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  CARDIOVASCULAR, CENTRAL NERVOUS SYSTEM & OTHER DISORDERS
 
AIMS & OBJECTIVE
Pharmacological profiling of a new drug entity

Basic Studies focused to unravel the pathophysiology of disease process with an aim to find out newer targets so as to develop better drugs for important diseases of the following groups:
 
Cardiovascular (stroke, thrombosis, hypertension)
Central Nervous System (dementia and stress)
Other Disorders (diabetic, dislipidemia, impaired wound, gastric ulcers, inflammation, allergy and asthama.)
 
Present Area of focus

In addition to the above, the scientists in this research area are deeply engaged in the development of predictive in vivo and in vitro paradigms including HTS target assays for bioactivity evaluation besides safely pharmacological studies of candidate drugs. QSAR and computer aided molecular modeling for rational designing and combinational sysnthesis of new compounds.

The area is enriched by basic studies involving role of nitric oxide in the modulation of neutrophil functions ( phagocytosis, apoptosis, free radical generation) cerebral ischemia, nociception and cardiovascular regulation. Elevated Lp(a) and its correlation with risk of coronary heart disease, acetyl cholinesterase in cognitive deficit and biochemical correlates in stress responses are currently being actively pursued in this programme. Electrophysiological and neurochemical investigations for analyzing the mechanism of action of drug candidates are important components of this area.
 
 
 
SCIENTISTS ASSOCIATED WITH THE PROJECT
 
Dr. Ram Raghubir
Dr. Anil Kumar Saxena
Dr. Gautam Palit
Dr. Rakesh Shukla

Dr. Chandishwar Nath

Dr. Gautam Panda
Dr. Madhu Dikshit
Dr. Arun Kumar Shaw
Mr. Amar Nath
Dr. S N Suryavanshi
Dr. A K Srivastava
Dr. Atul Goel
Dr. K Awasthi
Dr. Kalpana Bhandari
Dr. D P Sahu
Dr. Ram Pratap
Dr. D K Dikshit
Dr. Anju Puri
<< PHARMACOLOGY
 
 
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