinha, S - Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines (2006) - Bioorganic & Medicinal Chemistry, Volume 14, Issue 24, 8186-8196
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 Tripathi, R.P., Verma, S.S., Pandey, Jyoti, Agarwal, K.C., Chaturvedi, Vinita, Manju, Y.K., Srivastva, A.K., Gaikwad, A. and Sinha, S. - Search of antitubercular activities in tetrahydroacridines: Synthesis and biological evaluation (2006) - Bioorganic & Medicinal Chemistry Letters, Volume 16, Issue 19 , 5144-5147
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 Katiyar, D. , Tiwari, V.K., Tewari, N. , Verma, S.S. , Sinha, S. , Gaikwad, A. , Srivastava, A. , Chaturvedi, V. , Srivastava, R. , Srivastava, B.S. & Tripathi, R.P. - Synthesis and antimycobacterial activities of glycosylated amino alcohols and amines, (2005) - European Journal of Medicinal Chemistry, Volume 40, Issue 4, 351-360.
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 Panda, Gautam, Mishra, Jitendra Kumar, Sinha, Sudhir, Gaikwad, Anil K, Srivastava, Anil K, Srivastava, Ranjana & Srivastava, Brahm S. - 4-{10-(methoxybenzyl)-9-anthryl}phenol derivatives as new antitubercular agents. (2005) - Arkivoc, 29-45.
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 Sinha S., Kosalai K., Arora S., Namane A., Sharma P., Gaikwad A.N., Brodin P., Cole S.T. - Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics (2005) - Microbiology, 151, 2411-2419
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 Srivastava, T & Gaikwad, Anil K, Haq, Wahajul, Sinha, Sudhir & Katti, S.B. - Synthesis and biological evaluation of 4-thiazolidinone derivatives as potential antimicrobial agents. (2005) - Arkivoc, 120-30.
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 Tripathi, R.P. , Tiwari, V.K. , Tewari, N. , Katiyar, D. , Saxena, N. , Sinha, S. , Gaikwad, A. , Srivastava, A. , Chaturvedi, V. , Manju, Y.K. et al. - Synthesis and antitubercular activities of bis-glycosylated diamino alcohols, (2005) - Bioorganic & Medicinal Chemistry, 13, 5668-79
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 Tewari, N., Tiwari, V.K., Tripathi, R.P., Chaturvedi, V., Srivastava, A., Srivastava, R., Shukla, P.K., Chaturvedi, A.K., Gaikwad, A., Sinha, S. & Srivastava, B.S. - Synthesis of galactopyranosyl amino alcohols as a new class of antitubercular and antifungal agents. (2004) - Bioorganic and Medicinal Chemistry Letters, Volume 14, Issue 2, 2004, Pages 329-332.
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 R. Pathak, C. S. Pant, A. K. Shaw, A. P. Bhaduri, A. N. Gaikwad, S. Sinha, A. Srivastava, K. K. Srivastava, V. Chaturvedi, R. Srivastava and B. S. Srivastava, "Baylis-Hillman Reaction: Convenient Ascending Syntheses and Biological Evaluation of Acyclic Deoxy Monosaccharides as Potential Antimycobacterial Agents", Bioorganic & Medicinal Chemistry 10 :10, 2002, 3187-3196