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| DR.
RAVI S AMPAPATHI |
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Asst. Professor (AcSIR), Senior Scientist & In charge,
Centre for Nuclear Magnetic Resonance,
Divn. of Sophisticated Analytical Instrument Facility
CSIR-Central Drug Research Institute
Lucknow-226031, U.P., India.
Phone: +91-522-+91-0522-2772450, Ext: 4618 (NMR); 4813(Wet Lab)
Mobile: +91-789-704-5555
web page:www.cdriindia.org/rsampapathy.htm
Google Scholar:http://scholar.google.co.in/citations?user=mzVeI-4AAAAJ&hl;=en
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| EDUCATION
& AWARDS |
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Ph.D.
(Chemistry) Osmania University (2004) (Work carried
out at IICT, Hyderabad) |
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M.Sc.,(Chemistry)
Sri Krishna Devaraya University (1998). |
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Long term visitor
CERM, Florence, Italy (2002) |
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Pharmacoinformatics
Fellow Gulf Coast region, Texas, U.S.A. (2005)
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EMPOWER (Encouraging and Motivating Pursuit of World Class Exploratory Research) research grant by Council of Scientific and Industrial Research (CSIR) New Delhi. (2010)
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CDRI Incentive Awards for excellent research work for the years 2012, 2013.
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| POST-DOCTORAL
RESEARCH |
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Postdocotoral
Fellow, University of Houston, TX, U.S.A., 2004-2007 |
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Visiting
Fellow, National Cancer Institute, Frederick,
MD, U.S.A.2007-2009 |
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| RESEARCH
GROUP |
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Pancham Singh
Kandiyal (JRF)
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Design, Conformational studies of linear and cyclic sugar amino acid (SAA) foldamers,
Beta - Homoproline. |
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Studies involving
Beta- peptides as inhibitors for protein-protein interaction. |
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Shrikant Sharma (CSIR-SRF)
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Conformational studies of cyclic peptides with a3b and a3g architecture. |
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Solution structural analysis of SIX3-protein and its mutants involved in Holoprosencephaly. |
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Gajendra Singh (CSIR-JRF)
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Conformational studies of cyclic deca and tetrapeptides. |
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Studies on structural variations of Enzymatic domain of bacterial toxins by in-cell NMR. |
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Solution structure studies on DNA binding protein and its interaction with DNA. |
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Faiyaz Alam (ICMR-JRF)
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Conformational studies of linear Gramicidin-S analogous peptide in solution and membrane mimicking media. |
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Structural and conformational analysis of BRCT domain from Mycobacterium tuberculosis NAD dependent DNA ligase using solution NMR. |
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| RESEARCH
AREAS |
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Structure-Function
studies of proteins by NMR, CD and other Biophysical techniques. |
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Insitu protein folding followed by incell NMR. |
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Design, synthesis and conformational analysis of bio-active Peptides and Peptidomimetics. |
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| CURRENT
RESEARCH PROGRAMS |
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Structure-function
studies of bacterial toxin proteins |
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NMR Based screening of
ligands with the receptor targets |
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Conformational
Studies of Peptides & Peptidomimetics |
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| SELECTED
PUBLICATIONS |
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“Furan based Locked Z-Vinylogous γ-Amino Acid Stabilizing α-Turn in Water-Soluble Cyclic α3γ Tetrapeptides. Yarkali Krishna, Shrikant Sharma, Ravi Sankar Ampapathi,* Dipankar Koley.* Organic Letters, 2014 (DOI: 10.1021/ol5002126) |
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“Trifluoroacetic Acid-Catalyzed Domino Reaction for Amino Acids Derived 2,3-Dihydro-1H-1,5-benzodiazepines Cyclic tetra peptides. Saurav Bera, Pancham S. Kandiyal, Ravi Sankar Ampapathi and Gautam Panda* SynLett, 2014, 25, A-F, (DOI: 10.1055/s-0033-1340837) |
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“Peptidomimetics with tunable tertiary amide bond containing substituted -proline and beta-homoproline. Sandip Basu, Pancham S Kandiyal, Venkata Suresh Kumar Neelamraju, Harjinder Singh,* Ravi Sankar Ampapathi,* Tushar kanti Chakraborty.*Tetrahedron, 70, 1169-1175, 2014; (2014). |
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“Sugar-Modified Foldamers as Conformationally Defined and Biologically Distinct Glycopeptide Mimics. Aloysius Siriwardena,* Kiran Kumar Pulukuri, Pancham S Kandiyal, Saumya Roy, Omprakash Bande, Subhash Ghosh, José Manuel Garcia Fernández, Fernando Ariel Martin, Jean-Marc Ghigo, Christophe Beloin, Keigo Ito, Robert J Woods, Ravi Sankar Ampapathi,* Tushar Kanti Chakraborty.* Angew. Chem. Int. Ed., 52, 10221-10226 (2013). |
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“Ti(III)-mediated radical cyclization of epoxy-β-aminoacrylate in the synthesis of the substituted pyrrolidine core of necine bases: synthesis of 2-epi-rosmarinecine. Sandip Basu, Pancham S. Kandiyal, Ravi Sankar Ampapathi, Tushar Kanti Chakraborty.* RSC Advances, 3, 13630-13634 (2013). |
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“Total synthesis of 29S,37(S)-isomer of malevamide E, a potent ion-channel inhibitor. Gajula PK, Sharma S, Ravi Sankar Ampapathi and Tushar K. Chakraborty* Org. Biomol. Chem., 11, 257-260 (2012).(Cover page article) |
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“Diversity Oriented Synthesis of Pyran Based Polyfunctional Stereogenic Macrocyles and Their Conformational Studies. Ajay A,Sharma S, Gupt MP, Bajpai V, Kumar B, Kaushik MP, Konwar Ravi Sankar Ampapathi* and Rama P. Tripathi* Organic Letters, 14, 4306-4309 (2012). |
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“ Robust turn structures in alpha3beta cyclic tetrapeptides induced and controlled by Carbo-beta3 Amino acid. Anindra Sharma, Shrikant Sharma, Rama P. Tripathi,* Ravi Sankar Ampapathi
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“Stereoselective construction of quaternary chiral centers using Ti(III)-mediated opening of 2,3-epoxy alcohols: studies directed toward the synthesis of penifulvins.” T. K. Chakraborty,* A.K. Chattopadhyay, R. Samanta, Ravi S. Ampapathi. Tetrahedron letters, 51, 4425-4428 (2010). |
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