DR. GOPAL GUPTA
 


Senior Principal Scientist
Division of Endocrinology
Central Drug Research Institute
Lucknow 226 031, India

 
Phone +91-522-2772450 PABX Ext 4391
Fax +91-522-2441941
E-Mail [email protected]
Educational qualifications M.Sc., Ph.D.
Date of birth 09-03-1962
 
RESEARCH AREAS
 
Reproductive Health & Contraception, Spermatogenesis, Prostatic Hyperplasia, Prophylactic Contraceptives, Microbicides including topical anti-HIV agents, Biochemistry.
 
CURRENT AREAS OF INTEREST
 
Development of prophylactic topical contraceptives (microbicides/spermicides), Drugs for the management of Benign Prostatic Hyperplasia, Spermatogenesis, anti-HIV agents.
 
SELECTED PUBLICATIONS
 
Jain RK, Jain A, Maikhuri JP, Sharma VL, Dwivedi AK, Kumar ST, Mitra K, Bajpai VK, Gupta G. In vitro testing of rationally designed spermicides for selectively targeting human sperm in vagina to ensure safe contraception. Hum Reprod. 2009; 24(3):590-601.
This article appears on Journal Cover (Human Reproduction, March 2009)
Jain RK, Jain A, Maikhuri JP, Sharma VL, Dwivedi AK, Kiran Kumar ST, Mitra K, Bajpai VK, Gupta G. In vitro testing of rationally designed spermicides for selectively targeting human sperm in vagina to ensure safe contraception. Hum Reprod. 2008 Dec 16. [Epub ahead of print]
Ojha P, Dhar JD, Dwivedi AK, Singh RL, Gupta G. Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment--a flow cytometric study. Anim Reprod Sci. 2008; 103:135-48.
Jain RK, Maikhuri JP, Kiran Kumar ST, Sharma VL, Dwivedi AK, Mitra K, Bajpai VK, Gupta G. Novel disulphide esters of carbothioic acid as potent, non-detergent spermicides with low toxicity to Lactobacillus and HeLa cells in vitro. Hum Reprod. 2007; 22(3):708-16.
This article has been highlighted in the following:
“How to kill sperm softly” Research News & Discovery, New Scientist Vol. 193, No. 2593, p 18 (March 2007)
Ojha P, Dhar JD, Dwivedi AK, Singh RL, Gupta G. Effect of antispermatogenic agents on cell marker enzymes of rat Sertoli cells in vitro. Contraception. 2006; 73:102-6.
Gupta G, Jain RK, Maikhuri JP, Shukla PK, Kumar M, Roy AK, Patra A, Singh V, Batra S. Discovery of substituted isoxazolecarbaldehydes as potent spermicides, acrosin inhibitors and mild anti-fungal agents. Hum Reprod. 2005; 20(8):2301-8.
Gupta G. Microbicidal spermicide or spermicidal microbicide? Eur J Contracept Reprod Health Care. 2005. 10, 212-218.
Bajpai M, Gupta G, Setty BS. Changes in carbohydrate metabolism of testicular germ cells during meiosis in the rat. Eur J Endocrinol. 1998; 138(3):322-7.
Dwivedi A, Gupta G, Keshri G, Dhar JD. Changes in uterine ornithine decarboxylase activity and steroid receptor levels during decidualization in the rat induced by CDRI-85/287. Eur J Endocrinol. 1999; 141(4):426-30.