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| MALARIA |
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OBJECTIVE
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Development of new blood
schizontocidal antimalarials / drug combinations
for control of drug resistant parasites,
development of new safer Gametocytocidal,
Prophylactic and Anti-relapse agents, harnessing
of malaria parasite genome for identification
of new drug targets, molecular mechanism
of drug action, biochemical markers for
characterization of resistant parasites,
evaluation of immuno-prophylactic agents,
development of newer in vitro assay / tests
for parasiticidal activity
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| ONGOING RESEARCH
PROGRAMME |
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Chemotherapy of
Malaria
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Identification of New
Lead Molecules and preclinical development |
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Arteether suppository
formulations |
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Combination Chemotherapy |
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| Immunology
of Malaria |
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Immunoprophylactic
trials with recombinant proteins |
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| Biochemistry
of Malaria |
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Heme induced
oxidative stress |
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| Molecular
biology of Malaria |
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Analysis of
apicoplast genome |
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| SCIENTISTS
ASSOCIATED WITH THE PROJECT |
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| RESEARCH
FACILITIES |
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In vitro
screening against P. falciparum
strains |
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In vivo
screening for blood schizontocidal,
causal prophylactic and gametocytocidal
activities in rodent malaria models |
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Dose response
studies for blood schizontocidal, causal
prophylactic anti- relapse and gametocytocidal
activities in simian malaria models. |
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Models to
study drug response in combination |
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No part of this should be Downloaded or used
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CDRI. |
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