DR. SANJEEV KANOJIYA
 
....

Sr. Scientist
Mass spectrometry Laboratory, SAIF,
CSIR-Central Drug Research Institute, Sector 10, Janakipuram Extension, Sitapur Road, Lucknow 226 031 [INDIA]
 
E-Mail  [email protected]
Educational Qualifications M.Sc., Ph.D. (Chemistry ), D.E.C.H.E.
Date of Birth

August 27, 1977
 
CURRENT AREAS OF INTEREST
•
 Development of analytical methods for chemical analysis (metabolic profiling of bioactive natural product extracts) using high performance liquid chromatography mass spectrometry.
•
 Identification, estimation and structural characterization of bio-active principal compounds in herbs/extracts.
•
 Development of isolation methods for biologically active compounds.
•
 Development of tandem mass spectrum (MS/MS) database www.tmsdatabase.org of previously isolated bioactive compounds (secondary metabolite) from natural products.
•
 Mass Spectrometry-Based Research:
    • LC-MS/MS based dereplication approach for discovering New Chemical Entities (NCEs) from unexplored natural products.
    • Discovery of known bioactive compounds from previously unknown sources.
    • Distribution of known compounds in different biological source (Plants/herbs).
    • Identification of known/new derivatives of bioactive compounds in different biological source (Plants/herbs).
    • Stereochemical differentiation by metal cationization tandem mass spectrometric studies. Effect of transition metal chlorides complexation on collision induced dissociation of small molecules.
 
KEY SKILLSMass Spectrometry, LCMS, LC-MS/MS, Natural product and Medicinal chemistry.
 
WEB LINKhttp://www.researchgate.net/profile/Sanjeev_Kanojiya/
 
EDUCATION
•
 B. Sc (Biology) from Govt. Science collage Jabalpur (M.P.) in 1997.
•
 Diploma in Electronics and Computer Hardware Engineering, from SECT, Bhopal (M.P.) 1998
•
 M.Sc (App. Chemistry) from Govt. Engg. Collage Jabalpur (M.P.) in 2000.
•
 Ph.D. ( Chemistry) from Lucknow University Lucknow (U.P.) 2011
 
PROFESSIONAL BACKGROUND
•
 Project Assistant (2001-02) CSIR-Central Scientific Instrumentation Organization-Chandigarh
•
 Senior Research Fellow, (2002-03) Central Institute of Freshwater Aquaculture (ICAR) –Ludhiana
•
 J. Scientist (2004- 2008), CSIR-Central Drug Research Institute Lucknow
•
 Scientist (2008-2012) CSIR-Central Drug Research Institute Lucknow
•
 Sr. Scientist (2012-2008) CSIR-Central Drug Research Institute Lucknow
 

PROFESSIONAL TRAINING: Application of Mass spectrometry / GC-MS & DART-MS. From: JEOL, DATUM Ltd. 1156, Nakagami-Cho Akishima, TOKYO 196-022, JAPAN

 
MEMBERSHIP: Indian Society of Mass Spectrometry, Bombay (INDIA)
 

RESEARCH GROUP
•
 MsTrapti Joshi (SRF)
 
SELECTED PUBLICATIONS
•

Singh, S., et al., Callus culture and in vitro biosynthesis of echitamine from Alstonia scholaris (L.) R. Br. Plant Cell, Tissue and Organ Culture (PCTOC), 2015. 120(1): p. 367-372.
•

Khandelwal, K., et al., Improved oral bioavailability of novel antithrombotic S002-333 via chitosan coated liposomes: a pharmacokinetic assessment. RSC Advances, 2015. 5(49): p. 39168-39176.
•

Joshi Trapti, et al., Quantitative Analysis of Bioactive Carbazole Alkaloids in Murraya koenigii. Natural Product Communications, 2015. 10(2): p. 293-295.
•

Dighe, S.U., et al., Synthesis of 3,4,5-Trisubstituted Isoxazoles from Morita–Baylis–Hillman Acetates by an NaNO2/I2-Mediated Domino Reaction. Angewandte Chemie International Edition, 2015. 54(37): p. 10926-10930.
•

Rakesh Kumar Asthana, et al., Evaluation of Antidyslipidemic Effect of Mangiferin and Amarogentin from Swertia Chirayita Extract in HFD Induced Charles Foster Rat Model and In Vitro Antioxidant Activity and their Docking Studies. International Journal of Pharmaceutical Sciences and Research, 2014. 5(9): p. 3734-3740.
•

Chhonker, Y.S., et al., Pharmacokinetic and metabolism studies of rohitukine in rats by high performance liquid-chromatography with tandem mass spectrometry. Fitoterapia, 2014. 97: p. 34-42.

•

Tripathi, P., et al., Callus culture and in vitro biosynthesis of cardiac glycosides from Calotropis gigantea (L.) Ait. In Vitro Cellular & Developmental Biology - Plant, 2013. 49(4): p. 455-460.
•

Maurya, R., et al., Synthesis and Antimalarial Activity of 3,3-Spiroanellated 5,6-Disubstituted 1,2,4-Trioxanes. ACS Medicinal Chemistry Letters, 2013. 4(2): p. 165-169.
•

Kanojiya, S. and K.P. Madhusudanan, Rapid identification of calotropagenin glycosides using high-performance liquid chromatography electrospray ionisation tandem mass spectrometry. Phytochem Anal, 2012. 23(2): p. 117-25.
•
 Biswas, S., et al., Copper-Catalyzed Cascade Reaction for Practical and Efficient Synthesis of Alkyl 2H-Isoindole-1-carboxylates. Advanced Synthesis & Catalysis, 2011. 353(18): p. 3330-3334.
•
 Adaramoye, O.A., et al., Antiproliferative Action of Xylopia aethiopica Fruit Extract on Human Cervical Cancer Cells. Phytotherapy Research, 2011. 25(10): p. 1558-1563.
•
 Sashidhara, K.V., et al., Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula. Bioorganic & Medicinal Chemistry Letters, 2010. 20(19): p. 5767-5771
•
 Maurya, R., et al., Constituents of Caesalpinia Bonduc. Medicinal Chemistry Research, 2010. 19: p. S109-S109.
•
 Yadav, P.P., et al., Cassane Diterpenes from Caesalpinia bonduc. Phytochemistry, 2009. 70(2): p. 256-261.
7.        
•
 Nayak, M., S. Kanojiya, and S. Batra, The First Synthesis of Allyl Isonitriles from Baylis-Hillman Adducts, and Their Application in the Synthesis of Substituted Imidazo[1,2-a]pyridines and Tetraazadibenzoazulenes. Synthesis-Stuttgart, 2009(3): p. 431-437     
•
 Deeba, F., et al., Proteome Analysis of Detached Fronds from a Resurrection Plant Selaginella Bryopteris - Response to Dehydration and Rehydration. Journal of Proteomics & Bioinformatics, 2009. 2(2): p. 108-116
•
 Kanojiya, S. and P.P. Yadav, Fragmentation patterns of newly isolated cassane butenolide diterpenes and differentiation of stereoisomer by tandem mass spectrometry. Journal of Mass Spectrometry, 2008. 43(10): p. 1413-1420
•
 Yadav, P.P., et al., New cassane butenolide hemiketal diterpenes from the marine creeper Caesalpinia bonduc and their antiproliferative activity. Tetrahedron Letters, 2007. 48(40): p. 7194-7198.
•
 Singh, V., S. Kanojiya, and S. Batra, Studies on the reduction of the nitro group in 3-aryl-2-methylene-4-nitro-alkanoates afforded by the Baylis-Hillman adducts: synthesis of 4-aryl-3-methylene-2-pyrrolidinones and 3-(1-alkoxycarbonyl-vinyl)-1H-indole-2-carboxylates. Tetrahedron, 2006. 62(43): p. 10100-10110
•
 Pathak, R., et al., Alternate, easy and practical synthesis of allylamines from acetyl derivatives of Baylis-Hillman adducts using methanolic ammonia. Synthesis-Stuttgart, 2006(5): p. 813-816.
•
 Madhusudanan, K.P., et al., Tandem mass spectra of divalent metal ion adducts of glycosyl sulfides, sulfoxides and sulfones; distinction among stereoisomers. Journal of Mass Spectrometry, 2006. 41(10): p. 1322-1333.
•
 Pathak, R., et al., A cyclative cleavage approach to solid-phase synthesis of annulated pyrimidinones using Baylis-Hillman derivatives. Tetrahedron Letters, 2005. 46(32): p. 5289-5292.
•
 Madhusudanan, K.P., S. Kanojiya, and B. Kumar, Effect of stereochemistry on the electrospray ionization tandem mass spectra of transition metal chloride complexes of monosaccharides. Journal of Mass Spectrometry, 2005. 40(8): p. 1044-1054.