SARIKA, M.N.A.Sc
 
.. Sr. Scientist
Toxicology Division
Central Drug Research Institute
Lucknow-226 031
 
Educational Qualifications M.Sc., Ph D
Phone +91-522-2772450 Ext. 4577
Fax +91-522-2771941
E-Mail [email protected]
Date of Birth 01.01.1979
 
 
Positions and Employment
2002-2004
 Junior Research Fellow, CDRI and Lucknow University.
2005-2006
 Senior Research Fellow, CDRI and Lucknow University.
2006-2009
 Scientist B, CDRI, Lucknow
2009-2013
 Scientist / Assistant professor (AcSIR), CDRI, Lucknow
2013-2014    (on deputation)
 IUSSTF Fellow
2013-Present
Sr. Scientist / Assistant Professor (AcSIR), CDRI, Lucknow
   
Professional Memberships
1.
 Indian council of medical research - Fellowship for Senior Research Fellow
2.
 Graduate Aptitude Test in Engineering (GATE) Fellowship
3.
 Recognized as PhD guide in Jawaharlal Nehru University, New Delhi
4.
 Reviewer for the different Biology journals published by Elsevier, Springer and other publishers.
5.
 Course co-ordinator of Neurobiology Course in AcSIR.
6.
 Member of Indian Academy of Neurosciences.
7.
 External examiner for post graduation students in number of Universities.
8.
Member of Society of Toxicology, India
9.
 Member of Editorial board of World J. Of Pharmaceutical Sciences, USA.
10.
 In editorial board of journal Therapeutic targets in Neurological disorders, USA.
11.
 In editorial board of International Journal of Neurology Research, Italy.
12.
 Life-member of National Academy of Sciences, India
Honors
1.
 Receive the Raman Research Fellowship, CSIR, India
2.
 Awardee of Indo - US Fellowship, India
3.
 Team member of CSIR technology award, India.
   
CURRENT AREAS OF INTEREST
•
 Molecular and biochemical mechanisms of neurodegeneration
•
 Role of non-neuronal cells in neurodegeneration
•
 Regulatory Toxicology
   
Research Group Members
•
 Sonam Gupta - SRF
•
 Joyshree Biswas - SRF
•
 Dinesh Kumar Verma - SRF
•
 Parul Gupta - Project Fellow
•
 Abhishek Singh - Project Fellow
•
 Ms. Anupma - Technical Staff
•
 Sh. Shreekrishna - Lab staff
Past Lab Members
•
 Poonam Goswami
 
Area of Research Specialization : Neurodegenerative diseases mechanisms, Cell death mechanisms, Neurotoxicology and Regulatory Toxicology
 
Research Experience : More than 12 years in field of Neurodegenerative disease mechanisms and 8 years experience in field of Regulatory Toxicology
 
Research Grant
•
 Department of Biotechnology, India supported project entitled “Antioxidant capacity of astrocytes and neurotrophic factors in aging: Age and gender based analysis (National Initiative on Glial Cell Research in Health and Disease)", conducting as PI.
•
 Co investigator in Indo-Japanese Joint Project on "Circadian Modifications in Cancer Progression" (Status - Finished).
•
 Department of Science and Technology sponsored proposal entitled “Do glial activation, deprived level of nerve growth factor and extrinsic apoptotic pathway crosstalk during neuronal death?” under fast track scheme as PI.
•
 Co-principle investigator of project entitled “Characterization and expression of Nmethyl D-aspartate (NMDA) receptors subunits in astrocytes and microglia in dementia pathology” spopsored by Indian Council Medical Research, India.
 
Key Research Achievements and interest- :

Diagnosis and therapeutics of neurodegenerative mechanisms is still mysterious field in comparison to other peripheral disease. The exploration of disease mechanisms in patients of neurological disease is immposible due to late diagnosis of disease and scarcity of peripheral biomarkers. In CNS also there are no biomarkers and physicians can only depend on the imaging like techniques. In this view we are exploring the disease mechanisms by using experimental disease models. Our main focus if on Parkinson’s disease and Alzheimer’s disease. We have reported that PD pathology involves the specific role of inducible nitric oxide synthase (NOS) in initiation of dopaminergic neuronal death (Singh et al, 2005). The involvement of mitochondria dependant energy metabolism and intrinsic apoptotic has also been reported during in neuronal death at early phase of disease pathology (Singh et al, 2010). Our both research articles were nationally and internationally cited by number of authors by more than 50 times. We have also reviewed the diversity and expressional regulation of NOS and apoptotic pathways involved in apoptotic death of dopaminergic neurons which are impressively cited by more than 100 authors to date (Kavya et al, 2007; Singh and Dikshit, 2007). Reports have showed the pesticides-exposure induced symptoms of parkinsonism therefore, further I have investigated the pesticide rotenone induced neurodegenerative mechanisms. We have reported the rotenone and lipopolysacchride induced differential reponses of rat brain regions. Study showed that the mid brain and striata regions of the rat brain are more vulnerable towards rotenone induced oxidative stress in comparison to other rat brain regions like frontal cortex and hippocampus (Swarnkar et al, 2010). Further we have studied the role of calcium and glia activation in rotenone induced neuronal death. The findings showed that rotenone caused brain region specific activation of astrocytes and microglia and death of neurons (Swarnkar et al, 2013). We have also reported that astrocytes activation is the key step in rotenone induced cytotoxicity and DNA damage (Swarnkar et al, 2012). Involvement of calcium homeostasis has also been reported in roteneon induced neuronal death (Swarnkar et al, 2012). The involvement of endoplasmic reticulam stress in rotenone induced neurotoxicity has also been reported by us (Goswami et al, 2014). We have also reviewed the neuropathological responses of astrocytes and microglia under neurodegenerative conditions (Singh et al, 2011). We have also reported the involvement of nitric oxide and mitochondria in neurotoxins 6-hydroxydopamine and lipopolysacchride induced DNA damage in astrocytes (Gupta et al, 2015). We are also working in Alzheimer’s and dementia pathology and reported that in vitro mouse neuronal N2A cells could be utilized as fast screening test system for new antialzheimer’s therapeutic lead (abstract published in International conference in France, 2015 and MS accepted in Mol. Neurobiol., 2015 with minor revisions). Besides explorations of neurodegenerative mechanisms we have also investigated the neuroprotective mechanisms offered by clinically used drug piracetam. Piracetam is clinically being used at very high doses with no significant adverse effects. It has showed the significant protection in ischemia, stroke and epilepsy. Research has showed its effect on membrane fluidity and enhancement in mitochondrial activity but still its mechanism of action is not known. We have shown that DNA damage is key step in piracetam induced neuroprotective effects (Goswami et al, 2011). Study in leukocytes and peritoneal macrophage also showed that oxidative DNA damge is key event in piracetam induced cytoprotection (Singh et al, 2011). Further study in astrocytes showed that piracetam induced neuroprotective mechanism involves the caspase independent pathway through prevention in endonuclease G translocation (Gupta et al, 2014). I have also reviewed the promising role of melatonin and antioxidants as neuroprotectant (Joshi et al, 2015; Sarika Singh, 2015). In collaboration we have reported the improved oral delivery of CDRI’s patented antimalarial drug arteether with complete pharmacokinetic and toxicity profile (Dwevedi et al, 2014). Thymoquinone induced amelioration of iron induced clastogenecity and DNA damage has also been studied by us (Parveen et al, 2014). Polyphenols like (6)-Gingerol induced myeloid leukemia cell death involves reactive oxygen species and activation of miR-27b expression has also been reported (Rastogi et al, 2014). Presently we are investigating the neuron-astrocytes crosstalk in Alzheimer’s-dementia pathology and age dependant antioxidant capacity of astrocytes and neurotrophic factors.
 
Special contributions to teaching, promotion and management of science :

Presently I am supervising the three senior research fellows (fellowships are from CSIR, UGC and ICMR) for their fulfillment of doctoral degree. All the three students are registered from Jawaharlal Nehru University, New Delhi for the award of their doctoral degree. I have also guided more than 35 dissertation trainees for their partial fulfillment of postgraduate degree. One student has finished her doctoral work and published the research article in peer reviewed International Journal (Molecular Neurobiology) of impact factor 5.2. Two more MSs are in preparation from her research work.
SELECTED PUBLICATIONS
 
Research Articles
International
•
 1. Dinesh Kumar Verma, N. Joshi , K Sivarama Raju, M. Wahajuddin, R.K.Singh and Sarika Singh. Metabolic enhancer piracetam attenuate the rotenone induced oxidative stress: A study in different rat brain regions.,Acta Neurobiologiae Experimentalis, in press, 2015 (IF-1.5).
•
 2. Goswami P., Gupta S., Joshi Neeraj, Sharma S. and Singh S. (2015) Astrocyte activation and neurotoxicity: A study in different rat brain regions and in rat C6 astroglial cells. In press, Environmental Toxicology and Pharmacology (IF-2.08)
•
 3. Sarika Singh. Antioxidants as a preventive therapeutic option for age related neurodegenerative diseases. Ther. Targets in Neurol. Dis., 2015, 2: e592. doi: 10.14800/ttnd.592. (Invited Review).
•
 4. Faria Fatima, Preeti Bajpai, Neelam Pathak, Sarika Singh, Shivam Priya, Smita Verma. Antimicrobial and immunomodulatory efficacy of extracellularly synthesized silver and gold nanoparticles by a novel phosphate solubilizing fungus Bipolaris tetramera. BMC Microbiology 2015, 15:52. (IF-2.98)
•
 5. Dwivedi P, Khatik R, Chaturvedi P, Khandelwal K, Taneja I, Raju KS, Dwivedi H, Singh SK, Gupta PK, Shukla P, Tripathi P, Singh S, Tripathi R, Wahajuddin, Paliwal SK, Dwivedi AK, Mishra PR. Arteether nanoemulsion for enhanced efficacy against Plasmodium yoelii nigeriensis malaria: An approach by enhanced bioavailability. Colloids Surf B Biointerfaces. 2015 Feb 1;126:467-75. (IF-4.2)
•
 6. Biswas J, Goswami P, Gupta S, Joshi N, Nath C, Singh S. Streptozotocin Induced Neurotoxicity Involves Alzheimer's Related Pathological Markers: a Study on N2A Cells. Mol Neurobiol. 2015 Apr 1. (IF-5.2)
•
 7. Sonam Gupta, Poonam Goswami, Joyshree Biswas, N. Joshi, Sharad Sharma, C. Nath and Sarika Singh. 6-hydroxydopamine and lipopolysaccharides induced DNA damage in astrocytes: Involvement of nitric oxide and mitochondria. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Accepted, 2015, in press.(IF-2.4)
•
 8. Poonam Goswami, Sonam Gupta, Joyshree Biswas, Neeraj Joshi, Supriya Swarnkar, Chandishwar Nath and Sarika Singh. Endoplasmic reticulum stress plays a key role in rotenone induced apoptotic death of neurons. Mol Neurobiol. 2014, Nov. 10.1007/s12035-014-9001-5, in press. (IF-5.2)
•
 9. Pankaj Dwivedi, Renuka Khatik, Kiran Khandelwal, Richa Srivastava, Isha Taneja, Kanumuri Siva Rama Raju, Hemlata Dwivedi, Prashant Shukla, Pramod Gupta, Sarika Singh, Renu Tripathi, Sarvesh Kumar Paliwal, Wahajuddin, Anil Kumar Dwivedi and Prabhat Ranjan Mishra Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of arteether: pharmacokinetics, toxicity and antimalarial activity in mice. RSC Advances, 2014, in press (IF-3.7)
•
 10. Akhter F, Khan MS, Singh Sarika, Ahmed S. An immunohistochemical analysis to validate the rationale behind to enhanced immunogenicity of D-Ribosylated low density protein. PLoS One. 2014 Nov 13;9(11):e113144 (IF-3.5)
•
 11. Joshi N, Biswas J, Nath C, Singh S. Promising Role of Melatonin as Neuroprotectant in Neurodegenerative Pathology. Mol Neurobiol. 2014 Aug 27. (IF-5.2) (Citation-01).
•
 12. Gupta S, Verma DK, Biswas J, Rama Raju KS, Joshi N, Wahajuddin, Singh S. The metabolic enhancer piracetam attenuates mitochondrion-specific endonuclease G translocation and oxidative DNA fragmentation.Free Radic Biol Med. 2014 Aug;73:278-90. doi: 10.1016/j.freeradbiomed.2014.05.014. Epub 2014 May 29. (IF-5.2) (Citation-01)
•
 13. Rastogi N, Gara RK, Trivedi R, Singh A, Dixit P, Maurya R, Duggal S, Bhatt ML, Singh S, Mishra DP. (6)-Gingerol induced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression. Free Radic Biol Med. 2014 Mar;68:288-301. doi: 10.1016/j.freeradbiomed.2013.12.016. (IF-5.2) (Citation-03)
•
 14. Nuzhat Parveen, Ahmad Umar, Sonam Gupta, Sarika Singh, G.G.H.A. Shadab. Amelioration of Iron Induced Clastogenicity and DNA Damage in Wistar rats by Thymoquinone. Science of Advanced Materials, Volume 6, Number 5, May 2014, pp. 933-945(13). (IF-2.5) (Citation-01)
•
 15. S. Swarnkar, P. Goswami, P. K. Kamat, I. K. Patro, S. Singh and C. Nath. Rotenone-induced neurotoxicity in rat brain areas: A study on neuronal and neuronal supportive cells. Neuroscience, 2013, 230, 172–183. (IF-3.3) (citation-05)
•
 16. Pandey SK, Dwivedi H, Singh S, Siddiqui WA, Tripathi R. Antimalarial interaction of quinine and quinidine with clarithromycin. Parasitology. 2013 Mar;140(3):406-13. (IF-2.96) (citation-5)
•
 17. Swarnkar S, Singh S, Goswami P, Mathur R, Patro IK, Nath C. Astrocyte activation: a key step in rotenone induced cytotoxicity and DNA damage. Neurochem Res. 2012 37, 2178-89. (IF-2.2) (citation-12)
•
 18. Supriya Swarnkar, Poonam Goswami, Pradeep Kumar Kamat, Sonam Gupta, Ishan K. Patro, Sarika Singh, Chandishwar Nath. Rotenone-induced apoptosis and role of calcium: a study on Neuro-2a cells. Arch Toxicol, 2012, 86, 1387-97. (IF-5.2) (citations-18)
•
 19. Sarika Singh, Poonam Goswami, Supriya Swarnkar, Sheelendra P Singh, Wahajuddin, Chandishwar Nath, Sharad Sharma. A Study to evaluate the effect of nootropic drug - piracetam on DNA damage in leukocytes and macrophages. Mutation Research, 2011, 726, 66-74. (IF-2.7) (citation-03)
•
 20. Swarnkar Supriya, Singh Sarika, Sharma Sharad, Mathur Ramesh, Patro K Ishan, Nath Chandishwar Rotenone induced neurotoxicity in rat brain areas: A histopathological study. Neuroscience Letters 2011, 501, 123-7.(IF-2.1)(citations-14)
•
 21. Poonam Goswami, Supriya Swarnkar, Mohmed Sohail Harsoliya, Sarika Singh, Chandishwar Nath, Sharad Sharma. Attenuation of DNA damage: A key step in neuroprotective effect of piracetam against 6-hydroxydopamine induced neuronal death in SHSY5Y cells. J. Pharmacy Res., 2011, 4, 1716-1719. (IF-2.6) (citation-02)
•
 22. Sarika Singh, Supriya Swarnkar, Poonam Goswami, Chandishwar Nath. Astrocytes and microglia: responses to neurodegeneration. Int J of Neurosci., 2011, 121, 589-97. (IF-1.2) (citations-26)
•
 23. M. S. Harsoliya, M. J. Sabugar, Patel Vishnu M, Singh Sarika, Pathan Javed Khan. The New Multifunctional Plant Selected Cough Syrup: An Overview. Journal of Pharmacy Research 2011, 4, 411-412. (IF-2.6)
•
 24. Sarika Singh, Sachin Kumar and Madhu Dikshit. Involvement of mitochondrial apoptotic pathway and nitric oxide synthase in 6-hydroxydopamine and lipopolysacchride induced dopaminergic neuronal death. Redox Report, 2010, 15, 1-8. (IF-1.7)(citations-16)
•
 25. Supriya. Swarnkar, Sarika Singh, R. Mathur, I.K. Patro & C. Nath. A study to correlate rotenone induced biochemical changes and cerebral damage in brain areas with neuromuscular coordination in rats. Toxicology, 2010, 272, 17-22. (IF-3.6) (citations-19)
•
 26. Singh Sarika and Dikshit Madhu Apoptotic neuronal death in Parkinson’s disease: Involvement of nitric oxide. Brain Res. Rev., 2007, 54, 233-50 (IF-10.3, citations-78).
•
 27. Kavya Ramkumar, Saluja Rohit, Singh Sarika, Dikshit Madhu Nitric oxide synthase regulation and diversity: Implications in Parkinson’s disease. Nitric Oxide, 2006, 15, 280-94. (IF-3.5) (citations-70)
•
 28. Singh Sarika, 28. Singh Sarika, Das T., Ravindran A., Chaturvedi R. K., Shukla Y., Agarwal A.K. and Dikshit M., Involvement of nitric oxide in neurodegeneration: a study on the experimental models of Parkinson’s disease. Redox Report, 2005, 10, 103-109. (IF-1.7) (citation-51)
National
•
1. Sarika Singh, Sharad Sharma, C. Nath, Srikant Kumar Rath, R. K. Singh, Smrati Bhadauria, Poonam Singh, R.K. Shukla, Manoj Barthwal and M Dikshit. Essential Safety Pharmacology and safety evaluation of bioactive fraction of Xylocarpus moluccensis: an antidyslipidaemic agent. International journal of medical science and clinical Invention 2014, 1, 24-47.
•
 2. Renu Singh, Saumya Das, Dr. Sarika Singh and Dr. C. Nath. Rotenone: beyond pesticide its divergent role in causing Parkinson’s disease. International Journal of Health and Pharmaceutical Sciences, 21-34, 2, 2013
Abstracts
•
 1. Joyshree Biswas, Poonam Goswami, Sonam Gupta, Dinesh kumar Verma, Mohit Singh, C. Nath , N. Joshi and Sarika Singh. An in vitro model of alzheimer’s disease: an attempt to expedite the search for new drug entities. 12th International Conference AD/PD Nice, France, March 18-22, 2015. Neurodegener Dis 2015;15(suppl 1): 352-1969 - Page 659 .
•
 2. Sonam Gupta, Joyshree Biswas,Dinesh Kumar Verma, Poonam Goswami, Mohit Singh and Sarika Singh “6-hydroxydopamine and lipopolysaccharides induced DNA damage in astrocytes”. XXXII Annual Conference of Indian Academy of Neuroscience, 1-3 November, 2014, NIMHANS, Bengaluru, India. Pg no. 190.
•
 3. Joyshree Biswas, Poonam Goswami, Sonam Gupta, Dinesh kumar Verma, Mohit Singh and Sarika Singh “Streptozocin induced alterations and mitochondria mediated apoptotic death of astrocytes”. XXXII Annual Conference of Indian Academy of Neuroscience, 1-3 November, 2014, NIMHANS, Bengaluru, India. Pg no. 213.
•
 4. Dinesh kumar, Sonam Gupta, Joyshree Biswas, Mohit Singh, Dhirendra Kumar Singh and Sarika Singh “Minocycline attenuate the rotenone induced neurotoxicity”. XXXII Annual Conference of Indian Academy of Neuroscience, 1-3 November, 2014, NIMHANS, Bengaluru, India. Pg no. 112.
•
 5. Poonam Goswami, Sonam Gupta, Joyshree Biswas, Dinesh Kumar Verma and Sarika Singh. ER stress mediates the rotenone induced neurotoxicity: a study on Neuro 2A cells. Published in Annals of Neurosciences Volume 20,supplement October 2013 pg.36
•
 6. Sonam Gupta, Joyshree Biswas, Poonam Goswami, Dinesh Kumar Verma and Sarika Singh. Piracetam attenuate the lipopolysacchride induced oxidative DNA damage and death of astrocytes: A study in astrocyte C6 cells. Published in Annals of Neurosciences Volume 20, supplement October 2013 pg.67.
•
 7. Joyshree Biswas, Poonam Goswami, Sonam Gupta, Dinesh Kumar Verma and Sarika Singh Streptozotocin induced neurotoxicity: Involvement of Intrinsic apoptotic pathway and DNA damage. Published in Annals of Neurosciences Volume 20,supplement October 2013 pg.39.
•
 8. Dinesh Kumar Verma, Sonam Gupta, Joyshree Biswas, Poonam Goswami and Sarika Singh. Piracetam attenuate the rotenone induced oxidative stress: A study in different rat brain regions. Published in Annals of Neurosciences Volume 20,supplement October 2013 pg.41.
•
 9. Dhirendra Kumar Singh, Dinesh Kumar Verma and Sarika Singh Minocyclin attenuate the rotenone induced nitrosative stress and neuronal death: A study in different rat brain regions. Proceedings of International conference on neuroscience 9-11 Nov. 2013 held in Cuttack, Orissa.
•
 10. Dinesh Kumar Verma, Sonam Gupta and Sarika Singh. Piracetam attenuate the rotenone induced oxidative stress in different brain regions: A study in in vivo and ex vivo test system. Proceedings on National Seminar on Stress, Development and Adaptation: Biochemical Basis and Biotechnological Approaches, 2013.
•
 11. Sarika Singh, Joyshree Biswas, Sonam Gupta and Dinesh Kumar Verma. Neurodegeneration and neuroprotection: Role of glial cells. Proceedings on Emerging Trends in Neurosciences and XXIII Annual Meeting of Indian Academy of Neurosciences (2012).
•
 12. Supriya Swarnkar, Poonam Goswami, Pradeep K. Kamat, Ishan K. Patro, Sarika Singh & Chandishwar Nath. “Effect of melatonin on rotenone induced cytotoxicity: A study in astroglial and neuronal cells”. Proceedings of 1st Annual Conference of the Indian Academy of Biomedical Sciences (IABS) & International Symposium on Advances and Applications of Molecular Biology in Clinical Research– India, Lucknow, Feb. 21-22. 2012 p-37 (Oral).
•
 13. Poonam Goswami, Sarika Singh, Supriya Swarnkar, Gupta Sonam & Nath C. Involvement of Endoplasmic Reticulum stress and nitrosative stress in rotenone induced neurotoxicity: a study on in vivo and in vitro test systems. Proceedings on Emerging Trends in Neurosciences and XXIII Annual Meeting of Indian Academy of Neurosciences (2011).
•
 14. Supriya Swarnkar, Poonam Goswami, Pradeep K. Kamat, Ishan K. Patro, Sarika Singh, & Chandishwar Nath. “Rotenone induced DNA damage and apoptosis in astroglial and neuronal cells: A study on protective effect of melatonin”. Proceedings of International symposium on `Recent Trends in Neurosciences & XXIXth Annual meeting of Indian Academy of Neuroscience (2011) p-116.
•
 15. Supriya Swarnkar, Sarika Singh, Poonam Goswami and C. Nath. Evaluation of melatonin against DNA damage and nuclear condensation along with GFAP expression in rotenone treated rat C6 astrocytoma cells. Proceedings on Emerging Trends in Neurosciences and XXIII Annual Meeting of Indian Academy of Neurosciences (2010).
•
 16. Poonam Goswami, Supriya Swarnkar, Sarika Singh and C. Nath. Involvement of oxidative stress and nitric oxide in death of dopaminergic neuron terminals of nigrostriatal pathway: A study on parkinsonian model. Proceedings on Emerging Trends in Neurosciences and XXIII Annual Meeting of Indian Academy of Neurosciences (2010) pp, 85.
•
 17. Sarika Singh and Poonam Goswami. Comparative evaluation of effect of neurotoxins on C6 glial cells. Proceedings on International conference on Free radicals and Antioxidants in Health, Disease and Radiation & Annual Conference of Society for Free Radical Research- India (SFRR-India), (2010) pp, 208.
•
 18. Poonam Goswami and Sarika Singh Piraceatm protect against 6-hydroxydopamine induced DNA damage in human neuroblastoma SHSY5Y cells. Proceedings on International conference on Free radicals and Antioxidants in Health, Disease and Radiation & Annual Conference of Society for Free Radical Research- India (SFRR-India), (2010) pp, 192.
•
 19. Supriya Swarnkar, Sarika Singh and Poonam Goswami and C. Nath. Role of melatonin in Rotenone Induced oxidative stress and Glial Cell Death. Proceedings on International conference on Free radicals and Antioxidants in Health, Disease and Radiation & Annual Conference of Society for Free Radical Research- India (SFRR-India), (2010) pp, 207.
•
 20. Sarika Singh, Poonam Goswami and C. Nath Nootropic drug piraceatm protects brain and peripheral phagocytic cells against LPS induced DNA damage. Proceedings on Emerging Trends in Neurosciences and XXIII Annual Meeting of Indian Academy of Neurosciences (2009) pp, 106-107.
•
 21. Supriya Swarnkar, Sarika Singh and C. Nath. A study to correlate rotenone induced biochemical and histological changes in brainareas with motor coordination in rats. Proceedings on Emerging Trends in Neurosciences and XXIII Annual Meeting of Indian Academy of Neurosciences (2009) pp, 95.
•
 22. Singh Sarika, Mechanism of rotenone induced cell death in glial cells. Proceedings of International Conference on “The Interface of Chemistry-Biology in Biomedical Research” held at Birla Institute of Technology and Science, Pilani, Rajasthan (2008) pp
•
 23. Sarika Singh and Madhu Dikshit, Role of nitric oxide in Parkinson’s Disease. Proceedings of 41st Annual Conference of the Indian Pharmacological Society (2008) pp.
•
 24. Singh Sarika and Dikshit M. Mitochondrial impairment and caspase activation in experimental models of Parkinson’s disease. Proceedings on International conference on Free radicals and Antioxidants in Health, Disease and Radiation & Annual Conference of Society for Free Radical Research- India (SFRR-India), (2006) pp, 122.
•
 25. Singh Sarika and Dikshit M. Role of nitric oxide in the experimental models of Parkinson’s disease. Proceedings on International conference on Antioxidants & Free radicals in Health-Nutrition and Radio-protectors and IV Annual Conference of Society for Free Radical Research - India (SFRR-India), (2005) pp, 124.
•
 26. Singh Sarika and Dikshit M. Modulation of caspase activity by nitric oxide in experimental models of Parkinson’s disease. Proceedings on Emerging Trends in Neurosciences and XXIII Annual Meeting of Indian Academy of Neurosciences (2005) pp, 62-63.
•
 27. Singh Sarika, Jayakar S. S., Chaturvedi R., Shukla Y., Agarwal A. K. and Dikshit M., Role of nitric oxide in lipopolysacchride induced neurodegeneration. Ind. J. Pharmacol. 2004, 36.
•
 28. Singh Sarika, Jayakar S. S., Das. T., Ravindran A., Chaturvedi R. K., Shukla Y., Agarwal A.K. and Dikshit M., Role of nitric oxide in the experimental models of Neurodegeneration. Med. Chem. Res. 2003, 12, 364-365.