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DR. JAWAHAR LAL |
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Senior
Principal Scientist & In-Charge
Pharmacokinetics & Metabolism Division
CSIR-Central Drug Research Institute
B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow‐226031 (India) |
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| In 1991, I joined as a Scientist in the Pharmacokinetics & Metabolism Division of Central Drug Research Institute, Lucknow. I was a visiting scientist at Department of Clinical Pharmacology, University of Cologne, Germany. I am Vice-President of Indian Pharmaceutical Association, Lucknow Branch, Editorial Board Member of National and International research journals and Life Member of several Scientific Societies. |
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| Fax |
91-522-2771941 |
| Telephone |
Ext. 4841 |
| E-Mail |
[email protected] |
| Date of birth |
28 August
1957 |
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| EDUCATIONAL
QUALIFICATIONS |
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| RESEARCH ACTIVITIES |
| Development of new analytical procedures for monitoring investigational and known drugs and their metabolite(s) in the biological fluids. Preclinical and clinical pharmacokinetic studies including absorption, metabolism and excretion studies of investigational and known drugs. Pattern profiling of herbal preparations, bioequivalence study of new formulations and drug-drug interaction studies. |
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| MEMBERSHIP (LIFE) SCIENTIFIC
SOCIETIES |
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Indian Pharmaceutical Association
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Indian Pharmacological
Society |
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Society of
Biological Chemists (India) |
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Indian Chemical
Society |
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| AWARDS
AND HONOURS BEST POSTER AWARD |
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Editorial Board Member, American Journal of Chromatography, USA |
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Executive Member, Indian Society of Chemists and Biologists, Lucknow, India |
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Editorial Advisory Board Member, Current Trends in Pharmaceutical Research (Research Journal) |
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Editorial Advisory Board Member, Chemistry & Biology Interface (Research Journal) |
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Vice-President, Indian Pharmaceutical Association, Lucknow Branch, India |
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| PRESENTLY WORKING RESEARCH
GROUP MEMBERSSUPERVISION |
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Abhisheak Sharma, Senior Research Fellow, ICMR |
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Swati Jaiswal, Junior Research Fellow, CSIR |
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| SELECTED PUBLICATIONS |
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M. Sharma, K. Chauhan, R. Shivhare, M. Suthar, A. Sharma, S. Gupta, J.K. Saxena, J. Lal, P. Chandra, B. Kumar and P.M.S. Chauhan. Discovery of a new class of natural product-inspired quinazolinone hybrid as potent antileishmanial agents. J Med Chem 2013; 56(11): 4374-4392. |
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J. Lal and Nidhi Sharma. Simultaneous quantification of centchroman and its 7-demethylated metabolite in rat dried blood spot using LC-MS/MS. Biomed Chromatogr 2012; 26(9):1089–1095. |
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A. Sarswat, R. Kumar, L. Kumar, N. Lal, S. Sharma, Y.S. Prabhakar, S.K. Pandey, J. Lal, V. Verma, A. Jain, J.P. Maikhuri, D. Dalela, Kirti, G. Gupta and V.L. Sharma. Arylpiperazines for Management of Benign Prostatic Hyperplasia: Design, Synthesis, Quantitative Structure-Activity Relationships, and Pharmacokinetic Studies. J Med Chem 2011; 54(1):302-311. |
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J. Lal. Clinical pharmacokinetics and pnteraction of centchroman – A Mini Review. Contraception 2010; 81(4):275-280. |
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E. Muschler, J. Lal, A. Jetter, A. Rattay, U. Zanger, G. Zadoyan, U. Führ and J Kirchheiner. The role of human CYP2C8 and CYP2C9 variants in pioglitazone metabolism in vitro. Basic Clin Pharmacol Toxicol 2009; 105(6):374-379. |
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Lal
J, Tripathi RP and Gupta RC - Pharmacokinetics
and excretion of the novel anti-tuberculosis compound
1,2 : 5,6-di-O-isopropylidene-3-O-(phenyl cyclopropyl
methanonyl)-alpha-D-glucofuranose (S-001-14) after oral
doses in rats (2008) - Arzneimittel-Forschung-
Drug Research 58, 410-418 |
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Mehrotra N,
Lal J, Puri SK, Madhusudanan KP and Gupta
RC. - In vitro and In vivo pharmacokinetic studies of
bulaquine (analogue of primaquine), a novel antirelapse
antimalarial, in rat, rabbit and monkey-highlighting species
similarities and differences. (2007) - Biopharm
Drug Dispos 28, 209 -227 |
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Kumar, Vipul,
Lal, Jawahar, Singh, Man Mohan and Gupta,
Ram Chandra - Effect of concurrently coadministered drugs
on the pharmacokinetic/pharmacodynamic profile of centchroman,
a nonsteroidal oral contraceptive, in rats (2006)
- Contraception, 74, 165-173 |
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Kumar, V.,
Mehrotra, N., Lal, J. & Gupta, R.C.
- Pattern profiling of the herbal preparation picroliv
using liquid chromatography-tandem mass spectrometry.
(2004) - Journal of Chromatography A,
Volume 1045, Issue 1-2, 6 August 2004, Pages 145-152.
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Srivastava,
Pratima, Sharma, Preeti, Lal, Jawahar,
Dikshit, Dinesh K., Madhusudanan, Kunnath P., Gupta &
Ram, C. - Metabolism of CDRI-85/92, a new potent anti-ulcer
agent, involving cis-trans conversion. (2004)
- J. Pharma. Sc. Drug Metabolism And Drug Interactions,
Volume 20, Issue 1-2, 2004, Pages 57-76. |
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Khurana, M.,
Lal, J., Kamboj, V., Nityanand, S. &
Gupta, R.C. - Pharmacokinetic interaction of tetracycline
with centchroman in healthy female volunteers. (2003)
- Drugs R&D, 4, 293-99. |
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Lal,
J., Kumar, V., Gupta, R.C. - Pharmacokinetics
of oral and transdermal administration of a sulphur mustard
decontaminant CC-2 [N, N’-dichlorobis (2,4,6-trichlorophenyl)
urea] in rats: A preliminary study. (2003) - Indian
J. Pharmacol., 35, 297-303. |
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Mehrotra, N.,
Lal, J. & Gupta, R.C. - Analysis
and pharmacokinetics of bulaquine and its major metabolite
primaquine in rabbits using LC-UV method. (2003)
- J. Pharm. Biomed. Analysis, 32, 141-50. |
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M. Nitin, M.
Rajanikanth, J. Lal, K.P. Madhusudanan and R.C.
Gupta. A liquid chromatography-tandem mass spectrometric
assay with a novel method of quantitation for simultaneous
determination of bulaquine and its metabolite, primaquine,
in monkey plasma. J. Chromatogr. B: 2003; 793:253-63. |
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M.
Khurana, J. Lal, M. Kamboj, S. Nityanand, V.P.
Kamboj and R.C. Gupta. Uptake of centchroman by human
uterus. Clin. Drug Invest. 2002; 22:715-8. |
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M.
Khurana, J. Lal, M.M. Singh, J.K. Paliwal, V.P.
Kamboj and R.C. Gupta. Evaluation of interaction potential
of certain concurrently administered drugs with pharmacological
and pharmacokinetic profile of centchroman in rats. Contraception
2002; 66:47-56. |
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J.
Lal, S. Nityanand, O.P. Asthana and R.C. Gupta. Optimization
of contraceptive dosage regimen of centchroman. Contraception
2001;63:47-51. |
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J.
Lal, J.K. Paliwal, P.K. Grover and R.C. Gupta. Determination
of ampicillin in serum by high-performance liquid chromatography
with precolumn derivatization. J. Chromatogr. Biomed.
Appl. 1994;655:142-146 |
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