Biodata of Dr. Koneni V. Sashidhara :::: Central Drug Research Institute

Dr. Koneni V. Sashidhara

...

Senior Scientist (CSIR-CDRI)/Assistant Professor (AcSIR)
Lab No. CSS-SF-207, Medicinal and Process Chemistry Division
Central Drug Research Institute
B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road
Lucknow- 226031, U.P., India.

Educational Qualifications	M.Sc (Organic Chemistry, The M. S. University of Baroda, Vadodara, Gujarat.)
	Ph.D. (Chemistry, CSIR-Central Institute of Medicinal & Aromatic Plants, Lucknow, Uttar Pradesh)
Date of Birth	10th January, 1973
E- mail	[email protected],[email protected]
Phone No.	+91-0522-2772450, Ext. 4683
Mobile No.	09919317940
Fax No.	+91-522-2771942
Research Experience (Area)	Medicinal chemistry including natural Products.

POSTDOCTORAL RESEARCH ( ABROAD)

• University of California, Santa Cruz, USA. (Mentor- Prof. Phillip Crews)

• Scripps Institution of Oceanography, University of California, San Diego, USA. (Mentor- Prof. William Fenical)

CURRENT AREAS OF INTEREST

Organic, Synthetic, Medicinal Chemistry and Chemical Biology.

• The research in my group involves the rational design and synthesis of biologically important natural and synthetic compounds of biomedical significance and development of new organic synthetic methodologies.

Recognized Ph.D guide in Chemistry in the following Universities

•	Jawaharlal Nehru University (JNU), New Delhi
•	Acharya Nagarjuna University, Guntur, A.P.
•	Lucknow University, Lucknow, UP.


	Supervisory details: Supervised four students for their PhD and ten students for their Post Graduation degrees.
	Former Ph.D. Students
1.	Dr. J. Naga Rosaiah. (Research Scientist in GVK Pharma)
2.	Dr. Abdhesh Kumar (Post Doc., Prof. William Fenical, SIO, UCSD, California, USA)
3.	Dr. Manoj Kumar (Research Scientist, CALIBR, San Diego, California, USA)

4	Dr. Suriya P. Singh (TA, CSIR-CDRI)


	Current Ph.D.Students

1.	P. Gopala Reddy (SRF)
2.	A. Srinivasa Rao (SRF)
3.	M. Ram Kumar (SRF)
4.	K. Bhaskara Rao (SRF)
5.	Ranga Prasad Dodda (SRF)
6.	L. Ravithej Singh (SRF)
	Former Postgraduate students.
1.	Shakti Deep Pachauri (2005)
2.	Pratima Katiyar (2005)
3.	Ruchi Khandelwal (2006)
4.	Suman Rani (2006)
5.	Anchal Misra (2007)
6.	Bikash Kumar (2010)
7.	Bhanu Shankar Singh (2011)
8.	Shikha Agarwal (2011)
9.	Samar K. Mandal (2012)
10.	Priyanka Swami (2013)

AWARDS/ FELLOWSHIP RECEIVED

1.	Recipient of Indo-US Research Fellowship Award: 2012 by Indo-US Science and Technology Forum.
2.	Bioorganic and Medicinal Chemistry Letters Top 25 Cited Author Award in 2010 to 2011 by ELSEVIER.
3.	Certificate of Appreciation given by American Chemical Society for valuable contribution and dedicated service in the peer review of manuscripts submitted to ACS journals.
4.	Recipient of two CDRI Incentive Awards for excellent research work resulting in the research publication in high impact factor journals. (British Journal of Pharmacology, 2010 and Advanced Synthesis and Catalysis, 2012).
5.	Recipient of EMPOWER (Encouraging and Motivating Pursuit of World Class Exploratory Research) research grant by Council of Scientific and Industrial Research (CSIR) New Delhi. (2010)
6.	Recipient of BOYSCAST fellowship of DST, Govt. of India.
7.	FAST TRACK project for young scientist approved by DST Govt. of India.
8.	CRSI (Chemical Research Society of India), Bangalore, Life member.

SERVICE AND PROFESSIONAL ASSOCIATIONS

1. Regular proposal reviewer for various funding councils including-

Ø Indo-French Centre for the Promotion of Advanced Research (IFCPAR) Centre Franco-Indien pour la Promotion de la Recherche Avancee).

Ø Fundação para a Ciência e a Tecnologia (FCT),Portugal.

Ø Department of Science and Technology (DST), New Delhi.

Ø Council of Scientific and Industrial Research (CSIR), New Delhi.

2. Regular reviewer for VCH-Wiley, RSC, ACS, and ELSEVIER journals.

3. Ph.D thesis external examiner for thesis submitted to IIT-Guwahati ,IICT-Hyderabad,Banasthali University-Rajasthan, Nagarjuna University- Guntur(AP), etc.

PUBLICATIONS & PATENTS-

Total number of peer reviewed publications- 70 (seventy )

Total number of patents (12 US Patents and 8 National Patents) - 20 (twenty)

Citations to all publications: -Sum of times cited - 650, h-index- 16

LIST OF RECENT SELECTED PUBLICATIONS (LAST 5 YEARS, i.e., 2009-2013 only) :

•	Sashidhara KV, Kumar M, Khedgikar V, Kushwaha P, Modukuri RK, Kumar A, Gautam J, Singh D, Sridhar B, Trivedi R. Discovery of Coumarin-Dihydropyridine Hybrids as Bone Anabolic Agent. Journal of Medicinal Chemistry. 2013, 56(1), 109-122.
•	Sashidhara KV* , Modukuri RK, Sonkar R, Rao KB, Bhatia G. Hybrid benzofuran-bisindole derivatives: New prototypes with promising anti- hyperlipidemic activities. European Journal of Medicinal Chemistry. 2013, 68, 38-46.
•	Sashidhara KV, Palnati, GR, Dodda, RP, Avula, SR, Swami, P. One Pot Regioselective Synthesis of Imidazole and 2,3-Dihydroquinazolinone Derivatives- An easy access to “Nature Like Molecules. SYNLETT*. 2013, 24, 1795-1800
•	Sashidhara KV* , Palnati GR, Sonkar R, Avula SR, Awasthi C, Bhatia G. Coumarin chalcone fibrates: A new structural class of lipid lowering agents. European Journal of Medicinal Chemistry. 2013, 64, 422-431.
•	Sashidhara KV, Avula SR, Sharma K, Palnati GR, Bathula SR. Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent. European Journal of Medicinal Chemistry.* 2013, 60, 120-127.
•	Sashidhara KV, Singh SP, Singh SV, Srivastava RK, Srivastava K, Saxena JK, Puri SK. Isolation and identification of β-hematin inhibitors from Flacourtia indica as promising antiplasmodial agents. European Journal of Medicinal Chemistry.* 2013, 60, 497-502.
•	Sashidhara KV, Palnati, GR, Dodda, RP, Avula, SR, Swami, P. Studies on Novel Synthetic Methodologies, Part XII: An Efficient One-Pot Access to 6,6a-Dihydroisoindolo[2,1-a]quinazoline-5,11-diones and 5-Phenylisoindolo[2,1-a]quinazolin-11(6aH)-ones. SYNLETT*. 2013, 24(1), 105-113.
•	Sashidhara KV, Singh SP, Srivastava A, Puri A. Main extracts and hypolipidemic effects of the Bauhinia racemosa Lam. leaf extract in HFD-fed hamsters. Natural Product Research.* 2013, 27(12),1127-1131.
•	Sashidhara KV, Kumar A, Agarwal S, Kumar M, Kumar B, Sridhar B. A Simple and Efficient Access to New Functionalized 4-phenacylideneflavenes. Advanced Synthesis & Catalysis. 2012*, 354(6), 1129-1140.
•	Sashidhara KV, Kumar, A, Dodda, RP, Kumar, B. A new iodine catalyzed regioselective synthesis of xanthene synthons. Tetrahedron Letters.* 2012, 53(26), 3281-3283.
•	Sashidhara KV, Kumar, M, Kumar, A. A novel route to synthesis of flavones from salicylaldehyde and acetophenone derivatives. Tetrahedron Letters.* 2012, 53(18), 2355-2359.
•	Sashidhara KV, Kumar M, Modukuri RK, Srivastava RK, Soni A, Srivastava K, Singh SV, Saxena JK, Gauniyal HM, Puri SK. Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores. Bioorganic & Medicinal Chemistry*. 2012, 20(9), 2971-2981.
•	Sashidhara KV*, Kumar A, Dodda RP, Krishna NN, Agarwal P, Srivastava K, Puri SK. Coumarin-trioxane hybrids: Synthesis and evaluation as a new class of antimalarial scaffolds. Bioorganic & Medicinal Chemistry Letters. 2012, 22(12), 3926-3930.
•	Sashidhara KV* , Palnati GR, Dodda RP, Sonkar R, Khanna AK, Bhatia G. Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents. European Journal of Medicinal Chemistry. 2012, 57, 302-310.
•	Sashidhara KV, Palnati, GR, Avula, SR, Kumar, A. Efficient and general synthesis of 3-aryl coumarins using cyanuric chloride. Synlett.* 2012, 23(4), 611-621.
•	Sashidhara KV, Singh SP, Misra S, Gupta J, Misra-Bhattacharya S. Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi. European Journal of Medicinal Chemistry.* 2012, 50, 230-235.
•	Sashidhara KV,Kumar A, Rao KB, Kushwaha V, Saxena K, Murthy PK. In vitro and in vivo antifilarial activity evaluation of 3, 6-epoxy[1,5]dioxocines: A new class of antifilarial agents. Bioorganic & Medicinal Chemistry Letters*. 2012, 22(4), 1527-1532.
•	Sashidhara KV, Kumar M, Sonkar R, Singh BS, Khanna AK, Bhatia G. Indole-Based Fibrates as Potential Hypolipidemic and Antiobesity Agents. Journal of Medicinal Chemistry*. 2012, 55(6), 2769-2779.
•	Sashidhara KV, Avula, SR, Ravithej SL, Palnati, GR. A facile and efficient Bi(III) catalyzed synthesis of 1,1-dihydroperoxides and 1,2,4,5-tetraoxanes. Tetrahedron* Letters. 2012, 53(36), 4880-4884.
•	Sashidhara KV, Palnati GR, Avula SR, Singh S, Jain M, Dikshit M. Synthesis and evaluation of anti-thrombotic activity of benzocoumarin amide derivatives. Bioorganic & Medicinal Chemistry Letters*. 2012, 22(9), 3115-3121.
•	Sashidhara KV, Avula SR, Palnati GR, Singh SV, Srivastava K, Puri SK, Saxena JK. Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum. Bioorganic & Medicinal Chemistry Letters*. 2012, 22(17), 5455-5459.
•	Sashidhara KV*, Kumar M, Modukuri RK, Srivastava A, Puri A. Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents. Bioorganic & Medicinal Chemistry Letters. 2011, 21(22), 6709-6713.
•	Sashidhara KV, Singh SP, Srivastava A, Puri A, Chhonker YS, Bhatta RS, Shah P, Siddiqi MI. Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent. European Journal of Medicinal Chemistry*. 2011, 46(10), 5206-5211.
•	Sashidhara KV, Singh SP, Srivastava A, Puri A. Identification of the antioxidant principles of Polyalthia longifolia var. pendula using TEAC assay. Natural Product Research*. 2011, 25(9), 918-926.
•	Sashidhara KV, Kumar M, Modukuri RK, Sonkar R, Bhatia G, Khanna AK, Rai S, Shukla R. Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids. Bioorganic & Medicinal Chemistry Letters*. 2011, 21(15), 4480-4484.
•	Sashidhara KV, Kumar A, Bhaskar K. Synthesis of 3, 6-epoxy [1, 5] dioxocines from 2-hydroxyaromatic benzaldehydes. Tetrahedron Letters.* 2011, 52(43), 5659-5663.
•	Sashidhara KV*, Kumar A, Kumar M, Singh S, Jain M, Dikshit M. Synthesis of novel 3-carboxamide-benzocoumarin derivatives as orally active antithrombotic agents. Bioorganic & Medicinal Chemistry Letters. 2011, 21(23), 7034-7040.
•	Sashidhara KV, Kumar A, Chatterjee M, Rao KB, Singh S, Verma AK, Palit G. Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents Bioorganic & Medicinal Chemistry Letters.* 2011, 21(7), 1937-1941.
•	Sashidhara KV, Kumar A, Kumar M, Sarkar J, Sinha S. Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters*. 2010, 20(24), 7205-7211.
•	Sashidhara KV, Rosaiah JN, Kumar M, Gara RK, Nayak LV, Srivastava K, Bid HK, Konwar R. Neo-tanshinlactone inspired synthesis, in vitro evaluation of novel substituted benzocoumarin derivatives as potent anti-breast cancer agents. Bioorganic & Medicinal Chemistry Letters*. 2010, 20(22), 7127-7131.
•	Sashidhara KV, Kumar A, Kumar M, Srivastava A, Puri A. Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives. Bioorganic & Medicinal Chemistry Letters*. 2010, 20(22), 6504-6507.
•	Sashidhara KV, Singh SP, Kant R, Maulik PR, Sarkar J, Kanojiya S, Ravi Kumar K. Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula. Bioorganic & Medicinal Chemistry Letters*. 2010, 20(19), 5767-5771.
•	Sashidhara KV, Kumar A, Kumar M, Sonkar R, Bhatia G, Khanna AK. Novel coumarin derivatives as potential antidyslipidemic agents. Bioorganic & Medicinal Chemistry Letters.* 2010, 20(14), 4248-4251.
•	Sashidhara KV, Rosaiah JN, Kumar A, Bhatia G, Khanna AK. Synthesis of novel benzocoumarin derivatives as lipid lowering agents. Bioorganic & Medicinal Chemistry Letters*. 2010, 20(10), 3065-3069.
•	Sashidhara KV, Rosaiah JN, Kumar A. Unusual reaction of 6-formyl-2-ox-2H-benzo[h]chromene-3-carboxylic acid ethyl ester with aliphatic amines. Synthetic Communications*. 2010, 1, 21-28.
•	Johnson TA, Morgan MV, Aratow NA, Estee SA, Sashidhara KV, Loveridge ST, Segraves NL, Crews P*. Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge-derived natural products. Journal of Natural Products. 2010, 73(3), 359-364.
•	Misra P, Sashidhara KV, Singh SP, Kumar A, Gupta R, Chaudhaery SS, Gupta SS, Majumder HK, Saxena AK, Dube A. 16α-hydroxycleroda-3, 13 (14) z-dien-15, 16-olide from polyalthia longifolia: A safe and orally active antileishmanial agent. British Journal of Pharmacology. 2010, 159(5), 1143-1150.
•	Sashidhara KV*, Singh SP, Sarkar J, Sinha S. Cytotoxic clerodane diterpenoids from the leaves of Polyalthia longifolia. Natural Product Research. 2010, 24, 1687-1694.
•	Sashidhara KV, White KN, Crews P*. A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products. Journal of Natural Products. 2009, 72(3), 588-603.
•	Sashidhara KV, Singh SP, Shukla PK. Antimicrobial evaluation of clerodane diterpenes from Polyalthia longifolia var. pendula. Natural Product Communications*. 2009, 4(3), 327-330.
•	Sashidhara KV, Kumar A, Bhatia G, Khan MM, Khanna AK, Saxena JK. Antidyslipidemic and antioxidative activities of 8-hydroxyquinoline derived novel keto-enamine Schiffs bases. European Journal of Medicinal Chemistry*. 2009, 44(4), 1813-1818.
•	Sashidhara KV, Rosaiah JN, Tyagi E, Shukla R, Raghubir R, Rajendran SM. Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents. European Journal of Medicinal Chemistry*. 2009, 44(1), 432-436.
•	Johnson TA, Amagata T, Sashidhara KV, Oliver AG, Tenney K, Matainaho T, Ang KK, McKerrow JH, Crews P. The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis. Organic Letters*. 2009, 11(9), 1975-1978.