VINEETA CHATURVEDI
 
...




Senior Principal Scientist
Biochemistry Division
Central Drug Research Institute
LUCKNOW- 226031

 
Educational qualifications M. Sc.(Agra College Agra), Ph. D.(S N Medical College, Agra)
Date of Birth

10.07.1963

E mail [email protected]
 

POST-DOCTORAL RESEARCH

 
Dec., 1988- Dec.,1991
Division of Immunology, Central JALMA Institute of leprosy and Other Mycobacterial Diseases, Agra
 
 

AREA OF SPECIALIZATION

 
  • Microbiology and immunology of mycobacterial infections
  • TB Drug Discovery
 
ACADEMIC AWARDS/ HONOURS
 

IMMUNOLOGY FOUNDATION AWARD of Indian Association of Leprologists. 2007

ACWORTH LEPROSY HOSPITALRESEARCH SOCIETY AWARD of Indian Association of Leprologists.1992
HIGH QUAILTY RESEARCH WORK Award of Hamdard National Foundation .1987
YOUNG SCIENTIST Award of Indian Science Congress. 1989
 
LAB MEMBERS
 

Junior Technical Assistant(Gr. III)
  Ms. Priyanka Trivedi
Senior Technician (Gr.II)
  Mr. Hori Lal
Ph.D. Students
  Ms. Shubhra Singh (SRF)
  Ms. Richa Dwivedi (SRF)

 
 
PUBLICATIONS
 
  • Total  54 original research articles in SCI journals.

Citations to all publicatios: sum of times sited-571.

 
PATENTS (23)
 
  • 10 Foreign
  • 13 Indian


 
SELECTED PUBLICATIONS
 

 Chauhan K, Sharma M, Saxena J, Singh VS, Trivedi P, Srivastava K,  Puri SK, Saxena JK,   Chaturvedi V, Chauhan PMS. 2013. Synthesis and biological evaluation of a new class of   4-Amino quinoline- rhodanine hybrid as potent anti infective agents. Eur J  Medicinal Chem62: 693-704.

Singh S, Dwivedi R and Chaturvedi V. 2012. Influence of vehicles used for oral
dosing of test molecules on the progression of Mycobacterium tuberculosis infection in mice. Antimicrobial Agents Chemotherapy 56(11): 6026-6028.

Vijay K. Marrapu , Vinita Chaturvedi, Shubhra Singh , Shyam Singh , S Sinha,
 Kalpana Bhandari. 2011. Novel aryloxy azolyl chalcones with potent activity against Mycobacterium tuberculosis H37Rv. European Journal of Medicinal Chemistry . 46, 4302-4310.

Bisht, S. S., N. Dwivedi, V Chaturvedi, N. Anand, M.Misra, R. Sharma, B. Kumar, R.Dwivedi, S. Singh, S. K. Sinha,V. Gupta, P. R. Mishra, A. K. Dwivedi, and R. P. Tripathi.2010.Synthesis and Optimization of Antitubercular Activities in a Series of  4-(Aryloxy) Phenyl Cyclopropyl Methanols'. European Journal of Medicinal Chemistry 45(12), 5965-5978. [CI= 0, IF 3.193]

Sunduru Naresh, Gupta Leena, Chaturvedi Vinita, Dwivedi, Richa, Sinha Sudhir and Chauhan PMS. 2010. Discovery of New 1,3,5-TriazineScaffolds with Potent Activity against Mycobacterium tuberculosis. European Journal of Medicinal Chemistry 45(8), 3335-3345.

Pandey J, Tiwari VK,  Verma SS, Chaturvedi V, Bhatnagar S, Sinha S, Gaikwad AN and Tripathi RP. 2009. Synthesis and antitubercular screening of imidazole derivatives. Eur. J. Med. Chem 44(8), 3350-3355.

Sharma M, Chaturvedi V, Manju YK, Bhatnagar S, Srivastava K, Puri SK and 
 Chauhan PMS. 2009. Substituted quinolinyl chalcones and quinolinyl pyrimidines as  a new class of anti- infective agents. Eur. J. Med. Chem 44(5), 2081-2091.

Singh N, Pandey J, Yadav A, Chaturvedi V, Bhatnagar S, Gaikwad AN, Sinha SK,  Kumar A, Shukla PK and Tripathi RP. 2009. A facile synthesis of alpha,alpha'-(EE)-  bis(benzylidene)-cycloalkanones and their antitubercular evaluations. Eur. J. Med.   Chem 44(4), 1705-9. (CI=14, IF=  

Tripathi RP, Yadav AK, Bisht SS, Chaturvedi V and  Sinha SK. 2010 . Application of Huisgen (3+2)cycloaddition reaction: Synthesis of 1-(2,3- dihydrobnzofuran-2-yl methyl [1,2,3]-triazoles and their Antitubercular evaluations. Eur.  J. Med. Chem 45, 142-148.

Pandey J, Tiwari VK, Verma SS, Chaturvedi V, Bhatnagar S, Sinha S, Gaikwad  AN, Tripathi RP. 2009.     Synthesis and antitubercular screening of imidazole derivatives.  European J Medicinal Chem 44: 3350-3355.

Tripathi RP, Yadav AK, Bisht SS, Chaturvedi V and  Sinha SK. 2009. Application of Huisgen (3+2)cycloaddition reaction: Synthesis of 1-(2,3-dihydrobnzofuran-2-yl methyl [1,2,3]-triazoles and their Antitubercular evaluations. Eur. J. Med. Chem. 44, 335-355.

Singh N, Pandey J, Yadav A, Chaturvedi V, Bhatnagar S, Gaikwad AN, Sinha SK, Kumar A, Shukla PK and Tripathi RP. 2009. A facile synthesis of alpha,alpha'-(EE)-bis(benzylidene)-cycloalkanones and their antitubercular evaluations. Eur. J. Med. Chem. 44(4), 1705-9.

Sharma M, Chaturvedi V, Manju YK, Bhatnagar S, Srivastava K, Puri SK and Chauhan PMS. 2009. Substituted quinolinyl chalcones and quinolinyl pyrimidines as a new class of anti-infective agents. Eur. J. Med. Chem. 44(5), 2081-2091.

Pandey J, Tiwari VK, Verma SS, Chaturvedi V, Bhatnagar S, Sinha S, Gaikwad AN and Tripathi RP. 2009. Synthesis and antitubercular screening of imidazole derivatives. Eur. J. Med. Chem. 44(8), 3350-3355.

Pandey Jyoti, Sharma Anindra, Tiwari VK, Dube Divya, Ramachandran
Ravishankar, Chaturvedi Vinita, Sinha SK, Mishra NN, Shukla PK and Tripathi RP.2009. Solution-Phase Synthesis of a Library of Carbapeptide Analogues Based on  Glycosylamino Acid Scaffolds and Their In Silico Screening and Antimicrobial  Evaluation. Journal of Combinatorial Chemistry, 11(3), 422-427.

Pandey J, Tiwari VK, Verma SS, Chaturvedi V, Bhatnagar S, Sinha S, Gaikwad AN, Tripathi RP.  Synthesis and antitubercular screening of imidazole derivatives. 2009. European J Medicinal Chem 44: 3350-5.

Kumar A, Chaturvedi V, Bhatnagar S, Sinha S, Siddiqui MI. 2009. Knowledge based identification of potent antitubercular compounds using structure based virtual screening and interaction  of fingerprins. J Chemical Information and Modelling  49: 35-42.

G Panda, MK Parai, SK Das, Shagufta, M Sinha, Vinita Chaturvedi,  AK Srivastava, YK Manju, AN Gaikwad, S Sinha, 2007. Effect of substituents on diarylmethanes for antitubercular activity. European Journal of Medicinal Chemistry 42, 410-419.

M Saquib, MK Gupta, R Sagar, YS Prabhakar, AK Shaw, R Kumar, PR Maulik, A Gaikwad, S Sinha, AK Srivastava, Vinita Chaturvedi, R Srivastava, BS Srivastava. 2007. C-3 alkyl/arylalkyl1-2,3-dideoxy hex-2-enopyranosides as antitubercular agents: synthesis, biological evaluation and QSAR study. Journal of Medicinal Chemistry  50, 2942-50.

Vinita Chaturvedi, B K. Girdhar, U Sengupta and S Sinha, 2007. Semi-quantitative detection of Mycobacterium leprae antigens in skin scrapings: Suitability as a  laboratory aid for field diagnosis of leprosy. Transactions of Royal Society of Tropical Medicine and Hygiene 101, 699-706.

Vinita Chaturvedi, N Dwivedi, RP Tripathi and S Sinha, 2007. Identification and evaluation of Mycobacterium smegmatis as a possible surrogate screen for selecting  molecules active against multi-drug resistant Mycobacterium tuberculosis. Journal  of General and Applied Microbiology 53, 333-337.

D Katiyar, VK Tiwari, N Tewari, SS Verma, S Sinha, A Gaikwad, A Srivastava, Vinita Chaturvedi, R Srivastava, BS Srivastava, RP Tripathi, 2005. Synthesis and  antimycobacterial activities of glycosylated amino alcohols and amines. European Journal of Medicinal Chemistry 40, 351-360.

Chaturvedi V and Gupta HP. 2001. Evaluation of integral membrane antigens of 
Mycobacterium habana  for serodiagnosis of extrapulmonary tuberculosis : Association between levels of antibodies  and Mycobacterium Tuberculosis antigens. FEMS Immunol MED Microbiol 33, 1-7.

Chaturvedi V, Srivastava A, Gupta HP and Srivastava BS.1999. Protective proteins of Mycobacterium habana are distributed between peripheral and integral compartments of plasma membrane. A study in experimental tuberculosis of mouse. Vaccine 17: 2882-2887

Chaturvedi V, Sinha S,Girdhar B K,Katoch K, Bhatia A S and Sengupta U.1991. Association of mycobacterium –specific and M.leprae  specific antibody levels with clinical activity in tuberculoidleprosy: Acomparative study of three serological enzyme assays. Lepr Rev 62: 122-133.

Chaturved V, Sinha S, Girdhar B K and Sengupta U. 1991. On the value of sequentialserology with Mycobacterium leprae specific antibody competition ELISA in monitoring leprosy chemotherapy.

Patents

Foreign Patents

. Patent Number: US2007248704-A1
Title: Method, useful for treating tuberculosis, comprises administering an antitubercular extract or fraction obtained from a Salicrnia species.
Inventors: RATHOD M R; SHETHIA B D; PANDYA J B; GHOSH P K; DODIA P J; SRIVASTAVA B S; SRIVASTAVA R; SRIVASTAVA A; CHATURVEDI V.

Patent Number: US2005186291-A
Title: New bioactive fraction from extracts of salicornia species useful as anti tubercular agent for the treatment of tuberculosis.
Inventors: RATHOD M R; SHETHIA B D; PANDYA J B; GHOSH P K; DODIA P J; SRIVASTAVA B S; SRIVASTAVA R; SRIVASTAVA A; CHATURVEDI V.

. Patent Number: WO2005115424-A1; IN200400969-I1; US2007020351-A1; AU2005247206-A1; MX2006011593-A1; BR200510918-A; JP2008501041-W
Title: Bioactive fraction useful as antitubercular agent for treatment of tuberculosis, comprises extracts of Salicornia species e.g. Salicornia brachiata
Inventors: RATHOD M R; SHETHIA B D; PANDYA J B; GHOSH P K; DODIA P J; SRIVASTAVA B S; SRIVASTAVA R; SRIVASTAVA A; CHATURVEDI V; VIRAMANI M; RATHOD R M; BHUPENDRA D; MARIAPPANADAR V; VAIRAMANI M

Patent Number: WO2005021020-A1; AU2003259548-A1; EP1684778-A1
Title: Bioactive fraction from extracts of Salicornia plant species, useful for treating tuberculosis
Inventors: RATHOD M R; SHETHIA B D; PANDYA J B; GHOSH P K; DODIA P J; SRIVASTAVA B S; SRIVASTAVA R; SRIVASTAVA A; GUPTA C M; CHATURVEDI V.

US Patent No. 7442393                                                          
  Title: Herbal extract of  Salicornia species process of preparation thereof, use thereof against tuberculosis.
  Inventors: Rathod MK, Shethia BD, Pandya JB, Ghosh PK, Dodia J, Srivastava BS, Srivastava R, Srivastava A, Chaturvedi V.

Eur Patent No. 1684778                                              
   A novel use of herbal extracts of Salicornia species active against tuberculosis and process for the preparation thereof.
  Inventors : Rathod MK, Shethia BD, Pandya JB, Ghosh PK, Dodia J, Srivastava BS, Srivastava R, Srivastava A, Chaturvedi V.

Australian Patent No. 2003259548                              
   Title: Herbal extracts of Salicornia species process and preparation thereof , use thereof against tuberculosis.
   Inventors: Rathod MK, Shethia BD, Pandya JB, Ghosh PK, Dodia J, Srivastava BS, Srivastava R, Srivastava A, Chaturvedi V.

Patent No. AP/P/2006/003567                                             
 Title: Herbal extracts of Salicornia  species, process of preparation thereof, use thereof against tuberculosis.
Inventors: M R rathod, BD Shethia, JB Pandey, PK Ghosh, PJ Dodia, B S Srivastava, R Srivastava, A Srivastava, CM gupta and V Chaturvedi.

Patent No. AP/P/2006/003567                                             
 Title: Herbal extracts of Salicornia  species, process of preparation thereof, use thereof against tuberculosis.
Inventors: M R rathod, BD Shethia, JB Pandey, PK Ghosh, PJ Dodia, B S Srivastava, R Srivastava, A Srivastava, CM gupta and V Chaturvedi.

The patent has been granted by  the  following five countries,
Kenya, Sudan, Tanzania, Zambia and Zimbawe

Patent No. 2006/02576
Title: A novel use of herbal extracts of Salicornia species active against tuberculosis and process for the preparation thereof.
Inventors: MR Rathod, BD Shethia, J BPandya, PK Ghosh, PJ Dodia, BS Srivastava, R Srivastava, A Srivastava, Chittar CM Gupta & V Chaturvedi.

Patent No. AP2250
Title: Herbal extracts of salicornia species, process of preparation thereof, use thereof against tuberculosis.
Inventors: MR Rathod, BD Shethia, J BPandya, PK Ghosh, PJ Dodia, BS Srivastava, R Srivastava, A Srivastava, Chittar CM Gupta & V Chaturvedi.

Indian Patents

Patent Number: IN200401529-I1
Title: Novel combinatorial library of 3-substituted amino-3-glycosylated propionamides useful as antifungal and antibacterial agents.
Inventors: TRIPATHI R P; SHUKLA P K; SINHA S; SRIVASTAVA R; SRIVASTAVA K K; CHATURVEDI V; SRIVASTAVA A; SRIVASTAVA B S.

Patent Number: IN200402307-I1
Title: Novel N, N-di-glycosylated di-aminoalcohol useful in chemotherapy of tubercular infections.
Inventors: TRIPATHI R P; TIWARI V K; TEWARI N; SRIVASTVA R; SRIVASTAVA A; CHATURVEDI V; SRIVASTAVA K K; SINHA S; SRIVASTAVA B S.

Patent Number: IN200401098-I1
Title: Process for preparation of novel 1,3,5-thiazidine-2-thione.
Inventors: TRIPATHI R P; KATIYAR D; SRIVASTAVA R; SRIVASTAVA A; CHATURVEDI V; SRIVASTAVA B S.

Patent Number: IN200400716-I1
Title: Novel combinatorial library of 3-substituted amino-3-glycosylated propanoates useful as antifungal and antibacterial agents.
Inventors: TRIPATHI R P; KUNDU B; SHUKLA P K; SINHA S; SRIVASTAVA R; SRIVASTAVA K K; CHATURVEDI V; SRIVASTAVA A; SRIVASTAVA B S.

Patent Number: IN200400715-I1
Title: Novel combinatorial library of N1-glycosylated and N2-substituted ureas and thioureas.
Inventors: TRIPATHI R P; TIWARI V K; MISRA R C; SRIVASTAVA R; SRIVASTAVA K K; SRIVASTAVA A; CHATURVEDI V; SINHA S; SRIVASTAVA B S.

Patent Number: IN200401609-I1
Title: Process for preparation of galacto pyranosylated amino alcohols.
Inventors: TRIPATHI R P; TEWARI N; MISHRA R C; SRIVASTAVA R; SINHA S; SRIVASTAVA A; CHATURVEDI V; SRIVASTAVA B S.

Patent Number: IN200401100-I1
Title: Novel 1,3,5-thiazidine-2-thione for treating tuberculosis
Inventors: TRIPATHI R P; KATIYAR D; SRIVASTAVA R; SRIVASTAVA A; CHATURVEDI V; SRIVASTAVA B S.

Patent Number: IN200200999-I1
Title: Novel N',N''-diglycosylated diaminoalcohol combinatorial library useful in chemotherapy of tubercular infections.
Inventors: TRIPATHI R P; TIWARJ V K; TEWARI N; SRIVASTVA R; SRIVASTAVA A; CHATURVEDI V; SINHA S; SRIVASTAVA B S.

Patent Number: IN200200998-I1
Title: Preparation of novel N',N''-diglycosylated diaminoalcohol useful in chemotherapy of tubercular infections.
Inventors: TRIPATHI R P; TIWARJ V K; TEWARI N; SRIVASTVA R; SRIVASTAVA A; CHATURVEDI V; SRIVASTAVA K K; SINHA S; SRIVASTAVA B S.

Patent Number: IN194984-B
Title: A process for the preparation of 3-substituted amino-3-glycosylated propanoates useful as antifungal and antibacterial agents.
Inventors: TRIPATHI R P; KUNDU B; SHUKLA P K; SINHA S; SRIVASTAVA R; SRIVASTAVA K K; CHATURVEDI V; SRIVASTAVA A; SRIVASTAVA B S

Patent Number 242121                                      
   Title: A novel combinatorial library of 3-substitutedamino-3-glycosylatedpropanates, useful as     antifungal and antibacterial agents.
   Inventors: Rama pati tripathi,,Bijoy Kundu, Praveen Kumar shukla,
   Sudhir Sinha, Ranjana Srivastava, Kishore Kumar Srivastava, Vinita Chaturvedi, Anil  Srivastava and Brahm Shankar Srivastava.

Patent Number 227532                                     
Title: A novel use of herbal extracts of Salicornia species active against tuberculosis and process for the preparation thereof.
Inventors: Meena Rajnikanth Rathod, Bhupendra Dhanvantrai Shethia, Jayant Batukrai Pandya, Pushpito Kumar Ghosh, Prakash Jagjivanbhai Dodia, Brahm Shanker Srivastava, Ranjana Srivastava, Anil Srivastava, Chittar Mal Gupta & Vinita Chaturvedi.

Patent Number 199829                                                               
Title: A process for the preparation of novel N1,N,N-diglycosylated diaminoalcohols useful in  chemotherapy of tubercular infections.
Inventors: Rama Pati tripathi, Vinod Kumar Tiwari, Neetu Tiwar, Ranjana Srivastava, Anil Kumar Srivastava, Vinita Chaturvedi, Kishore Kumar Srivastava, Sudhir Sinha and Brahm Shankar Srivastava.