Biodata of Dr P M S Chauhan :::: Central Drug Research Institute

Dr. P.M.S. Chauhan

Senior Principal Scientist
Medicinal and Process Chemistry Division
Central Drug Research Institute,Lucknow

E- mail	[email protected]
Educational Qualifications	M.Sc. Ph.D
Date of Birth	28th June 1958

Dr.P.M.S.Chauhan has received his PhD from Central Drug Research Institute ,Lucknow/ Agra University , Agra, India, in the year 1984 under supervision of Dr.R.N.iyer. He has joined CDRI during year 1988 as scientist. Currently, he is working as Senior Principal Scientistat Central Drug Research Institute, Lucknow, India.
He was also served as Senior research associate in University of Liverpool, UK (Jan.1987-Oct.1988) and University East Anglia (April-2002-june.2003).He was recipient of DAAD fellowship(2000).He has visited RWTH Achen,Germany (April-2000 to June2000).
He has authored 119. Research articles/books and six Indian patents. He is a member of Royal Society of Chemistry ,UK, American chemical society,USA, He is founder of Indian Society of Chemists and Biologists(General Secretary since 1995).He has honored as award for outstanding contributions in Medicinal chemistry and international scientific collaboration (Scientific PartnershipRashtriya Gaurav Award 2010, Indian International Friendship Society, New Delhi and Fellow of Royal Society Chemistry( FRSC) etc.
He is serving as an editorial advisory board member of several reputed journals like Future Medicinal Chemistry (future science group) , Global Journal of Organic Chemistry ( Simplex Academic Publishers), Journal Research and Reports in Medicinal Chemistry , Mycobacterial Diseases. He is founder Editor-in-Chief of journal Chemistry and Biology Interface.
He has delivered several plenary lectures and keynote lectures.
He has supervised 14 Ph.D students, 8students presently working for their Ph.D programme

POST DOCTORAL EXPERIENCE

•	Jan 1987 - Oct. 1988	Senior Research Associate (Science and Engineer Research Council (SERC), U.K.) Robert Robinson Laboratory, University of Liverpool, UK With Prof.R.C.Storr
•	April 2000-July, 2000	Senior DAAD Visiting Scientist, Instituted of Organic Chemistry(RWTH), Aachen, Germany, With Prof.D.Enders and Prof Stefan Brease)
•	April 2002- 2003	Visiting Scientist, School of Chemical Sciences, University East Anglia, Norwich, UK, (With Prof.David Horwell)
•	August 2-9 , 2009	Deputation to Glasgow, UK (To deliver KeyNote,Lecture,42nd IUPAC/RSC, Conference)

RESEARCH EXPERIENCE

•	26 Years (24 years as Scientist and Group leader)

FIELD OF SPECIALIZATION

•	Synthetic Organic chemistry/Medicinal chemistry (26 Years), Combinatorial chemistry (11 Years)

MEMBER: EDITORIAL BOARD

•	Founder Editor- in- Chief: Chemistry & Biology Interface
•	Member of Editorial board , Future Medicinal Chemistry,Future science group
•	Member of Editorial board - Mycobacterial Diseases

HONORS AND AWARDS

•	Recipient of the CDRI incentive award for the year 2000.,2001,2010,2013
•	Fellow of Royal Society Chemistry( FRSC) ,2003
•	AWARD for outstanding contributions in Medicinal chemistry and international scientific collaboration ( Scientific Partnership Foundation,Moscow,Russia,2005).
•	Most Cited paper,(2005-2008) award by Elsevier Prem M.S. Chauhan , Bioorganic and Medicinal Chemistry Letters , 2005, 15, 531-533
•	Rashtriya Gaurav Award, 2010, Indian International Friendship Society, New Delhi
•	Founder General Secretary Indian Society of Chemists and Biologists since 1995.

SELECTED PUBLICATIONS

Paper published in peer reviewed Journals 119
Patents (Indian) Filed                                    6
Ph. D. Thesis supervised                               14
Ph. D. Students currently working                8
Total Citaion        : 1355
Average Citation : 12.5
H index                  : 22

•	Discovery of a New Class of Natural Product-Inspired Quinazolinone Hybrid as Potent Antileishmanial agents,Moni Sharma, Kuldeep Chauhan, Rahul Shivahare, Preeti Vishwakarma, Manish K. Suthar, Abhisheak Sharma, Suman Gupta, Jitendra K. Saxena, Jawahar Lal, Preeti Chandra, Brijesh Kumar, and *Prem M. S. Chauhan† Journal of Medicinal Chemistry, 2013,2013,56,(11), pp 4374–4392 IF:5.2**
•	Total Synthesis of Perspicamide A and Related Point Diverse Analogues: Their Bioevaluation as Potential Antileishmanial Agents, Anand Kumar Pandey†, Rashmi Sharma†, Rahul Shivahare#, Ashish Arora, Neeraj Rastogi‡, Suman Gupta# and Prem M. S. Chauhan, Journal of Organic Chemistry,2013,78,1534, IF:4.45* , DOI: 10.1021/jo3025626 IF:4.45
•	Cyanuric chloride catalyzed mild protocol for synthesis of biologically active dihydro/spiro quinazolinones, spirooxyindole and quinazolinone-glycoconjugates, Moni Sharma†, Shashi Pandey, Deepty Sharma, Brijesh Kumar and Prem M. S. Chauhan* Journal of Organic Chemistry,2012,77(2),929-937, DOI: 10.1021/jo2020856 IF:4.45
•	Highly Skeletal Diverse Synthesis of N-Fused Polycyclic Heterocycles via Ugi- type MCR followed by CuI Catalyzed Coupling/ Tandem Pictet-Spengler Reaction, Vikas Tyagi, Shahnawaz Khan, Vikas Bajpai, Harsh M. Gauniyal, Brijesh Kumar and Prem M. S. Chauhan, Journal of Organic Chemistry,2012, 77(3), 1414–1421 DOI: 10.1021/jo202255v IF:4.45
•	A novel ligand free Pd-catalyzed cascade reaction: An access to the highly diverse Isoquinolin-1(2H)-one derivatives via isocyanide and Ugi-MCR synthesized amide precursorsTyagi, Vikas; Shahnawaz Khan, Archana Giri, Harsh Gouniyal, Balasubramaniam Sridhar, Prem M.S. Chauhan, Organic Letters, 2012, 14 (12), 3126–3129 IF:5.862*
•	Access to indole- and pyrrole-fused diketopiperazines via tandem Ugi-4CR / intramolecular cyclization and its regioselective ring opening by intermolecular transamidation,Shashi Pandey,Shahnawaz Khan, Awantika Singh,Harsh M. Gauniyal, Brijesh Kumar and Prem M. S. Chauhan, Journal of Organic Chemistry, 2012, 77 (22), pp 10211–10227 , DOI:* 10.1021/jo3018704 IF:4.45
•	Synthesis and biological evaluation of a new class of 4-aminoquinoline- rhodanine hybrid as potent anti-infective agents, Kuldeep Chauhan, Moni Sharma, Juhi Saxenab, Shiv Vardan Singh, Priyanka Trivedi, Kumkum Srivastava, Sunil K. Puri, J. K. Saxena, Vinita Chaturvedi and Prem. M. S. Chauhan, , European Journal of Medicinal Chemistry, 2013*,693-704, DOI:10.1016/j.ejmech.2013.01.017 IF.3.269
•	Synthesis and Antibacterial Evaluation of Novel 8-Fluoro Norfloxacin Derivatives as Potential Probes for methicillin and vancomycin-resistant Staphylococcus aureus, Naresh Sunduru, Leena Gupta, Kuldeep Chauhan, Nripendra N. Mishra ,P. K. Shukla and Prem. M. S. Chauhan*,European Journal of Medicinal Chemistry , 46 , (2011), 1232-1244 DOI: 10.1016/ j.ejmech.2011.01.44 IF:3.59
•	Substituted Quinolinyl Chalcones and Quinolinyl Pyrimidines : New class of Antiinfective agents Agents, Moni Sharma,Vinita Chaturvedi, and Prem M. S. Chauhan,* *European Journal of Medicinal Chemistry,44 , 2009, 2081–2091. IF:3.59*
•	Synthesis and antileishmanial activity of novel 2,4,6-trisubstituted pyrimidines and 1,3,5-triazines,Naresh Sunduru, Nishi, Shraddha Palne, Neena Goyal ,Prem M. S. Chauhanand Suman Gupta, European Journal of Medicinal Chemistry, 44, 2009, 2473–2481. IF:3.59*.
•	Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4-aminoquinoline with potent antiplasmodial activity , N.Sunduru, M.Sharma, K. Srivastava, S. Rajakumar, S. K. Puri, J. K. Saxena, Prem M. S. Chauhan, Bioorganic and Medicinal Chemistry, 17 ,2009, 6451-6462. IF:3.15*
•	Discovery of novel antileishmanial agents in an attempt to synthesize aplysinopsin pentamidine hybrid molecule ,Sharad Porwal,Shikha Chauhan, Prem M. S. Chauhan,* Nishi Shakya, Aditya Verma, Suman Gupta , Journal of Medicinal Chemistry,52,2009, 5793-5802. IF:5.31
•	Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-ß -carbolines as a new class of antimalarial agents,Leena Gupta, Kumkum Srivastava, Shubhra Singh, S. K. Puri and *Prem M. S. Chauhan, Bioorganic and Medicinal Chemistry Letters, 18, 2008**, 3306-3309.
•	One-pot chemoselective S-alkylation and acetylation of thiohydantoins using alkyl orthoformate-ZnCl2-Ac2O reagent system,Ravi Kumar and Prem M. S. Chauhan Ravi Kumar and *Prem M. S. Chauhan, Tetrahedron Letters , 49 ,2008**, 5475-5479.
•	Synthesis of 4-amino-5-cyano -2, 6-Disubsituted pyrimidines as a potential antifilarial DNA topoisomerase II Inhibitors ,Ashok Kumar,J.K.Saxena and Prem M. S. Chauhan, Medicinal Chemistry, 4(6), 2008 , 577-585.
•	Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents, Ashok Kumar , Kumkum Srivastava , S. Raja Kumar , S. K. Puri , Prem M. S. Chauhan, Bioorganic and Medicinal Chemistry Letters, 18, 2008, 6530-6533.
•	Synthesis of Marine alkaloid: 8, 9-Dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents,Leena Gupta, Archna Talwa, Nishi, Shraddha Palne,Suman Gupta and *Prem M. S. Chauhan, Bioorganic and Medicinal Chemistry Letters,2007**,17, 4075-4079.
•	Bis and Tris Indole Alkaloids from Marine Organisms:New Leads For Drug Discovery, Leena Gupta, Archna Talwar and Prem M.S.Chauhan, Current Medicinal Chemistry, 2007*, 14, 16, 1789-1803.
•	Syntheses of new substituted triazino tetrahydro-isoquinlines and ß-carbolines as novel antileishmanial agents, Arun Kumar, Sanjay Babu Katiyar, Suman Gupta and Prem M. S. Chauhan, European Journal of Medicinal Chemistry, 2006, 41 ,106-113,
•	A Multicomponent Reaction: Efficiently furnishing Phenylmethylene-2-thiohydantoin with some unusual consequences.Sharad Porwal, Rishi Kumar,b Prakas R. Maulik,and Prem M. S. Chauhan, Tetrahedron Letters ,2006 , 47,5863-5866
•	Facile synthesis of pyrazolo[3,4-d]pyrimidines and pyrimido [4,5-d]pyrimidin-4-one derivatives,Sanjay Babu Katiyar, Arun Kumar and Prem M. S. Chauhan, Synthetic communications, 36(20), 2006 ,2963-73
•	Synthesis of 2,4,6-trisubstituted pyrimidine and triazineheterocycles as antileishmanial agents ,Naresh Sunduru, Anu Agarwal,Sanjay Babu Katiyar,Nishi, Neena Goyal,,Suman Gupta and Prem M.S. Chauhan, Bioorganic and Medicinal Chemistry, 14,2006,7706-7715
•	Microwave assisted one pot synthesis of new bis-imidazolyl indoles, Anu Agarwal ,Sharad porwal and Prem M. S. Chauhan,, Letters in Organic Chemistry, 3,2006,712-714
•
SELECTED PATENTS
•	A process of synthesis of 2,7-diamidino xanthine , thioxantene of Biological Interest. P.M.S. Chauhan , R.N. lyer , Veena Shankhadhar , P.Y. Guru , A.B. Sen Indian Pat. No. 373/DEL/87
•	A process of synthesis of 2,7-diamidino xanthine , thioxantene of Biological Interest. P.M.S. Chauhan , R.N. lyer , Veena Shankhadhar , P.Y. Guru , A.B. Sen Indian Pat. No. 626/DEL/87
•	A process for the synthesis of antifilarial 2-(aryl) amino-4,6 -dihydrazinotriazines . P.M.S. Chauhan , Somnath Singh Puvada Kalpana Murty , R.K. Chatterjee Patent Indian No. CSIR India DEL/882/92
•	A process for the synthesis of Antifilarial N-(4-cyano pyrazoler-5-ylldithiomethyl carbamidate , P.M.S. Chauhan , Somnath Singh,Puvada Kalpana Murty , R.K. Chatterjee. Patent filed in Indian APP No. NF-201/92-PAT
•	A process for the synthesis of Antifilarial 4-cyano-5-quanidino pyrazoles P.M.S. Chauhan , Somnath Singh, Puvada Kalpana Murty , R.K. Chatterjee Patent No. 1239/DEL 192 (No. 1146 DEL-92.
•	A process for the synthesis of Antifilarial 2,4 -di-(4 -Chloro-3-nitroanilinyl)-6-amino-S- Triazine P.M.S. Chauhan, Nigar Fatima , R.K. Chatterjee Patent filed in India 3rd Dec. 1992. Pat. No.1148 (Del-92 dt. 3.12.92.)