DR. (Mrs) KUMKUM SRIVASTAVA ( NEE TYAGI)
 
 

Principal Scientist
Division of Parasitology
Central Drug Research Institute
Lucknow 226031, INDIA

 

Dr. Kumkum Srivastava nee Tyagi, a PhD in Zoology from Kanpur University, Kanpur worked as Research fellow and Post doctoral fellow in CSIR-CDRI, Lucknow in 1979-2000. She served as scientist in CSIR-CDRI Lucknow from 2000 and continuing as Principal Scientist in the same Institute. During 1991-1992 she was visiting scientist in NUS, Singapore.
Dr. Srivastava focused her research on two parasitic diseases, Lymphatic Filariasis and Malaria with special emphasis on Model Development, Drug Discovery and host-parasite interaction.
She had Published 80 Papers and one book Chapter.
Educational Qualifications

Degree

Subject

University

Year

Ph.D.

Zoology

Kanpur University, Kanpur

1986

M.Sc.

Zoology (Parasitology)

Lucknow University Lucknow

1978

B.Sc.

Zoology, Botany, Chemistry

Lucknow University Lucknow

1976
E-Mail [email protected]
Date of Birth 11th October 1957
 
POSITIONS HELD
 
•

Post

Organization

Dates

Scientist E-II

CSIR-CDRI, LUCKNOW

May, 2009 to contd.

Scientist E-I

CSIR-CDRI, LUCKNOW

May, 2005 to April, 2009

Scientist C

CSIR-CDRI, LUCKNOW

May, 2000 to April, 2005
 
 
AREAS OF SPECIALISATION
 
•

Lymphatic Filariasis-

  • Chemotherapy and immunology of experimental Lymphatic Filariasis

 Malaria-

  • In vitro culture of Plasmodium falciparum
  • Bioevaluation of Synthetic molecules and extracts from plant and Marine fauna for antimalarial activity.
 
MAJOR RESEARCH ACTIVITIES
 
•

Lymphatic Filariasis-

  • Model Development: Establishment of human lymphatic filarial infections, Brugia malayi and Wuchereria bancrofti in rodents and non human primates.
  • Host-Parasite relationship with special emphasis on immune status of host and immuno-modulation
  • Development of immunodiagnostic test using Infective larvae of Human Lymphatic filarial parasite, Brugia malayi
  • Identification and optimization of lead molecules with promising antifilarial activity
•

Malaria-

  • Identification of new lead molecules for development of new antimalarials
  • Up gradation of existing model system and assaysfor evaluation of antimalarial activity of novel moieties against Plasmodium falciparum.
  • Selection and characterization of Arteether resistant parasite line using laboratory maintained Plasmodium falciparum clones.
  • Management of Mycoplasma contamination in P. falciparum cultures
  • In vitro exploration for Drug Combinations for therapeutic intervention
 
RECOGNISED FOR Ph.D.
 
•
  • JNU
  • AcSIR
 
Ph.D. Guidance to Students
 
•
  • Rajeev K Srivastava (SRF)
  • Pooja Agarwal (SRF)
  • Vishakha Swarnkar (JRF)
 
HONOURS and AWARDS
 
•
 M. B. Mirza Award of Indian Society for Parasitology (1988)
•
 CSIR Technology Award for Innovation for development of Synthetic Endoperoxide Antimalarials as substitute to Artemisinine Derivatives (2009) (As team member)
 

SELECTED PUBLICATIONS

80 Book Chapter- 01 Honours and Awards

 
 

Malaria
•
 Management of mycoplasma contamination in in-vitro culture of Plasmodium falciparum without antibiotic(s) treatment –A preliminary report.  Pooja Agarwal, Rajeev K. Srivastava, Sunil K. Puri, Kumkum Srivastava. Research in Microbiology  2013, 164, 211-15
•
 Isolation and identification of β-hematin inhibitors from Flacourtia indica as promising antiplasmodial agents.  Koneni V. Sashidhara , Suriya P. Singh , Shiv Vardan Singh , Rajeev K. Srivastava, Kumkum Srivastava, J.K. Saxena, Sunil K. Puri. European J Med chem 2013, 60, 497-502
•
 Synthesis and Insight into the Structure-Activity relationships of Chalcones as Potent Antimalarial agents. T. Narender, K.Venkateswarlu Shweta, K. Papireddy, Tanvir Khaliq, Awakash Soni, R.K.Srivastava, K. Srivastava, S.K.Puri, K.S.R.Raju, Wahajuddin and P.S.Sijwali. J Med Chem 2012, 56 (1), 31-45
•

Design and synthesis of 4- aminoquinoline derived thiazolidines for their antimalarial activity  V. Raja Solomon, W. Haq, Kumkum Srivastava, Sunil
K. Puri, and S. B. Katti. Journal of Enzyme Inhibition & Medicinal Chemistry 2012, 28, (3), 619-626
•
 Synthesis of hybrid 4-anilinoquinoline triazine as potent antimalarial agents,  their in silico modeling and bioevaluation as Plasmodium falciparum transketolase and β-hematin inhibitors.  Moni Sharma, Kuldeep  Chauhan, Shikha S. Chauhan, Ashok Kumar, Shiv Vardan Singh, Jitendra K. Saxena, Pooja Agarwal, Kumkum Srivastava, S. Raja Kumar , Sunil K. Puri, Priyanka Shah,  M.I. Siddiqi and Prem M. S. Chauhan. Med. Chem.  Commun 2012, 3,  71-79
•
 4-Anilinoquinoline triazines: A novel class of hybrid antimalarial agents.  Ashok Kumar, Kumkum Srivastava, S. RajaKumar, Siddiqui, M.I., S. K. Puri, J. K. Saxena and P. M. S.Chauhan.  Eur J Med Chem 2011, 46, 676-690
•
 In-vitro culture of Plasmodium falciparum: Utility of modified (RPNI) medium for drug-sensitivity studies using SYBR Green I assay.  Shubhra Singh, Rajeev Kumar Srivastava, Mukesh Srivastava, S.K. Puri, K. Srivastava. Experimental Parasitology 2011, 127, 318-321
•
 4-Aminoquinoline derived antimalarials: synthesis, antiplasmodial activity and heme polymerization inhibition studies.  Solomon V R; Haq W; Smilkstein M; Srivastava Kumkum; Puri Sunil K; Katti S. B. European journal of medicinal chemistry 2010, 45 (11), 4990-96
•
 Synthesis of 9-anilinoacridine triazines as new class of hybrid antimalarial agents.  Ashok Kumar, Kumkum Srivastava, S. Raja Kumar, S.K. Puri, Prem M.S. Chauhan. Bioorganic & Medicinal Chemistry Letters 2009, 19, 6996-6999
•
 Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4-aminoquinoline with potent antiplasmodial activity.  Naresh Sunduru, Moni Sharma, Kumkum Srivastava, S. Rajakumar, S. K. Puri, J. K. Saxena, Prem M. S. Chauhan. Bioorganic & Medicinal Chemistry  2009, 17, 6451–6462
•
 Search for new pharmacophores for antimalarial activity (Part I): Synthesis and antimalarial activity of new 2-methyl-6-ureido-4- quinolinamides.  S. Madapa, Z. Tusi, D. Sridhar, K. Srivastava, A. Rizvi, R. Tripathi,S. K. Puri,G.B. Shiva, Keshava,P. K. Shukla and S. Batra. Biorganic & Medicinal Chemistry 2009, 17, 203-221
•
 Substituted quinolinyl chalcones and quinolinyl pyrimidines as a new class of anti-infective agents.  Moni Sharma, Vinita Chaturvedi, Y. K. Manju, Shalini Bhatnagar, Kumkum Srivastava, S. K. Puri, and Prem M. S. Chauhan. European Journal of Medicinal Chemistry 2009, 44, 2081-91
•
 Treatment and Control of Mycoplasma contamination in Plasmodium falciparum culture.  Shubhra Singh, S. K. Puri and Kumkum Srivastava. Parasitology Research 2008, 104 (1), 181-84
•
 In vitro cultivation of Plasmodium falciparum: Studies with modified medium supplemented with albumax and various animal sera.  Kumkum Srivastava, Shubhra Singh, Pratibha Singh and S. K. Puri. Experimental Parasitology 2007, 116 , June (2), 171-174
•
 Design, synthesis and antimalarial activity of a new class of iron chelators.  Solomon V Raja, Haq W, Puri Sunil K, Srivastava Kumkum, Katti SB. Medicinal Chemistry 2006, 2, 133-38.
•
 Clotrimazole inhibits heme-peroxidase of Plasmodium falciparum and induces oxidative stress: proposed antimalarial mechanism of clotrimazole.  Trivedi, V., Chand, P., Srivastava, K., Puri, S. K., Maulik, P. R. and Bandopadhyay, U. J. Biol. Chem. (2005) 280, 41129-41136
•
 Purification and biochemical characterization of a heme containing peroxidase from the human parasite P. falciparum.  Vishal Trivedi, Kumkum Srivastava, Sunil K.Puri, Prakas R.Maulik and Uday Bandopadhyay. Protein Expression and Purification 2005, 41, 154-161
•
 Plasmodium falciparum: modified medium composition supports continuous cultivation with foetal bovine serum.  Kumkum Srivastava, S.K. Puri. Experimental Parasitology 2004, 108, 74-75.
 

Book Chapter
•
 Recent Developments in Plasmodium falciparum in-vitro model for Drug Discovery.  Kumkum Srivastava and S.K. Puri. Proceedings of the National Academy of Sciences, India. Vol. 79 (special issue on Parasitology) 2009.
 

Filaria
•
 Wuchereria bancrofti: Effect of single and multiple larval inoculations on infection dynamics and development of clinical manifestations in non-human primate Presbytis entellus.  Srivastava Kumkum, Vedi Satish, Srivastava Sudhir & Misra-Bhattacharya shailja. Experimental Parasitology 2007, 115, 305-09.
•
 Tetracycline, a tool for transmission blocking of Brugia malayi in  Mastomys coucha.  K. Srivastava and Shailja Misra- Bhattacharya. Current Science  2003, 85, 588-589.
•
 Transmission efficiency of Culex quinquefasciatus and Aedes aegypti to Wuchereria bancrofti infection:  An experimental study.  Shailja Misra- Bhattacharya & K. Tyagi. Indian Journal of Experimental Biology, 2001, 39, 98-100 
•
 Brugia malayi in Mastomys coucha: establishment in immunosuppressed animals.  Tyagi K, Murthy PK, Chatterjee RK. Acta Trop 1998, 70: 157-162.  
•
 Brugia malayi in Indian leaf monkey (Presbytis entellus)- Response to repeated exposures of infective larvae.  Tyagi, K., Murthy, P. K. and Chatterjee, R. K. Curr. Sci., 1996, 70, 164–167
•
 Brugia malayi in Mastomys natalensis: Influence of  immunostimulators on exertion of antifilarial activity of diethylcarbamazine.  K. Tyagi, P.K. Murthy, R.K. Chatterjee. Trop. Med. Parasitology, 1994, 45, 24–26
•
 Brugia malayi in Mastomys natalensis: exposure during pregnancy and lactation.  K. Tyagi, P.K. Murthy, R.K. Chatterjee . Acta Parasitologica  1994, 39, 158-161
•
 Evaluation of filarial skin test with Brugia malayi larval antigen in the field.  AK Singh, K. Tyagi, P.K. Murthy, CK Gupta, SK. Mandal,  R. Chandra, AR. Sircar and JC. Katiyar. Indian J Med Res. 1990, 91, 52-54
•
 Suceptibility of Mastomys natalensis to Brugia malayi following pretreatment with antifilarials.  K Tyagi, P K Murthy, A B Sen. Folia Parasitol., 1990, 37, 261–265
•
 Chemotherapeutic response of Brugia malayi to antifilarialsin Mastomys natalensis.  Tyagi K, Murthy PK, Roy Chowdhury TK, RK. Chatterjee and AB. Sen. Indian J Parasitology  1986,  10, 195-207
•
 Effect of some known antifilarials on the immune responses of Mastomys natalensis infected with Brugia malayi.  K Tyagi, P K Murthy, A B Sen. Indian J Med Res. 1986,  83, 155-61 
•
 Sequential changes in the antibody response of Mastomys natalensis consequent to Brugia malayi infection.  K Tyagi, PK. Murthy and A B Sen. Indian J Med Res. 1985, 81, 269-74
•
 Suceptibility of Mastomys natalensis (GRA strain) to a sub-periodic strain of human  Brugia malayi.  Murthy PK, Tyagi K, Roy Chowdhury TK, Sen, AB. Indian J Med Research 1983, 77, 623-630