DR. BRIJESH KUMAR
 
  Senior Principal Scientist and In-charge
Sophisticated Analytical Instrument Facility (SAIF)
CENTRAL DRUG RESEARCH INSTITUTE LUCKNOW-226031
 
E-Mail [email protected]
Educational qualifications M.Sc.
Date of birth

5th Jan. 1960

 
RESEARCH EXPERIENCE
 
Medicinal Chemistry (12 years)
Mass Lab. (12 year)
 
 
Current Areas of Interest
 

My current area of research is application of Mass Spectrometry tools (DART MS/Q-TOF LCMS/4000 Q Trap LCMS) for qualitative and quantitative evaluation small molecules for quality control and authentication of Indian Medicinal Plant. I am also involved in identification of marker compounds using statistical software.

List of Students in my Group

Ms Preetichandra (SRF)
Mr Vikas Bajpai      (SRF)
Ms Awantika Singh(JRF)
Ms Renu Pande     (JRF)
Mr Sunil Kumar      (JRF)

 
Selected Publications
 

Namrata Anand, Kapil Upadhyaya, Arya Ajay, Rohit Mahar, Sanjeev K Shukla, Brijesh Kumar, Rama Pati Tripathi, A Strategy for the Synthesis of Anthraquinone based Aryl-C-Glycosides. Journal of Organic Chemistry 04/2013; DOI:10.1021/jo302589t

Moni Sharma,Kuldeep Chauhan,Rahul Shivahare,Preeti Vishwakarma,Manish K. Suthar,Abhisheak Sharma,Suman Gupta,Jitendra K. Saxena,Jawahar Lal,Preeti Chandra,Brijesh Kumar,and Prem M. S. Chauhan*, Discovery of a New Class of Natural Product-Inspired Quinazolinone Hybrid as Potent  Antileishmanial agents, Journal Of Medicinal Chemistry, 2013

Ajay A,Sharma S, Gupt MP, Bajpai V, Kumar B, Kaushik MP, Konwar R Ampapathi RS and Tripathi RP, Diversity Oriented Synthesis of Pyran Based Polyfunctional Stereogenic Macrocyles and Their Conformational Studies, Organic Letters, 2012,14,17,4306

Diastereoselective One Pot Wittig Olefination - Michael Addition and Olefin Cross Metathesis Strategy for Total Synthesis of Cytotoxic Natural Product (+)-Varitriol and its Higher Analogues, Partha Ghosala, Deepty Sharmab, Brijesh Kumarb, Sanjeev Meenac, Sudhir Sinhac and Arun K. Shawa, Organic and biomolecular chemistry, 2011

Skeletal Diverse Synthesis of N-Fused Polycyclic Heterocycles via the Sequence of Ugi-Type MCR and CuI-Catalyzed Coupling/Tandem Pictet−Spengler Reaction, Vikas Tyagi,† Shahnawaz Khan,† Vikas Bajpai,† Harsh M. Gauniyal,‡ Brijesh Kumar,‡and Prem M. S. Chauhan, J. Org. Chem. 2012, 77, 1414−1421

Cascade Intermolecular Michael Addition_Intramolecular Azide/Internal Alkyne 1,3-Dipolar Cycloaddition Reaction in One Pot, Rajesh K. Arigela,† Anil K. Mandadapu,† Sudhir K. Sharma,† Brijesh Kumar,‡ and Bijoy Kundu*,Organic Letters 2012,1804

Validation and quality determination of an ethnobotanical lead for osteogenic activity isolated from Ulmus wallichiana Planch.: A traditional plant for healing fractured bones. K R Arya1* Deepty Sharma2 and Brijesh Kumar2,  Journal of Scientific & Industrial Research , Vol. 70, May 2011, pp. 360-364

Bajpai, V; Pandey, R; Negi, MPS; Kumar, N; Kumar, B, DART MS Based Chemical Profiling for Therapeutic Potential of Piper betle Landraces, Natural Product Communications, 2012,7.12,1627

Bajpai V, Pandey R, Negi MPS, Bindu KH, Kumar N and  Kumar B, Characteristic differences in metabolite profile in male and female plants of dioecious Piper betle L, Journal Of Biosciences, 2012,37,6,1061

Vikas Bajpaia, Deepty Sharma, Brijesh Kumara*, K. P. Madhusudananb , Profiling of  Piper betle  Linn.  cultivars  by   direct analysis in real time mass spectrometric technique, Biomedical Chromatography , 2010, 1283-1286

Madhusudanan, K P; Kumar, Brijesh; Kanojiya, Sanjeev; Agnihotri, Geetanjali and Misra, Anup Kumar - Tandem mass spectra of divalent metal ion adducts of glycosyl sulfides, sulfoxides and sulfones; distinction among stereoisomers - Journal Of Mass Spectrometry: 41, 1322-1333, (2006).

Madhusudanan, K P, Kanojiya, Sanjeev, Kumar, Brijesh - Effect of stereochemistry on the electrospray ionization tandem mass spectra of transition metal chloride complexes of monosaccharides - Journal Of Mass Spectrometry, 40, 1044-1054, (2005).
Madhusudanan, K.P ; Kumar, Brijesh ; Tiwari, Pallavi ; Madhusudan, Soni Kamlesh ; Misra, A.K. - Tandem mass spectra of transition-metal ion adducts of glycosyl dithioacetals; distinction among stereoisomers, - Rapid Communications In Mass Spectrometry: RCM, Volume 19, Issue 4, 470-476, (2005).
Madhusudanan, K. .P ; Kumar, Brijesh ; Tiwari, Pallavi ; Madhusudan, Soni Kamlesh ; Misra, A.K. - Effect of metal cationization on the tandem mass spectra of glycosyl dithioacetals, - Journal Of Mass Spectrometry:  Volume 40, Issue 1, 25-35, (2005)