Life Time Member of Society of Toxicology, India

Member of Editorial/Advisory Board of International Journal of Comprehensive Pharmacy (IJCP)

1. Hematotoxicity studies: Understanding the adverse effects of synthetic/natural compounds on the blood forming system using in vitro, in vivo and in silico approach.
2. Reproductive toxicity studies: Male Fertility, Teratogenicity and Foetotoxicity.
3. In vitro antileukemic activity Screening of different plants and their phytoconstituents for evaluation of antileukemic activity.
4. Repositioning the compounds: Various molecules possess multiple roles but not been explored. We aim to target several molecules against various targets to discover their novel role.
   • The HIV-1 and HTLV-I are retroviral proteases which share 31% sequence identity and high structural similarities. Yet, their substrate specificities and inhibition profiles are differing from each other and due to these reasons; most of the HIV-PR inhibitors fail to interact with HTLV-PR. Here we examined the approved drugs of HIV-PR inhibitors towards retroviral protease and examined the difference between both proteases through the binding energy, interaction energy and molecular dynamics studies.
   • Similar strategy can be explored against several targets like MDM2 etc, which is a well known cancer target that regulates the activity of p53 tumor suppressor protein to regulate cancer.
5. Computational exploration of roles of miRNAs in Leukemia: miRNAs are ~22-nt long ncRNAs which play a very important role in gene regulation by binding to mRNA. The role of a number of miRs is still unrevealed and a major challenge is to assign novel roles to already existing miRNAs.