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  COMBINATORIAL CHEMISTRY
 
Combinatorial chemistry has emerged as a powerful tool for accelerating drug discovery process. Compared to traditional drug discovery approach, which requires many days of work to synthesize and analyze a single new compound, combinatorial chemistry can produce and screen thousands of compounds in weeks
for the discovery of novel drug entities against various disease targets. The continuous development of high throughput bioassay screening formats coupled with human genomics as a potential source of new biological targets, has created an acute need for a large number of structurally diverse molecules.
Significant Achievement with Respect to Publication of papers and patents filed.. Click more..
 
 OBJECTIVES
   
Synthesis of libraries based on lead molecules
Synthesis of libraries based on heterocyclic structures
Syntheses of libraries based on drug-like structures
Synthesis of libraries based on natural- product like structures
Synthesis of libraries based on novel structures
Synthesis of peptide libraries
Automated multiple organic synthesizer with 7 robotic pipettes.
 
Automated multiple organic synthesizer with 2 robotic pipettes.
 METHODOLOGY
   
Functional group transformation
Multicomponent reactions
Scaffold/template derivatisation
Cyclative cleavage
Macrocyclization/cyclization
Bicyclic ring formation reaction
Mixture based libraries of peptides
Disulfide bridge formation of peptides
 
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