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DR. GAUTAM PANDA |
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Principal Scientist
Associate Professor, Academy of Scientific and Innovative Research, New Delhi
Medicinal and Process Chemistry Division
CSIR-Central Drug Research Institute
Lucknow 226031, UP, India
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| RESEARCH EXPERIENCE |
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1993-1999: Doctoral Research, University of Hyderabad with Prof. Goverdhan Mehta on classical synthesis of Bucky-Bowls |
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1999 (August)-2001 (June): Visiting Fellow, National Chiao Tung Univ., Hsinchu, Taiwan with Prof. Tse Lok Ho; NSERC Visiting Postdoctoral Fellow, Department of Chemistry, University of Ottawa with Prof. Howard Alper and National Research Council, Ottawa, Canada with Prof. Prabhat Arya |
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2002 (February)-to date, Scientist, CDRI, Lucknow.
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2007 (three months): INSA, India - DFG, Germany Exchange Fellowship with Prof. Matthias Kassack, University of Duesseldorf, Germany |
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2011 (Sept.)-2012 (July): JSPS Invitation Fellowship Program in Japan for 10 months at National Centre for Molecular Scale Nanoscience, Institute for Molecular Science Myodaiji, Okazaki, Japan with Prof. Hidehiro Sakurai |
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| RESEARCH INTEREST |
| The overall aim of my research group is to discover and develop some therapeutic viable small molecules
through synthetic organic and medicinal chemistry approach utilizing both traditional and computer-aided drug design techniques. The group utilizes Chiron
approach to access diverse chiral molecules in order to integrate diversity oriented organic synthesis in solving problems of biological interest.
The current research is focused on Anti-tuberculosis and Breast Cancer. In the following some selected projects and our current research interest are described:
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| Synthetic Organic and Medicinal Chemistry |
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Development of target and cell
based new chemical entities for Breast Cancer, Tuberculosis.
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Organic synthesis of target and diversity oriented natural products (alkaloids) and amino acid based natural product like designed chiral molecules;
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Enantioselective synthesis of Trisubstitutedmethanes and analogs as possible anti-tubercular agents
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| Computer-Aided Drug Design & Discovery |
| Currently, we are focusing our research on some novel anti-tubercular and breast cancer agents
targeting unique pathogen and cancerous cell-survival mechanisms. Broadly, the methodologies which we are implementing are structure- and ligand- based
drug design principle. We are involved in in-silico screening of a large chemical library to identify some small molecules having capabilities to interfere
with the identified targets and based on the chemical diversity of the identified hits, we utilize synthetic methodology to access the selective compounds. |
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| Awards/Fellowships |
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JSPS Invitation Fellowship Program for Research in Japan (2011-2012)
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Chemical Research Society of India Bronze Medal in Chemistry for 2012
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CDRI Incentive Award 2007, 2008, 2009 in Chemical Sciences from CDRI,
Lucknow
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Visited Heinerich Heine University, Duesseldorf, Germany for three months
under Indian National Science Academy, India - DFG, Germany Exchange
Fellowship
Programme |
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Member of National Academy of Sciences, Allahabad, 2014
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| Our Research Work at CDRI: |
| Under Broad Area of Synthetic Organic Chemistry |
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| Under Broad Area of Bioorganic and Medicinal Chemistry |
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| L-Proline derived 14-Azasteroids for targeting Progesterone Metabolites in Breast Cancer |
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| L-Proline derived 14-Azasteroids for targeting Progesterone Metabolites in Breast Cancer |
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| Azasteroids on level of SRD5A1 in MCF-7 cells Effect of lead on migration of MDA-MB-231 |
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| S006-830 against H37RV, single, multi-drug resistant M. tuberculosis; CFU in the lungs with S006-830, EMB, PZA (European Journal of Medicinal Chemistry 2015, 95, 357-368, J Antimicrob Chemother. 2012; 67(5):1188-97, Bioorg Med Chem Lett, 2008, 18, 289-292)
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| S006-830 kills intracellular M. tb H37Rv in human monocyte derived macrophages; In vitro and ex vivo bactericidal property of S006-830 in comparison with rifampicin (RFM) |
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| LAB
MEMBERSS |
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| Present Group Members: |
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Mr. ASHOK SHARMA, Technical Officer |
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TIASH SAHA (PA) |
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SRINIVAS LAVANYA KUMAR (JRF) |
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ASHA RANI (JRF) |
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BIDHU BHUSAN KARKARA (JRF) |
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MANGERAM MANGYAN (TATA CSIR OSDD trainee) |
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PANKAJ MISHRA (TATA CSIR OSDD Trainee) |
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SAROJ MAJI (PA) |
| Past Group Members: |
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SHAGUFTA, Assistant Professor, United Arab Emirates |
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JITENDRA KUMAR MISHRA, Staff Scientist, St. Jude Children's Research Hospital, Memphis, TN, USA |
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AJAY KUMAR SRIVASTAVA, Scientist C, Indian Institute of Chemical Technology, Hyderabad |
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SAJAL KUMAR DAS, Assistant Professor, Tezpur Central University, Assam |
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MALOY KUMAR PARAI, postdoc with Tariq M. Rana, Birmingham Institute, California, USA. |
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KRISHNANANDA SAMANTA, Postdoc, Professor Jean-Francois Hernandez, Institut des Biomolécules Max Mousseron, CNRS UMR5247, Faculté de Pharmacie, 34093 Montpellier cedex 5, France |
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SANJIT KUMAR DAS, working in Sai Life Sciences, Pune, will go to Broad Institute at Harvard, USA |
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SUBAL KUMAR DINDA, working in a company |
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RITESH SINGH, Inspire Faculty, IICT, Hyderabad |
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PRIYANKA SINGH, Postdoc with Professor Jean-Francois Hernandez, Institut des Biomolécules Max Mousseron, CNRS UMR5247, Faculté de Pharmacie, 34093 Montpellier cedex 5, France |
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SAURAV BERA, Dr. KPC life Sciences, Kolkata as research scientist |
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AMIT KUMAR JANA, TCG Life Sciences, Kolkata |
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SUDIPTA KUMAR MANNA, Postdoc, Prof. Masato Kitamura’s group, University of Nagoya, Japan |
| PAST TRAINEES; : |
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Ms. DEEPSHIKHA, M.Sc. Pharmaceutical Chemistry, Banasthali University, Banasthali, Rajasthan |
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MANISH SINHA, M. Pharm. Birla Institute of Technology, Mesra, Ranchi |
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MONICA, M. Pharm. Pharmaceutical Chemistry, Banasthali University, Banasthali, Rajasthan |
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Ms. NANCY GUPTA, M.Sc. in Pharmaceutical Chemistry, Banasthali University, Banasthali, Rajasthan |
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SARPATE NIKHIL DATTA, M. Pharm, Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli |
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PRERNA GANWIR, M. Pharm, Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli |
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RAGINEE NIRANJAN, M.Sc. Applied Chemistry, Bundelkhand University, Jhansi |
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SANDIP CHAKRABORTY, M. Tech, Vellore Institute of Technology-University, Vellore, Tamil Nadu, |
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SONIA KHURANA, M. Pharm, Uttar Pradesh Technical University, Lucknow, India |
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| SELECTED PATENTS & PUBLICATIONS (2004-ONWARDS) |
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| PATENTS |
| 1. DiaryloxyMethanoPhenanthrenes: A New Class of Antituberculosis Agents, G. Panda,Shagufta, Jitendra Kumar
Mishra, Vinita Chaturvedi, Anil K. Srivastava, Manju, RanjanaSrivastava and Brahm S. Srivastava, 1178DEL2004 Filing date 24/06/04 |
| 2. Thiophene containing Trisubstituted Methanes (TRSMs) as antitubercular agents, Gautam Panda, Maloy Kumar
Parai, Priyanka Singh, Sudhir Sinha, Vinita Chaturvedi, Anil Gaikwad, PCT in process (685/DEL/2010) dt 20-2-2010 |
| 3. Aryl aryl methyl thio arenes (aamtas) as antimalarial agents and a process for the preparation thereof;
Gautam Panda, Priyanka Singh, Sanjit Kumar Das, Subal Kumar Dinda, Manish Goyal, Uday Bandyopadhyay; 0020NF2011/IN; 0364DEL2011; 31-Jan-2012 |
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| Total Publications:
85, total citations up to March, 2015: 1130, h-index: 21 |
| Selected Publications> |
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Pankaj Mishra, Senthil Raja Ayyannan, Gautam Panda, Re-look at Ab-aggregation inhibition through a structure-based drug design perspectives, ChemMedChem Accepted. |
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| Priyanka Singh, Sudipta Kumar Manna, Amit Kumar Jana, Tiash Saha, Pankaj Mishra, Saurav Bera, Maloy Kumar Parai, Srinivas Lavanya Kumar M., Sankalan Mondal, Priyanka Trivedi, Vinita Chaturvedi, Shyam Singh, Sudhir Sinha and Gautam Panda; Thiophene containing Trisubstituted Methanes [TRSMs] as identified lead against Mycobacterium Tuberculosis; European Journal of Medicinal Chemistry, Volume 95, 5 May 2015, Pages 357-368.
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• | Saurav Bera, Sanjit Kumar Das, Tiash Saha and Gautam Panda, Total Synthesis of C3-epi-(+)-Lycoricidine from Garner aldehyde via Intramolecular Aldol Cyclization, Tetrahedron Letters, Volume 56, Issue 1, 1 January 2015, 146-149 (Highlighted in ChemBioEng Reviews: http://www.chemweb.com/articles/00404039/00560001). |
• | Asymmetric Assembly of Steroidal Tetracyclic Skeletons, Preeti Gupta and Gautam Panda; Eur J Org Chem 2014, Issue 36, December 2014, 8004-8019 (Review). Highlighted in http://www.chemeurope.com/en/publications/724042/asymmetric-assembly-of-steroidal-tetracyclic-skeletons.html. |
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Priyanka Singh and Gautam Panda; Linearization of carbohydrate derived polycyclic frameworks, RSC Adv., 2014, 4, 31892-31903. |
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Sudipta Kumar Manna and Gautam Panda; Benzofused Enantiomerically Pure Bicyclic Heterocycles: Asymmetric Friedel-Crafts Reaction towards Indolines and Tetrahydroisoquinolines through S-Amino Acids Derived Chiral Carbocation, Org. Biomol. Chem, 2014, 11, 8318-24 (Highlighted in http://europepmc.org/abstract/med/25208820). |
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α-Amino Acids Chirons: A Tool for Asymmetric synthesis of Heterocycles: Priyanka Singh, Krishnananda Samanta, Sanjit Kumar Das and Gautam Panda, Org. Biomol. Chem., 2014, 12, 6297-6339 (Review). Highlighted in http://www.pubfacts.com/detail/24989176/Amino-acid-chirons:-a-tool-for-asymmetric-synthesis-of-heterocycles. |
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Sankalan Mandal and Gautam Panda, Synthetic Methodologies of Achiral Diaryl Methanols, Diaryl and Triaryl Methanes (TRAMs) and Medicinal Properties of Diaryl and Triaryl Methanes-An Overview, RSC Adv., 2014, 4 (54), 28317 - 28358 (Review). |
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Priyanka Singh, Sudipta Kumar Manna and Gautam Panda; Synthesis of polyhydroxylated indolizidines and piperidines from Garner's aldehyde: total synthesis of (−)-swainsonine, (+)-1,2-di-epi-swainsonine, (+)-8,8a-di-epi-castanospermine, pentahydroxy indolizidines, (−)-1-deoxynojirimycin, (−)-1-deoxy-altro-nojirimycin, and related diversity, Tetrahedron, 2014, 70, 1363-1374. |
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Ritesh Singh and Gautam Panda: L-Proline derived nitrogenous steroidal systems: an asymmetric approach to 14-azasteroids, RSC Adv., 2013, 3, 19533-19544. |
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Ritesh Singh and Gautam Panda; An Overview of Synthetic Approaches for Heterocyclic Steroids, Tetrahedron Report, 2013, 69, 2853-2884. |
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Manish Goyal; Priyanka Singh; Athar Alam; Sajal K Das; Mohd S Iqbal; Sumanta Dey; Samik Bindu; Chinmay Pal; Sanjit K Das; Gautam Panda; Uday Bandyopadhyay; Aryl aryl methyl thio arenes prevent multi-drug resistant malaria in mouse by promoting oxidative stress in parasite; Free Radical Biology & Medicine, 2012, 53, 129-42. |
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Bera S, Panda G: I2-mediated diversity oriented diastereoselective synthesis of amino acid derived trans-2,5-disubstituted morpholines, piperazines, and thiomorpholines. ACS Comb Sci. 2012, 14(1):1-4. |
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Krishnananda Samanta and Gautam Panda; One Pot Synthesis of Amino Acids Derived Chiral Disubstituted Morpholines and 1,4-Oxazepanes via Tandem Aziridine/Epoxide Ring Opening Sequences; Org. Biomol. Chem. 2011, 9, 7365-7371. |
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Singh, R.; and Panda, G.: Application of Nazarov type electrocyclization to access [6-5-6] and [6-5-5] core embedded new Polycycles: an easy entry to tetrahydrofluorene scaffolds related to Taiwaniaquinoids and C-nor-D homosteroids, Org. Biomol. Chem., 2011, 9, 4782-4790 (selected as cover page article). |
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Samanta, K.; and Panda, G.: BF3.OEt2 Mediated Regioselective Ring Opening of Amino Acids Derived Chiral Aziridines: An Easy Route Towards 2,5-Substituted Chiral Piperazines, and Piperazine Core of the Natural Product Piperazinomycin; Chemistry an Asian Journal, 2011, 6, 189-197. |
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Singh, R., Parai, M. K., and Panda, G.: Application of Nazarov cyclization to access [6-5-6] and [6-5-5]tricyclic core embedded New Heterocycles : An easy entry to structures related to Taiwaniaquinoids. Organic and Biomolecular Chemistry, 2009, 7, 1858-1867. |
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Kumar, S., Das, S. K., Dey, S., Maity, P., Guha, M., Choubey, V., Panda, G., and Bandyopadhyay, U.: Antiplasmodial Activity of [(Aryl)arylsulfanylmethyl]pyridines. Antimicrobial Agents and Chemotherapy, 2008, 52, 705-715. |
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Srivastava, A. K., and Panda, G.: Total Synthesis of (-)-Balanol, its all Stereoisomers, their N-tosyl analogues and fully protected Ophiocordin: An easy access to hexahydroazepine cores from Garner aldehydes. Chemistry A European Journal, 2008, 14, 4675-4688. |
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Mishra, J. K., and Panda, G.: Diversity-oriented synthetic approach to naturally abundant S-amino acid based benzannulated enantiomerically pure medium ring heterocyclic scaffolds employing inter- and intramolecular mitsunobu reactions. Journal of Combinatorial Chemistry; 2007, 9, 321-338. |
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Shagufta and Panda, G.: A new example of a steroid-amino acid hybrid: construction of constrained nine membered D-ring steroids; Organic Biomolecular Chemistry; 2007, 5, 360-366. |
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| REVIEW ASSIGNMENTS | Ad hoc reviewer for the following journals since 2004: |
| Journal of Combinatorial Chemistry (JCC); Journal of Organic Chemistry (JOC), Indian Journal of Chemistry Sec B. (IJC); Proc. Ind. Acad. Sci.
(Chemical Sciences) (PINSA), Bioorg. Med. Chem. Lett. (BMCL); Bioorg. Med. Chem. (BMC), Tetrahedron Letters (TL); Tetrahedron (T); Current Medicinal
Chemistry (CMC), European Journal of Organic Chemistry (EJOC); European Journal of Medicinal Chemistry (EJMC); Organic & Biomolecular Chemistry (OBC) |
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| Ad hoc Grant Reviewer for agencies; |
| Council of Scientific and Industrial Research (CSIR), New Delhi,
Department of Science and Technology (DST), Indian Council of Medical Research (ICMR), New Delhi
Thesis Reviewer: Thesis on Chemical Sciences from various Universities, National Labs and Institutes.
Jadavpur University, Jadavpur; National Chemical Laboratory, Pune; Regional Research Laboratory,
Trivandrum; Indian Institute of Chemical Technology, Hyderabad
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| TEACHING EXPERIENCE |
| • Taught for the course work on “Synthetic Methodologies and Structure Elucidation of Drug-like Molecules” for the candidates working at CDRI, Lucknow and registered for Ph.D. in Jawaharlal Nehru University (JNU), New Delhi as part of the Ph.D. course work. |
| • Courses Taught: a) Conformational Analysis b) Reactive Intermediates c) Heterocyclic Chemistry, nitrogen, oxygen and sulfur containing rings d) Selected reagents for organic synthesis e) Methods for stereoselective synthesis f) Selected name reactions g) structure based drug design
- on an average 20-25 graduate students (NET JRFs) each year
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| • Teaching for the course work on “Logic in Organic Synthesis-I (MC-520, 3 credits) in Semester-I and “Logic in Organic Synthesis-II (MC-620, 3 credits) in Semester-II at NIPER, Raebareli from 2010 onwards |
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