Dr. J Venkatesh Pratap
  Principal Scientist
Molecular and Structural Biology Division
Central Drug Research Institute
Lucknow- 226031
U.P., India
 
Educational Qualifications M.Sc. (Madurai Kamaraj University), Ph.D. (Ind. Inst. Of Science)
Telephone +91 522 2772450  extn- 4439/4440
Fax +91 522 2771941
E- Mail [email protected]
Date of Birth 27.06.1972
 
POST-DOCTORAL RESEARCH
 
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 Nov 2001 - Sep 2006 Department of Biochemistry, University of Cambridge
Cambridge, England - Structure elucidation of protein-protein complexes, understanding helical assemblies
CURRENT RESEARCH AREAS
 
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The group works primarily on the structural and functional characterization of proteins from pathogens, with emphasis on Leishmania.  The proteins are chosen based on their importance to the pathogen and significant differences with their human homologues.  The study incorporates aspects of molecular biology, protein biochemistry, in silico analysis and X-ray crystallography
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 The group is also interested in the mechanistic aspects of helical assembly, especially in coiled-coils and helical bundles
 
SELECTED PUBLICATIONS
(for a complete list, click here ) 
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 Singh S.P., Agnihotri P. and Pratap, J.V. (2013) Characterization of a novel putative S-adenosylmethionine decarboxylase-like protein from Leishmania donovani.  PLOS ONE 8(6): 10.1371/0065912.
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 Pratap, J.V., Calladine, C.R. and Luisi, B.F. (2013)  Geometric principles in packing of helices. 2013(Phil. Trans. Roy. Soci. A. doi: 10.1098/rsta.2012.0369. Print 2013 Jun 28.).
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 Srivastava, V.K., Rana, A.K.,Sahasrabuddhe, A.A., Gupta, C.M. & Pratap, J.V. (2013). Cloning, Overexpression, Purification and Crystallization of CRN12 coiled-coil domain from Leishmania donovani. Acta Cryst. F69, 535-539.
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 Srivastava, V.K., Srivastava, S., Arora, A and Pratap, J.V. (2013). Structural Insights into Putative Molybdenum Cofactor Biosynthesis Protein C (MoaC2) from Mycobacterium tuberculosis H37Rv. PLOS ONE 8(3) : 10.1371/ 0058333.
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 Calladine, C.R., Luisi, B.F. & Pratap, J.V. (2013). A mechanistic Explanation of the Multiple Helical Forms Adopted by Bacterial Flagellar Filaments. J. Mol. Biol. (425), 914-928.
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 Frank, R.A.W., Pratap, J.V.,  Pei, X.Y., Perham, R.N. & Luisi, B.F. (2005). The molecular origins of specificity in the assembly of a multienzyme complex. Structure 13(8), 1119-1130.
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 Frank, R.A.W., Titman, C.M., Pratap, J.V., Luisi, B.F. & Perham, R.N. (2004). A molecular switch and proton wire synchronize the active sites in thiamine enzymes. Science:306, 872-876.
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 Calladine, C.R., Pratap, J.V., Chandran, V., Mizuguchi, K. & Luisi, B.F. (2003). Cylindrical channels from concave helices. Science 299:661-662.
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 Pratap, J.V., Jeyaprakash, A.A., Rani, P.G., Sekar, K., Surolia, A. & Vijayan, M. (2002).  Crystal structures of artocarpin, a Moraceae lectin with mannose specificity, and its complex with methyl-alpha-D-mannose: implications to the generation of carbohydrate specificity. J. Mol. Biol. 317(2):237-247.
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 Pratap, J.V., Bradbrook, G.M., Reddy, G.B., Surolia, A., Raftery, J., Helliwell, J.R. & Vijayan, M. (2001). The combination of molecular dynamics with crystallography for elucidating protein-ligand interactions: a case study involving peanut lectin complexes with T-antigen and lactose. Acta Cryst. D57:1584-1594.