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| Diagnostic
Vaccine |
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PCR-based diagnostic probe for
leishmaniasis |
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A
probe for early detection of visceral
leishmaniasis has been developed
by using a pair of oligonucleotide
primers constructed from predominant
sequence class of kinetoplast
DNA minicircle of Leishmania donovani.
Indian patent has been filed for
the technology. |
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Direct agglutination test (DAT)
for leishmaniasis |
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A
sensitive, specific (98%) and
inexpensive assay for diagnosis
of visceral leishmaniasis has
been developed and validated in
sera of over 3,000 human subjects
from endemic and non-endemic areas
and can be performed on very small
quantities of blood. This is the
first global introduction of a
simple and reliable test developed
for the early diagnosis of kala-azar.
The application potential of DAT
test has been increased with the
preparation of freeze-dried antigen.
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LDH-based diagnosis of malaria
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This
comprises an immunodot enzyme
staining test, employing anti-LDH
polyclonal antibodies for the
diagnosis of malaria. The test
is highly specific and sensitive.
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PCR based diagnostic probe for
tuberculosis |
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A
novel DNA fragment of M. tuberculosis
useful in early diagnosis of tuberculosis
coupled with PCR technology has
been developed. Indian patent
has been filed. |
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Lipoprotein |
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A potential marker of coronary
heart disease and atherosclerosis
Clinical significance of serum
lipoprotein Lp(a), a cholesterol
rich protein, in determining degree
of risk of coronary heart disease
(CHD) has been established. Serum
Lp(a) concentration of 10mg/dl
or more has been demonstrated
as a potential risk marker in
the Indian population. The assay
will be a potential risk marker
in the Indian population. The
assay will be useful in the diagnosis
of human subjects at a higher
risk of CHD. |
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Cholera
Vaccine |
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The
role of plasmid in the regulation
of toxin biosynthesis, virulence
factors, novel adhesive and colonisation
factors of Vibrio cholerae have
been demonstrated. A new subunit
vaccine based on these colonisation
antigens is being developed.
An anti-leprosy vaccine developed
using Mycobacterium habana antigen
could not be taken to phase II
and III trials because other two
anti-leprosy vaccines developed
in the country were showing equally
promising protection. The same
strain of M. habana is being evaluated
as anti-TB vaccine, as an alternative
to BCG. |
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Email : drcmg[at]satyam Dot net Dot in
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website
copyright © Central Drug Research Institute.
All rights reserved.
No part of this should be Downloaded or used
in any way other than the non-commercial purposes
without prior permission of the Director,
CDRI. |
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<%
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'conn.open mydsn
Dim rsHits
Set rsHits=Server.CreateObject("ADODB.Recordset")
rsHits.CursorLocation=adUseClient
rsHits.Open "Select visits from Hits", conn, adOpenKeyset, adLockOptimistic
session("iNumber")=rsHits("visits") + 1
rsHits("visits")=rsHits("visits") + 1
rsHits.Update
rsHits.Close
set rsHits=Nothing
end if
If Len(session("iNumber")) > 0 then
'Display iNumber
Response.Write "" & ConstructDigits(session("iNumber")) & ""
End If
''''
Function ConstructDigits(iValue)
'This function accepts a single parameter, iValue, and
'returns HTML containing a series of images representing
'a graphical image of the value in iValue
'Start by ensuring iValue is a number
If Not IsNumeric(iValue) then
ConstructDigits = iValue & " IS NOT A NUMBER!"
Exit Function
End If
'Can't show decimals!
If InStr(1, iValue, ".") then
ConstructDigits = "CANNOT CONTAIN DECIMALS!"
Exit Function
End If
'Can't show negative numbers!
If iValue < 0 then
ConstructDigits = "CANNOT DISPLAY NEGATIVE NUMBERS!"
Exit Function
End If
Dim iLoop, strResults
For iLoop = (Len(iValue) - 1) to 0 STEP -1
strResults = strResults & ""
Next
ConstructDigits = strResults
End Function
''''
%>
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