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Dr. Shakil Ahmed |
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Senior Scientist
Molecular and Structural Biology Division
Central Drug Research Institute
Lucknow- 226031
U.P., India
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| Educational Qualifications |
M.Sc., Ph.D (Institute of Microbial Technology, Chandigarh (Panjab University) |
| Telephone |
+91 522 2772450 ext- 4453 |
| Fax |
+91 522 2771941 |
| E- Mail |
[email protected] |
| Date of Birth |
03.05.1970 |
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| POST-DOCTORAL
RESEARCH |
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Aug. 2003-July
2006: Research Teaching Specialist, Department of Pharmacology,
UMDNJ RWJMS, Piscataway, NJ. USA |
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Nov. 2000-July 2003: Post
doctoral Fellow, Department of Pharmacology, UMDNJ RWJMS,
Piscataway, NJ, USA |
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| AREA OF
RESEARCH SPECIALIZATION |
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Cellular and Molecular Biology, Genetics and Cell Cycle Checkpoints |
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| CURRENT
AREA OF RESEARCH |
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All unicellular or multicellular organisms have to maintain faithful chromosome segregation from mother cells to daughter cell. Any defect in this process can leads to aneuploidy which is the most common characteristic of human solid tumors. Cell cycle checkpoints are required to maintain the integrity of the genome. Our laboratory is applying genetic, molecular and biochemical approaches in fission yeast S. pombe to understand the mechanism of mitotic checkpoint. |
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| RESEARCH GROUP MEMBERS |
| Current Lab Members |
Rajeev Ranjan, Senior Research Fellow, CSIR
Amit Kumar Sonkar, Senior Research Fellow, UGC
Gaurav Kumar Singh, Senior Research Fellow, UGC
Saman Khan, Junior Research Fellow, ICMR
Nafees Ahamad, Junior Research Fellow, ICMR
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| Past Members |
Sudhanshu Yadav, Post doctoral fellow at Tel Aviv University, Israel
Sumit Kumar Verma
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| SELECTED
PUBLICATIONS |
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Khan S. Sonkar A.K. and Ahmed S. (2013) Synthetic lethal genetic interaction network and their utility for anticancer therapy. In: Management of Microbial Resources in the environment. Malik A. Grohmann E. and Alves M (ed). Springer, Heildelberg, pp 413-428. |
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Yadav S. Verma S.K. and Ahmed S. (2011) DNA topoisomerase II mutant activates DNA damage checkpoint protein kinase Chk1 in fission yeast S. pombe. Genetics Research. 93 (4): 275-283 |
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Ranjan, R. Verma, S.K. and Ahmed, S. (2010) Flag tag module for PCR based gene targeting. Journal of Yeast and Fungal Research. 1: 165-169 |
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Ahmed S
and Singh J . RTPCR method for selective detection of
silent gene transcripts in silencing mutants in homothallic
strains of S. pombe.(2008) Biotechniques
44, 54-58 |
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Bisht K, Arora S, Ahmed
S, and Singh J. Role of heterochromatin in suppressing
subtelomeric recombination in Fission Yeast.(2008)
Yeast 25, 537-548 |
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Ahmed, S.
Dul, B. Qui, X. and Walworth, N. (2007)
Msc1 Acts through Histone H2A.Z to Promote chromosome
stability in Schizosacchromyces pombe. Genetics,
177: 1487-1497. |
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Ahmed, S.
Palermo, C. Wan, S. and Walworth, N. (2004)
A novel protein with similarities to Rb Binding Protein
2 compensate for the loss of Chk1 function and affects
histone modification in fission yeast. Mol. Cell
Biol. 24 (9): 3660-3669. |
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Ahmed, S.
Saini, S. Arora, S. and Sing, J. (2001)
Chromodomain Protein swi6-meadiated role of DNA polymerase
? in establishment of silencing in fission yeast.
J. Biol. Chem. 276 (51): 47814-47821. |
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Ahmed, S.
and Singh, J. (2001) An imprinting function
of DNA polymerase ? in establishment of mating type silencing
in Schizosacchromyces pombe. Current Science.
80 (10): 1337-1343. |
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Yadav S. and Ahmed
S. DNA topoisomerase II mutant activates DNA
damage checkpoint protein kinase Chk1 in fission yeast
S. pombe. Communicated. |
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