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| GUGULIPID
(Hypolipidaemic) |
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Gugulipid
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| CDRI has developed gugulipid,
a cholesterol lowering drug taking the
lead from ancient Indian system of medicine,
Ayurveda. The Drug has been developed
from the plant, Commiphora mukul.
Ayurvedic Practitioners have been
utilizing the gum of the tree of
Commiphora mukul commonly known
as "Gugglu".
Ayurvedic literature also mentions
the gugglu as a drug for the treatment
of goutt, arthritis, rheumatism and
lipid disorders.
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The establishment of promising hypolipidaemic
activity in a non-toxic fraction of guggulu
led to the identification of the active
constituents, gugulsterones. However,
as the fraction was equally active as
the individual active entities, this fraction
designated Gugulipid has been developed
as a drug. Gugulipid passed through all
the three phases of clinical trials successfully
and was found to possess hypolipidaemic
activity comparable to the present drug
of choice, Clofibrate.
Clinical trials conducted on a large number
of patients have clearly indicated the
supremacy of gugulipid over other drugs
due to absence of any significant side
effect. The cholesterol lowering effect
is also quite remarkable
The use of Gugulipid led to the average
reduction in serum cholesterol and triglycerides
by 24% and 22% respectively and there
were 80% responders in a group of 330
hyperlipidemic patients. As clofibrate
is on the verge of being phased out on
account of toxic manifestations, there
is a scope for introduction of Gugulipid
at international level. The future of
this material as a drug will, however,
depend on the availability of the plant
material.
Drug controller General of India, after
the three phases of clinical trials approved
the drug for marketing in 1986.
Guggulipid is being manuactured and marketed
by Cipla Ltd,
Mumbai under the brand name
Guglip.
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copyright © Central Drug Research Institute.
All rights reserved.
No part of this should be Downloaded or used
in any way other than the non-commercial purposes
without prior permission of the Director,
CDRI. |
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