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Dr D P Mishra |
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Principal Scientist
Endocrinology Division
Central Drug Research Institute,
Lucknow-226 031 |
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| Summary
of Research |
Research in the laboratory is focused
on understanding the epigenetic basis of male infertility
and chemo resistance in cancers. We aim to correlate the
epigenetic changes to signal transduction mechanisms using
a cell death model in cancers, male infertility, cerebral
stroke and diabetes and explore the clinical implications
of our findings.
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| Current
Projects in the Lab |
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Effect
of Cancer chemotherapeutic Drugs on Spermatogonial Stem
Cell Niche, Chromatin remodeling and Epigenetic programming
in Male Germ Cells. |
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SERM induced apoptosis in Cancer Cells. |
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Mechanistic studies on novel Proteasome inhibitors as
anticancer drugs. |
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Endoplasmic
Reticulum stress mediated apoptosis in cerebral ischemia. |
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| Lab
Members |
Preeti Dohare,Rishi Kumar
Gara,Vikas Srivastava,Amit Tripathi,Mohd Shoaib,Shraddha Tiwari
Rachna Trivedi,Namrata Rastogi,Priyanka Gupta |
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| Selected
Publications |
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Nuclear Regulator
Pygo2 controls Spermiogenesis and Histone H3 Acetylation.(2008)
Mishra DP, Nair M, Nagamori I ,
Sun P , Rheaume C,Li B,Sassone- Corsi P, Dai X.
Dev
Biol ;320 (2) 446-55. |
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Epigenetic
Control in Male Germ cells : A transillumination Assisted
Microdissection Method
For the Analysis of Developmentally Regulated Events (2008).
Mishra DP & Sassone Corsi P.
Methods in Molecular Biology ; 450 :
119-26. |
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Endotoxin Induces Luteal
Cell Apoptosis through the Mitochondrial Pathway (2007)
Mishra DP & Dhali A . Prostaglandins
Other Lipid Mediators ; 83: 75-88. |
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Changes in cytosolic Calcium
Levels regulate Bcl-Xs and Bcl-Xl expression in Spermatogenic
Cells During Apoptotic Death ( 2006).Mishra
DP, Pal R & Shaha C. J Biol Chem
; 281 (4) 2133-43. |
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