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| DR. THOTA JAGADESHWAR REDDY |
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Senior Scientist (CSIR-CDRI)/Assistant Professor (AcSIR)
(Since February 2011)
Sophisticated Analytical Instrument Facility Division
SEN-F3, CSIR-Central Drug Research Institute
B.S.10/1, Sector-10, Jankipuram Extension
Lucknow 226 031. India.
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| EDUCATION AND AWARDS |
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Post-Doctoral Research 1. Prof. Jean-Claude Tabet’s Laboratory, Department of Mass Spectrometry, Université Pierre et Marie Curie (UPMC), Paris, France-Dec. 2006- June 2008.
2. Dr. Eric Verdon’s Laboratory, Agence Francaise De Securites Sanitaire Des Aliments (AFSSA), Jevene, France-May 2009-Dec 2010.
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Doctor of Philosophy (Organic Mass Spectrometry) :Doctoral Research was carried out at Indian Institute of Chemical Technology (IICT), Hyderabad, India, Yr. 2001- 2006. Degree from Osmania University |
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Master of Science (Chemistry): Osmania University, Hyderabad, Andhra Pradesh, India, 1998-2000 |
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| RESEARCH AREAS |
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MATRIX development for MALDI-MS analysis. |
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Identification of metal complexe catalyzed reaction intermediates in the gas phase. |
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Identification of metabolites/drug degradation products and their quantitation using liquid chromatography coupled with mass spectrometry. |
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Proteins identification by using mass spectrometry |
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| SELECTED
PUBLICATIONS |
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“Protection against filarial infection by 45–49 kDa molecules of Brugia malayi via IFN- γ-mediated iNOS induction”. Shiv K. Verma, Sujith K. Joseph, Richa Verma, Vikas Kushwaha, Naveen Parmar,Pawan K. Yadav, Jagadeshwar Reddy Thota, Susanta Kar, P. Kalpana Murthy. Vaccine, 2015, 33, 527. |
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“Structural characterization of flavonoid C- and O-glycosides in an extract of Adhatoda vasica leaves by liquid chromatography with quadrupole time-of- flight mass spectrometry”. Awantika Singh, Sunil Kumar, Vikas Bajpai, T. Jagadeshwar Reddy, K. B. Rameshkumar and Brijesh Kumar. Rapid Commun. Mass Spectrom. 2015, 29,1. |
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“Screening of tricyclic quinazoline alkaloids in the alkaloidal fraction of Adhatoda beddomei and Adhatoda vasica leaves by high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry”. Awantika Singh, Sunil Kumar, T. Jagadeshwar Reddy, K. B. Rameshkumar and Brijesh Kumar. Rapid Commun. Mass Spectrom. 2015, 29, 485. |
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“Synthesis of 3 Sulfonylamino Quinolines from 1 (2-Aminophenyl) Propargyl Alcohols through a Ag(I)-Catalyzed Hydroamination, (2 +3) Cycloaddition, and an Unusual Strain-Driven Ring Expansion”. Yalla Kiran Kumar, Gadi Ranjith Kumar, Thota Jagadeshwar Reddy, Balasubramanian Sridhar, and Maddi Sridhar Reddy. Org. Lett., 2015, 17, 2226. |
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“Characterization of stress degradation products of mirabegron using UPLC-QTOF-MS/MS and in silico toxicity predictions of its degradation products”.
Pradipbhai D. Kalariya, Mahesh Sharma, Prabha Garg, Jagadeshwar Reddy Thota, Srinivas Ragampeta and M. V. N. Kumar Talluri. RSC Adv., 2015, 5, 31024.
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“3′-Amino-5′-carboxymethyl-3′,5′-dideoxy nucleosides for the synthesis of fully amide-linked RNA mimics”. Yashoda Krishna Sunkari, Chandan Pal, Thota Jagadeshwar Reddy, and Tushar Kanti Chakraborty. Tetrahedron, 2014, 70 (35), 5455. |
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“Development of a new screening method for the detection of antibiotic residues in muscle tissues using liquid chromatography and high resolution mass spectrometry with a LC-LTQ-Orbitrap instrument”. D. Hurtaud-Pessel, T. Jagadeshwar-Reddy and E. Verdon. Food Additives and Contaminants, 2011: 28 (10): 1340–1351. |
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“High-Resolution Mass Spectrometry (HR-MS) for screening drug residues”
E. Verdon, T. Jagadeshwar-Reddy, D. Hurtaud-Pessel. Euro Reference: Journal of Reference: Journal No. 5 (2011).
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“Gas Phase Study of Phenylacetylene and Norbornadiene on Palladium (II)-Phosphinous Acid Complex: Importance of the Order of Introduction of the Organic Partners”. Reddy Thota, Denis Lesage, Yves Gimbert, Laurent Giordano, StéphaneHumbel, Anne Milet, Gérard Buono and Jean-Claude Tabet. Organometallics, 2009, 28 (9), 2735–2743.
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“Gas chromatographic–mass spectrometric determination of alkylphosphonic acids from aqueous samples by ion-pair solid-phase extraction on activated charcoal and methylation”.U.V.R. VijayaSaradhi, S. Prabhakar, T. Jagadeshwar Reddy and M. Vairamani.J. Chromatogr. A. 2007:1157 (1-2):391-398.
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“Ion-pair solid-phase extraction and gas chromatography–mass spectrometric determination of acidic hydrolysis products of chemical warfare agents from aqueous samples”. U.V.R. VijayaSaradhi, S. Prabhakar, T. Jagadeshwar Reddy and M. Vairamani.J. Chromatogr. A. 2006:1129 (1):9-13. |
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“In-situ nucleophilic substitution reaction of N,N-dialkyl aminoethyl-2-chlorides: Monitored by GC/MS”. V.V.S.Lakshmi, T. Jagadeshwar Reddy, M.R.V.S. Murty, S. Prabhakar, and M. Vairamani.Rapid Commun.Mass Spectrom.2006: 20: 981-986. |
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“Generation of alkoxide anions from a series of aliphatic diols and alcohols and their ion-molecule reactions with carbon dioxide in the gas phase”. M. Ravi Kumar, S. Prabhakar, T. Jagadeshwar Reddy and M. Vairamani. Eur .J.MassSpectrom. 2006; 12: 19-24. |
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“Electrospray ionisation mass spectral studies on hydrolysed products of sulfur mustards”. V.V.S. Lakshmi, M.R.V.S. Murty, T. Jagadeshwar Reddy, M. Ravikumar, S. Prabhakar and M Vairamani. Rapid Commun.Mass Spectrom.2006; 20: 981-986. |
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“Mass Spectral Analysis of Chloropicrin under Negative Ion Chemical Ionization Conditions”. M. R. V. S. Murty, S. Prabhakar, V. V. S.Lakshmi, Saradhi, U. V. R. VijayaSaradhi,T. Jagadeshwar Reddy, M. Vairamani. Anal.Chem. 2005; 77(10); 3406-3410. |
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“Evaluation of methyl 3-(4-methoxy-1-naphthyl)-(E)-2-propenoate and methyl 5-(4-methoxy-1-naphthyl)-(2E,4E)-2,4-pentadienoate as new charge-transfer matrices for matrix-assisted laser desorption/ionization mass spectrometry”. M. Ravi Kumar, N. PrasadaRaju, T. Jagadeshwar Reddy, A. Narahari, MarutiJanaki Ram Reddy, M. Vairamani. Rapid Commun.Mass Spectrom.2005; 19: 3171-3174. |
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“Dissociation of gas-phase dimeric complexes of lactic acid and transition-metal ions formed under electrospray ionization conditions; the role of reduction of the metal ion”. M. Ravi Kumar, S. Prabhakar, M. Kiran Kumar, T. Jagadeshwar Reddy, M. Vairamani. Rapid Commun.Mass Spectrom.2005; 19:113-120. |
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“Negative ion electrospray ionization mass spectral study of dicarboxylic acids in the presence of halide ions”. M. Ravi Kumar, S. Prabhakar, M. Kiran Kumar, T. Jagadeshwar Reddy, M. Vairamani. Rapid Commun.Mass Spectrom.2004; 18: 1109-1115. |
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“Coordination chemistry of chromium-Salen complexes studied by electrospray ionization mass spectrometry”. M. Kiran Kumar, S. Prabhakar, M. Ravi Kumar, T. Jagadeshwar Reddy, S. Premsingh, S. Rajagopal, M. Vairamani. Rapid Commun.Mass Spectrom.2004; 18: 1103-1108. |
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“Conformational studies of 3,4-dideoxy furanoid sugar amino acid containing analogs of the receptor binding inhibitor of vasoactive intestinal peptide”.
Tushar K. Chakraborty, V. Ramakrishna Reddy, G. Sudhakar, S. Uday Kumar, T. Jagadeshwar Reddy, S. Kiran Kumar, Ajit C. Kunwar, ArchnaMathur, Rajan Sharma, Neena Gupta and Sudhanand Prasad. Tetrahedron.2004; 60: 8329-8339.
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“Synthesis of highly substituted tetrahydropyrans: preparation of the C20–C28 moiety of phorboxazoles”. Tushar K. Chakraborty, V. Ramakrishna Reddy and T. Jagadeshwar Reddy. Tetrahedron.2003; 59: 8613-8622. |
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“Mass spectral studies of a series of N,N-dialkyl aminoethyl-2-chlorides and trimethylsilyl ethers of N,N-dialkyl aminoethane-2-ols under electron impact conditions”. T. Jagadeshwar Reddy, S. Prabhakar, M. Ravi Kumar, U. V. R. VijayaSaradhi, M. Vairamani. J. Mass Spectrom. 2005; 41: 59-70. |
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“Trace level detection and identification of chemicals related to the chemical weapons convention from complex organic samples”. T. Jagadeshwar Reddy, U. V. R. VijayaSaradhi, S. Prabhakar and M. Vairamani. J. Chromatogr. A.2004; 1038: 225-230. |
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“Mass spectral study on O,O-dialkyl N,N-dialkylphosphoramidates under electron-impactconditions”. T. Jagadeshwar Reddy, S. Prabhakar, U. V. R. VijayaSaradhi, V. JayathirthaRao and M. Vairamani. J. Am. Soc. Mass Spectrom. 2004; 15: 547-557. |
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“Mass spectral studies of N,N-dialkylaminoethanols”.
T. Jagadeshwar Reddy, Shama P. Mirza, U. V. R. VijayaSaradhi, V. JayathirthaRao, M. Vairamani. Rapid Commun.Mass Spectrom.2003; 17: 746-752.
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CHAPTERS/BOOKS |
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“A Role of High Resolution Mass Spectrometry in the High Throughput Analysis and Identification of Veterinary Medicinal Product Residues and their Metabolites in Foods of Animal Origin”. A Handbook on "high throughput analysis for food safety" , year: 2014. E. Verdon D. Hurtaud-Pessel and T. Jagadeshwar-Reddy |
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