R S Bhatta
 
...

Sr. Scientist
Pharmacokinetics & Metabolism Division,
CSIR-Central Drug Research Institute
Lucknow - 226031
 
Educational Qualifications M. Pharm. (Pharmaceutics),  PhD (Pharm.)
Telephone 91-522-2772450, Ext. 4853
E-Mail [email protected] [email protected]
Date of Birth 26.09.1978
 

POSITION/EMPLOYMENT

 
•
 Scientist, CSIR-Central Drug Research Institute, Lucknow, India (Since Feb 2006)
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 Research fellow, CSIR-JNU, New Delhi, India (Dec 2002 – Feb 2006)
•
 Scientist (R&D), Aristo Pharmaceutical Ltd, Mandideep, India (Feb 2001 – Dec 2002)
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 Asst. Professor, SV College of Pharmacy, Hyderabad, India (Jun 2001 – Feb 2001)
 

AREA OF RESEARCH
 
•
 Bioanalytical and Analytical Method Development :
Development of bioanalytical and analytical method using HPLC and LC-MS/MS platform for estimation of NCE’s, drugs, metabolites, peptides etc in different biological matrices and formulations  as by regulatory guidelines such as US-FDA, ICH etc.
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 Clinical and Preclinical Pharmacokinetic Studies
Regulatory pharmacokinetic and toxicokinetic studies of NCE’s.  Estimation pharmacokinetic parameters,  bioavailability, dose-proportionality, gender variation, inter-species comparison, tissue distribution characteristics, excretion studies  etc.
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 In-vitro Metabolism, Metabolite Identification and Drug-Drug Interaction
In-vitro-In-vivo Extrapolation (IVIVE) for prediction of human clearance.  Elucidation of metabolism pathway of NCE’s, metabolite identification. Drug-drug, herb-drug and food-drug interaction studies.
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 Biopharmaceutics
Permeability/Absorption characterization Studies across Caco-2, MDCK cell line, inverted gut sac method and in situ rat model. Protein binding and simulated gastro-intestinal stability for NCE’s/drugs. In-vitro-In-vivo correlation (IVIVC)
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Drug Delivery

Designing formulation for NCE’s, ocular drug delivery.
 

RESEARCH ACTIVITIES
 
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Novel antihyperlipidemic combination therapy  of 80-574 and other lipid lowering drugs:The combination of 80-574 and atorvastatin exhibits synergistic lipid lowering activity. Statins inhibits cholesterol synthesis and 80-574 up-regulate cholesterol catabolism.  Thus combination of 80-574 and statins exhibits synergistic lipid lowering activity in preclinical evaluation.

Development of webbased tool for dereplication of natural product by using mass spectrometry-www.tmsdatabase.org: The web based mass spectra database and dereplication tool consists of algorithm for prediction of mass fragmentation, literature search spectral matching analysis for dereplication of natural product. 

Development of corneal targeted formulation for fungal keratitis treatment: The conventional ocular suspension preparations of antifungal drug natamycin and amphotericin B are limited with low ocular bioavailability and frequent dosing. The developed novel formulation significantly improved ocular bioavailability and reduce dose and dosing frequency.
 

HUMAN RESOURCE DEVELOPMENT
 
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Current Ph.D students:  Mr. Rajbir Singh (CSIR-SRF), Mr. Yashpal Singh Chhonker (ICMR-SRF), Mr. Hardik Chandasana (ICMR-SRF), Ms. Manisha Bhateria (CSIR-SRF), Mr. Rachumallu Ramakrishna (CSIR-SRF).

Training to post-graduate students: 28
 

AWARDS/FELLOWSHIPS/GRANTS
 
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  • Recipient of DBT Twinning Programme grant 2013
  • Recipient of DST travel grant 2013
  • Recipient of EMPOWER (Encouraging and Motivating Pursuit of World Class Exploratory Research) research grant by Council of Scientific and Industrial Research (CSIR) New Delhi. (2010)
  • CSIR Technology Award 2008 (Team Member)
  • Junior and Senior Research Fellowship from Council of Scientific and Industrial Research, New Delhi.
  • Junior Research Fellowship from University Grant Commission, New Delhi.
 
 

RECENT PUBLICATIONS/PATENTS
 
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S.N. Suryawanshi, S. Kumar, A. Tiwari, R. Shivahare, Y.S. Chhonker, S. Pandey, N. Shakya, R.S. Bhatta, S. Gupta, Synthesis and biological evaluation of a novel series of aryl S,N-ketene acetals as antileishmanial agents, Bioorganic & medicinal chemistry letters, 23 (2013) 3979-3982.
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R. Singh, J. Panduri, Y.S. Chhonker, H. Chandasana, P. Shrivastava, D. Kumar, R.S. Bhatta, Dose Dependent Evaluation of Intestinal P-GP Activity After One Week Oral Administration of Bacopa Monniera, Value in Health, 15 (2012) A297-A297.
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D. Kumar, A.K. Khanna, R. Pratap, J.K. Sexana, R.S. Bhatta, Dose escalation pharmacokinetics and lipid lowering activity of a novel farnesoid X receptor modulator: 16-Dehydropregnenolone, Indian J. Pharmacol., 44 (2012) 57-62.
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R.S. Bhatta, D. Kumar, Y.S. Chhonker, D. Kumar, S.P. Singh, K.V. Sashidhara, G.K. Jain, Simultaneous estimation of 16alpha-hydroxycleroda-3,13(14) Z-dien-15,16-olide from Polyalthia longifolia and its metabolite in hamster plasma: application to pharmacokinetic study, Biomed Chromatogr, 26 (2012) 559-565.
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R.S. Bhatta, H. Chandasana, Y.S. Chhonker, C. Rathi, D. Kumar, K. Mitra, P.K. Shukla, Mucoadhesive nanoparticles for prolonged ocular delivery of natamycin: In vitro and pharmacokinetics studies, International journal of pharmaceutics, 432 (2012) 105-112.
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K.V. Sashidhara, S.P. Singh, A. Srivastava, A. Puri, Y.S. Chhonker, R.S. Bhatta, P. Shah, M.I. Siddiqi, Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent, European journal of medicinal chemistry, 46 (2011) 5206-5211.
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P. Prakash, A. Misra, W.R. Surin, M. Jain, R.S. Bhatta, R. Pal, K. Raj, M.K. Barthwal, M. Dikshit, Anti-platelet effects of Curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis, Thromb Res, 127 (2011) 111-118.
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B. Chakravarti, J.A. Siddiqui, S. Dwivedi, K. Dhar, S. Deshpande, K. Samanta, R.S. Bhatta, G. Panda, Y.S. Prabhakar, R. Konwar, S. Sanyal, N. Chattopdhyay, Specific Targeting of Insulin-like Growth Factor 1 Receptor Signaling in Human Estrogen Dependent Breast Cancer Cell by a Novel Tyrosine-based Benzoxazepine Derivative, Molecular and Cellular Endocrinology, 338 (2011) 68-78.
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R.S. Bhatta, C. Rathi, H. Chandasana, D. Kumar, Y. Chhonker, G. Jain, LC–MS Method for Determination of Amphotericin B in Rabbit Tears and Its Application to Ocular Pharmacokinetic Study, Chromatographia, 73 (2011) 487-493.
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R.S. Bhatta, D. Kumar, Y.S. Chhonker, G.K. Jain, Simultaneous estimation of E- and Z-isomers of guggulsterone in rabbit plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study, Biomed Chromatogr, (2011).
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R.S. Bhatta, Y. Chhonker, D. Kumar, A. Saxena, G. Jain, Bioanalytical method development and validation for simultaneous estimation of (R)- and (S)-isomers of S002-333: a potent novel anti-thrombotic agent using LC–MS/MS Medicinal Chemistry Research, (2011) 1-8.
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R.S. Bhatta, H. Chandasana, C. Rathi, D. Kumar, Y.S. Chhonker, G.K. Jain, Bioanalytical method development and validation of natamycin in rabbit tears and its application to ocular pharmacokinetic studies, J Pharm Biomed Anal, 54 (2011) 1096-1100.
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R.S. Bhatta, D. Kumar, Y.S. Chhonker, A.K. Saxena, G.K. Jain, Bioanalytical method development and validation of novel antithrombotic agent S002-333 by LC-MS/MS and its application to pharmacokinetic studies, Biomed Chromatogr, 24 (2010) 1234-1239.
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M.Lakshmi., S.B.Jadhav, R.S.Bhatta, T.Narendar, V.Laxmi, G.K.Jain, A selective and sensitive LC-MS/MS method for determination of gedunin in rabbit plasma, Medicinal Chemistry Research, 15 (2007) 179.
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M.Lakshmi., S.B.Jadhav, R.S.Bhatta, T.Narendar, V.Laxmi, G.K.Jain, A selective and sensitive LC-MS/MS method for simultaneous determination of xylocensin-I and xylocensin-J using protein precipitation method in rabbit plasma, Medicinal Chemistry Research, 15 (2007) 177.

Patents
•
 Patent application number: 523/DEL/2006. 
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 Patent application number: 1052MUM2009.
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 Patent application number : PCT/IB2010/000898. 
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 Patent application number: 208DEL2011.
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 Patent application number: PCT/IN2011/000628.