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| Dr. Niti Kumar |
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Parasitology
CSIR-Central Drug Research Institute,
Lucknow 226031, India. |
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| Phone No. |
EXt:- 4496
Lab LSN105: 4486
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| Fax No. |
+91-522-2771941 |
| E- mail |
[email protected],[email protected] |
| Educational Qualifications |
Ph.D.: CSIR-Institute of Genomics and Integrative Biology (IGIB), Delhi
MSc.: Biomedical Sciences, University of Delhi
BSc.: Microbiology, University of Delhi |
| Date of Birth |
17.07.1981 |
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| AWARDS & RECOGNITIONS |
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Ramalingaswami Fellowship(2013-2018)
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EMBO Post Doctoral Fellowship (2010-2012)
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INSA Medal for Young Scientist (2010) by Indian National Science Academy
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Alexander von Humboldt
Fellow(2010)
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Max Planck Post-doctoral fellowship at Max Planck Institute of Biochemistry (2009)
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Marie Curie Early Stage Research Fellowship by European Union under 6th Framework Programme (2005-2006)
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Shanti Swarup Bhatnagar CSIR Sports Award in Badminton (2005 and 2006)
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| PROFESSIONAL EXPERIENCE |
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2009-13: Post-Doctoral Fellow at Max Planck Institute of Biochemistry
Investigated the conformation of Ribosome-Nascent Chain complexes and how the conformational dynamics of nascent chain is affected upon its interaction with chaperones
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2004-09: Ph.D. at CSIR-Institute of Genomics and Integrative Biology
Investigated the structural transition between unusual secondary structures formed by Guanines rich sequences (Quadruplexes) and Watson-Crick duplex, and how this structural equilibrium
modulate their respective biological functions
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2005-06: Marie Curie Early Stage Research fellow at Southern Denmark University
Investigated the role of modified nucleic acids (Locked Nucleic Acids) on the structure and thermodynamics of alternative secondary structures (Triplexes and i-Motifs)
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| RESEARCH AREAS OF
INTEREST |
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Investigating the Extra-ribosomal functions of Ribosomal proteins during Stress and Infection.
- Specific goals include understanding the (i) Cellular quality control mechanisms adopted by ribosomal proteins during stress, and (ii) Role of ribosomal proteins in Host-Pathogen interaction
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Understanding the role of Heat Shock Proteins during stress using Plasmodium falciparum model.
- This involves understanding the role of heat-shock proteins in productive folding of asparagine rich proteome of Plasmodium falciparum and how this provides survival advantage to the parasite.
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| SELECTED
PUBLICATIONS |
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Kumar, N , Basundra, R. and Maiti S. Elevated polyamines induce c-MYC over-expression by perturbing quaduplex-WC duplex equilibrium. Nucleic Acids Research, 2009, 37, 3321-3331. |
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Kumar, N ,Petersen M, Maiti S. Tunable c-MYC LNA i-motif. ChemComm2009, 12, 1532-4. |
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Kumar, N Patowary, A., Sivasubbu, S., Petersen, M., Maiti, S. Silencing c-MYC Expression by Targeting Quadruplex in P1 Promoter Using Locked Nucleic Acid Based Trap. Biochemistry,2008, 47, 13179-88. |
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Kumar, N , Shukla, S., Kumar, S., Suryawanshi, A., Chaudhary, U., Ramachandran, S., Maiti, S. An Intrinsically Disordered Protein from a pathogenic Mesophile Mycobacterium tuberculosis adopts structured conformation at high temperature. Proteins, 2008, 71, 1123-1133. |
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Kumar, N , Nielsen, J. T., Maiti, S., Petersen, M. i-motif formation with LNA (Locked Nucleic Acid). Angew. Chem. Int. Ed., 2007, 46, 9220-9222 |
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Chakraborty, T. K., Arora, A., Roy, S., Kumar, N , Maiti, S. Furan Based Cyclic Oligopeptides Selectively Target G-Quadruplex. J. Med. Chem. 2007, 50, 5539-5542. |
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Kumar, N , Nielsen, K. E., Maiti, S., Petersen, M. Triplex Formation with -L-LNA ( -L-Ribo-Configured Locked Nucleic Acid). J. Am. Chem. Soc., 2006, 128, 14-15. |
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Kumar, N and Maiti, S. The effect of osmolytes and small molecule on Quadruplex–WC duplex equilibrium: a fluorescence resonance energy transfer study. Nucleic Acids Research, 2005, 33, 6723-6732. |
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