Dr. Sabyasachi Sanyal
 
...




Principal Scientist
Division of Biochemistry
Central Drug Research Institute
Lucknow- 226031
 
Educational qualifications M.Sc. (Visvabharati University. 1996), Ph.D. [Hormone Research Center, Chonnam National University, Kwangju (Now Gwangju) South Korea. (2002)]
Date of Birth

23.07.1973
E mail  [email protected]
 
AREA OF RESEARCH SPECIALIZATION
 
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 Molecular mechanism of ligand & target-specific gene regulation by Nuclear receptors.
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Nuclear receptors as drug targets in Diabetes & Dyslipidemia.
 

RESEARCH INTERESTS
 
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 Cell signaling in osteoporosis, metabolic disorders and cancer
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Mechanistic elucidation of CDRI lead compounds
 
POST DOCTORAL POSITION
 
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 . 2002-2007 Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Stockholm, Sweden.
 

REVIEW ARTICLES
 
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 Divya Singh, Sabyasachi Sanyal, Naibedya Chattopadhyay (2011) The role of estrogen in bone growth and formation: changes at puberty. Cell Health and Cytoskeleton. Volume 2011:3 Pages 1 – 12.
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Kanaujiya JK, Lochab S, Pal P, Christopeit M, Singh SM, Sanyal S, Behre G, Trivedi AK. (2011) Proteomic approaches in myeloid leukemia. Electrophoresis. 32(3-4):357-67.

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Båvner A, Sanyal S, Gustafsson J-Å, Treuter E. (2005) Transcriptional co-repression by SHP: Molecular mechanism and physiological consequences.  Trends in Enocrinol and Metabol 16, 478-488.
 
 
SELECTED PUBLICATIONS
 
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 Dwivedi SK, Singh N, Kumari R, Mishra JS, Tripathi S, Banerjee P, Shah P, Kukshal V, Tyagi AM, Gaikwad AN, Chaturvedi RK, Mishra DP, Trivedi AK, Sanyal S, Chattopadhyay N, Ramachandran R, Siddiqi MI, Bandyopadhyay A, Arora A, Lundåsen T, Anakk SP, Moore DD, Sanyal S. (2011) Bile Acid Receptor Agonist GW4064 Regulates PPAR{gamma} Coactivator-1{alpha} Expression Through Estrogen Receptor-Related Receptor {alpha}. Mol Endocrinol. Jun;25(6):922-32.
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 Sharan K, Mishra JS, Swarnkar G, Siddiqui JA, Khan K, Kumari R, Rawat P, Maurya R, Sanyal S, Chattopadhyay N.(2011) A novel quercetin analog from a medicinal plant promotes peak bone mass achievement, bone healing after injury and exerts anabolic effect on osteoporotic bone: The role of aryl hydrocarbon receptor as a mediator of osteogenic action. J Bone Miner Res. 2011 Jun 2. doi: 10.1002/jbmr.434. [Epub ahead of print]
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 Bhargavan B, Singh D, Gautam AK, Mishra JS, Kumar A, Goel A, Dixit M, Pandey R, Manickavasagam L, Dwivedi SD, Chakravarti B, Jain GK, Ramachandran R, Maurya R, Trivedi A, Chattopadhyay N, Sanyal S. (2011) Medicarpin, a legume phytoalexin, stimulates osteoblast differentiation and promotes peak bone mass achievement in rats: evidence for estrogen receptor β-mediated osteogenic action of medicarpin. J Nutr Biochem. 2011 Feb 16. [Epub ahead of print]
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 Chakravarti B, Siddiqui JA, Dwivedi SK, Deshpande S, Samanta K, Bhatta RS, Panda G, Prabhakar YS, Konwar R, Sanyal S, Chattopadhyay N.  (2011) Specific targeting of insulin-like growth factor 1 receptor signaling in human estrogen dependent breast cancer cell by a novel tyrosine-based benzoxazepine derivative. Mol Cell Endocrinol. 2011 Mar 30. [Epub ahead of print]
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 Pal P, Kanaujiya JK, Lochab S, Tripathi SB, Bhatt ML, Singh PK, Sanyal S, Trivedi AK. (2011) 2-D gel electrophoresis-based proteomic analysis reveals that ormeloxifen induces G0-G1 growth arrest and ERK-mediated apoptosis in chronic myeloid leukemia cells K562. Proteomics. 11(8):1517-29.
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 Gautam AK, Bhargavan B, Tyagi AM, Srivastava K, Yadav DK, Kumar M, Singh A, Mishra JS, Singh AB, Sanyal S, Maurya R, Manickavasagam L, Singh SP, Wahajuddin W, Jain GK, Chattopadhyay N, Singh D. (2011) Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats. J Nutr Biochem. 22(4):318-27
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 Pal P, Lochab S, Kanaujiya J, Sanyal S, Trivedi AK. Ectopic expression of hC/EBPs in breast tumor cells induces apoptosis. (2010) Mol Cell Biochem. 2010 Apr;337(1-2):111-8.
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 Jacobsson, T, Venteclef N, Toresson G, Damdimopoulos AE, Ehrlund A, Lou X, Sanyal S, Steffensen KR, Gustafsson JA, Treuter E (2009) GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus (2009). Mol Cell. 34:510-518.
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 Bhargavan B, Gautam AK, Singh D, Kumar A, Chaurasia S, Tyagi AM, Yadav DK, Mishra JS, Singh AB, Sanyal S, Goel A, Maurya R, Chattopadhyay N. (2009) Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling. J Cell Biochem 1;108(2):388-99
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 Sanyal S*, Båvner A, Haroniti A, Nilsson LM, Lundåsen T, Rehnmark S, Witt MR, Einarsson C, Talianidis I, Gustafsson JA, Treuter E*. (2007) Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis. Proc Natl Acad Sci U S A. 104, 15665-15670. (*Co-Corresponding author)
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 Lundåsen T, Hunt MC, Nilsson LM, Sanyal S, Angelin B, Alexson SE, Rudling M. (2007) PPARalpha is a key regulator of hepatic FGF21.Biochem Biophys Res Commun. 360, 437-440.
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 Ann Båvner, Jason Matthews, Sabyasachi Sanyal, Jan-Åke Gustafsson and Eckardt Treuter. (2005) EID3; a novel EID family member and an inhibitor of CBP dependent coactivation. Nucleic Acids Research, 33 (11) 3561-3569
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 Sanyal S*, Matthews J, Bouton D, Kim HJ, Choi HS, Treuter E, Gustafsson JA. (2004) Deoxyribonucleic acid response element-dependent regulation of transcription by orphan nuclear receptor estrogen receptor-related receptor gamma. Molecular Endocrinology, 18, 312-325. (*Corresponding author)
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 Sanyal S, Kim JY, Kim HJ, Takeda J, Lee YK, Moore DD, Choi HS. (2002)
Differential regulation of the orphan nuclear receptor small heterodimer
Partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms.
Journal of Biological Chemistry. 277, 1739-1748.
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 Wang L*, Sanyal S*, Oh da Y, Kim JY, Ju JW, Song KH, Kim JW, Kwon HB, Choi HS. (2004) Molecular cloning and characterization of an amphibian progesterone receptor from Rana dybowskii. General and comparative Endocrinology.135, 142- 149. (*equal contribution).
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 Seo YW*, Sanyal S*, Kim HJ, Won DH, An JY, Amano T, Zavacki AM, Kwon HB, Shi YB, Kim WS, Kang H, Moore DD, Choi HS. (2002) FOR, a novel orphan nuclear receptor related to farnesoid X receptor. Journal of Biological Chemistry. 277, 17836-17844. (*equal contribution)
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 Sanyal S, Handschin C, Podvinec M, Song KH, Kim HJ, Kim JY, Seo YW, Kim SA, Kwon HB, Lee K, Kim WS, Meyer UA, Choi HS. (2003) Molecular cloning and characterization of chicken orphan nuclear receptor cTR2. General and comarative Endocrinology. 132, 474-484.
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 Båvner A, Sanyal S, Gustafsson J-Å, Treuter E. (2005) Transcriptional co- repression by SHP: Molecular mechanism and physiological consequences. (Review article), Trends in Endocrinol and Metabol 16, 478-488.
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 Kim JY, Chu K, Kim HJ, Seong HA, Park KC, Sanyal S, Takeda J, Ha H, Shong M, Tsai MJ, Choi HS. (2004) Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. Molecular Endocrinology. 18, 776-790