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| DR.
NEENA GOYAL |
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Senior Principal Scientist
Division of Biochemistry
CSIR-Central Drug Research Institute
Lucknow-226 031 |
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| Educational qualifications |
M.Sc., Ph.D. |
| Date of birth |
February 17, 1962 |
| E Mail |
[email protected] |
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| POST-DOCTORAL
RESEARCH |
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Imperial
College, London, UK |
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Department
of Transfusion Transmitted Diseases CBER/FDA, Maryland,
USA |
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| RESEARCH
EXPERIENCE |
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Biochemistry and Molecular Biology |
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| CURRENT
AREAS
OF INTEREST |
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Leishmaniasis
Our lab is mainly involved in identification and characterization of novel drug targets and drug resistance mechanism in leishmania. This protozoan parasite causes a disease commonly called as "Kala-Azar" (black-fever), the “Leishmaniasis”. There are no vaccines available at present, therefore, chemotherapy is the main weapon against this disease. Unfortunately, since the last decade, first line treatment by pentavalent animonials has been eroded by development of resistance and other treatment regimens are either highly toxic or very costly. Therefore, studies are required to understand fundamentals of the cell and molecular biology of Leishmania and also resistance mechanism to facilitate the development of effective treatment for this disease. At present we are focusing on few novel drug targets, identified in Leishmania donovani (dd8) by microarray analysis. Following rational drug development approach and various techniques, efforts are underway to develop specific inhibitors against these targets. We have also explored multiplicity drug resistance in field isolates by transcriptome analysis and identified novel gene(s). Detailed characterization of these genes will help to understand molecular and biochemical pathways of clinical resistance and hence to treatment resistant leishmania. |
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| SELECTED
PUBLICATIONS |
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Bhaskar, Neeti Kumari, Neena Goyal. Cloning, characterization and sub-cellular localization of gamma subunit of T-complex protein-1 (chaperonin) from Leishmania donovani. BBRC, 2012 429: 70-74. |
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Ravinder, Bhaskar, Sonali Gangwar, Neena Goyal. Development of luciferase expressing Leishmania donovani axenic amastigotes as primary model for in vitro screening of antileishmanial compounds. Current Microbiology, 2012 65: 696-700 |
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Gangwar S, Baig MS, Shah P, Biswas S, Batra S, Siddiqi MI, Goyal N. Identification of novel inhibitors of dipeptidylcarboxypeptidase of Leishmania donovani via ligand-based virtual screening and biological evaluation.Chem Biol Drug Des. 79(2):149-56. 2012 |
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Ashutosh, Garg M, Sundar S, Duncan R, Nakhasi HL, Goyal N. Downregulation of mitogen-activated protein kinase 1 of Leishmania donovani field isolates is associated with antimony resistance. Antimicrob Agents Chemother. 56:518-25. 2012 |
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Baig, M. S., Gangwar, S. and Goyal, N. Biochemical characterization of dipeptidylcarboxypeptidae of Leishmania donovani. Cell. Mol. Biol. 57 (1): 54-61. |
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M. S. Baig, Ashutosh Kumar, M.I. Siddiqi, Neena Goyal. Characterization of dipeptidylcarboxypeptidase of Leishmania donovani: a molecular model for structure based design of antileishmanials. J Comput Aided Mol Des 24, 77–87, 2010 |
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Smita Rai, Upendra Nath Dwivedi, and Neena Goyal.Leishmania donovani trypanothione reductase: Role of urea and guanidine hydrochloride in modulation of functional and structural properties. Biochimica et Biophysica Acta : Proteins and Proteomics, 1794,1474-1484 2009 |
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Mittal, M. K., Rai, S., Ashutosh, Ravinder, Gupta, S., Sundar, S. and Goyal, N.Characterization of natural antimony resistance in Leishmania donovani isolates. Am. J. Trop. Med. Hyg. 76, 681-688, 2007 |
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Ashutosh, Shyam Sundar and N. Goyal. Mechanism of antimony resistance in Leishmania J. Medical Microbiology 56, 143-153, 2007. |
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