Our group is focusing on systemic and pulmonary hypertension. We are interested to know how systemic hypertension contributes in the progression of neurodegeneration. We found that there is activation of glial cells in hippocampus and cortex in the model of chronic hypertension induced by ligation of renal artery and deoxycorticosteron acetate (DOCA) along with inflammatory changes. Further, our group is trying to dissect out the role of poly (ADP-Ribose) polymerase-1 (PARP-1) and Fatty Acid Synthase (FAS) in pulmonary hypertension and found that pharmacological inhibition of PARP-1 and FAS attenuates the pulmonary hypertension and right ventricular hypertrophy. As a part of CDRI drug development programme, we are also evaluating plant/herbal for their antihypertensive potential and also found that Pomegranate and Ashwagandha imparted protection in model of pulmonary hypertension. 

Rajasekar N, Dwivedi S, Tota SK, Kamat PK, Hanif K, Nath C, Shukla R.Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice. Eur J Pharmacol. 2013 May 16. doi:pii: S0014-2999(13)00338.

Tota S, Goel R, Pachauri SD, N R, Najmi AK, Hanif K, Nath C. Effect of angiotensin II on spatial memory, cerebral blood flow, cholinergic neurotransmission, and brain derived neurotrophic factor in rats. Psychopharmacology (Berl). 2013; 226 (2):357-69.

Singh N, Sharma G, Singh N, Hanif K. A comparative study of neuroprotective effect of single and combined blockade of AT1 receptor and PARP-1 in focal cerebral ischemia in rat. 2012 Sep 27. doi: 10.1111/j.1747-4949.2012.00916.

Tota S, Nath C, Najmi AK, Shukla R, Hanif K. Inhibition of central angiotensin converting enzyme ameliorates scopolamine induced memory impairment in mice: Role of cholinergic neurotransmission, cerebral blood flow and brain energy metabolism. Behave Brain Res. 2012 Jun 15; 232(1):66-76.

Tota S, Hanif K, Kamat PK, Najmi AK, Nath C. Role of central angiotensin receptors in scopolamine-induced impairment in memory, cerebral blood flow, and cholinergic function. Psychopharmacology (Berl). 2012; 222(2):185-202.

Tota S, Kamat PK, Saxena G, Hanif K, Najmi AK, Nath C. Central angiotensin converting enzyme facilitates memory impairment in intracerebroventricular streptozotocin treated rats. Behavioural Brain Research 2012; 226(1):317-30.

Pachauri SD, Tota S, Khandelwal K, Verma PR, Nath C, Hanif K, Shukla R, Saxena JK, Dwivedi AK. Protective effect of fruits of Morinda citrifolia L. on scopolamine induced memory impairment in mice: a behavioral, biochemical and cerebral blood flow study. J Ethnopharmacol 2012; 139 (1):34-41.

Bid HK, Manchanda PK, Konwar R, Hanif K, Nayak VL, Singh V. Does angiotensin-converting enzyme polymorphism have association with symptomatic benign prostatic hyperplasia? Indian J Urol. 2010 Oct; 26(4):497-501.

Verma R, Hanif K, Sasmal D, Raghubir R. Resurgence of herbal antihypertensives in management of hypertension.Current Hypertension Reviews, 2010; 6 (3):190-198.

Tota S, Awasthi H, Kamat PK, Nath C, Hanif K. Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice. Behav Brain Res. 2010 May 1; 209(1):73-9.

Awasthi H, Tota S, Hanif K, Nath C, Shukla R. Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow. Life Sci. 2010 Jan 16; 86(3-4):87-94.

Hanif K, Bid HK, Konwar R. Reinventing the ACE inhibitors: some old and new implications of ACE inhibition. Hypertens Res. 2010 Jan; 33(1):11-21.

Tota S, Kamat PK, Awasthi H, Singh N, Raghubir R, Nath C, Hanif K. Candesartan improves memory decline in mice: involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin. Behav Brain Res. 2009; 199(2):235-40.

Hanif K, Snehlata, Pavar MC, Arif E, Fahim M, Pasha MA, Pasha S. Effect of 3-thienylalanine-ornithine-proline, new sulfur-containing angiotensin-converting enzyme inhibitor on blood pressure and oxidative stress in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 2009; 53(2):145-50.

Hanif K, Fahim M, Pavar MC, Bansal V, Pasha S.Hypotensive effect of novel chimeric peptides of met-enkephalin and FMRFa. Regul Pept. 2005 Feb 15; 125(1-3):155-61

Ms Gurpreet Kaur (SRF), Mr Shanawaz Bhatt (JRF), Mrs Neetu Singh (SRF)