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Manju Y K |
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Sr. Scientist
Microbiology Division
Central Drug Research Institute
LUCKNOW
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| Educational qualifications |
M. Sc (University of Calicut, Kerala), Ph. D (RGCB, Thiruvanathapuram |
| E mail |
[email protected] |
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| POST-DOCTORAL
EXPERIENCE |
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Dept. of Pathobiological Sciences, School of Vet Med, University of Wisconsin-Madison, WI, USA (July 2007-May 2009) |
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| RESEARCH
SPECIALIZATION |
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Cellular and molecular microbiology of tuberculosis, anti-tubercular drug discovery |
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| CURRENT AREA
OF RESEARCH |
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Host-pathogen interactions during long term persistence of M. tuberculosis with special focus on the role of non-immune cells |
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Identification of crucial enzymes of M. tuberculosis essential for survival on host derived lipids and validation of potential drug targets |
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Characterization of M. tuberculosis genes associated to persistence during anti-TB treatment |
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Targeting ATP synthesis in M. tuberculosis to identify novel inhibitors |
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| Lab Members |
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Ms.Shivangi Rastogi (SRF)
Mr. Shaheb Raj Khan (SRF)
Mr. Gyan Chandra(JRF)
Ms.Suman Bharti(JRF)
Mr. V. Umamageswaran [Tech. asst. Grp III(1)]
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| SELECTED
PUBLICATIONS |
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Kalia D, KSAK, Meena G, Sethi KP, Sharma R, Trivedi P, Khan SR, Verma AS, Singh S, Sharma S, Roy KK, Kant R, Krishnan MY, Singh BN, Sinha S, Chaturvedi V, Saxena AK, Dikshit DK (2015). Synthesis and anti-tubercular activity of conformationally-constrained and bisquinoline analogs of TMC207. MedChemComm 6:1554–1563. |
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Shukla H, Kumar V, Singh AK, Rastogi S, Khan SR, Siddiqi MI, Krishnan MY, Akhtar MS (2015). Isocitrate lyase of Mycobacterium tuberculosis is inhibited by quercetin through binding at N-terminus. Int J Biol Macromol 78:137-141. |
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Shukla H, Kumar V, Singh AK, Singh N, Kashif M, Siddiqi MI, Yasoda Krishnan MY, Sohail Akhtar M ( 2015). Insight into the structural flexibility and function of Mycobacterium tuberculosis isocitrate lyase. Biochimie 110:73-80. |
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Singh S, Roy KK, Khan SR, Kashyap VK, Sharma A, Jaiswal S, Sharma SK, Krishnan MY, Chaturvedi V, Lal J, Sinha S, Gupta AD, Srivastava R, Saxena AK (2015). Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis. Bioorg Med Chem 23:742-752. |
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Agarwal P, Khan SR, Verma SC, Beg M, Singh K, Mitra K, Gaikwad AN, Akhtar MS, Krishnan MY (2014). Mycobacterium tuberculosis persistence in various adipose depots of infected mice and the effect of anti-tubercular therapy. Microbes Infect 16:571-580. |
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Verma SC, Venugopal U, Khan SR, Akhtar MS, Krishnan MY (2014). Coupling reporter expression to respiration detects active as well as dormant mycobacteria in vitro and in mouse tissues. Int J Mycobacteriol 3: 25-35. |
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Khan SR, Singh S, Roy KK, Akhtar MS, Saxena AK, Krishnan MY (2013). Biological evaluation of novel substituted chloroquinolines targeting mycobacterial ATP synthase. Int J Antimicrob Agents., 41(1):41-6. |
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Dubuisson T, Bogatcheva E, Krishnan MY, Collins MT, Einck L, Nacy CA, and Reddy VM (2010). In vitro antimicrobial activities of capuramycin analogues against non-tuberculous mycobacteria. J Antimicrob Chemother., 65(12):2590-7. |
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Krishnan MY, Manning EJB and Collins MT (2009). Effects of interactions of antibacterial drugs with each other and with 6-mercaptopurine on in vitro growth of Mycobacterium avium subspecies paratuberculosis. J Antimicrob Chemother., 64(5):1018-23. |
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Krishnan MY, Manning EJB and Collins MT (2009). Comparison of three methods for susceptibility testing of Mycobacterium avium subsp. paratuberculosis to 11 antimicrobial drugs. J Antimicrob Chemother., 64(2), 310-316. |
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Krishnan MY, Manning EJB and Collins MT (2009). Stability of antibacterial agents in MGIT (TM) Para TB Medium. Int J Antimicrob Agents, 33(2): 186-7. |
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Sharma M, Chaturvedi V, Manju YK, Bhatnagar S, Srivastava K, Puri SK, Chauhan PM (2009). Substituted quinolinyl chalcones and quinolinyl pyrimidines as a new class of anti-infective agents. Eur J Med Chem 44(5):2081-91. |
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Parai MK, Panda G, Chaturvedi V, Manju YK, Sinha S (2008). Thiophene containing triarylmethanes as antitubercular agents. Bioorg Med Chem Lett 18(1):289-92. |
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Krishnan MY, Radhakrishnan I, Joseph BV, Madhavilata GK, Kumar A and Mundayoor S (2007). Combined use of amplified fragment length polymorphism and IS6110-RFLP in fingerprinting clinical isolates of Mycobacterium tuberculosis from Kerala, South India. BMC Infect Dis.,7:86. |
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Das SK, Panda G, Chaturvedi V, Manju YK, Gaikwad AK, Sinha S (2007). Design, synthesis and antitubercular activity of diarylmethyinaphthol derivatives. Bioorg Med Chem Lett 17(20):5586-9. |
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Panda G, Parai MK, Das SK, shagufta, Sinha M, Chaturvedi V, Srivastava AK, Manju YK,Gaikwad AN and Sinha S (2007). Effect of substituents on diarylmethanes for antitubercular activity. Eur J Med Chem. 42(3):410-419. |
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Tripathi RP, Saxena N, Tiwari VK, Verma SS, Chaturvedi V,Manju YK, Srivastava AK, Gaikwad A, Sinha S (2006). Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines. Bioorg Med Chem. 14(24):8186-96 |
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Tripathi RP, Verma SS, Pandey J, Agarwal KC, Chaturvedi V, Manju YK, Srivastava AK, Gaikwad A,Sinha S (2006). Search of antitubercular activities in tetrahydroacridines: Synthesis and biological evaluation. Bioorg Med Chem Lett. 16(19):5144-47 |
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Dwivedi, N, Tewari N, Tiwari VK, Chaturvedi V, Manju YK, Srivastava A, Gaikwad, A, Sinha S., Tripathi RP (2005). An efficient synthesis of aryloxyphenyl cyclopropyl methanones: a new class of anti-mycobacterial agents. Bioorg Med Chem Lett. 15(20): 4526-30. |
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Tripathi RP., Tiwari, VK, Tewari N, Katiyar D, Saxena N, Sinha S, Gaikwad A, Srivastava A, Chaturvedi V, Manju YK, Srivastava R, Srivastava BS (2005). Synthesis and antitubercular activities of bis-glycosylated diamino alcohols. Bioorg. Med Chem 13 (19); 5668-79 |
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Radhakrishnan I, Manju YK, Kumar RA, Mundayoor S (2001). Implications of low frequency of IS6110 in fingerprinting field isolates of Mycobacterium tuberculosis from Kerala, India. J Clin Microbiol. 39(4):1683. |
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