Genotoxicity evaluation of new drug entities: Genotoxicity tests are being performed with new chemical/drug entities to determine and evaluate its health hazards,using standard testing guidelines (e.g. OECD, ICH and Schedule Y).
The Tests included are in vitro chromosomal aberrations experiments in human lymphocytes, in vitro mutagenic experiments in Salmonella typhimurium and

Escherichia coli, in vitro and in vivo micronucleus assay, in vivo chromosomal assay in rodents, in vitro Sister chromatid exchange assays in human lymphocyte and in vivo Sister Chromosomal exchange assays in rodents. The laboratory is also involved in delineating detailed molecular mechanism of candidate drugs and NCEs in different target organs using new models and biomarkers.

Hit map showing differential gene expression

Studying single nucleotide polymorphisms in different genes of drug metabolizing enzymes, DNA repair genes and genes involved in p53 pathway in breast and head and neck cancer patients and their association with the disease in Indian sub-populations is the other focus of the laboratory. In addition to that the lab also explore newer methods for better therapeutic outputs of candidate drugs.

Rflp method for DNA                                     Polymorphism identification and Different SNPs in populations