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Dr. JIAUR R. GAYEN |
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Scientist
Pharmacokinetics & Metabolism Division
Assistant Professor AcSIR
Pre-Clinical North Block, Lab # 104
CSIR- Central Drug Research Institute
Sitapur Road, Lucknow - 226031
India |
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| Educational Qualifications |
Ph.D. (Pharmacy) [Bose Institute, Jadavpur University, India]
M. Pharm. [Jadavpur University, India] |
| Date of Birth |
25.12.1977 |
| E-Mail |
[email protected] |
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| POSITION/EMPLOYMENT |
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02/2011-
present :Scientist, CSIR- Central Drug Research Institute, Lucknow, India. |
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11/2014-04/2015: Visiting Scientist, Deutsches Diabetes Zentrum, Dusseldorf, Germany |
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11/2010-01/2011:
Assistant Project Scientist Step II; University of California-San
Diego, USA. |
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02/2005-10/2010:
Postdoctoral Fellow; School of Medicine, University of
California-San Diego, USA. |
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06/2001-12/2004:
Research Fellow; Bose Institute, Calcutta, India. |
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03/2001-05/2001:
Lecturer; Himalayan Pharmacy College, Gangtok, India |
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| HONORS/AWARDS |
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ICMR International Fellow (Young Scientist) 2014-15, ICMR, Govt. of India. |
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Innovative Young Biotechnologist Award (IYBA) 2011, DBT, Govt. of India. |
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Rapid Grant for Young Investigator (RGYI) Award 2011-12, DBT, Govt. of India. |
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Fast Track Scheme for Young Scientist, DST, Govt. of India. |
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Senior Scientist Award 2011, Association of Biotechnology and Pharmacy, India |
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Fellow of Association of Biotechnology and Pharmacy (FABAP), India |
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Associateship
of Institution of Chemists (India) (A.I.C.) |
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Prof. Anupam Sengupta
Memorial Medal from Jadavpur University, India. |
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| LAB MEMBERS |
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Ph.D. Student: Guru R Valicherla, Anand P Gupta, Mohd. Riyazuddin |
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MS/M.Pharm Student: Minakshi Shukla |
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Project Assistant: Anees A Syed |
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Alumni: Ph.D. student: Amrita Saxena, Zakir Hossain,
MS student: Mahabub Hussain, Anil Bakkasani, Kandarp Dave, Vishal Makadia, Italiya Kishan |
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| RESEARCH
INTEREST |
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Metabolic
syndrome : [Hypertension, Obesity and Diabetes].
Regulation of hypertension, obesity and insulin-sensitivity by peptides derived from chromogranin-A using animal model and cell and molecular biology techniques. Exploring pharmacological/therapeutical activity of natural products against hypertension, obesity and diabetes. Exploration of mode of action of new antidiabetic molecule or plant extract.
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Pharmacokinetics
& Metabolism :
Preclinical Pharmacokinetics and metabolism studies of pharmacologically/ therapeutically active compounds or plant extract. |
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RECENT PUBLICATION:
Google Scholar Citations:
http://scholar.google.co.in/citations?user=ZQ51GqEAAAAJ&hl=en&oi=ao>
Research Gate Profile:
https://www.researchgate.net/profile/Jiaur_Gayen |
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Khan MP, Singh AK, Joharapurkar AA, Yadav M, Shree S, Kumar H, Gurjar A, Mishra JS, Chandra Tiwari M, Nagar GK, Kumar S, Ramachandran R, Sharan A, Jain MR, Trivedi AK, Maurya R, Godbole MM, Gayen JR, Sanyal S, Chattopadhyay N.; Pathophysiological mechanism of bone loss in type 2 diabetes involves inverse regulation of osteoblast function by PPARγ coactivator-1α and skeletal muscle atrogenes: adiponectin receptor 1 as a potential target for reversing diabetes-induced osteopenia. Diabetes. (2015) 64(7):2609-23 (IF- 8.3). |
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Saxena A, Valicherla GR, Joshi P, Saxena R, Cheruvu SH, Bhunia SS, Jain GK, Siddiqui HH, Saxena AK, Gayen JR*.; Pharmacokinetics, dose proportionality and permeability of S002-333 and its enantiomers, a potent antithrombotic agent, in rabbits. Xenobiotica. (2015) 45(11):1016-23 (IF- 2.38). |
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Wahajuddin M, Singh SP, Taneja I, Raju KS, Gayen JR, Siddiqui HH, Singh SK; Development and validation of an LC-MS/MS method for simultaneous determination of piperaquine and 97-63, the active metabolite of CDRI 97-78, in rat plasma and its application in interaction study. Drug Test Anal. (2015) [in press] (IF- 2.82) |
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Rama Raju KS, Taneja I, Singh SP, Tripathi A, Mishra DP, Hussain KM, Gayen JR, Singh SK, Wahajuddin M.; Simultaneous determination of centchroman and tamoxifen along with their metabolites in rat plasma using LC-MS/MS. Bioanalysis. (2015) 7(8):967-79 (IF- 3.03). |
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Wahajuddin M, Singh SP, Taneja I, Raju KS, Gayen JR, Siddiqui HH, Singh SK.; Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97-78 in rat plasma using the HPLC-ESI-MS/MS method: application to drug interaction study. Malar J. (2015) 14(1):172 (IF- 3.49). |
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Atul Goel, Shahida Umar, Pankaj Nag, Ashutosh Sharma, Lalit Kumar, Shamsuzzama, Zakir Hossain, Jiaur R. Gayen and Aamir Nazir; A dual colorimetric-ratiometric fluorescent probe NAP-3 for selective detection and imaging of endogenous labile iron(III) pools in C. elegans; Chem Commun (Camb). (2015) 51(24):5001-4 (IF- 6.72) |
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Navneet kumar Yadav, Karan Singh Saini, Zakir Hossain, Ankur Omer, Chetan Sharma, Jiaur R. Gayen, Poonam Singh, K R Arya and R. K. Singh; Saraca indica bark extract shows in-vitro antioxidant, anti-breast cancer activity and does not exhibit toxicological effects., Oxid Med Cell Longev, (2015) 2015:205360 (IF-3.4) |
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Bandyopadhyay GK, Lu M, Avolio E, Siddiqui JA, Gayen JR, Wollam J, Vu CU, Chi NW, O'Connor DT, Mahata SK. Pancreastatin-dependent inflammatory signaling mediates obesity-induced insulin resistance. Diabetes (2015), 64(1):104-16 (IF-8.3) |
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Singh SK, Bharati AP, Singh N, Pandey P, Joshi P, Singh K, Mitra K, Gayen JR, Sarkar J, Akhtar MS. The prophage encoded hyaluronate lyase has broad substrate specificity and regulated by the N-terminal domain. J Biol Chem (2014), 289(51):35225-36 (IF-5.3) |
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Vu CU, Siddiqui JA, Wadensweiler P, Gayen JR, Avolio E, Bandyopadhyay GK, Biswas N, Chi NW, O'Connor DT, Mahata SK.Nicotinic cholinergic receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggest dual opposing roles of the receptors in male mice. Endocrinology, (2014), 155(10):3793-805 (IF-5.0) |
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Singh A; Joharapurkar A; Khan MP; Mishra J; Singh N; Yadav M; Hossain Z; Khan K; Kumar S; Dhanesha N; Mishra D; Godbole M; Gayen JR; Chattopadhyay N; Sanyal S; Orally Active Osteoanabolic Agent GTDF Binds to Adiponectin Receptors, With a Preference for AdipoR1, Induces Adiponectin-Associated Signaling, and Improves Metabolic Health in a Rodent Model of Diabetes.; Diabetes (2014), 63(10):3530-44 (IF-8.3) |
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Shikha S. Chauhan, Anup K. Singh, Sanjeev Meena, Minaxi Lohani, Akhilesh Singh, Rakesh K. Arya, Srikanth H. Cheruvu, Jayanta Sarkar, Jiaur R. Gayen, Dipak Datta, Prem M.S. Chauhan; Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells; Bioorganic & Medicinal Chemistry Letters (2014), 24(13); 2820-24 (IF 2.6). |
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Srikanth H Cheruvu; Pankaj Joshi; Anilkumar Bikkasani; Konica Porwal; Jiaur R Gayen*; Bone distribution study of anti-leprotic drug clofazimine in rat bone marrow cells by a sensitive reverse phase liquid chromatography method, J Chrom B (2014) 960; 82-86 (IF 2.9) |
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Nagendu B. Dev, Saiful A. Mir, Jiaur R. Gayen, Jawed A. Siddiqui, Maja Mustapic and Sucheta M. Vaingankar; Cardiac electrical activity in a genomically “humanized” chromogranin a monogenic mouse model with hyperadrenergic hypertension. J Cardiovasc Transl Res (2014) 7(5):483-93 (IF-2.69] |
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Tripathi A, Shing SP, Raju KSR, Wahajuddin, Gayen JR*; Effect of Red Clover on CYP Expression: An Investigation of Herb-Drug Interaction at Molecular Level; Ind J Pharm Sci (2014); 76(3); 161-66. |
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Biswas N, Friese RS, Gayen JR, Mahata SK, O'Connor DT; Discovery of a novel target for the dysglycemic chromogranin A fragment pancreastatin: Interaction with the chaperone GRP78 to influence metabolism. PLOS ONE (2014), 9(1):e84132 (IF-4.09) |
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Amrita Saxena, G K Jain, H H Siddiqui, S S Bhunia, A K Saxena, Jiaur R Gayen*. In-vitro Metabolism of a Novel Antithrombotic Compound, S002-333 and its Enantiomers: Quantitative Cytochrome P450 Phenotyping, Metabolic Profiling and Enzyme Kinetic Studies, Xenobiotica (2014), 44(4):295-308 (IF-2.38). |
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Kuixing Zhang, Nilima Biswas, Jiaur R. Gayen, Jose Pablo, Miramontes-Gonzalez, C. Makena Hightower, Maja Mustapic, Manjula Mahata, Chun-Teng Huang, Vivian Y. Hook, Sushil K. Mahata, Sucheta Vaingankar and Daniel T. O’Connor. Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms. J Neurochem, (2014), 129(1): 48-59. (IF-4.34) |
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Valicherla GR, Hossain Z, Mahata SK, Gayen JR*. Pancreastatin is an endogenous peptide that regulates glucose homeostasis. Physiol Genomics. (2013), 45(22):1060-71 (IF-3.4) |
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Friese RS, Altshuler AE, Zhang K, Miramontes-Gonzalez JP, Hightower CM, Jirout ML, Salem RM, Gayen JR, Mahapatra NR, Mahata SK, Schmid-Schönbein GW, O'Connor DT. MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension.Hum Mol Genet. (2013) [Epub ahead of print] (IF-7.64) |
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Biswas N,Gayen JR, Su Y, Mahata SK, O'Connor DT. Novel Peptide Isomer Strategy for Stable Inhibition of Catecholamine Release: Application to Hypertension. Hypertension(2012), 60(6), 1552-59. (IF-6.21) |
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Chakraborty J, Hossain MZ, Tripathi A, Ghosh W, Samanta TB, Wahajuddin and Gayen JR;Taxonomical characterization of a penicillin amidase producing novel strain of Achromobacterxylosoxidans: Proposal of A. xylosoxidans subsp. indiges subsp. nov. ; Developmental Microbiology and Molecular Biology(2012), 3(1), 55-65. |
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Mahata M, Zhang K, Gayen JR, Nandi S, Brar, BK, Ghosh, S, Mahapatra NR, Taupenot L, O’Connor DT, Mahata SK: Catecholamine biosynthesis and secretion: physiological and pharmacological effects of secretin. Cell Tissue Res(2011), 345(1): 87-102. (IF-3.12) |
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LuM, Sarruf D, TalukdarS,Sharma S, Li P, Bandyopadhyay G, Nalbandian S, FanW, Gayen JR, Mahata SK, WebsterN, Schwartz M, Olefsky JM; Brain Peroxisome Proliferator-Activated Receptor Gamma Promotes Obesity and is Required for the Full Insulin-Sensitizing Effect of Thiazolidinediones. Nature Medicine(2011), 17(5): 618-22. (IF-25.5) |
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Zhang K, Chen Y, Wen
G, Mahata M, Rao F, Fung MM, Vaingankar S, Biswas N, Gayen
JR, Friese RS, Mahata SK, Hamilton BA, O'Connor
DT; Catecholamine Storage Vesicles: Role of Core Protein
Genetic Polymorphisms in Hypertension. Curr Hypertens
Rep. (2011), 13(1): 36-45. |
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Chen Y, Rao F, Wen G,
Gayen JR, Zhang K, Vaingankar SM, Biswas
N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt
C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton
BA, O’Connor DT; Naturally occurring genetic variants
in human chromogranin A (CHGA) associated with hypertension
as well as hypertensive renal disease. Cell Mol
Neurobiol (2010), 30(8): 1395-1400. |
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Gayen JR,
Zhang K, RamachandraRao S, Mahata M, Chen Y, Kim HS, Naviaux
RK, Sharma K, Mahata SK, O’Connor DT; Role of reactive
oxygen species in hyperadrenergic hypertension: Biochemical,
physiological, and pharmacological evidence from targeted
ablation of the chromogranin A (Chga) gene. Circulation
Cardiovasc Genet (2010), 3(5):
414-25. [Featured on www.MDLinx.com site. MDLinx is the
world's most up-to-date index of articles that matter
in the daily lives of physicians and other healthcare
professionals]. |
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Dev NB, Gayen
JR, O’Connor DT, Mahata SK; Chromogranin
A and the autonomic system: Decomposition of heart rate
variability and rescue by its catestatin fragment.
Endocrinology (2010), 151(6):
2760-68. |
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Vaingankar SM, Li Y, Corti
A, Biswas N, Gayen JR, O’Connor
DT, Mahata SK: Long human CHGA flanking chromosome 14
sequense required for optimal BAC transgenic rescue of
disease phenotypes in the mouse Chga knockout.
Physiol Genomics (2010), 41(1):
91-101. |
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Vaingankar SM, Li Y, Biswas
N, Gayen JR, Choksi S, Rao F, Mahata
SK, O’Connor DT; Effect of Chromogranin-A deficiency
and excess in vivo: biphasic blood pressure and catecholamine
response. J Hypertension (2010),
28(4): 817-25. |
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Friese RS,
Gayen JR, Mahapatra NR, Schmid-Schonbein
G, Mahata SK and O’Connor DT; Global metabolic consequences
of a monogenic model of hypertension: Transcriptomic detection,
pathway identification, and experimental verification
of dissociated features of the metabolic syndrome. Physiol
Genomics (2010), 40(3): 195-207. |
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Gayen JR,
Saberi M, Schenk S, Biswas N, Vaingankar S, Cheung W,
Bandyopadhyay G, O’Connor DT, Mahata SK; A novel
pathway of insulin sensitivity in chromogranin A null
mice: A crucial roll for pancreastatin in glucose homeostasis.
J Biol Chem (2009),
284(42): 28498-509. |
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Gayen JR,
Gu Y, O’Connor DT, Mahata SK; Global disturbances
in autonomic function yield cardiovascular instability
and hypertension in the chromogranin A null mouse.
Endocrinology (2009), 150(11):
5027-35. |
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Rana B, Wessel J, Mahaboubi
M, Rao F, Haeller J, Gayen JR, Eskin
E, Valle A, Das M, Mahata SK, O’Connor DT, Taylor
P; Natural variation within the neuronal nicotinic acetylcholine
receptor cluster on human chromosome 15q24: Influence
on heritable autonomic traits in the twin pairs. J
Pharmacol Exp Therapeutics (2009),
331(2): 419-28. |
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Biswas N, Rodriguez-Flores
JL, Courel M, Gayen JR, Vaingankar SM,
Mahata M, Torpey JW, Taupenot L, O'Connor DT, Mahata SK:
Cathepsin L co-localizes with chromogranin A in chromaffin
vesicles to generate active peptides. Endocrinology
(2009), 150(8): 3547-57. |
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Zhang K, Rao F, Rana
BK, Gayen JR, Calegari F, King A, Rosa
P, Huttner WB, Stridsberg M, Mahata M, Vaingankar S, Mahboubi
V, Salem RM, Rodriguez JR, Smith D, Schork NJ, Ziegler
M, Taupenot L, Mahata S and O’Connor DT: Autonomic
function in hypertension: Role of genetic variation at
the catecholamine storage vesicle protein chromogranin
B (CHGB). Circulation Cardiovasc Genet
(2009), 2: 46-56. |
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GM Portela-Gomes,
JR Gayen, L Grimelius, M Stridsberg and SK Mahata:
The importance of chromogranin A in the development and
function of endocrine pancreas. Regulatory Peptides
(2008), 151(1-3): 19-25. |
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Biswas N, Vaingankar SM,
Mahata M, Das M, Gayen JR, Taupenot L,
Torpey JW, O'Connor DT, Mahata SK: Proteolytic cleavage
of human chromogranin A containing naturally occurring
catestatin variants, differential processing at catestatin
region by plasmin. Endocrinology (2008),
Feb 149(2): 749-757. |
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JR Gayen,
S B Majee, S Das and T B Samanta: Antibacterial and toxicological
evaluation of ?eta-lactams synthesized by immobilized
?eta-lactamase-free penicillin amidase produced by Alcaligenes
sp. Ind J Exp Biol (2007),
45: 1068-1072. |
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Rao F, Wen G,
Gayen JR, Das M, Vaingankar SM, Rana BK, Mahata
M, Kennedy BP, Salem R, Stridsberg M, Abel K, Smith D,
Hamilton BA, Ziegler MG, Mahata SK and O’Connor
DT; Catecholamine Release Inhibitory Peptide Catestatin
(Chromogranin A352-372), naturally occurring amino acid
varient Gly364Ser causes profound changes in human autonomic
activity and alters risk of hypertension, Circulation
(2007), May; 115(17):2271-81. |
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NR Mahapatra, M Mahata,
S Ghosh, JR Gayen, DT O’Connor,
S Mahata: Molecular basis of neuroendocrine cell type-specific
expression of the chromogranin B gene: crucial role of
the transcription factors CREB, AP-2, Egr-1 and Sp1;
J Neurochem, (2006), 99: 119-133. |
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S Das, JR Gayen,
A Pal, K Ghosh, JPN Rosazza and TB Samanta: Purification,
substrate specificity, and N-terminal amino acid sequence
analysis of a beta-lactamase-free penicillin amidase from
Alcaligenes sp.; Applied Microbiol Biotechnol,
(2004), 65: 281-286. |
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JR Gayen,
P. Roy and T B Samanta (2004): 16S rDNA
sequence of Alcaligenes sp. (A-13); EMBL/ DDBJ/GenBank
accession number AJ716013. |
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L Ghosh, JR Gayen, T Murugesan, S Sinha, M Pal and BP Saha: Evaluation of purgative activity of roots of Rumexnepalensis; Fitoterapia; (2003), 74: 372-374. (IF-1.9) |
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L Ghosh, JR Gayen, S Sinha, S Pal, M Pal and BP Saha: Antibacterial efficacy of RumexnepalensisSpreng. Roots; Phytotherapy Research;(2003); 17: 558-559. (IF-2.1) |
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Biswas S, Murugesan T, Sinha S, Maiti K, Gayen JR, Pal M and Saha BP: Antidiarrhoeal activity of Strychnospotatorum seed extract in rats;Fitoterapia; (2002); 73(1): 43-47. (IF-1.9) |
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S Sinha, T Murugesan, K Maiti, JR Gayen, B Pal, M Pal and BP Saha: Antibacterial Evaluation of BergeniaciliataSternb rhizome extract. Fitoterapia,(2001); 72: 550-552. (IF-1.9) |
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S Sinha, T Murugesan, K Maiti, JR Gayen, M Pal, BP Saha: Evaluation of Anti inflammatory potential of BergeniaciliataSternb. rhizome extract in rats; J Pharmacy and Pharmacol, (2001); 53: 193-196. (IF-1.92) |
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L Ghosh, JR Gayen, S Sinha, M Pal and BP Saha: Pharmacognostical profile of roots of RumexnepalensisSpreng. Ancient Science of Life, (2000);XX (4): 93 - 96. (IF-0.22) |
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S Sinha, T Murugesan, K Maiti, JR Gayen, M Pal, BP Saha: Evaluation of Anti-pyretic potential of BergeniaciliataSternb. rhizome extract; Pharm PharmacolCommun, (2000); 6(12): 549-551. |
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T Murugesan, JR Gayen, J Poddar, S Biswas, M Pal, BP Saha: Evaluation of Tincture Prepared from Jussiaeasuffruticosa Linn. J Scientific and Indus Res,(2000); 59: 587-590. (IF-0.58) |
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| MEMBERSHIP |
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Life-Member of Association of Biotechnology and Pharmacy, India |
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Life-Member of Indian Society for Mass Spectrometry |
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Life-Member of Indian Pharmacological Society |
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Life-Member of Society of Biological Chemists, India |
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Life-Member of The Indian Science Congress Association |
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Life-Member of Laboratory Animal Science Association of India |
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Life-Member of Society of Applied Biotechnology, India |
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Life-Member of Association of Pharmacy Professionals, India |
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