| MICROBIAL
INFECTION |
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OBJECTIVE
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| The objective of
the project area cover the development of
vaccines for cholera and tuberculosis, development
of rapid molecular screens for drug screening,
screening of synthetic compounds and natural
products for antituberculosis, antifungal
and antibacterial activity, development of
diagnostics for tuberculosis infection, construction
of mycobacterial vectors, novel antigens and
drug targets, identification of genes and
proteins expressed during in vivo infection
and persistence in mycobacteria, basic studies
on mycobacterial, bacterial and HIV proteins
and virulence genes. Survival strategy of
pathogenic bacteria in different ecological
niches. |
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Cholera
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Vaccine
development |
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•
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Basic
studies |
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| Tuberculosis |
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Screening
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Diagnosis |
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Molecular
studies and Cellular Immunology |
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•
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Identification
of mycobacterial genes induced during
physiological stress/latency |
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| Fungal
Infections |
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| Viral
infections |
| |
| SCIENTISTS
ASSOCIATED WITH THE PROJECT |
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| FACILITIES
AVAILABLE |
| |
| Cloning and expression
in prokaryotes. |
| Facilities for
ultra and high speed centrifugation |
| Protein purification |
| Tissue culture
facility. |
| DNA sequencing
facility (central) |
| Microarray facility
(central) |
| Proteome facility
(central) |
| BACTEC |
| Luminometer, Fluorimeter
and Spectrophotometer |
| Electrophoretic
separation of nucleic acids and proteins. |
| Screening of anti-tubercular,
anti-microbial and anti-fungal compounds in
vitro, |
| ex-vivo and in
vivo. |
| Antibodies and
cytokine assays. |
| Synthesis of new
chemical entities (NCE) |
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