Dr. ATUL KUMAR
 



Senior Principal Scientist
Medicinal Chemistry Division
CSIR-Central Drug Research Institute
Lucknow, 226031, INDIA
 
Educational Qualifications M.Sc. Ph.D.
Phone No. +91-0522-2772450-Ext 4757
Fax No. +91-0522-2771941
E- mail [email protected], [email protected]
Date of Birth April 28th 1963
 
POST DOCTORAL EXPERIENCE
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 2002-2003 State University Of New York At Buffalo, USA
 
RESEARCH & TEACHING EXPERIENCE
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 25 Years research experience in the area of Medicinal Chemistry
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 Course Coordinator- Green Chemistry and Sustainable Chemistry- Academy of Scientific and Innovative Research (AcSIR) and Jawaharlal Nehru University  (JNU)
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 Course Coordinator-( Medicinal Chemistry) National Institute of Pharmaceutical Education and Research (NIPER, Rae Bareli) ( Mentor Institute CSIR-CDRI)
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 Area Coordinator Cancer and Related areas CSIR-CDRI
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 Nodal Scientist : Medicinal Chemistry for Stem cell and Regenerative medicine
 
AREA OF RESEARCH SPECIALISATION
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 Medicinal Chemistry & Drug Design
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 Green Chemistry and Synthetic Organic Chemistry
 
CURRENT AREAS OF INTEREST
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  • Medicinal Chemistry & Drug Design
  • Design and Synthesis of Anti-osteoporosis, and Anti-diabetic agents
  • Design and Synthesis of anti-tubercular Agents
  • Design, synthesis of anti-cancer agents        
  • Chemical Approach to Stem cell and Regenerative medicine
  • Green Chemistry and Organic Chemistry
  • Development of green synthesis for natural products and  bioactive compounds  Biomimetic/bioorganic chemistry
 
AWARDS & HONOURS
Awards
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 Vigyan Ratna Samman, UPCST 2012
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 Organization of Pharmaceutical Producers of India (OPPI) OPPI SCIENTIST AWARD-2007,
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 CDRI Incentive Award in the years 2004, 2005, 2006, 2007, 2008, 2010 and 2011
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 CDRI Incentive Award four awards in 2012
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 CDRI Incentive Award Three awards in 2013
Honours
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 Global  Advisor council member of  SciFinder - Chemical Abstracts service ( CAS)  A division of the American Chemical Society (ACS) Columbus, USA
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 Synthesis of Benzimidazoles, Benzoxazoles and Benzothiazoles with PDAIS J. Combinatorial Chemistry 2009 was listed in SYNFACT issue 6, 2009. as distinguish paper.
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 Organic Chemistry Portal listed our publication SYNLET  2008(6): 883-885 as distinguish paper Web Links URL: http://www.organic-chemistry.org/abstracts/lit2/076.shtm
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  “Nature” eMagazine Nature India Research highlights Covered our Bioorganic Medicinal Chemistry 2010, 18  4138–4148. publication.
 Web Links: http://www.nature.com/nindia/2009/091224/full/nindia.2009.359.html
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  Nature” eMagazine Nature India Covered our Advanced Synthesis & Catalysis 2010 in its Research highlights
WEB links : http://www.nature.com/nindia/2010/100929/full/nindia.2010.132.html , http://www.nature.com/nindia/2009/091224/full/nindia.2009.359.html
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 Our compound 99-373 (Anti-osteoporosis) is listed in Report of Steering committee of Science and Technology for eleventh Five year plan (2007-2012) Government of India Planning Commission, December, 2006 as notable Science and technological achievements
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 Tetrahedron Letter 37,3463- 3466, 1993, Tetrahedron Letter  34, 4751- 4754,  1996 were listed in the "HEART CUT" Column of the CHEM TECH ( ACS Publication ) as a distinguish paper of the years 1993,1996
 

RESEARCH ACTIVITIES
 
PUBLICATIONS AT A GLANCE: Total – Original Research Publications -77,  Reviews-3 and Patents-42  
 
SELECTED PUBLICATIONS
2013
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 Nano-particle Catalysed Reaction (NPCR) : ZnO-NP catlyzed Ugi-reaction in aqueous medium, Atul Kumar,* Deepti Saxena and Maneesh; Green Chemistry 2013 (Press)
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 Novel diastereoselective synthesis of spiropyrrolidine-oxindole derivatives as anti-breast cancer agents Atul Kumar, * Garima Gupta, Suman Srivastava, Ajay Kumar Bishnoi, Ruchi Saxena, Ruchir Kant, Ranjana S. Khanna, Prakas R. Maulik and Anila Dwivedi   RSC Advances, 2013,  3, 4731-4735
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 Functional ionic liquid [bmim][Sac] mediated synthesis of ferrocenyl thiopropanones via the “dual activation of the substrate by the ionic liquid ,   Atul Kumar, * Suman Srivastava, Garima Gupta, Promod Kumar and Jayanta Sarkar   RSC Advances, 2013 3, 3548-3552
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 Micelle promoted multicomponent synthesis of 3-amino alkylated indoles via a Mannich-type reaction in water Atul Kumar,* Maneesh Kumar Gupta, Mukesh Kumar and Deepti Saxena   RSC Advances, 2013 3, 1673-1678
2012
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 L-Proline catalysed multicomponent synthesis of 3-amino alkylated indoles via a Mannich-type reaction under solvent-free conditions Atul Kumar, Maneesh Kumar Gupta and Mukesh Kumar; Green Chemistry, 2012 14, 290-295
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 Cascade [4 + 1] annulation via more environmentally friendly nitrogen ylides in water: synthesis of bicyclic and tricyclic fused dihydrofurans Atul Kumar, Suman Srivastava and Garima Gupta; Green Chemistry, 2012 14, 3269-3272
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 Catalyst-free hydroarylation of in situ generated ortho-quinone methide (o-QM) with electron rich arenes in water Atul Kumar,*  Maneesh K Gupta and Mukesh Kumar;
 Green Chemistry, 2012 14, 2677-2681
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 A catalyst-free C–H hydroarylation of coumarin derived ortho-quinone methide (o-QM) with electron rich arenes in glycerol Atul Kumar,*  M. K Gupta, Mukesh Kumar and  Lalit, P. Gupta RSC Advances, 2012 2, 8277-8280
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 Micelle promoted supramolecular carbohydrate scaffold-catalyzed multicomponent synthesis of 1,2-dihydro-1-aryl-3H-naphth[1,2-e][1,3]oxazin-3-one and amidoalkyl naphthols derivatives in aqueous medium Atul Kumar,*  Maneesh K Gupta and Mukesh Kumar RSC Advances, 2012 2, 7371-7376
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 Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice Atul Kumar,* S. Sharma, Lalit.P. Gupta P.Ahmad, Neha Rahuja, Swayam P. Srivastava, A.K. Tamrakar, Arvind K. Srivastava. Bioorganic & Medicinal Chemistry, 2012, 20, 2172-79
2011
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 Synthesis of New Class of Alkyl Azarene Pyridinium Zwitterions via IodineMediated sp3 C-H Bond Activation, Atul Kumar,* Garima Gupta, and Suman Srivastava;
Organic Letters, 2011 13, 24, 6366-6369
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 Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast
cancer agents Atul Kumar,* Vishwa Deepak Tripathi, Promod Kumar, Lalit Prakash Gupta, Akanksha, Ritu Trivedi, Hemant Bid, V.L. Nayak,  Jawed A. Siddiqui ,Bandana Chakravarti,  Ruchi Saxena , Anila Dwivedi , M.I. Siddiquee , U. Siddiqui  Rituraj Konwar , Naibedya Chattopadhyay Bioorganic & Medicinal Chemistry 2011 9, 5409–5419
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 Functional Ionic Liquid Mediated Synthesis (FILMS) of Dihydrothiophenes and Tacrine Derivatives Atul Kumar *, Garima Gupta,  Suman Srivastava;
Green Chemistry 2011 13, 2459-2463
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 A grinding-induced catalyst- and solvent-free synthesis of highly functionalized 1,4-dihydropyridines via a domino multicomponent reaction Atul Kumar*, Siddharth Sharma; Green Chemistry 2011, 13,2017–2020
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 β-Cyclodextrin catalysed synthesis of tryptanthrin in water Atul Kumar,* Vishwa Deepak Tripathi, and Promod Kumar Green Chemistry 2011, 13, 51
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 Natural Product Inspired Diversity Oriented Synthesis of Tetrahydroquinoline Scaffolds as Antitubercular agent, Atul KumarSuman Srivastava, Garima Gupta, Vinita Chaturvedi, Sudhir Sinha, R.Srivastava; ACS Combinatorial Science 2011;13(1):65-71
2010
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 Single Nucleotide Catalysed Biomimetic reductive Amination,
Atul Kumar Siddharth Sharma, Ram Awatar Maurya; Advanced Synthesis & Catalysis 2010,352, 2227-2232
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 Synthesis of chalcones and flavanones using Julia–Kocienski olefination  Atul Kumar Siddharth Sharma, , Vishwa Deepak Tripathi, Suman Srivastava, Tetrahedron  2010, 48,9445 -9449
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 Diversity Oriented Synthesis of Benzoxanthene and Benzochromene Libraries via One-Pot, Three-Component Reactions and Their Anti-proliferative Activity Atul Kumar Siddharth Sharma, Ram Awatar Maurya and Jayant Sarkar  J. Comb. Chem., 2010, 12, 20–24
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 Diversity Oriented Synthesis of Pyrrolidines via Natural Carbohydrate Solid Acid Catalyst  Atul Kumar*, Garima Gupta and Suman Srivastava, J. Comb. Chem., 2010 . 12, 458–462.
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 Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents Atul Kumar*, Siddharth Sharma, Vishwa Deepak Tripathi, Ram Awatar Maurya, Swayam Prakash Srivastava, Gitika Bhatia, A.K. Tamrakar, Arvind Kumar Srivastava, Bioorg. & Med. Chem, 2010, 18  4138–4148.
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 Diversity-oriented synthesis of benzimidazole, benzoxazole, benzothiazole and quinazolin-4(3H)-one libraries via potassium persulfate–CuSO4-mediated oxidative coupling reactions of aldehydes in aqueous micelles Atul Kumar*,Ram Awatar Maurya and Deepti Saxena, Molecular Diversity, 2010, 14.
 
SELECTED FOREIGN PATENTS
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 New mercapto phenyl naphthyl methane compounds and synthesis thereof  prevention /treatment of osteoporosis and other estrogen dependent disorders Sangita,                            Atul Kumar,  M. M.Singh, Ray,S., Murthy,P.S.R, Jain, G. K  US Patent no.7582653 9/1/2009
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 Process for preparation of diaryl naphthyl methane derivatives in the treatment and prophylaxes of breast cancer, osteoporosis, contraception and estrogen replacement therapy N.Srivastava, Atul Kumar, A.Grover, Sangita, M. M. Singh, J. D. Dhar S. Ray US Patent : 6,610,705 B1
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 (3R,4R)-Trans-3,4-diaryl chroman derivatives With estrogenic activity Sangita, Atul Kumar,  M. M. Singh,Ray,S, Jain, G.K. WO2005/035517 A1
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 New (3R, 4R) trans-3, 4-diaryl chroman derivatives with estrogenic activity for the prevention and/ or treating estrogen related conditions, e.g. anti cancer breast, post menopausal and related disorders like osteoporosis or hyperlipidiemia Ray,S, Jain, G.K. Sangita, , M. M. Singh,  Atul Kumar AU2005035517-A1
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 Novel (3R,4R)-Trans-3,4-diaryl chroman derivatives With estrogenic activity Sangita, Atul Kumar,   M. M. Singh, Ray,S, Jain, G. K. EP-1675843-A1
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 New (3R,4R)-Trans-3,4-diaryl chroman derivatives with  selective estrogen receptor modulatory activity Sangita, Atul Kumar,   M. M. Singh, Ray,S, Jain, G. K. CN-1839125-A
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 (3R,4R)-Trans-3,4-diaryl chroman derivatives with estrogenic activity Sangita, Atul Kumar,   M. M. Singh, Ray,S, Jain, G. K. JP2007516155-W
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 Mercapto phenyl naphthyl methane compounds and synthesis thereof for the prevention/treatment of osteoporosis and other estrogendependent disorders Sangita, Atul Kumar, Jain, G. K., Murthy,P.S.R Ray,S., M. M.Singh WO2004/087644 A1
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 New mercapto phenyl naphthyl methane compounds and synthesis thereof Murthy,P.S.R, Ray,S., M. M.Singh, Atul Kumar,  Jain, G. K., CA 2524568
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 Novel Mercapto phenyl naphthyl methane compounds and synthesis thereof Sangita,
Atul Kumar, Jain, G. K., Murthy,P.S.R M. M.Singh, Ray,S., EP1692101 (A)
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 New mercapto-phenyl-naphthyl-mathane derivatives useful for trating osteoporosis, bone formation and cardiovascular disorders Sangita, Atul Kumar, Jain, G. K., Murthy,P.S.R M. M.Singh, Ray,S., CN 1802348 (A)
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 Mercapto phenyl naphthyl methane compounds and synthesis thereof Atul Kumar M M.Singh Jain, G. K. Murthy, P.S .  R., Ray,S., Sangita AU 2003 288644
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 New mercaptophenyl naphthyl-mathane derivatives useful for trating osteoporosis, bone formation and cardiovascular disorders Sangita, Atul Kumar, Jain, G. K., Murthy,P.S.R M. M.Singh, Ray,S., US 2004 229869
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 New (3R,4R)-Trans-3,4-diaryl chroman derivatives With estrogenic activity Sangita, Atul Kumar,  M. M. Singh,Ray,S, Jain, G.K. US2005070597
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 New mercapto-phenyl-naphthyl-mathane derivatives useful for trating osteoporosis, bone formation and cardiovascular disorders Sangita, Atul Kumar, Jain, G. K., Murthy, P.S.R M. M.Singh, Ray,S US 2007 244161-A1
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 New omega-naphthyloxy amino alkane derivatives are peroxisome proliferator-activated receptor gamma agonists, useful to treat and prevent hyperglycemia and cardiovascular disorders, and to act in non-insulin dependent diabetes mellitus D Chaturvedi, Atul Kumar, A.K. Srivastava, P.Tewari,Ahmad,R,Puri A.,Bhatia,G, Ray,S A.K.Rastogi  WO 2005 042465-A1
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 Omega-Substituted-Naphthyloxy alklamino Derivatives As Anti- hyperglycemic Agents D.Chaturvedi, Atul Kumar, A.K. Srivastava, P.Tewari, Ahmad, R, Puri A.,Bhatia,G, Ray,S A.K.Rastogi EP1682484-A1;
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 Alpha- substituted naphthyloxy omega-subsituted alkyl/aryl amino substituted alkane derivatives As Anti- hyperglycemic Agents D.Chaturvedi, Atul Kumar, A.K. Srivastava, P.Tewari, Ahmad, R, Puri A.,Bhatia,G, Ray,S A.K.Rastogi CN1894200
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 New omega-naphthyloxy amino alkane derivatives are peroxisome proliferator-activated receptor gamma agonists, useful to treat and prevent hyperglycemia and cardiovascular disorders, and to act in non-insulin dependent diabetes mellitus D.Chaturvedi, Atul Kumar,A.K. Srivastava, P.Tewari, Ahmad, R, Puri A.,Bhatia, G, Ray,S A.K.Rastogi AU 2003 276500-A1;
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 Alpha- substituted naphthyloxy omega-subsituted alkyl/aryl amino substituted alkane derivatives as agent for treatment orprophylaxis of diabetes and related metabolic disorders D.Chaturvedi, Atul Kumar, A.K. Srivastava, P.Tewari, Ahmad, R, Puri A.,Bhatia,G, Ray,S A.K.Rastogi US7081465 (B2)
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 (3R,4R)-Trans-3,4-diaryl chroman derivatives With estrogenic activity Jain, G. K. Ray,S Sangita, ,   M. M. Singh,  Atul Kumar CA 2539502
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 Novel (3R,4R)-Trans-3,4-diaryl chroman derivatives With estrogenic activity Jain, G. K. Ray,S Sangita, ,   M. M. Singh,  Atul Kumar CA2539502 A1.
 
HUMAN RESOURCE DEVELOPMENT
RESEARCH GROUP
Former Ph.D. student
•
 Pervez Ahmad (Asstt. Prof. King Saud University)
•
 Akanksha Gupta (Los Angeles, California)
•
 Ram Awatar Maurya (CSIR-Indian Institute of Chemical Technology, India)
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 Siddharth Sharma (PDF. With Professor Dong Pyo Kim Kyungbuk, Korea)
•
 Suman Srivastava (Kothari fellowship, Research associate in Delhi University)
•
 Garima Gupta (Scientist at Defence Research and Development Organisation, (DRDO), Pune, India)
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 Vishwa Deepak Tripathi (Executive Scientist ·  Zydus Cadila Healthcare LTD,  Vadodara, Gujarat, India)
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 Maneesh Kumar Gupta (Thesis Submitted. Research associate in Delhi University)
•
 Mukesh Kumar (Thesis Submitted)
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 Deepti Saxena (Thesis Writing)
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 Promod Kumar(Thesis Writing)

Research Trainee
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 Sanjeev Soni (Integral Bioscience Pvt. Ltd.)
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 Shailendra Tripathi (Integral Bioscience Pvt. Ltd.)
•
 Megha Joshi (Delhi University)
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 Prem Prakash (University of Iowa, USA)
•
 Sandeep Miglani (Integral Bioscience Pvt. Ltd.)

Current Research Group
•
 Lalit Prakash Gupta (SRF-CSIR)
•
 Ajay Kumar bishnoi (SRF-CSIR)
•
 Shivam Maurya (JRF-CSIR-UGC)
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 Byanju Rai (JRF-CSIR-UGC)
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 Ratnakar Dutt Shukla (Project Assistant)