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| DR. T. NARENDER,
M.Sc., Ph.D. |
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Principal Scientist,
Medicinal and Process Chemistry Division
Central Drug Research Institute
Lucknow-226 031 (U.P), India |
| Educational Qualifications |
M Sc., Ph.D (KU Warnagal). |
| Phone No. |
: +91-522-2772450/2550 PABX 4737 (O), 4738
(Lab) |
| Fax No. |
+91-522-2771941 |
| Mobile No. |
9415019297 |
| E-Mail |
[email protected] |
| Date of Birth |
20.06.1969 |
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| CURRENT
RESEARCH AREA |
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Development of low cost drugs/leads for cancer, diabetes,
lipid lowering, malaria, filaria, HIV treatment from the
Indian Medicinal plants, Marine organisms and Marine bacteria
and fungus |
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| POST-DOCTORAL
EXPERIENCE |
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At the Scripps Institution of Oceanography, Unversity
of California, San Diego, USA with Prof. William Fenical
on Marine microorganisms (bacteria and fungus) |
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| AWARDS |
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DST, New Delhi awarded BOYSCAST fellowship to visit University
of California, USA in the year 2007 |
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CDRI Incentive Award in the year 2008 for the publication in Organic Letters |
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CDRI Incentive Award in the Year 2012 for the publication in Organic Letters |
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CDRI Incentive Award in the Year 2014 for the publication in J.Med.Chem |
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CDRI Incentive Award in the Year 2014 for the publication in Adv.Synth&Catalysis; |
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CDRI Incentive Award in the Year 2015 for the best publication in Organic Letters |
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Eli Lilly and Company Asia Outstanding Thesis Award for 2014 |
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| RESEARCH
SUPERVISED |
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(Ph.D degrees awarded/submitted) |
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1 |
Dr. Shweta (Post-Doctoral Fellow at Portland Univ and Turku University, Finland) |
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Dr. Tanvir Khaliq (Post-Doctoral Fellow at Washington University and Kansas Univ.USA) |
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Dr. Papi Reddy (Currently Post-Doctoral Fellow at Portland State University, USA) |
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Dr. Gaurav Madhur (Currently Employed as Govt Lecturer in UPTE) |
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Dr. Venkateswarlu (Post Doctoral fellow at Huazhong University of Sciences and Technology, China, Currently working as a Lecturer) |
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Dr. Satinath Sarkar (working as Post-Doct. in Calcutta Univ, West Bengal) |
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Dr. Kandhikonda Rajender (Currently Post-Doctoral Research fellow in Tel-Aviv University, Israel)
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Dr. Vinay Kr. Singh (Working as Research Scientist at TCG Life sciences (chembiotek- Kolkata)
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Dr. Janki Prasad Chaturvedi (Retired)
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Dr. G. Naresh (Currently post-doc at Arizona University)
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International students (CSIR-TWAS fellowship) |
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Dr. Ismail O. Ishola University of Lagos, Nigeria |
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Dr. Kehinde Olurotimi Ogunniran, University of Covenant, Nigeria |
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Dr. Tunji Onasanwo, University of Ibadan, Nigeria |
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(PG dissertations) |
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Mr. Rajesh (M.Pharma) |
2 |
Ms. Vandana (M.Pharma) |
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Mr. Pankaj Agrawal (M.Pharma) |
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Ms. Manali (M.Pharma) |
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Ms. Richa (M.Pharma) |
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Ms. Anita (M.Pharma) |
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Ms. Preeti (M.Pharma) |
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Ms. Tanu verma (M.Sc. Chem) |
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Mr. Vishnu Nayak (M.Pharma, NIPER) |
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Ms. Deepika (M.Pharma) |
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Mr. Patnaik (M.Fisheries) |
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Mr. Anand (M.Fisheries) |
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Mrs. Usha Kumari(M.Sc.Ayurveda) |
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Mr. Sandeep (NIPER; M.Pharma) |
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Mr. Arun (M.Pharma) |
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Ms. Khyati Das (M.Pharma; Manipal Univ) |
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Mr. Deepak Kumar (M.Pharma, NIPER) |
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Ms. Saritha (M.Pharma) |
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CURRENT RESEARCH GROUP
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Mr. Krishna Kumar Chaudhary (Technical staff) |
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Ms. P. Sukanya (CSIR-SRF) |
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Mr. Rohit Singh (CSIR-Project Assistant) |
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Mr. Sathish Reddy (CSIR-Project Assistant) |
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Ms. Pragya Yadav (MoES-Project Assistant) |
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Ms. Tripti Mishra (CSIR-JRF) |
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Mr. Amrendra Kumar (CSIR-JRF) |
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Mr. Ashok Kumar (UGC-JRF) |
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Mr. Ramanand (UGC-JRF) |
9 |
Ms. Stephy Elza John (M.Pharma trainee from NIPER) |
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Ms. Sukanya, Mr. Ashok, Mr. Amrendra Kumar, Mr. Rohit Singh, Dr. T. Narender, Mr. Ramanand, Mr. Sathish Reddy, Ms. Tripti Mishra, Ms. Pragya Yadav,
Ms. Stephy Elza John
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| CURRENT
AREAS OF INTEREST |
Written
records of the use of natural products as medicinal agents date
back thousands of years. The oldest records come from Mesopotamia
and date from about 2600 BC, however, it was not until the early
1800’s that the active principles from plants were isolated.
Natural products isolated from plants, animals and microorganisms
have made an important impact on curing the dreadful diseases
for example taxol, vinca alkaloids, podophyllotoxins camptothecin
derivatives for cancer treatment; pencillins, streptomycins,
tetracyclines as antibiotics; quinine and artemisinin for malaria
treatment.
Our major research activities are identification of biologically
active lead molecules through activity guided fraction and
isolation work on the medicinal plants, marine organisms and
microorganisms for metabolic diseases (hyperglycemia, dyslipidemia),
parasitic diseases (leishmania and malaria), cancer, HIV etc.,
and chemical transformation of natural products of biological
importance to improve their potency. We synthesize these biologically
active lead molecules and their analogues in our laboratory.
We have identified several lead molecules from the Indian medicinal plants
for various disease areas as described below and further work is in
progress to develop natural products based drugs.
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Antihyperglycemic
and Antidyslipidemic Agents
India leads the world with largest number of diabetic subjects earning the dubious distinction of being termed
the “diabetes capital of the world”. According to the Diabetes Atlas 2006 published by the International
Diabetes Federation, the number of people with diabetes in India currently around 40.9 million is expected to
rise to 69.9 million by 2025 unless urgent preventive steps are taken. According to World Health Organization
(WHO), Cardiac diseases have nearly doubled in India, an alarming fact. Latest data collected from WHO,
suggest that by 2010 there would be close to 100 million cardiac patients in India.
Obesity, insulin resistance (Diabetes) and dyslipidemia are generally found as a part of
a complex mixture of metabolic abnormalities collectively known as the metabolic syndrome.
As a part of our natural products program we identified few lead molecules from Indian
medicinal plants for metabolic disorder diseases for example Aegeline,
an alkaloidal amide isolated from the leaves of Aegle marmelos (bael),
exhibits the potent lipid lowering activity and mild antihyperglycemic activity;
4-hydroxyisoleucine an unusual amino acid from Trigonella foenum graecum (methi seeds)
exhibits dual activity (antidyslipidemic and antihyperglycemic).
terpenoid derivatives (α-amyrin and lupeol) exhibits antihyperglycemic activity.
Modified furanoflavonoids (pseudosemiglabrin and semiglabrin) isolated
from Indigofera tinctoria showed good lipid lowering activity. |
Aegeline |
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Antileishmanial agents
Kala-azar (Leishmaniasis) has re-emerged from near eradication. The annual estimate for
the incidence and prevalence of kala-azar cases worldwide is 0.5 million and
2.5 million, respectively. Of these, 90% of the confirmed cases occur in India,
Nepal, Bangladesh and Sudan. In India, it is a serious problem in Bihar,
West Bengal and eastern Uttar Pradesh The protozoan parasite Leishmania cause a
broad spectrum of diseases ranging from cutaneous healing skin lesions
caused by L. major to a fatal visceral form called kala azar
caused by L. donovani.
We identified an orally active antileishmnaial agent i. e., Peganine
from the seeds of Peganum harmala. It induces apoptosis- like
cell death in L. donovani. The binding interactions between
peganine and DNA topoisomerase I in molecular modeling studies (docking)
and experimental studies suggested that the apoptosis like cell death
appears to be due to L. donovani’s topoisomerase I
inhibition. We also obtained few natural chromenodihydrochalcones,
which exhibits antileishmanial activity in in-vitro studies.
We synthesized several analogues of these chalcones and studied their
in-vitro and in-vivo antileishmanial activity. |
Peganine (yellow) docked in active site of L. Donovani Topoisomerase I Chromenochalcones
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| Anticancer Agents
Cancer is a class of diseases in which a group of cells display
uncontrolled growth, invasion that intrudes upon
and destroys adjacent tissues, and sometimes metastasis, or spreading to other locations
in the body via lymph
or blood. Based on the cancer registry data of Indian Cancer Society,
it is estimated that there will be about
800,000 new cancers cases in India every year.
At any given point there is likely to be 3 times this load that
about 240,000 cases.
In continuation of our drug discovery program on anticancer agents we
isolated 2-deacetoxytaxinine J (2-DAT-J) in reasonably good yield (0.1%)
from the Indian T. baccata (ssp. wallichiana). It has effects
on the Ca2+ induced microtubule depolymerization. 2-DAT-J is a powerful inhibitor
of P-glycoprotein (P-gp) activity, acting as efficient reversing agent in multi-drug
resistant (MDR) cancer cells. |
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Anti HIV Agents
According to National Family Health Survey-II figures, India had an
estimated 2.5 million people (range 2 and 3.1 million) between the ages
of 15 and 49 years living with HIV in 2006. The country’s adult
HIV prevalence is halved as well, and is now estimated to be approximately
0.36%. HIV prevalence among adult women is 0.29%; for men it is 0.43%.
This puts India behind South Africa and Nigeria in numbers living with HIV.
Recently we initiated research programme on the calanolide class
of compounds, which are known for their HIV reverse transcriptase
inhibiting activity. We isolated few coumarins from Calophyllum
inophyllum to develop anti HIV and anti TB compounds.
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We also isolate novel compounds
from natural sources and identify their complex chemical structures
using modern NMR tools. For example we isolated few novel limonoids
from Xylocarpus molluccensis,a triterpene
from Peganum harmala and bisuracil derivative from marine sea
hare (Dolabella auricularia). |
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Hands on experience in identifying
the bioactive compounds from marine microorganisms. DST, New Delhi
awarded BOYSCAST fellowship during 2007-2008 to visit University
of California to learn advance technique on marine microorganisms.
As part of the program six new anthraquinone-γ-pyrones,
saliniquinones A–F (1–6),
which are related to metabolites of the pluramycin/altromycin class,
were isolated from a fermentation broth of the marineactinomycete Salinispora
arenicola (strain CNS-325). Their structures were determined by analysis of
one- and two-dimensional NMR spectroscopic and high-resolution
massspectrometric data. The relative and absolute configurations of
compounds 1–6 were determined by
analysis of NOESY NMR spectroscopic data and by comparison of circular
dichroism and optical rotation data with model compounds found in the literature.
Saliniquinone A (1) exhibited potent inhibition of the human colon
adenocarcinoma cell line (HCT-116) with an IC50 of 9.9 × 10–9 M. In the
context of the biosynthetic diversity of S. arenicola, compounds 1–6 represent
secondary metabolites that appear to be strain specific and thus occur
outside of the core group of compounds commonly observed from this species. |
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| PUBLICATIONS IN INTERNATIONAL JOURNALS |
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2015 |
96 |
Rakesh Arya, Akhilesh Singh, Navneet Yadav, Srikanth Cheruvu, Zakir Hossain, Sanjeev Meena, Shrankhla Maheshwari, Anup Singh, Uzma Shahab, Chetan Sharma, Kavita Singh, Tadigoppula Narender, Kalyan Mitra, Kamal Arya, Rama Singh, Jiaur Gayen, and Dipak Datta. Anti-breast tumor activity of Eclipa extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis. Scientific Reports, 2015, 5, 18457 (IF: 5.578)
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95 |
G Naresh, R Kant, T Narender* Silver (I)-Catalyzed Regioselective Construction of Highly Substituted α-Naphthols and Its Application toward Expeditious Synthesis of Lignan Natural Products Organic Letters 2015, 17 (14), 3446-3449 ( IF: 6.324)
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GD Katkar, RD Sharma, GJ Vishalakshi, SK Naveenkumar, G Madhur, T. Narender, Lupeol derivative mitigates Echis carinatus venom-induced tissue destruction by neutralizing venom toxins and protecting collagen and angiogenic receptors on inflammatory cells, Biochimica et Biophysica Acta (BBA)-General Subjects 2015, 1850 (12), 2393-2409 (IF: 4.381) |
93 |
D Arha, S Pandeti, A Mishra, SP Srivastava, AK Srivastava, T Narender, Deoxyandrographolide promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic effect in vivo. European journal of pharmacology, 2015, 768, 207-216 (IF: 2.532) |
92 |
Sudeep Gautam, Nayab Ishrat, Rohit Singh, Tadigoppula Narender, Arvind K. Srivastava. Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1 European Journal of Pharmacology, 2015, 762, 5, 419-429 (IF: 2.684). |
91 |
Rohit Singh, Vaibhav Mishra, Sukanya Pandeti, Gautam Palit, Manoj K. Barthwal, Haushila Prasad Pandey and T. Narender* Cytoprotective and anti-secretory effects of Azadiradione isolated from the seeds of Azadirachta indica (neem) on gastric ulcers in rat models. Phytotherapy Research publication date: 2015, 29, 910-916 ( IF: 2.397) |
90 |
Chetan Sharma, Manisha Dixit, Mohd Nizam Mansoori, Jyoti Kureel, Divya Singh, and T. Narender,* K.R.Arya*. Potential osteogenic activity of ethanolic extract and oxoflavidin isolated from Pholidota articulate. J. Ethnopharmacology, 2015, 170, 21, 57-65 ( IF: 3.284) |
89 |
Vinay Kr. Singh, Pawan K. Doharey, Vikash Kumar, J. K. Saxena, Sushma Rathaur, M. I. Siddiqi, T. Narender.* Synthesis, molecular docking and Brugia malayi thymidylate kinase (BmTMK) enzyme inhibition study of novel derivatives of [6]-shogaol. European Journal of Medicinal Chemistry 2015, 93,74-82 (IF: 3.432)
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88 |
Natasha Jaiswal, Naresh Gunaganti, Chandan Kumar Maurya, T. Narender, Akhilesh Kumar Tamrakar* Free fatty acid induced impairment of insulin signaling is prevented by the diastereomeric mixture of calophyllic acid and isocalophyllic acid in skeletal muscle cells 2015, European Journal of Pharmacology, 746, 70-77 (IF: 2.684) |
87 |
Venkateswarlu Korthikunta, Jyotsana Pandey, Rohit Singh, Rohit Srivastava, Arvind K. Srivastava, Akhilesh K. Tamrakar*, T. Narender* In vitro anti-hyperglycemic activity of 4-hydroxyisoleucine derivatives Phytomedicine 2015, 22, 66-70 (IF: 2.877) |
86 |
KO Ogunniran, MA Mesubi, K Raju, T Narender Structural and in vitro anti-tubercular activity study of (E)-N’-(2, 6-dihydroxybenzylidene) nicotinohydrazide and some transition metal complexes Journal of the Iranian Chemical Society 2015, 12 (5), 815-829 (IF:1.087)
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85 |
KO Ogunniran, MA Mesubi, JA Adekoya, OO Siyanbola, AI Inegbenebor, OO Ojo, EA Adedapo, A Edobor-Osoh, T Narender Synthesis of (E)-N'-(5-bromo-2-hydroxybenzylidene) nicotinohydrazide) and its Pt (II), Zn (II), Mn (II), Ni (II) and Mo (V) complexes as potential antitubercular agents Canadian Journal of Pure and Applied Science2015, 9 (2), 3519-3534 (IF: 2.657) |
84 |
Kehinde O Ogunniran, Joseph A Adekoya, Cyril O Ehi-Eromosele, Tolutope O Siyanbda, Akinlolu Kayode, Micheal A Mesubi, Tadigoppula Narender Transition Metal Complexes of (E)-N'-(4-cyanobenzylidene) nicotinohydrazide): Synthesis, Structural and Anti-Mycobacterial Activity Study Journal of Applied Sciences 2015, 15 (10), 1210 |
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2014 |
83 |
Naresh Gunaganti, Ruchir Kant, and T. Narender* Copper (II) catalyzed expeditious synthesis of Furoquinoxalines through a one-pot three-component coupling strategy Organic Lett, 2014, 6, 4528-4531. ( IF: 6.324)
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82 |
Rahul Shivahare, Venkateswarlu Korthikunta, Hardik Chandasana, Manish K. Suthar, Pragati Agnihotri,Preeti Vishwakarma, Telaprolu K. Chaitanya, Papireddy Kancharla, Tanvir Khaliq, Shweta Gupta, RabiSankar Bhatta, J. Venkatesh Pratap, Jitendra K. Saxena, Suman Gupta,* and T. Narender* Synthesis, structure-activity relationships, and biological Studies of Chromenochalcones as potential antileishmanial agents J. Med.Chem 2014, 57, 3342-3357.(IF: 5.480)
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81 |
Gunaganti Naresh, Ruchir Kant, and T. Narender* Molecular iodine promoted divergent synthesis of benzimidazoles, benzothiazoles, and 2-Benzyl-3-phenyl-3,4-dihydro-2Hbenzo[e][1,2,4]thiadiazines, J.Org.Chem, 2014, 79, 3821-3829.(IF: 4.638)
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80 |
Satinath Sarkar and T. Narender* PhI(OAc)2-BF3-OEt2 mediated domino imine activation, intramolecular C-C bond formation and β-elimination: New approach for the synthesis of Fluorenones, Xanthones and Phenanthridines RSC Adv. 2014, 4, 40964-40968. (IF: 3.708) |
79 |
Arun Kumar Rawat, Venkateswarlu Korthikunta, Sudeep Gautam, Savita Pal, T. Narender, Akhilesh Kumar Tamrakar, Arvind Kumar Srivastava. 4-Hydroxyisoleucine improves insulin resistance by promoting mitochondrial biogenesis and act through AMPK and Akt dependent pathway, Fitoterapia, 2014, 99, 307-317. (IF: 2.216) |
78 |
Chandan Kumar Maurya, Rohit Singh, Natasha Jaiswal, K Venkateswarlu, T. Narender,* Akhilesh Kumar Tamrakar* 4-Hydroxyisoleucine ameliorates fatty acid-induced insulin resistance and inflammatory response in skeletal muscle cells Molecular and Cellular Endocrinology 2014, 395, 51-60. (IF: 4.219) |
77 |
Chetan Sharma, Mohd. Nizam Mansoori, Manisha Dixit, Priyanka Shukla, Tejaswita Kumari, T Narender, Divya Singh and K R Arya* Ethanolic extract of Coelogyne cristata and its compound coelogin promote osteoprotective activity in ovariectomized estrogen deficient mice Phytomedicine 2014, 21, 1702-1707
(IF: 2.877) |
76 |
Satinath Sarkar, Ravi Sonkar, Gitika Bhatia, T. Narender* Synthesis of new N-acryl-1amino-2-phenylethanol and N-acyl-1-amino-3-aryloxypropanols and evaluation of their antihyperlipidemic, LDL oxidation and antioxidant activity, European Journal of Medicinal Chemistry 2014, 80, 135-144. (IF: 3.432)
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75 |
Shweta Gupta, Rahul Shivahare, Venkateswarlu Korthikunta, Rohit Singh, Suman Gupta, T. Narender* Synthesis and biological evaluation of chalcones as potential antileishmanial agents European Journal of Medicinal Chemistry, 2014, 81, 359-366. (IF: 3.432)
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Gunaganti Naresh and T. Narender* Molecular iodine mediated synthesis of polysubstituted oxazoles by oxidative domino cyclization in water, RSC Adv., 2014, 4, 11862-11866. (IF: 3.708) |
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Sukanya Pandeti, Komal Sharma, Surender Reddy Bathula* and T. Narender* Synthesis of novel anticancer Iridoid derivatives and their Cell cycle arrest and Caspase dependent Apoptosis, Phytomedicine 2014, 21, 333-9 (IF: 2.877)
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72 |
Arvind Kumar Srivastav,* Priti tiwari, Swayam Prakash Srivastav,, Rohit Srivastav, Akansha Mishra, Neha Rahuja, Sukanya Pandeti, Akhilesh Kumar Tamarkar, T. Narender, Mahendra Nath Srivastav, Vijai Lakshmi. Antihyperglycaemic and antidyslipidemic activities in ethylacetate fraction of the marine mangrove Xylocarpus moluccensis, Journal of Pharmacy and Pharmaceutical Sciences, 2014,6, 809-826.(IF: 2.530)
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71 |
FW Bansode,* KR Arya, RK Singh, T Narender. Dose-dependent effects of Asparagus adscendens root (AARR) extract on the anabolic, reproductive, and sexual behavioral activity in rats Pharmaceutical Biology, 2014, 1-9. (IF: 1.337)
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70 |
Onasanwo SA, Faborode SO, Agrawal M, Ijiwola OL, Jaiyesimi BO and T. Narender. Antidepressant and anxiolytic potentials of Chebulinic acid in laboratory rodents. Ann Depress Anxiety, 2014, 1, 1-5.
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69 |
Pandeti S, Gunjan S, Paidipelli S, Tripathi R, T. Narender*Anti-malarial Activity of New emodin derivatives against Plasmodium falciparum chloroquine resistant strain. Nat. Prod. Chem. Res. 2014, 2, 150. (IF: 1.225)
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68 |
Sukanya Pandeti, Ravi Sonkar, Gitika Bhatia and T. Narender* Andrographolide ameliorates dyslipidemia via activation of lecithin cholesterol acyltransferase (LCAT) and inhibition of LDL-oxidation Proceedings of Andhra Pradesh Academy of Sciences, 2014, 6, 31-37 (National journal)
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67 |
Vinay Kr. Singh, Pragya Yadav and Narender Tadigoppula*Recent advances in the synthesis, chemical transformations and pharmacological studies of some important dietary spice’s constituents, Chemistry & Biology Interface+, 2014, 4, 2, 66-99
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2013
66 |
K.Rajendar and T. Narender*,
Molecular Iodine Mediated Domino Reaction for Synthesis of Benzamides,
2,2-diazidobenzofuran-3(2H)-ones and Benzoxazolones,Advances Synthesis and
Catalysis2013, 355,
3591-3596. (IF: 5.542)
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65 |
Janki Prasad, Vinay Kr. Singh, Atul Shrivastava, Upma Chaturvedi, Gitika Bhatia, K.R. Arya, S.K.
Awasthi, and T. Narender,* Antidyslipidemic and antioxidant activity of an unusual amino acid (2
Amino-5-hydroxyhexanoic acid) isolated from the seeds of Crotalaria juncea accepted by
Phytomedicine
2013, 21, 15-19.
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64 |
Sukanya Pandeti, Ravi Sonkar, Astha Shukla Gitika Bhati and
Narender Tadigoppula* Synthesis of new
Andrographolide derivatives and evaluation of their Antidyslipidemic,LDL-oxidation and antioxidant
Activity. Europ. J. Med. Chem. 2013, 69, 439-448.
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63 |
Satinath Sarkar, Manoranjan Jana, Narender Tadigoppula* Metal-Free Directed ortho C-H Iodination:
Synthesis of 2′-Iodobiaryl-2-carbonitriles Europ. J. Org. Chem. 2013, 6491-6495.
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62 |
Satinath Sarkar, Manoranjan Jana, and Narender Tadigoppula* Transition metal-free domino
sequential synthesis of (E)-stilbenes, biaryl methanes and biaryl ethers using Et2AlCl as a Lewis acid
RSC Adv., 2013, 3, 18755-18758
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61 |
Vinay Kumar Singh, Vaibhav Mishra, Sriniwas Tiwari, Tanvir Khaliq, Manoj Kumar Barthwal, Haushila
Prasad Pandey, Gautam Palit,* Tadigoppula Narender* Anti-secretory and cyto-protective effects of peganine
hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers Phytomedicine, 2013, 20, 1180
1185
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60 |
Vaibhav Mishra, Astha Shukla, Sukanya Pandeti, Manoj Kumar Barthwal, Haushila Prasad Pandey, Gautam
Palit * and Tadigoppula Narender* Evaluation of anti-ulcerogenic and ulcer-healing Properties of Arbortristoside-A and
7-O-Trans-cinnamoyl- 6-β-
hydroxyloganin isolated from Nyctanthes arbortristis Phytomedicine, 2013, 20, 1055-1063 |
59 |
Jankiprasad, Gunaganti Naresh, Jyoti Gupta, Shailja M. Bhattacharya,* Siron M. Rajendran, Shailendra K.
Awasthi and Tadigoppula Narender Antifilarial Activity of Constituents of Calophyllum inophyllum and Their
Derivatives Natural Products Communications, 2013, 8, 803-804. |
58 |
J.P. Chaturvedi, Chandan K. Maurya, Jyotsana Pandey,Natasha Jaiswal, Gaurav Madhur, Arvind K.
Srivastava, T. Narender*, Akhilesh K. Tamrakar* Diastereomeric mixture of calophyllic acid and
isocalophyllic acid stimulates glucose uptake in skeletal cells: Involvement of PI-3-Kinase- and ERK1/2
dependent pathways Molecular and Cellular Endocrinology 2013, 370, 11-19. |
57 |
T. Narender,* P. Sukanya,a Komal Sharma, and Surendar Reddy Bathula* Report on in vitro anticancer,
apoptosis, cell cycle arrest and DNA intercalating activities of novel emodin derivatives.
RSC Advances, 2013, 3, 6123-6131 |
56 |
T. Narenderender Reddy Bathula* Synthesis of Emodin derivatives
and their in-vitro anticancer activity, Phytomedicine 2013,, 20, 890-896 |
55 |
Vaibhav Mishra, Manali Agarwal, Samuel Adetunji Onasanwo, Gaurav Madhur, Preeti Rastogi, Haushila
Prasad Pandey, Gautam Palit* and T. Narender* Anti-secretory and cyto-protection effects of Chebulinic
acid isolated from the fruits of Terminalia chebula on gastric ulcers,
Phytomedicine, 2013, 20, 506-511. |
54 |
T. Narender,*, Gaurav Madhur, Natasha Jaiswal, Manali Agrawal, Chandan K. Maurya, Neha Rahuja,
Arvind K. Srivastava, Akhilesh K. Tamrakar,* Synthesis of Novel Triterpene and N-Allylated/N-Alkylated
niacin Niacin hybrids Hybrids as α-Glucosidase Inhibitors, European Journal of Med. Chemistry, 2013, 63,
162-169. |
53 |
Ismail O. Ishola, Santoshkumar Tota, Olufunmilayo O. Adeyemi, Esther O. Agbaje, T. Narender, Rakesh
Shukla* Protective effect of Cnestis ferruginea Vahl ex DC (Connaraceae) and its active constituent on
scopolamine induced memory impairment in mice: A behavioral and biochemical study. Pharmaceutical Biology2013 51, 825-835 |
52 |
I. Ishola, J.P. Chaturvedi, S. Rai, N. Rajasekar, O.O. Adeyemi, R. Shukla* and T. Narender * Evaluation of
amentoflavone isolated from Cnestis ferruginea Vahl ex DC (Connaraceae) on production of inflammatory
mediators in LPS stimulated rat astrocytoma cell line (C6) and THP-1 cells. Journal of Ethnopharmacology 2013, 146, 440-448 |
51 |
T. Narender,* K.Venkateswarlu, Shweta, K. Papireddy, T. Khaliq, S. Awakash, R. K. Srivastava, K.
Srivastava, S. K. Puri, K. S. R. Raju, Wahajuddin, P. S. Sijwali, Vikash Kumar, and Mohammad Imran
Siddiqi. Synthesis and Insight into the Structure – Activity Relationships of Chalcones as Antimalarial Agents, Journal of Medicinal Chemistry, 2013, 56, 31-45. |
50 |
T. Narender,,*, K. Venkateswarlu,G. Madhur and K. Papi Reddy Highly efficient and selective deprotection method for prenyl, geranyl and phytyl ethers and esters using borontrifluoride-etherate 2013 Syn. Comm, 43 (1), 26-33 |
| |
2012 |
49 |
Natasha Jaiswal, Swayam P Srivastava, Vikram Bhatia, Akansha Mishra, Amit K Sonkar, Tadigoppula
Narender, Arvind K Srivastava, and Akhilesh K Tamrakar Inhibition of Alpha-Glucosidase by Acacia nilotica
Prevents Hyperglycemia along with Improvement of Diabetic Complications via Aldose Reductase Inhibition
2012, J Diabetes Metab.
http://dx.doi.org/10.4172/2155-6156.S6-004 |
| 48
Narender T.* (2012) R.* (2012) Recent advances in the natural products drug discovery. Journal of Pharmacognosy,
2012, 3, 108-111. |
|
47
Janki Prasad, Atul Shrivastava, A.K. Khanna, G. Bhatia, S.K. Awasthi, T. Narender.* Antidyslipidemic and antioxidant activity of the constituents isolated from the leaves of CalophCalophyllum inophyllum
Phytomedicine
2012, 19, 1245-1249 |
|
46 |
Ismail O. Ishola, Manavi Chatterjee, Santoshkumar Tota, Narender Tadigopulla, Olufunmilayo O.
Adeyemi, Gautam Palit, Rakesh Shukla. Antidepressant and anxiolytic effects of amentoflavone isolated from
Cnestis ferruginea in mice. Pharmacology Biochemistry and Behavior 2012, 103, 322-331 |
45 |
G. Naresh, N. Jaiswal, P. Sukanya, A.K. Srivastava, A.K. Tamrakar,* T. Narender.* Glucose uptake stimulatory effect of 4-hydroxypipecolic acid by increased GLUT 4 translocation in skeletal muscle cells.
Bioorganic and Medicinal Chemistry Letters 2012, 22, 5648-5651 |
44 |
Natasha Jaiswal, Chandan K. Maurya, K. Venkateswarlu , P. Sukanya, Arvind K. Srivastava, Tadigoppula Narender,* Akhilesh K. Tamrakar.* 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface
GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinasE dependent pathway Eur. J. Nutr;
2012, 51(7):893-8. |
43 |
Ismail O. Ishola, Oluwatoyin E. Agbaje, T. Narender, Olufunmilayo O. Adeyemi, Rakesh Shukla Bioactivity guided isolation of analgesic and anti-inflammatory constituents of Cnestis ferruginea Vahl Vahl ex DC (Connaraceae) root
Journal of Ethnopharmacology, 2012, 142,383./p> |
42 |
Amar Singh, T. Khaliq, T. Narender and Aand A.K.Srivastava. Anti-diabetic and anti-oxidative effects of 4 hydroxypipecolic acid in C57BL/KsJ-db/db mice.
Human and Experimental Toxicology, 2012, 31 (1), 57-65 |
| |
2011 |
41 |
T. Narender,* Sat,* Satinath Sarkar, Kandikonda Rajendar and Sriniwas Tiwari. Synthesis of Biaryals via AlCl3 catalyzed Domino Reaction.
Organic Letters, 2011, 13, 6140. |
40 |
Vikram Bhatia, Swayam P. Srivastava, Rohit Srivastava, Akansha Mishra and T. Narender and A.K.Srivastava. Antihyperglycaemic and aldose reductase inhibitory potential of Acacia catechu hard wood and Tectona grandis leave leaves.
Medicinal Chemistry Research. 2011 20 (9), 1724-1731 |
39 |
Swayam Prakash Srivastava, Akansha Mishra, Vikram Bhatia, T. Narender and Arvind K. Srivastava. Acacia catechu hard hard wood: potential anti-diabetic cum anti-dyslipidemic. Medicinal Chemistry Research.
Online First™, 13 December 2011, 20 (9), 1732-1739 |
38 |
T. Narender, K. V, K. Venkateswarlu, B. Vishnu Nayak, S. Sarkar. A new chemical access for 3′acetyl-4′
hydroxychalcones using borontrifluoride etherate via a regioselective Claisen Schmidt condensation and its
application in the synthesis of chalcone hybrids Tetrahedron
Letters, 2011, 52, 5794-5798. |
37 |
T. Narender, K. Rajendar, S. Sarkar, V.K. Singh, Upma Chaturvedi, A.K. Khanna, G. Bhatia Synthesis of
novel N-(2-hydroxy-2-p-tolylethyl)-amide and N-(2-oxo-2-p-tolyl-tolylethyl) amid derivatives and their
antidyslipidemic and antioxidant activity Bioorganic & Medicinal
Chemistry Letters, 2011 21, 6393-6397 |
36 |
T. Narender,* Gau,* Gaurav Madhur, Dharamsheela, K. Papi Reddy, S. Sarkar, J.Sarkar, and R.K.Tripathi.* One
pot Synthesis of Cationic Amphiphiles from n-Alcohols and Allylalcohols Syn. Lett 2011(12): 1687-169
|
35 |
T. Narender,* K.P,* K.Papi Reddy and Sriniwas Tiwari H2SO4 Promoted Synthesis of (E)-Stilbenes from
substituted Phenylacetones and substituted Benzaldehydes through tandem Aldol-Grob reaction SyntheticCommunications 2011, 41, 572-1583. |
| |
2010 |
34 |
T. Narender, S. Sarkar, K. Venkateswarlu, J.K. Kumar. New chemical access for pyran core embedded derivatives from bisalkenylated 1,3-diketones and 1,3-diketoesters via tandem C-dealkenylation and cyclization Tetrahedron Letters,
2010, 51, 6576-6579 |
33 |
T. Narender, K. Papi Reddy, V. K. Singh, K. Rajendar and J. Sarkar. An Unprecedented Biogenetic-Type Chemical Synthesis of 1(15→11) Abeotaxanes from Normal Taxanes.
J. Nat. Prod.2010, 73, 747 |
32 |
B.T. Murphy, T Narender, C. A. Kauffman, M. Woolery, P. R. Jensen, W. Fenical. Saliniquinones A–F, New Members of the Highly Cytotoxic Anthraquinone-γ-Pyrones from the Marine Actinomycete Salinispora arenicola. J. Australian Chem. 2010, 63, 929. |
31 |
A.B. Singh, A.K. Tamarkar, T. Narender, A.K. Srivastava. Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice.
Nat Prod Res. 2010, 24, 258 |
| |
2009 |
30 |
T.Narender, K.P.Reddy, and G. Madhur. Synthesis of (E)-Stilbenes and (E,E)-1,4-Diphenylbuta-1,3-diene promoted by Borontrifluoride-etherate complex. Synthesis
2009, 22, 3791-3796.
|
29 |
T. Narender,* Khaliq, A.B. Singh, M.D. Joshi, P. Mishra, J.P. Chaturvedi, A.K. Srivastava, R. Maurya, S.C. Agarwal. Synthesis of α-amyrin derivatives and their in vivo antihyperglycemic activity. European Journal of Medicinal Chemistry
2009, 44, 1215-1222. |
28 |
Tanvir Khaliq, Pragya Misra, Swati Gupta, K. Papi Reddy, Ruchir Kant, P. R. Maulik, Anuradha Dube and
T Narender.* Peganine hydrochloride dehydrate an orally active antileishmanial agent. Bioorg. Med. Chem. Lett. 2009, 19, 2585-2586 |
27 |
K. Papi Reddy, Hemant K Bid, V. Lakshma Nayak, Preeti Choudhury, J. P. Chaturvedi, K. R. Arya, Rituraj Konwar,
T Narender.* In vitro and in vivo anticancer activity of 2-deacetoxytaxinine J and synthesis of novel taxoids and their in vitro anticancer activity.
Europ. J. Med.Chem. 2009, 44, 3947-3953. |
26 |
K. Papi Reddy, A. B. Singh, A. Puri, A. K. Srivastava and
T Narender* Synthesis of novel Triterpenoid (Lupeol) derivatives and their in vivohyper Antihyperglycemic and Antidyslipidemic activity
Bioorg. and Med. Chem. Lett. 2009, 19, 4463-4466.
|
25
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T. Narender,* Papi Reddy and Shweta.BF3.OEt2 mediated One-pot Synthesis of Acetylchromans from Polyhydroxyacetophenones and Isoprene/Allylalcohol. Synthetic Communications.
2009, 39, 384-394. |
24 |
T. Narender,* Papi Reddy and G.
Madhur. NaOAc mediated selective deprotection of aromatic acetates and its
application in the synthesis of natural products. Synthetic
Communications 2009, 39, 1949-1956. |
| |
2008 |
23 |
T. Narender,* Papi Reddy, Brijesh Kumar. BF3.OEt2 mediated regioselective deacetylation of polyacetoxyacetophenones and its application in the synthesis of natural products.
Tetrahedron Letters 2008, 49,2008, 49, 4409–4415.
|
22 |
T. Narender *, Khaliq and Shweta 13C-NMR Spectroscopy of B,D-Ring Seco Limonoids of Meliaceae family. Natural Product Research.
2008, 22, 763,-800..
|
21 |
P. Misra, T. Khaliq, A. Dixit, S. Sengupta, M. Samant, S. Kumari, A. Kumar, P. Kushawaha, H. Majumder, A.K.Saxena,
T. Narender and A. Dube. Antileishmanial activity mediated by apoptosis and structure based target study of Peganine hydrochloride dihydrate: An approach for rational drug designing Journal of Antimicrobial Chemotherapy,,
2008, 62, 998-1002.
|
20 |
A.B. Singh, J.P. Chaturvedi, T Narender and A.K. Srivastava. Preliminary studies on the hypoglycemic effect of Peganum harmala seeds eth seeds ethanol extract on normal and streptozotocin induced diabetic rats.
Indian Journal of Clinical Biochemistry 2008, 23, 391-393. |
| |
2007 |
19 |
T. Narender,* Khaliq and M.N.Srivastava. 2007 Naturally occurring Uracil dimer from the Marine sea hare Dolabella auricularia
Natural Products Communications 2, 71-73 |
18 |
T. Narender,*weta, P. Tiwari, K. Papi Reddy, T. Khaliq, A. K. Srivastava, S. C. Agarwal, and K. Raj Antihyperglycemic agent and Antidyslipidemic agent from Aegle marmelos
Bio-org. Med. Chem. Letters 2007, 17, 1808-1811. |
17 |
T. Narender,* Khaliq, T. Khaliq, Shweta, K.Papi Reddy, R.K. Sharma Occurrence, Biosynthesis, Biological activity and NMR Spectroscopy of D and B, D Ring Seco-limonoids of Meliaceae Family.
Natural Products Communication 2007, 2, 203-221 |
16 |
T. Narender*d T. Khaliq. A New Triterpenoid from Peganum har Peganum harmala.
Natural Products Communications 2007, 2, 1079-1081. |
15 |
K.V.Shashidhara,* N. Rosiah, T Narender*. Highly Efficient and Regioselective Synthesis of 7-Hydroxy-4-methyl-2-oxo-2H-benzo[h]chromene-8,10 dicarbaldehyde’s and 1-Hydroxynaphthalene-2,4-dicarbaldehyde’s Keto-Enamine Schiff bases.
Tetrahedron Letters.2007, 48, 1699-1702. |
14 |
T. Narender,* Papi Reddy, Shweta, Kumkum Srivastava, D. K. Mishra and S. K. Puri. Total Synthesis of Munchiwarin, a Triprenylated Chalcone from Crotalaria medicagenia.
Organic letters2007, 9, 5369-5372. |
13 |
T. Narender*d K. Papi Reddy. BF3.OEt2 mediated biogenetic type synthesis of chromanochalcones from prenylated chalcones via a regioselective cyclization reaction.
Tetrahedron Letters 2007, 48, 7628–7632. |
12 |
T. Narender*d K. Papi Reddy. A simple and highly efficient method for the synthesis of chalcones by using borontrifluoride-etherate. Tetrahedron Letters
2007, 48, 2007, 48, 3177–3180. |
11 |
ASankaranarayanan, T Narender, S.Kumar and M. Dikshit. Allium sativum constituents: effect on free radical generation from rat neutrophils.
Cellular and Molecular Biology 2007, 53, 63-67. |
10 |
A. Puri, T. Khaliq, R. Saxena, G. Bhatia and R. Chander Narender*, 2007. Antidyslipidemic activity of Indigofera tinctoria. J. Herbal Pharmacotherapy,1, 57-64 |
| |
2006
|
9 |
T. Narender* Puri, Shweta, T. Khaliq, R. Saxena, G. Bhatia and R. Chander, 2006. 4- Hydroxyisoleucine an unusual Amino acid as Antidyslipidemic and Antihyperglycemic agent. Bioorg. Med. Chem. Lett.16, 293-296. |
8 |
T. Narender* Khaliq A. Puri and R. Chander, 2006. Antidyslipidemic activity of Modified flavonoids Bio-org.Med.Chem Letters 16, 3412-3414. |
7 |
A. D. Roya, R. Kumar, P. Gupta, T. Khaliq,
T Narender, Vijailakshmi* and R. Roy* 2006. Xyloccensin X and Y, Two New Limonoids from Xylocarpus molluccensis: NMR Investigation in Mixture
Magn. Reson. Chem, 44, 1054-1057. |
| |
2005
|
6 |
T. Narender,*.Shweta, T.Khaliq, M.S. Rao, K. Srivastava and S.K. Puri. 2005. Prenylated Chalcones isolated from Crotalaria genus inhibits the in-vitro growth of Human malaria parasite Plasmodium, Biorg .Med. Chem. Lett,15, 2453-2455.. |
| 4 |
T. Narender, T. Khaliq, Shweta., Nishi. N. Goel, S. Gupta, 2005. Synthesis of Chromenochalcones and Evaluation of their in-vitro Antileishmanial activity. Bio-org. Med. Chem. 13, 6543-6550 |
| |
2004
|
| 3
| T. Narender, Shweta and S. Gupta, 2004. A Convenient and Biogenetic type Synthesis of Few Naturally Occurring Chromenodihydrochalcones and their in-vitro Antileishmanial activity, Bio-organic Med. Chem. Letters, 14, 3913-3916. |
| |
1999 |
2 |
J.K.Kumar, strong> Narender, M.S. Rao, P.S. Rao, G. Toth, G, B. Balazs and H. Duddeck, 1999. Further Dihydro chalcones from Crotalaria ramosissima, J.Braz.Chem.Soc., 10, 4, 2., 10, 4, 278-280. |
| 1 |
B. Balazs, G. Toth, P.S. Rao, strong> Narender, N. Subba Rao,. Gy. Horvath and H. Duddeck. 1999. A New Indole alkaloid from the heart wood of Adina cordifolia, Magn.Resn.Chem., 37, 751-753 |
| Invited Book Chapters (2)
|
|
1 |
T. Narender,* T. Khaliq and G. Madhur. Naturally occurring antihyperglycemic and antidyslipidemic agents In Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry, 2011, page 152-180: Publisher: Research Signpost, Trivandrum-695 023, Edited by Vinod .K.Tiwari and Bhuwan B. Mishra. |
2 |
Dube, A., Misra, P., Khaliq, T., Tiwari, S., Kumar and T. Narender. Therapeutic Potential of Harmala (Peganum harmala L.) Seeds with Array of Pharmacological Activities: In Nuts & Seeds in Health and Disease Prevention (1st ed.) 2011, pages 601-609, Publisher: Academic Press is an imprint of Elsevier, Edited by V. R. Preedy, R. R. Watson, V. B. Patel. |
|
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| Patent (International) |
1 |
An extract from Xylocarpus useful for the treatment of Diabetes and Dyslipidemia,
International Application No.: 11/519327, Publication Date: 06/14/2011; United States Patent 7959954 |
| Invited Lectures Delivered in conference/Guest lectures: 23 |
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