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CARDIOVASCULAR,
CENTRAL NERVOUS SYSTEM & OTHER
DISORDERS |
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CENTRAL
NERVOUS SYSTEM |
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| Team:
S Singh, S Bhadauria, A Nazir, K Hanif, R
Shukla, C Nath, G Palit, R Pratap, R Maurya,
AK Saxena |
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Anti-anxiety,
anti-depressant and anti-psychotic activity
(Team: G Palit)
Various models of anxiety, depression and
schizophrenia in rodents are being used/
developed to explore the behavioural, neurochemical,
hormonal and molecular aspects. Crude extracts
from plants and compounds isolated from
them are primarily evaluated for their respective
activity.
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| Animal models
and in vitro screening |
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Gross behavior: Locomotor
activity, rotarod test |
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Anti
anxiety: Elevated Plus maze |
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Anti-depressant:
Tail suspension and forced swim test |
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NMDA
receptor modulated animal model of Schizophrenia
(under development) |
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| Papers
published |
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Misra
UK, Kumar S, Kalita J, Ahmad A, V. K. Khanna,
M.Y.Khan, G.Palit. A study of motor activity
and catecholamine levels in different brain
regions following Japanese encephalitis virus
infection in rats. Brain Res 2009 (In press).
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K.V,Kumar,
D.R.Krishna, Palit,G. Histaminergic H1 receptors
mediated L-histidine- induced anxiety in elevated
plus- maze test in mice. Behavioural Pharmacology.
18:213-218, 2007. |
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Kalita,J.,
Kumar,S., Kuchibhotla.V,K., Palit,G., Misra,U.K.
A study of CSF catecholamine and its metabolites
in acute and convalescent period of encephalitis.
J Neurol Sci. 232: 24-28, 2007. |
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| DEMENTIA |
(Team:
K Hanif, A Nazir, R Shukla, R Pratap, C
Nath) |
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| Team:
K Hanif, A Nazir, R Shukla, R Pratap, C Nath |
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| Ever
since Gugulipid was licensed to industry for
lipid lowering activity, we continued our
research with Gugulipid for life style diseases
and recently discovered a new utility as anti-dementia
profile and have secured patent rights for
the discovery [US Patent 6896901, 2005]. |
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| Animal models
and in vitro screening |
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Cholinergic
deficits : Scoploamine muscarinic antagonist,
reversible effects |
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Cholinergic
deficits : Scoploamine muscarinic antagonist,
reversible effects |
These animal models are
tested for deficits in learning and memory
functions by various tests.
Passive Avoidance test
Morris Water Maze test
Ex vivo biochemical studies: Acetylcholinesterase
activity (In different brain regions)
Oxidative stress (GSH, MDA)
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Anti-amyloid
activity: C. elegans |
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| Product
in Pipeline |
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Bacopa monniera
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Evolvulus
alsinoides |
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Gugulipid
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Standardized
extract of Bacopa monniera (Bacosides 50-60%)
develped at CDRI as memory enhancer |
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Bacosides
A & B (Bacoside A is a mixture of 3 triterpenoid
saponins bacogenin A1, A2 and A3) |
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| Papers
published |
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Das
A, Dikshit M, Nath C, Role of Molecular Isoforms
of Acetylcholinesterase in Learning and Memory
Functions. Pharmacol Biochem Behav. 2005,
81: 89-99 |
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Saxena
G, Singh SP, Agrawal R, Nath C, Effect of
donepezil and tacrine on oxidative stress
in intracerebral streptozotocin induced model
of dementia in mice. Eur J Pharmacol, 2008,
581: 283-289. |
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Saxena
G, Singh SP, Pal R, Singh S, Pratap R, Nath
C, Gugulipid, an extract of Commiphora whighitii
with lipid-lowering properties, has protective
effects against Streptozotocin-induced memory
deficits in mice. Pharmacol Biochem Behav,
2007, 8: 797-805 |
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US Patent
# 6896901 ; Euopean patent #1224938 |
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website
copyright © Central Drug Research Institute.
All rights reserved.
No part of this should be Downloaded or used
in any way other than the non-commercial purposes
without prior permission of the Director,
CDRI. |
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Set rsHits=Server.CreateObject("ADODB.Recordset")
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session("iNumber")=rsHits("visits") + 1
rsHits("visits")=rsHits("visits") + 1
rsHits.Update
rsHits.Close
set rsHits=Nothing
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''''
Function ConstructDigits(iValue)
'This function accepts a single parameter, iValue, and
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''''
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