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| DR.
RITU TRIVEDI |
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Sr. Scientist
Division of Endocrinology
CSIR-Central Drug Research Institute
Lucknow 226031 |
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| Educational Qualifications |
MSc., PhD (SGPGI, Lucknow) |
| E-Mail |
[email protected], [email protected] |
| Phone |
+91 522 2772450, Ext.
4397 |
| Fax: |
+91 522 2771941 |
| Date of Birth |
24.05.1971 |
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| POST-DOCTORAL
RESEARCH EXPERIENCE |
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2000-2002
- National Institute of Health, USA |
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SCIENTIFIC SUMMARY:
Our research programme addresses the problem of osteoporosis.The major focus is to study relationship of declining sex steroid levels in aging women and men to bone loss. These studies are complimented by animal studies and basic bone biology tools examining bone cells at different stages of differentiation. Our studies represent the leading edge of osteoporosis research, especially in the area of female osteoporosis and basic bone cell biology. |
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RESESARCH INTERESTS |
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Potential new drug targets for osteoporosis |
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Lactational physiology that includes studies on the role of miRNAs responsible for bone mass reversal at the time of weaning |
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Development of novel delivery system for bone |
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Comparative proteomic approach to study the changes in the protein expression profiles of the potential anabolics in osteoblasts |
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| CURRENT
RESESARCH INTEREST |
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Bone growth mechanisms and regulation including nutritional intervention.Here we are interested in understanding the mechanism for normal bone growth and currently focussing on understanding the growth plate biology and regulation of bone lengthening. |
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Relationship between fat and bone mass in high fat diet(HFD) induced osteoporosis model. We hypothesize that HFD aggravates ovariectomy related complications. We test this by investigating lipid metabolism, adipose tissue remodelling, adipokines and inflammatory cytokines. |
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| FUNCTIONAL IMAGING OF BONE |
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| RESEARCH GROUP |
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1. Priyanka Kushwaha, Senior Research Fellow (SRF) |
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2. Dharmendra Choudhary, Senior Research Fellow (SRF) |
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3. Anirudha Karvande, Senior Research Fellow (SRF) |
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4. Sulekha Adhikary, Senior Research Fellow (SRF) |
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5. Naseer Ahmad, Senior Research Fellow (SRF) |
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6. Priyanka Kothari, Junior Research Fellow (JRF) |
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7. Ashish Kumar Tripathi, Junior Research Fellow (JRF) |
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| ALUMINI
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1. Dr. Avinash Kumar Rai (Post-Doctoral Fellow at Cleveland Clinic Foundation Cleveland, Ohio, USA) |
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2. Dr.Vikram Khedgikar (Post-Doctoral Research associate at University of Massachusetts Amherst USA) |
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3. Ms. Jyoti Gautam (Ph.D. Thesis Submitted) |
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| SELECTED
PUBLICATIONS |
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Pandey A, Misra P, Choudhary D, Yadav R, Goel R, Bhambhani S, Sanyal I Trivedi R.Kumar Trivedi P.(2015)AtMYB12 expression in tomato leads to large scale differential modulation in transcriptomeand flavonoid content in leaf and fruit tissues. Sci Rep 24;5:12412. doi: 10.1038/srep12412. (IF 5.578) |
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Sharma S, Verma A, Teja BV, Pandey G, Mittapelly N, Trivedi R.Mishra PR.(2015) An insight into functionalized calcium based inorganic nanomaterials in biomedicine: Trends and transitions. Colloids Surf B Biointerfaces.1;133:120-39. doi: 10.1016/j.colsurfb.2015.05.014. Epub 2015 May 16. Review. (IF 4.152) |
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Shukla P, Mathur V, Kumar A, Khedgikar V, Teja VB, Chaudhary D, Kushwaha P, Bora HK, Konwar R, Trivedi R, Mishra PR. (2014)Nanoemulsion based concomitant delivery of curcumin and etoposide: impact on cross talk between prostate cancer cells and osteoblast during metastasis.J Biomed Nanotechnol. 10(11):3381-91. (IF 5.338) |
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Gautam J, Kumar P, Kushwaha P, Khedgikar V, Choudhary D, Singh D, Maurya R, Trivedi R(2015)Neoflavonoiddalbergiphenol from heartwood of Dalbergiasissoo acts as bone savior in an estrogen withdrawal model for osteoporosis.Menopause. [Epub ahead of print] (IF 3.36) |
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Khan MF, Dev K, Lahiri S, Dixit M, Trivedi RSingh D, Maurya R.(2014) Osteogenic activity of natural diterpenoids isolated from Cupressussempervirens fruits in calvarial derived osteoblast cells via differentiation and mineralization.Phytomedicine. 15; 21(14):1794-800. doi: 10.1016/j.phymed.2014.09.004. Epub 2014 Nov 6(IF 3.126) |
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Khedgikar V, Ahmad N, Kushwaha P, Gautam J, Nagar GK, Singh D, Trivedi PK, Mishra PR, Sangwan NS, Trivedi R.(2015) Preventive effects of withaferin A isolated from the leaves of an Indian medicinal plant Withaniasomnifera (L.): comparisons with 17-β-estradiol and alendronate. Nutrition.31(1):205-13. doi: 10.1016/j.nut.2014.05.010. Epub 2014 Jun 10.(IF 2.926) |
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Kushwaha P, Khedgikar V, Gautam J, Dixit P, Chillara R, Verma A, Thakur R, Mishra DP, Singh D, Maurya R, Chattopadhyay N, Mishra PR, Trivedi R.(2014)A novel therapeutic approach with Caviunin-based isoflavonoid that en routes bone marrow cells to bone formation via BMP2/Wnt-β-catenin signaling. Cell Death Dis.18;5:e1422. doi: 10.1038/cddis.2014.350. (IF 5.014) |
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Kumar P, Kushwaha P, Khedgikar V, Gautam J, Choudhary D, Singh D, Trivedi R, Maurya R. (2014) Neoflavonoids as potential osteogenic agents from Dalbergiasissoo heartwood. Bioorg Med Chem Lett.15;24(12):2664-8. doi: 10.1016/j.bmcl.2014.04.056. Epub 2014 Apr 24. (IF 2.793) |
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Tyagi AM, Mansoori MN, Srivastava K, Khan MP, Kureel J, Dixit M, Shukla P, Trivedi RChattopadhyay N, Singh D.(2014) Enhanced immunoprotective effects by anti-IL-17 antibody translates to improved skeletal parameters under estrogen deficiency compared with anti-RANKL and anti-TNF-α antibodies. J Bone Miner Res..;29(9):1981-92. doi: 10.1002/jbmr.2228. (IF 6.832) |
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Gautam J, Choudhary D, Khedgikar V, KushwahaP, Singh RS, Singh D, Tiwari S, Trivedi R.(2014) Micro-architectural changes in cancellous bone differ in female and male C57BL/6 mice with high-fat diet-induced low bone mineral density. Br J Nutr. 28;111(10):1811-21. doi: 10.1017/S0007114514000051. Epub 2014. (IF 3.302) |
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Sashidhara KV, Modukuri RK, Choudhary D, BhaskaraRao K, Kumar M, Khedgikar V,Trivedi R.(2013) Synthesis and evaluation of new coumarin-pyridine hybrids with promising anti-osteoporotic activities. Eur J Med Chem..; 70:802-10. doi: 10.1016/j.ejmech.2013.10.060. Epub 2013. (IF 3.447) |
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Pandey A, Misra P, Khan MP, Swarnkar G, Tewari MC, Bhambhani S, Trivedi R.Chattopadhyay N, Trivedi PK.(2014) Co-expression of Arabidopsis transcription factor, AtMYB12, and soybean isoflavone synthase, GmIFS1, genes in tobacco leads to enhanced biosynthesis of isoflavones and flavonols resulting in osteoprotectiveactivit. Plant Biotechnol J. Jan;12(1):69-80. doi: 10.1111/pbi.12118. Epub 2013 Sep 14.(IF 5.752) |
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Srivastava K, Khan K, Tyagi AM, Khan MP, Yadav DK, Trivedi R.Maurya R, Singh D, Chattopadhyay N.(2013) Greater Skeletal Gains in Ovary Intact Rats at Maturity Are Achieved by Supplementing a Standardized Extract of Buteamonosperma Stem Bark that Confers Better Bone Conserving Effect following Ovariectomy and Concurrent Treatment Withdrawal. Evid Based Complement Alternat Med. 2013; 2013:519387. doi: 10.1155/2013/519387. Epub 2013 Apr 27. (IF 2.175) |
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Khedgikar V, KushwahaP, Gautam J, VermaA, Changkija B, KumarA, Sharma S, Nagar GK, SinghD, TrivediPK, SangwanN S, Mishra PR, Trivedi R.(2013)Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts bone anabolic effect. Cell Death and Dis. (In press) (I F 6.044) |
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Girish K Gupta, Avinash Kumar, Vikram Khedgikar, Priyanka Kushwaha, Jyoti Gautam, Geet K Nagar, Varsha Gupta, Ashwini Verma, Anil Kumar Dwivedi, Amit Misra, Ritu Trivedi and Prabhat Ranjan Mishra. (2013) Enhancement of osteogenic efficacy of kaempferol through engineered layer-by-layer matrix: A study in ovariectomized rats. Nanomedicine 8(5) 757-771(2013). (IF 5.33) |
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Sashidhara KV, Kumar M, Khedgikar V, Kushwaha P, Modukuri RK, Kumar A, Gautam J, Singh D, Sridhar B, Trivedi R (2013) Discovery of coumarin-dihydropyridine hybrids as bone anabolic agents. J Med Chem. 56:109-22. (IF 5.6) |
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Srivastava K, Tyagi AM, Khan K, Dixit M, Lahiri S, Kumar A, Changkija B, Khan MP, Nagar G K, Yadav DK, Maurya R, Singh SP, Jain GK, Wahajuddin,TrivediR, Chattopadhyay N, Singh D (2013)Isoformononetin, a methoxydaidzein present in medicinal plants, reverses bone loss in osteopenic rats and exerts bone anabolic action by preventing osteoblast apoptosis. Phytomedicine.20:470-480 (IF 3.2) |
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Dixit P, Chillara R, Khedgikar V, Gautam J, Kushwaha P, Kumar A, Singh D, Trivedi R,Maurya R (2012) Constituents of DalbergiasissooRoxb. leaves with osteogenic activity. Bioorg Med Chem Lett. 22:890-7. (IF 2.4) |
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Tyagi AM, Srivastava K, SinghAK, Kumar A, Changkija B, Pandey R, Lahiri S, Nagar GK, Yadav DK, Maurya R, Trivedi R, Singh D (2012)Formononetin reverses established osteopenia in adult ovariectomized rats. Menopause19:856-63 (IF 3.16) |
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Khedgikar V, Gautam J, Kushwaha P, Kumar A, Nagar GK, Dixit P, Chillara R, Voruganti S, Singh SP, Uddin W, Jain GK, Singh D, Maurya R, Chattopadhyay N, Trivedi R (2012) A standardized phytopreparation from an Indian medicinal plant (Dalbergiasissoo) has antiresorptive and bone-forming effects on a postmenopausal osteoporosis model of rat. Menopause 19:1336-46. (IF 3.16) |
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Kumar A, Gupta GK, Khedgikar V, Gautam J, Kushwaha P, Changkija B, Nagar GK, Gupta V, Verma A, Dwivedi AK, Chattopadhyay N, Mishra PR, Trivedi R (2012) In vivo efficacy studies of layer-by-layer nano-matrix bearing kaempferol for the conditions of osteoporosis: a study in ovariectomized rat model. Eur J Pharm Biopharm. 82:508-17 (IF 4.26) |
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Gautam J, Kushwaha P, Swarnkar G, Khedgikar V, Nagar GK, Singh D, Singh V, Jain M, Barthwal M, Trivedi R (2012) EGb 761 promotes osteoblastogenesis, lowers bone marrow adipogenesis and atherosclerotic plaque formation.Phytomedicine19:1134-42.(IF 3.2) |
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Goel A, Kumar A, Hemberger Y, Raghuvanshi A, Jeet R, Tiwari G, Knauer M, Kureel J, Singh AK, Gautam A, Trivedi R, Singh D, Bringmann G (2012)Synthesis, optical resolution, absolute configuration, and osteogenic activity of cis-pterocarpans.Org Biomol Chem. 28:9583-92 |
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Tyagi AM, Srivastava K, Mansoori MN, Trivedi R,Chattopadhyay N, Singh D (2012) Estrogen deficiency induces the differentiation of IL-17 secreting Th17 cells: a new candidate in the pathogenesis of osteoporosis. PLoS One 7(9):e44552 (IF 3.7) |
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Kumar A, Tripathi VD, Kumar P, Gupta LP, Akanksh,Trivedi R, Bid H, Nayak VK,Siddiqui JA,Chakravarti B, Saxena R, DwivediA, Siddiquee MI, Siddiqui U, Konwar R, Chattopadhyay N (2011) Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents. Bioorganic & Medicinal Chemistry16: 8482–8491(IF 2.4) |
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Trivedi R, Gupta V, Dwivedi A, Mishra P, Kumar A, Khedgikar V, Gautam J, Kushwaha P, Changgekij B, Nagar G, Gupta G, Verma A. A novel formulation with Kaempferol: Comparison of its osteogenic effects with (2011) Osteoporosis International, Volume: 22 Supplement: 1 Pages: 41-41 |
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Trivedi R,Goswami R, Chattopadhyay N (2010)Investigational anabolic therapies for osteoporosis.Expert OpinInvestig Drugs19:995-1005. |
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Chhavi, Saxena M, Singh S, Negi MP, Srivastava AK, Trivedi R, Singh U, Pant MC, Bhatt ML (2010)Expression profiling of G2/M phase regulatory proteins in normal, premalignant and malignant uterine cervix and their correlation with survival of patients. J Cancer Res Ther. 6:167-71 |
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Trivedi R, Mithal A, Chattopadhyay N (2010)Anabolics in osteoporosis: the emerging therapeutic tool. Curr. Mol Med. 10:14-28 (IF 4.1) |
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Trivedi R, Mithal A, Chattopadhyay N (2009) Pharmacological manipulation of calcium sensing receptor: Prospect as anabolic therapy for postmenopausal osteoporosis. Drugs of Future 34: 803-809 |
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Pandey R, Gautam AK, Bhargavan B, Trivedi R, Swarnkar G, Nagar GK, Yadav DK, Kumar M, Rawat P, Manickavasagam L, Kumar A, Maurya R, Goel A, Jain GK, Chattopadhyay N, Singh D (2010) Total extract and standardized fraction from the stem bark of Buteamonosperma have osteoprotective action: evidence for the nonestrogenicosteogenic effect of the standardized fraction. Menopause 17:602-10 (IF 3.16) |
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Trivedi R, Kumar A, Gupta V, Kumar S, Nagar GK, Romero JR, Dwivedi AK, Chattopadhyay N (2009) Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: Possible roles of quercetin and kaempferol. Mol Cell Endocrinol. 302:86-91(IF 4.0) |
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Kumar A, Singh AK, Gautam AK, Chandra D, Singh D, Changkija B,Singh MP,Trivedi R(2010)Identification of Kaempferol-Regulated Proteins in Rat Calvarial Osteoblasts during Mineralization by Proteomics. Proteomics10:1730-9 (IF 4.1) |
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Singh US, Shankar R, Kumar A, Trivedi R, Chattopadhyay N, Shakya N, Palne S, Gupta S, Hajela K (2009) Synthesis and Biological Evaluation of Indolyl Bisphosphonates as Anti-bone Resorptive and Antileishmanial Agents. Trivedi R, Mithal A, Chattopadhyay N (2008)Recent updates on the Calcium-Sensing Receptor as a Drug Target. Curr Med Chem. 15:178-86 (IF 4.0) |
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Trivedi R, Kumar S, Kumar A, Siddiqui JA, Swarnkar G, Gupta V, Kendurker A, Dwivedi AK, Romero JR, Chattopadhyay N (2008)Kaempferol has osteogenic effect in ovariectomized adult Sprague- Dawley rats. Mol Cell Endocrinol. 289:85-93 (IF 4.0) |
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| NEWS AND VIEWS |
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| PATENTS |
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Trivedi Ritu,P R Mishra, Neelam S Sangwan, PrabodhTrivedi, Divya Singh, Rajendra S Sangwan, PriyankaKushwaha, VikramKhedgikar, SulekhaAdhikari, DharmendraChoudhary, JyotiSwarup, Avinash Kumar, AnirudhaKarvande, AshwniVerma&Shweta; Sharma (2013) Proteasomal inhibitors useful for osteogenic activity and pharmaceutical composition thereof (2013). |
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Maurya Rakesh, Dixit Preety, Trivedi Ritu, Khedgikar Vikram, GautamJyoti, Kumar Avinash, Singh Divya, SheelendraPratap. Phytoprepration from an Indian Medicinal Plant for anti-osteoporotic action by non-estrogenic mode. India and Abroad, DSTM/PAT/7/2011 |
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Atul Goel,Amit Kumar,Sumit Chaurasia,Divya Singh,Abnish K Gautam, Rashmi Pandey,Ritu Trivedi, Man Mohan Singh,Naibedya Chattopadhyay, Lakshmi Manckavasagam, Girish Kumar Jain, Anil Kumar Dwivedi. Substituted benzfurochromenes and related compounds having osteogenic and anti osteoclastogenic properties.Indian Patent 0095/NF/2008. |
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PR Mishra, Ritu Trivedi, GK Gupta, A Kumar, V Gupta, SK Rath, K Srivastava, N Chattopadhyay Controlled Release Micro-Capsule for osteogenic action EP Patent 2, 400,957 (2012). |
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PR Mishra, Ritu Trivedi, GK Gupta, A Kumar, V Gupta, SK Rath, K Srivastava, N Chattopadhyay Controlled Release Micro-Capsule for osteogenic action US Patent 13/203,603 (2010). |
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PR Mishra, Ritu Trivedi, GK Gupta, A Kumar, V Gupta, SK Rath, K Srivastava, N Chattopadhyay Controlled Release Micro-Capsule for osteogenic action Australia Patent 2010217238 (2010) |
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PR Mishra, Ritu Trivedi, GK Gupta, A Kumar, V Gupta, SK Rath, K Srivastava, N Chattopadhyay Controlled Release Micro-Capsule for osteogenic action Canada Patent 2753993 (2010) |
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| ARTICLES IN BOOK |
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Godbole MM, Gupta SK, Trivedi R. Skeletal Growth factors, cytokines and Prostaglandins In: Teotia SPS, Teotia M, editors. Nutritional and Metabolic bone and stone disease: An Asian Perspective, 1sted. New Delhi: CBS Publishers; 2008. p. 109-118. |
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Gupta SK, Trivedi RGodbole MM.Matrix Proteins of Bone. In: Teotia SPS, Teotia M, editors. Nutritional and Metabolic bone and stone disease: An Asian Perspective, 1sted. New Delhi: CBS Publishers; 2008. p. 21-25. |
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Gupta SK, Trivedi R,Godbole MM. Matrix minerals of bone In: Teotia SPS, Teotia M, editors. Nutritional and Metabolic bone and stone disease: An Asian Perspective, 1sted. New Delhi: CBS Publishers; 2008. P.26-29 |
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| AWARDS TO STUDENTS |
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Dr Avinash Kumar Rai
Dr MM Dhar Memorial Distinguished Career Achievement Award in Biological Sciences 2014 at CSIR-CDRI Lucknow |
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Priyanka Kushwaha
Young Investigator Award in ASBMR 2014 Houston,Texas,USA |
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Dr. Vikram Khedgikar
Young Investigator Award 2014 by International osteoporosis foundation (IOF) and International society for clinical densitometry (ISCD), 2014, Orlando, Florida |
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Dharmendra Choudhary
Awarded Best Oral Presentation Award at ISBMR (2013) for“Micro-architectural changes in cancellous bone differ in female and male C57BL/6 mice with high-fat diet-induced osteoporosis model.” |
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Priyanka Kushwaha
Awarded Best Oral Presentation Award for “CAFG a novel orally active molecule from natural source is potent than genestein in promoting bone formation (2012) |
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Vikram Khedgikar
Awarded Best Paper Award for Krt-14 regulates matrix mineralization during differentiation in osteoblast cells (2010). |
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| LICENSE |
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Dalbergia ssissoo for bone health a Technology Transferred to Pharmanza Pvt.Ltd on 10th April 2015 |
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