Molecular biology and pathogenesis of neurodegenerative disorders particularly exploring pharmacological means to restore motor function and protect vulnerable neurons in these disorders.

Post Doctoral Fellow: Weill Medical College of Cornell University, New York, USA (2006-2008)

Shukla S, Chaturvedi RK, Seth K, Roy NS, Agrawal AK. Enhanced survival and function of neural stem cells-derived dopaminergic neurons under influence of olfactory ensheathing cells in parkinsonian rats. J Neurochem. 2009 Apr; 109(2):436-51

Chaturvedi RK, Adhihetty P, Shukla S, Hennessy T, Calingasan N, Yang L, Starkov. A, Kiaei M, Cannella M, Sassone J, Ciammola A, Squitieri F, Beal MF. Impaired PGC-1alpha function in muscle in Huntington's disease. Hum Mol Genet. 2009 Aug 15; 18(16):3048-65

Chaturvedi RK, Shukla S, Seth K, Chauhan S, Sinha C, Shukla Y, Agrawal AK. Neuroprotective and neurorescue effect of black tea extract in 6-hydroxydopamine lesioned rat model of Parkinson’s disease. Neurobiol Dis. 2006; 22(2): 421-34.

Chaturvedi RK, Shukla S, Seth K, Agrawal AK. Nerve growth factor increases survival of dopaminergic graft, rescue nigral dopaminergic neurons and restores functional deficits in rat model of Parkinson’s disease. Neurosci Lett. 2006; 398(1-2): 44-9.

Sinha C, Seth K, Islam F, Chaturvedi RK, Shukla S, Mathur N, Srivastava N, Agrawal AK. Behavioral and neurochemical effects induced by pyrethroid-based mosquito repellent exposure in rat offsprings during prenatal and early postnatal period. Neurotoxicol Teratol. 2006; 28(4): 472-81.

S. Shukla, A.K. Agrawal, R.K. Chaturvedi, K. Seth, N. Srivastava, C. Sinha, Y Shukla, V.K. Khanna, and P.K. Seth. Co-transplantation of carotid body and ventral mesencephalic cells as an alternative approach towards functional restoration in 6-hydroxydopamine lesioned rats: implications for Parkinson’s disease. J. Neurochemistry. 2004, 91(2), 274-284.

A.K. Agrawal, S. Shukla, K. Seth, R.K. Chaturvedi, C. Sinha, A. Ahmad and P.K. Seth. Olfactory ensheathing cell transplantation restores functional deficits in rat model of PD: A co-transplantation approach with fetal ventral mesencephalic cells. Neurobiology of Diseases. 2004, 16(3), 516-526. (Cited in World PD association news archive at the website http://www.wpda.org/news.php).

A.K. Agrawal, R.K. Chaturvedi, S. Shukla, K. Seth, S. Chauhan, A. Ahmad and P.K. Seth. Restorative potential of dopaminergic grafts in presence of antioxidants in rat model of Parkinson’s disease. Journal of Chemical Neuroanatomy. 2004, 28(4), 253-64.

C. Sinha, A.K.Agrawal, F. Islam, K. Seth, R.K. Chaturvedi, S. Shukla, and P.K. Seth. Mosquito repellent (pyrethroid-based) induced dysfunction of Blood-Brain Barrier permeability in developing brain. Int. J. Devl. Neurosci. 2004, 22, 31-37.

R.K Chaturvedi, A.K. Agrawal, Seth K, S Shukla, and P.K. Seth. Effect of glial cell line-derived neurotrophic factor (GDNF) co-transplantation with fetal ventral mesencephalic cells (VMC) on long term functional restoration in 6-hydroxy dopamine (6-OHDA) lesioned rat model of Parkinson’s disease: Neurobehavioral, neurochemical and immunohistochemical studies. Int. J. Devl. Neurosci. 2003, 21, 391-400.