Lymphatic filariasis
has been and still is a major public health
problem in India. The disease though is
not fatal, but in chronic state is disabling
and a cause of social stigma. Development
of a macrofilaricide and/or female worm
sterilizing agent is today's urgent need.
The project is being pursued with the
objective to develop orally active macrofilaricides
and female worm sterilizing agents, to
define biochemical and immunological functions
of parasites and host, and to utilize
genomic information in the identification
of molecular targets for in vitro screening
and rational design of potential antifilarials
and also to understand pathogenesis of
the disease.
