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  MALARIA
 

OBJECTIVE
 
Development of new blood schizontocidal antimalarials / drug combinations for control of drug resistant parasites, development of new safer Gametocytocidal, Prophylactic and Anti-relapse agents, harnessing of malaria parasite genome for identification of new drug targets, molecular mechanism of drug action, biochemical markers for characterization of resistant parasites, evaluation of immuno-prophylactic agents, development of newer in vitro assay / tests for parasiticidal activity
 
ONGOING RESEARCH PROGRAMME
 

Chemotherapy of Malaria

•
 Identification of New Lead Molecules and preclinical development
•
 Arteether suppository formulations
•
 Combination Chemotherapy
Immunology of Malaria
•
 Immunoprophylactic trials with recombinant proteins
Biochemistry of Malaria
•
 Heme induced oxidative stress
Molecular biology of Malaria
•
 Analysis of apicoplast genome
 
SCIENTISTS ASSOCIATED WITH THE PROJECT
 
•
 Dr S. K. Puri
•
 Dr. Bijoy Kundu
•
 Dr. R. P. Tripathi
•
 Dr. Yenamandra S. Prabhakar
•
 Dr. Saman Habib
•
 Dr P.M. S Chauhan
•
 Dr Kumkum Srivastava
•
 Dr Renu Tripathi
•
 Mr Raja Kumar
 
 
 
RESEARCH FACILITIES
 
•
 In vitro screening against P. falciparum strains
•
 In vivo screening for blood schizontocidal, causal prophylactic and gametocytocidal activities in rodent malaria models
•
 Dose response studies for blood schizontocidal, causal prophylactic anti- relapse and gametocytocidal activities in simian malaria models.
•
 Models to study drug response in combination
 
 
 
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